Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 59, Issue 16, Pages 8895-8900Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf200678q
Keywords
oat products; type II diabetes mellitus; hypoglycemic effects; hypoglycemic mechanism
Funding
- earmarked fund for China Agriculture Research System [CARS-08-D1]
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Oat products are abundant in beta-glucan, which could lower the glycemic index of products or foods. A low glycemic index is beneficial in the control of postprandial glycemia. The study examined the hypoglycemic effects of oat products that had the same percentage of oat beta-glucan and were added into the diet fed to streptozotocin-induced diabetic mice for 6 weeks, and potential mechanisms are discussed here. Oat products significantly decreased fasting blood glucose and glycosylated serum protein (p < 0.05), but the hypoglycemic effect was not more than that of metformin (p > 0.05). Oat products increased glycogen, hormone, and nuclear receptor levels (p < 0.05), decreased free fatty acid content and succinate dehydrogenase activity (p < 0.05), and inhibited pancreatic apoptosis (p < 0.05). The results showed oat products had hypoglycemic effects. Hypoglycemic effects of oat products might be regulating glucose and fat metabolisms, stimulating hormone secretion, activating the nuclear receptor, and protecting organ function.
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