Article
Biochemistry & Molecular Biology
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Maria Leonia da Costa Gonzaga, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Renata Ferreira de Carvalho Leita, Maria Elenir Nobre Pinho Ribeiro
Summary: This study investigated the potential of polysaccharides from Agaricus blazei Murill mushroom (PAbs) as wound dressings. The results showed that PAbs had no significant impact on the viability of human neutrophils in a concentration range of 1-100 μg mL-1. Moreover, PAbs improved the mechanical properties, thickness, and water vapor permeation of the films, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Matheus da Silva Campelo, Cecilia Brilhante Araga, Izabell Maria Martins Teixeira, Erlania Alves de Siqueira, Carlos Jose Alves da Silva-Filho, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Cristiani Lopes Capistrano Goncalves de Oliveira, Celli Rodrigues Muniz, Francisco Geraldo Barbosa, Jair Mafezoli, Tiago Lima Sampaio, Maria Elenir Nobre Pinho Ribeiro
Summary: Pentacyclic triterpene-loaded emulsions were stabilized using polysaccharides from Agaricus blazei Murill mushroom (PAb). Compatibility tests showed no physicochemical incompatibilities between the drug and excipient. The addition of PAb at 0.75% resulted in stable emulsions with small droplet size, moderate polydispersity, and high zeta-potential. Encapsulation of the drug in PAb-stabilized emulsions improved its cytocompatibility against PC12 and murine astrocyte cells, reducing cytotoxicity and maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Wenshuai Wang, Min Liu, Mengyu Zhang, Wenxue Sun, Jianjun Zhang, Le Jia
Summary: The study evaluated the protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung in MODS mice induced by zymosan. Results showed that ABMP improved the survival rate, alleviated abnormal physiological behavior, and reduced tissue oxidative stress in MODS mice. Additionally, ABMP inhibited the activation of NF-kappa B signaling pathway and decreased the expressions of inflammatory cytokines.
Article
Plant Sciences
Joao Francisco Camara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, Joao Antonio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Juliao Zocolo, Icaro Gusmao Pinto Vieira, Nagila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to characterize the chemical profile of Agaricus blazei Murill extract and evaluate its gastroprotective effect. The results showed that the extract had antioxidant activity and could protect the gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Food Science & Technology
Kaiyuan Huang, Hesham R. El-Seedi, Baojun Xu
Summary: This study comprehensively summarizes the chemical composition of Agaricus blazei Murrill (AbM) and thoroughly characterizes its health promotion effects such as antitumor and antidiabetic impacts. AbM is composed of abundant bioactive substances including polysaccharides, lipids, proteins, and vitamins. Research has shown that AbM polysaccharides have immunoregulation, anti-inflammatory, hepato-protective, and antitumor functions. Furthermore, AbM extracts are believed to have potential in treating diabetes and bacterial infections, as well as exhibiting anticarcinogenic and antimutagenic functions. However, some of the mechanisms behind these health promotion effects remain unclear, and there is a need for further clinical trials.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yanping Zhao, Nana Tian, Hongjun Wang, Hong Yan
Summary: Sulfated modifications of Agaricus blazei Murill (AbM) polysaccharides have shown strong anti-HIV properties, making them promising candidates for biomedical applications in HIV/AIDS treatment.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Physical
Thiago Magalhaes Farias Menezes, Matheus da Silva Campelo, Ana Beatriz Nogueira Lima, Joao Francisco Camara Neto, Matheus Morais Saraiva, Joao Antonio Costa de Sousa, Maria Leonia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria Elenir Nobre Pinho Ribeiro, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares
Summary: This study evaluated the effects of polysaccharides from Lentinus edodes Berk and Agaricus blazei Murill mushrooms on the gelation process of the Pluronic (R) F127 copolymer. The results showed that these polysaccharides have good rheological properties and potential for pharmaceutical formulation development.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Endocrinology & Metabolism
Anthony L. McCall, David C. Lieb, Roma Gianchandani, Heidemarie MacMaster, Gregory A. Maynard, M. Hassan Murad, Elizabeth Seaquist, Joseph Wolfsdorf, Robin Fein Wright, Wojtek Wiercioch
Summary: This study reviewed and updated the management of hypoglycemia in people with diabetes, aiming to reduce and prevent it. A multidisciplinary panel of experts identified 10 clinical questions and made 10 recommendations. These recommendations can be used to inform clinical practice and improve healthcare systems, as hypoglycemia is an important complication for people with diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Richa Garg, Roshan Katekar, Shahid Parwez, Arun Agarwal, Sudhanshu Sahu, Shailesh Dadge, Saurabh Verma, Umesh K. Goand, Mohammad Imran Siddiqi, Jiaur R. Gayen
Summary: The PST inhibitor PSTi8 has been found to improve diabetes by enhancing skeletal muscle glucose disposal and reducing hepatic gluconeogenesis, as well as lowering plasma PST levels. These findings provide a new approach for the treatment of diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Critical Care Medicine
Yasmine Ali Abdelhamid, Alan Bernjak, Liza K. Phillips, Matthew J. Summers, Luke M. Weinel, Kylie Lange, Elaine Chow, Palash Kar, Michael Horowitz, Simon Heller, Adam M. Deane
Summary: Hypoglycemia is common in ICU survivors with type-2 diabetes, especially during the night, and is often asymptomatic and prolonged. While hypoglycemia was associated with an increased risk of bradycardia, it did not impact atrial or ventricular ectopics, heart rate variability, or cardiac repolarization.
CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xuan Hu, Xueming Liu, Yujiao Guo, Yi Li, Zhengfeng Cao, Yu Zhang, Yang Zhang, Guohong Chen, Qi Xu
Summary: The effects of chicken serum metabolite treatment on blood glucose control and inflammatory response in STZ-induced T2DM rats were investigated. DL-arginine was identified as a potential marker for chronic hyperglycemia in chickens, and its function in blood glucose control and inflammation suppression was evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Matheus da Silva Campelo, Lucas Barroso Mota, Joao Francisco Camara Neto, Maria Lucianny Lima Barbosa, Maria Leonia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to develop and evaluate the wound healing activity of films based on sodium alginate, polyvinyl alcohol, and Agaricus blazei extract. The films showed promising water vapor barrier properties and enhanced antioxidant and tissue repairing capabilities for wound healing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Review
Endocrinology & Metabolism
Afif Nakhleh, Naim Shehadeh
Summary: Hypoglycemia is a common complication in diabetes patients, with impairments in counterregulatory responses and hypoglycemia unawareness as main risk factors for severe episodes. Hypoglycemia is associated with physical and psychological morbidity, and fear of hypoglycemia can hinder glycemic control in patients.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Aika Miya, Akinobu Nakamura, Takahisa Handa, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Hideaki Miyoshi, Tatsuya Atsumi
Summary: The study identified a CV of 40 as the threshold that distinguishes unstable glucose variability and hypoglycemia from stable GV in Japanese outpatients with type 2 diabetes. Impaired insulin secretion might affect the stability of glucose variability.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Cell Biology
Hitoshi Watanabe, Wen Du, Jinsook Son, Lina Sui, Shun-ichiro Asahara, Irwin J. Kurland, Taiyi Kuo, Takumi Kitamoto, Yasutaka Miyachi, Rafael de Cabo, Domenico Accili
Summary: Sulfonylureas are effective and affordable antidiabetic drugs, but chronic use leads to secondary failure. Cytochrome b5 reductase 3 (Cyb5r3) down-regulation is identified as a mechanism of secondary SU failure and can be successfully reversed. Cyb5r3 activators can rescue secondary SU failure and potentially rehabilitate SU use in diabetes.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kyungho Kim, Hyun Ju Do, Tae Woo Oh, Kwang-Youn Kim, Tae Hoon Kim, Jin Yel Ma, Kwang-Il Park
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Integrative & Complementary Medicine
Kwang-Youn Kim, Tae-Woo Oh, Hye-Jin Yang, Young-Woo Kim, Jin-Yeul Ma, Kwang-Il Park
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Cell Biology
Hyun Ju Do, Tae Woo Oh, Kwang-Il Park
MEDIATORS OF INFLAMMATION
(2019)
Article
Biochemistry & Molecular Biology
Su Youn Baek, Eun Hye Lee, Tae Woo Oh, Hyun Ju Do, Kwang-Youn Kim, Kwang-Il Park, Young Woo Kim
Article
Integrative & Complementary Medicine
Ly Thi Huong Nguyen, Tae-Woo Oh, Uy Thai Nguyen, Min-Jin Choi, In-Jun Yang, Heung-Mook Shin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Tae Woo Oh, Kwang-Youn Kim, Hyun Ju Do, Young-Woo Kim, Kwang-Il Park
MOLECULAR & CELLULAR TOXICOLOGY
(2020)
Article
Plant Sciences
Tae Woo Oh, Hyun Ju Do, Jae-Han Jeon, Kyungho Kim
Summary: The study demonstrated that quercitrin has inhibitory effects on platelet activity, can block thrombus formation, reduce infarct volume in stroke, and does not prolong bleeding time.
Article
Integrative & Complementary Medicine
Ly Thi Huong Nguyen, Uy Thai Nguyen, Min-Jin Choi, Tae-Woo Oh, In-Jun Yang, Heung-Mook Shin
Summary: The study found that GGDE can alleviate the inflammatory response of atopic dermatitis models caused by psychological stress, inhibit mast cell/eosinophil infiltration, and prevent decreases in the levels of skin keratin proteins. In addition, GGDE can also reduce the increase in corticotropin-releasing hormone and corticosterone levels caused by social isolation stress, as well as reduce the locomotor hyperactivity of mice in the OFT.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tae Woo Oh, Won-Kyung Cho, Kwang Il Park, Jin Yeul Ma
Summary: The study showed that KIOM-2015E had a therapeutic effect on steroid-induced ocular hypertension, preventing retinal degeneration by regulating protein levels and histological parameter expression in the retina.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ly Thi Huong Nguyen, Tae-Woo Oh, Min-Jin Choi, In-Jun Yang, Heung-Mook Shin
Summary: The study examined the anti-psoriatic effects of components of indigo naturalis, particularly indirubin, on IL-22-treated HaCaT cells. Indirubin was found to significantly decrease ROS production and lower the production of certain inflammatory markers, showing therapeutic potential in an IL-22-induced psoriasis model in mice.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Young-Suk Kim, Jong-Min Lim, Jae Suk Shin, Hyun Jun Kim, Kwang-Il Park, Tae Woo Oh
Summary: These results demonstrate that Polycan can improve and protect muscle atrophy by preventing apoptosis via pathway regulation related to myogenic transcription factors and energy metabolism in mdx mice.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo Oh
Summary: Fermented glutinous rice can improve ulcerative colitis by regulating the expression of tight junction proteins, reducing inflammation, and inhibiting apoptosis. The treatment with fermented glutinous rice can protect the intestinal barrier function, suppress inflammation, and prevent apoptosis, making it a potential candidate for treating and preventing inflammatory bowel disease.
Article
Immunology
Jang-Gi Choi, Young Soo Kim, Ji Hye Kim, Tae In Kim, Wei Li, Tae Woo Oh, Chang Hyun Jeon, Su Jin Kim, Hwan-Suck Chung
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yeoun-Hee Kim, Tae Woo Oh, Eunhee Park, Nam-Hui Yim, Kwang Il Park, Won Kyung Cho, Jin-Yeul Ma
Article
Chemistry, Medicinal
Tae Woo Oh, Kwang-Il Park, Hyun Ju Do, Kyungho Kim, Hye Jin Yang, Won Kyung Cho, Jin Yeul Ma
NATURAL PRODUCT SCIENCES
(2020)