Article
Immunology
Sadiq Umar, Anil K. Singh, Mukesh Chourasia, Stephanie M. Rasmussen, Jeffrey H. Ruth, Salahuddin Ahmed
Summary: This study investigates the role of O-GlcNAcylation in rheumatoid arthritis (RA) and its regulation using human RA patient-derived synovial fibroblasts (RASFs). The results suggest that O-GlcNAcylation could be a potential therapeutic target and PGG has the potential to inhibit inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
He Zhang, Liangliang Zhang, Lihua Tang, Xinyu Hu, Man Xu
Summary: The study found that metal ions reduce the solubility of PGG-protein complex and increase precipitation, with Al3+ and Fe2+ showing greater effects. Metal ions form complexes with PGG, interact with proteins, and enhance PGG-protein precipitation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ashish Rao Sathyanarayana, Chung-Kuang Lu, Chih-Chuang Liaw, Chia-Chuan Chang, Hsin-Ying Han, Brian D. Green, Wei-Jan Huang, Cheng Huang, Wen-Di He, Lin-Chien Lee, Hui-Kang Liu
Summary: Phytochemicals like PGG can interrupt the lifecycle of adipocytes, providing anti-obesity effects. In this study, the effects of PGG isomers on cell viability and adipogenesis were examined using various cell types. Additionally, the administration of beta-PGG reduced adiposity and fatty liver development in diet-induced obese mice. These findings suggest that PGG could be useful in clinical management of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jinming Peng, Guiqiang Liang, Wenjun Wen, Zihui Qiu, Wenye Huang, Qin Wang, Gengsheng Xiao
Summary: This study prepared Penta-O-galloyl-beta-D-glucose (PGG) from tannic acid methanolysis products and investigated its protective effects and mechanism on glucose-induced glycation for the first time. PGG was found to have strong anti-AGEs effects in bovine serum albumin (BSA)-glucose (Glu) and BSA-methylglyoxal (MGO) glycation systems. It inhibits AGEs formation by blocking glycated intermediates, eliminating radicals, and chelating metal ions. Mechanism analysis showed that PGG prevents BSA from glycation by hindering amyloid fibril accumulation, stabilizing BSA secondary structures, and binding partial glycation sites. PGG also displays effective trapping capacities on MGO reactive intermediate. This research suggests PGG as a potential functional ingredient in food materials for preventing diabetic syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Yu-han Jiang, Jing-hui Bi, Min-rui Wu, Shi-jie Ye, Lei Hu, Long-jie Li, Yang Yi, Hong-xun Wang, Li -mei Wang
Summary: By using network pharmacology, this study predicted that 1,2,3,4,6-Penta-O-galloyl-0-D-glucose (0-PGG) may inhibit the growth of hepatocellular carcinoma (HepG2) cells through the p53 signaling pathway. The experimental results confirmed that 0-PGG significantly inhibited the survival of HepG2 cells, promoted apoptosis, and induced apoptosis by activating the p53 signaling pathway.
FOOD & NUTRITION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Wen Li, Li-ping Liao, Ning Song, Yan-jun Liu, Yi-luan Ding, Yuan-yuan Zhang, Xiao-ru Zhou, Zhong-ya Sun, Sen-hao Xiao, Hong-bo Wang, Jing Lu, Nai-xia Zhang, Hua-liang Jiang, Kai-xian Chen, Chuan-peng Liu, Jie Zheng, Ke-hao Zhao, Cheng Luo
Summary: Aerobic glycolysis, also known as the Warburg effect, is a key characteristic of cancer cell metabolism. GAPDH, an important enzyme in glycolysis, is a potential therapeutic target for cancer treatment. PGG has been identified as a novel reversible inhibitor of GAPDH, suggesting potential for future therapeutic applications.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Huihai Yang, Grace Gar-Lee Yue, Ping-Chung Leung, Chun-Kwok Wong, Ying-Jun Zhang, Clara Bik-San Lau
Summary: This study found that the natural gallotannin PGG has anti-tumor effects on colon cancer cells and inhibits cell proliferation, colony formation, motility, and migration. It also demonstrated that PGG suppresses liver and lung metastasis in mouse models and regulates immune cell populations and cytokine levels. These findings suggest that PGG has the potential to be developed as an anti-metastatic agent for metastatic CRC.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Acharya Balkrishna, Vallabh Prakash Mulay, Sudeep Verma, Jyotish Srivastava, Savita Lochab, Anurag Varshney
Summary: The plant extract from Pistacia integerrima containing PGG effectively combats lung cancer progression through autophagic cell death by altering ERK/AMPK-ULK1/STAT3 signaling axes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Dong Wang, Yan Li, Liheng Dai, Yanxia Wang, Congna Zhao, Wangang Wang, Yu Zhang, Yinrui Zhao, Tingting Yu
Summary: This study found that 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) can alleviate inflammation and oxidative stress in diabetic nephropathy, thus protecting against kidney injury. The protective effects of PGG are mediated by the suppression of the MAPK/NF-kappa B and ERK/Nrf2/HO-1 signaling pathways.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Acharya Balkrishna, Vallabh Prakash Mulay, Sudeep Verma, Jyotish Srivastava, Savita Lochab, Anurag Varshney
Summary: The extract from Pistacia integerrima contains penta-O-galloyl-beta-D-glucose (PGG), which shows potential in inhibiting lung cancer progression by modulating the ERK/AMPK-ULK1/STAT3 signaling axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Man Ren, Yuan Yang, Dan Li, Nannan Zhao, Yuping Wang, Yongning Zhou
Summary: In this study, the mechanisms of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) against gastric cancer were explored through network pharmacology and molecular docking. The results revealed that PGG exerts a therapeutic efficacy on gastric cancer by multiple targets (MAPK14, BCL2L1, and VEGFA) and pathways (MAPK, PD-L1 checkpoint, PI3K-Akt, Ras, and HIF-1 pathways).
Article
Chemistry, Physical
A. Milicevic, I. Novak Jovanovic
Summary: The study examined the relationship between the first electrochemical oxidation potential of flavonoids and their electronic structures. Results showed that two models yielded similar statistical data, indicating that the electrochemical oxidation of these flavonoids begins with ionization.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Medicinal
Lewis Marquez, Yunjin Lee, Dustin Duncan, Luke Whitesell, Leah E. Cowen, Cassandra Quave
Summary: This study evaluated the activity of the bioactive natural product, penta-O-galloyl-& beta;-d-glucose (PGG), against multidrug-resistant Candida species. PGG showed potent anti-Candida activity with minimal cytotoxicity for human cells. The antifungal activity of PGG is mediated through an iron-chelating mechanism, suggesting its potential use as a topical treatment for Candida infections.
ACS INFECTIOUS DISEASES
(2023)
Article
Food Science & Technology
Xiaoyue Yang, Christophe Blecker, Huan Liu, Dequan Zhang, Zhenyu Wang
Summary: To understand the regulation of different polyphenolic compounds with m-hydroxy and o-hydroxy groups in inhibiting the formation of heterocyclic amines (HAs), the reactions between categorized polyphenols and roasted lamb patties were studied and validated in vitro. The study found that chalcone, coumarin, and stilbene compounds were more effective in inhibiting HAs in comparison to flavonoids, while phenolic acid had the weakest effect. The inhibitory action of polyphenols on HAs was attributed to their ability to scavenge free radicals and trap active carbonyls, with m-hydroxy polyphenols having a stronger inhibition on certain HAs and o-hydroxy polyphenols having a stronger inhibitory effect on another HA.
Article
Mathematical & Computational Biology
Karthick Dharmalingam, Velvizhi Dharmalingam, Satheesh Durairaj, Praveen Sharma, Selvaraj Jayaraman
Summary: The data documents optimal binding affinities of penta-galloyl-glucose with VEGF signaling molecules in the context of cancer, suggesting potential implications for further research.
Article
Chemistry, Physical
Sylwia Zielinska, Adam Matkowski, Karolina Dydak, Monika Ewa Czerwinska, Magdalena Dziagwa-Becker, Mariusz Kucharski, Magdalena Wojciak, Ireneusz Sowa, Stanislawa Plinska, Karol Fijalkowski, Daria Ciecholewska-Jusko, Michal Broda, Damian Gorczyca, Adam Junka
Summary: In this study, a bi-functional bacterial-nano-cellulose (BNC) carrier system was developed for cell cultures of Chelidonium majus, a medicinal plant producing antimicrobial compounds. The unpurified BNC synthesized for 3 days exhibited the highest content and most complex composition of pharmacologically active substances, showing anti-inflammatory and antimicrobial activities. This modified composite material has potential applications in combating microbial pathogens.
Article
Agricultural Engineering
Simon Vlad Luca, Lukasz Kulinowski, Cristina Ciobanu, Gokhan Zengin, Monika E. Czerwinska, Sebastian Granica, Jianbo Xiao, Krystyna Skalicka-Wozniak, Adriana Trifan
Summary: This study investigated the phytochemical and biological properties of two varieties of Cynara scolymus leaf extracts. The extracts showed a complex composition rich in phenolic acids, flavonoids, and sesquiterpene lactones. They exhibited strong antioxidant activity, anti-enzymatic effects, and potent inhibition of pro-inflammatory cytokine production.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Weronika Skowronska, Sebastian Granica, Monika E. Czerwinska, Ewa Osinska, Agnieszka Bazylko
Summary: The study confirms the anti-inflammatory and antioxidant activity of elderberry leaves, particularly against reactive oxygen species. This suggests that elderberry leaves may be a potential medicinal plant with anti-inflammatory and antioxidant properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Magiera, Monika Ewa Czerwinska, Aleksandra Owczarek, Anna Marchelak, Sebastian Granica, Monika Anna Olszewska
Summary: This study investigated the phytochemical composition of Prunus spinosa L. fruits and evaluated their potential as functional products in human immune cells. The extracts showed a rich content of polyphenols, which contributed to their antioxidant and anti-inflammatory effects. The extracts displayed significant ability to modulate pro-oxidant, pro-inflammatory, and anti-inflammatory functions of immune cells. The results support the traditional use of fresh blackthorn fruits in inflammatory disorders and indicate the potential of the extracts for functional applications.
Article
Nutrition & Dietetics
Agata Oledzka, Katarzyna Cichocka, Konrad Wolinski, Matthias F. Melzig, Monika E. Czerwinska
Summary: The study aimed to investigate the targeting effect of Cornus mas fruit extract on pancreatic lipase and alpha-amylase, as well as the changes in metabolites and kinetics during gastrointestinal digestion. The results showed that the extract inhibited the activity of pancreatic lipase and alpha-amylase, and compounds such as loganic acid, kaempferol hexoside, and phenolic acids were found to be potentially bio-accessible.
Article
Pharmacology & Pharmacy
Monika Czerwinska, Piotr Michel, Sylwia Zielinska, Katarzyna Dos Santos Szewczyk, Christian Zidorn, Monika E. Czerwinska
Summary: This study provides a comprehensive analysis of the chemical composition of Lamium species and demonstrates their inhibitory effects on cytokine secretion. The main compounds found in Lamium herbs' extracts are lamalbid, rutin, and chlorogenic acid. These findings suggest the potential role of Lamium species in inflammation resolution.
ACTA POLONIAE PHARMACEUTICA
(2022)
Article
Biochemistry & Molecular Biology
Anna Magiera, Monika Ewa Czerwinska, Aleksandra Owczarek, Anna Marchelak, Sebastian Granica, Monika Anna Olszewska
Summary: Dried sloes exhibit anti-inflammatory and antioxidant effects by regulating immune cell functions. The main active components are polyphenolic compounds and Maillard reaction products.
Article
Biochemistry & Molecular Biology
Janusz Malarz, Klaudia Michalska, Agnieszka Galanty, Anna Karolina Kiss, Anna Stojakowska
Summary: Plants of the genus Pulicaria are valuable for their traditional medicinal, culinary, and insect-repelling properties. A specific species within the genus, Pulicaria inuloides, has been less studied chemically. By analyzing hydroalcoholic extracts of the roots and aerial parts of P. inuloides, it was found to contain several caffeoylquinic and caffeoylhexaric conjugates, as well as hydroxykaempferol dimethyl ether and quercetagetin trimethyl ether. Additionally, chloroform extracts from P. inuloides plants revealed the presence of caryophyllene derivatives, thymol derivatives, and polymethoxylated flavonols. The cytotoxicity of two major flavonols isolated from the plant, 6-Hydroxykaempferol 3,7-dimethyl ether and quercetagetin 3,7,3'-trimethyl ether, were tested on various cell types with moderate activity against prostate cancer cells.
Article
Biochemistry & Molecular Biology
Izabela Grzegorczyk-Karolak, Marta Krzeminska, Anna K. Kiss, Aleksandra Owczarek-Januszkiewicz, Monika A. Olszewska
Summary: The aim of this study was to establish an effective system for propagating S. bulleyana shoots rich in bioactive compounds. It was found that a medium supplemented with 0.1 mg/L IAA and 1 mg/L M-T was most favorable for shoot growth and the accumulation of polyphenols, with a 4.5-fold increase in total polyphenol content compared to medium without growth regulators.
Review
Biochemistry & Molecular Biology
Agata J. Oledzka, Monika E. Czerwinska
Summary: Inflammation is the initial response to infection and injury but prolonged inflammation can lead to malignant cell transformation and cancer. Pyroptosis, an inflammatory necrosis, has recently gained attention for its role in activating inflammasomes and cytokine secretion. This review focuses on the molecular pathways associated with inflammation and the role of phenolic compounds in chronic inflammatory disorders. The selected phenolic compounds, including flavonoids, tannins, phenolic acids, and phenolic glycosides, were found to regulate NF-kappa B, Nrf2, and MAPK signaling pathways, suggesting their potential in the treatment of diseases such as osteoarthritis, neurodegenerative diseases, cardiovascular, and pulmonary disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Koltun-Jasion, Paulina Sawulska, Andrzej Patyra, Marta Wozniak, Marta Katarzyna Dudek, Agnieszka Filipek, Anna Karolina Kiss
Summary: Inflammation is the body's defense mechanism against external and internal stimuli. However, an inappropriate immune response can lead to chronic diseases. Phytotherapy, especially raw materials with a long tradition of use, may play a role in alleviating inflammatory processes. This study aims to analyze the phytochemicals in ash leaves and evaluate their effects on anti-inflammatory cytokines in monocyte/macrophage cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Adriana Trifan, Monika E. Czerwinska, Gokhan Zengin, Nils Esslinger, Andreas Grubelnik, Evelyn Wolfram, Krystyna Skalicka-Wozniak, Simon Vlad Luca
Summary: In this study, comfrey root extracts with PA depletion and mucilage depletion were evaluated for their phytochemical characteristics and biological activities. The results showed that PA-depleted extracts had lower antioxidant activity, while mucilage-depleted extracts had higher radical scavenging and metal reducing abilities. Neither PA depletion nor mucilage depletion significantly affected the inhibitory activities of cholinesterases, tyrosinase, amylase, and glucosidase, as well as the release of pro-inflammatory cytokines from LPS-stimulated neutrophils. Therefore, PA-depleted comfrey extracts can be further utilized in cosmetic and pharmaceutical products.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maria Bialik, Piotr Kurkowski, Katarzyna Strzelecka, Marzena Kuras, Marcin Sobczak, Karolina Mulas, Anna Zgadzaj, Monika E. Czerwinska, Marianna Gniadek, Ewa Oledzka
Summary: The fundamental objective of this work was to develop double-layered nanosystems based on biodegradable polymers for combination therapy of arterial hypertension. The nanosystems were designed and characterised with furosemide and atenolol as model antihypertensive drugs. The release kinetics and cytotoxicity of the nanosystems were evaluated, showing good release performance and non-toxicity in cell experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Edyta Krzych-Falta, Monika E. Czerwinska, Slawomir Bialek, Konrad Furmanczyk, Boleslaw Samolinski, Blazej Grodner, Adam Sybilski, Grazyna Nowicka, Oksana Wojas
Summary: Nasal provocation tests have the potential to be an alternative to oral food challenges due to their valuable assessment possibilities. However, standardization of the methodology is necessary to determine the threshold dose and develop a lyophilisate form. This study aimed to establish the methodological foundation for nasal food allergen provocation tests.