Article
Biochemistry & Molecular Biology
Javier I. Ottaviani, Jodi L. Ensunsa, Reedmond Y. Fong, Jennifer Kimball, Valentina Medici, Gunter G. C. Kuhnle, Alan Crozier, Hagen Schroeter, Catherine Kwik-Uribe
Summary: Flavan-3-ols are bioactive compounds found in various fruits and vegetables that have positive health benefits. Increasing their intake is challenging due to low consumption of fruits and vegetables. Smoothies are commonly used to increase the intake of these compounds, but fruits with high PPO activity can potentially affect the content and bioavailability of flavan-3-ols.
Article
Behavioral Sciences
Emilson Donizete Pereira Jr, Laurival A. De Luca Jr, Jose Vanderlei Menani, Carina Aparecida Fabricio Andrade
Summary: The study found that spontaneously hypertensive rats (SHRs) have enhanced responses to sweet taste and increased aversive responses to bitter taste, which are independent of challenges in bodily fluid balance.
Article
Medicine, Research & Experimental
Weiquan Zeng, Xiuli Zhang, Yao Lu, Ying Wen, Qiurong Xie, Xuan Yang, Shuyu He, Zhi Guo, Jiapeng Li, Aling Shen, Jun Peng
Summary: This study investigates the effect of neferine on hypertensive vascular remodeling and its underlying mechanisms. The results demonstrate that neferine can effectively reduce blood pressure, pulse wave velocity, and abdominal aortic thickening in hypertensive rats. It also suppresses the abnormal activation of PI3K/AKT and TGF-beta/Smad2/3 signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Shohei Yamaguchi, Yuzumi Hayasaka, Miho Suzuki, Wenhao Wang, Masahiro Koyama, Yasuko Nagasaka, Kozo Nakamura
Summary: This study demonstrates that low-dose orally administered ACh can lower blood pressure in spontaneously hypertensive rats by acting on gastrointestinal M3 muscarinic ACh receptors to increase afferent vagal nerve activity, resulting in decreased sympathetic nervous activity and noradrenaline release.
Article
Immunology
Xiaohua Li, Changhong Ren, Sijie Li, Wenbo Zhao, Peifu Wang, Xunming Ji
Summary: This study investigates the effect of limb remote ischemic conditioning (LRIC) on blood pressure regulation in spontaneously hypertensive rats (SHR) by modulating the hypertensive inflammatory response. The results demonstrate that LRIC lowers blood pressure in SHR by reducing the percentage of monocytes and CD8 T cells, as well as decreasing pro-inflammatory cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Physiology
Dominga Lapi, Giuseppe Federighi, Maria Serena Lonardo, Martina Chiurazzi, Espedita Muscariello, Giancarlo Tenore, Antonio Colantuoni, Ettore Novellino, Rossana Scuri
Summary: Oxidative stress is involved in the development of arterial hypertension. Physical exercise and intake of antioxidants can improve the redox state and protect the cerebral microvasculature in hypertensive rats. The combination of physical exercise and antioxidant-rich diet did not have a greater effect than either treatment alone. In conclusion, physical activity or antioxidants-enriched diet can effectively reduce microvascular damage caused by hypertension in spontaneously hypertensive rats.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuta Okamura, Ryo Niijima, Satoshi Kameshima, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: Hypertension is a major risk factor for cardiovascular diseases, caused by various abnormalities including blood vessel contractibility. This study investigated the effects of human omentin-1 on hypertensive complications in aged SHR. It was found that omentin-1 tended to improve left ventricular and renal failure in SHR, indicating its potential therapeutic role in hypertensive complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Patricia Oteiza, Cesar G. Fraga, Monica Galleano
Summary: The review explores the relationship between flavonoid consumption, oxidative stress mitigation, and improvement of human diseases. It focuses on the role of (-)-epicatechin in inflammation, endothelial dysfunction/hypertension, and insulin resistance/diabetes, and discusses the indirect antioxidant actions of EC and its metabolites in these pathologies. Human studies show promising results regarding the beneficial effects of EC on disease biomarkers, but more research is needed to establish conclusive associations between oxidative stress biomarkers and flavonoid consumption. The discovery of metabolites as reliable markers of flavonoid intake offers a powerful tool for linking flavonoid consumption to disease prevention and oxidative stress mitigation in human populations.
Article
Biochemistry & Molecular Biology
Atsunori Yamamoto, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: The study revealed that the increased protein expression of CMKLR1 in the PVN of rats with hypertension is at least partly responsible for the systemic hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
E. D. Pereira, A. M. Faria, G. M. F. Andrade-Franze, J. Menani, L. A. De Luca, C. A. F. Andrade
Summary: SHRs ingest more NaCl than normotensive rats, with increased hedonic responses to intra-oral infusions of NaCl. Treatment with diuretics and an ACE blocker increased hedonic responses in normotensive rats but had no effect on SHRs. Central AT1 receptors play a role in increasing NaCl intake and palatability in SHRs.
HORMONES AND BEHAVIOR
(2021)
Article
Neurosciences
Hua Zhang, Jing-Jing Zhou, Jian-Ying Shao, Zhao-Fu Sheng, Jingxiong Wang, Peiru Zheng, Xunlei Kang, Zhenguo Liu, Zixi Jack Cheng, David D. Kline, De -Pei Li
Summary: Elevated levels of CRH and CRHR1 in the PVN are associated with increased sympathetic outflow in primary hypertension, potentially contributing to the hyperactivity of PVN presympathetic neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yanan Li, Dadi Xie, Luxi Li, Pei Jiang
Summary: This study aimed to explore the metabolic changes induced by hypertension at different ages. The results showed that spontaneously hypertensive rats (SHR) at 5 weeks old and 32 weeks old had different metabolic characteristics, mainly involving amino acid metabolism, glycolysis, lipid metabolism, and amino acid metabolism.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Medicine, Research & Experimental
Qingqing Hou, Shiming Zhang, Yuan Li, Huanjun Wang, Dan Zhang, Dongmei Qi, Yunlun Li, Haiqiang Jiang
Summary: This study aimed to investigate the association of lipid metabolites, circadian genes, and lipid metabolism associated genes in spontaneously hypertensive rats. Through lipidomics and gene expression analysis, it was found that SHR exhibited significant differences in lipid metabolites levels compared to WKY, as well as disturbances in circadian and lipid metabolism associated gene expressions. Moreover, a strong association between the levels of lipid metabolites and circadian genes and lipid metabolism associated genes was identified.
Article
Pharmacology & Pharmacy
Carlos Jose Dias, Herikson Araujo Costa, Carlos Alberto Alves Dias-Filho, Andressa Coelho Ferreira, Bruno Rodrigues, Maria Claudia Irigoyen, Antonio Carlos Romao Borges, Vicenilma de Andadre Martins, Flavia Castello Branco Vidal, Rachel Melo Ribeiro, Natalino Salgado Filho, Cristiano T. Mostarda
Summary: The use of carvacrol in spontaneously hypertensive rats (SHR) showed antihypertensive effects and increased expression of MAS receptors in kidney tissue.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhi-Bin Wang, Shi-Long Jiang, Shao-Bo Liu, Jing-Bo Peng, Shuo Hu, Xu Wang, Wei Zhuo, Tong Liu, Ji-Wei Guo, Hong-Hao Zhou, Zhi-Quan Yang, Xiao-Yuan Mao, Zhao-Qian Liu
Summary: This study evaluated the effect of artichoke bud extract (ABE) on heart tissue metabolomics of hypertensive rats. The results showed that artichoke significantly lowered blood pressure in hypertensive rats and affected the levels of eight metabolites. This suggests that ABE may play a role in affecting oxidative stress and purine, nicotinate, and nicotinamide metabolism.
Article
Nutrition & Dietetics
Ma Josefina Ruiz de Azua, Alvaro Cruz-Carrion, Begona Muguerza, Gerard Aragones, Anna Arola-Arnal, Maria Paz Romero, Francisca Isabel Bravo, Manuel Suarez
Summary: This study evaluated the metabolic consequences of consuming Ekstasis tomatoes from different geographical origins and in different seasons in Fischer 344 rats. The results showed that seasonal consumption of local tomatoes reduced cardiovascular risk and atherogenic coefficient. Additionally, the photoperiod significantly affected blood glucose, insulin levels, and the expression of Srep1-c, Fas1, and Acc1 in the liver.
Article
Nutrition & Dietetics
Francisca Isabel Bravo, Enrique Calvo, Rafael A. Lopez-Villalba, Cristina Torres-Fuentes, Begona Muguerza, Almudena Garcia-Ruiz, Diego Morales
Summary: Hypertension is a major contributor to premature deaths worldwide and can be prevented by managing cardiovascular diseases. Protein hydrolysates containing antihypertensive peptides derived from agri-food industry byproducts, such as chicken slaughterhouse byproducts, have shown potential in lowering blood pressure. These byproducts, including blood, bones, skins, and chicken feet, have been used to produce protein hydrolysates with angiotensin-converting enzyme (ACE) inhibitory activity. Mechanisms underlying their effects include increased levels of antioxidant compounds, reduced ACE activity, and improved endothelial dysfunction associated with hypertension. However, further clinical studies are needed to confirm these antihypertensive properties and enhance the value of these byproducts in the circular economy model of slaughterhouses.
Article
Nutrition & Dietetics
Veronica Arreaza-Gil, Javier Avila-Roman, Ivan Escobar-Martinez, Begona Muguerza, Manuel Suarez, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: Seasonal rhythms can influence gut microbiota, bioactive compounds, and inflammation. This study aimed to investigate the effects of photoperiod on the modulation of oxylipins (OXLs) in healthy and obesogenic conditions. The results showed that photoperiods affected OXLs levels influenced by gut microbiota, and the grape seed proanthocyanidin extract (GSPE) had an impact on prostaglandin E2 (PGE2) levels under certain photoperiod conditions. This is the first study to demonstrate the effects of photoperiod on OXLs metabolites.
Article
Plant Sciences
Alvaro Cruz-Carrion, Ma Josefina Ruiz de Azua, Begona Muguerza, Miquel Mulero, Francisca Isabel Bravo, Anna Arola-Arnal, Manuel Suarez
Summary: A study compared thirteen plant-based foods cultivated in organic (ORG) and non-organic (NORG) farming systems in terms of antioxidant capacity and phenolic compound content. The results showed that NORG fruits had higher phenolic compounds content, while ORG fruits had more antioxidant capacity. NORG legume stood out for having higher values from all parameters analyzed. ORG nuts had higher flavan-3-ols and flavonols content but lower antioxidant capacity compared to their NORG counterparts. ORG vegetables displayed higher phenolics and anthocyanins content, resulting in higher antioxidant capacity than NORG ones. These findings suggest that farming systems modulate phenolic compound composition and antioxidant capacity based on the plant species studied.
Review
Endocrinology & Metabolism
Cristina Cuesta-Marti, Friederike Uhlig, Begona Muguerza, Niall Hyland, Gerard Clarke, Harriet Schellekens
Summary: Oxytocin is closely related to gut microbiota and plays an important role in appetite regulation and social behavior.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Veronica Arreaza-Gil, Ivan Escobar-Martinez, Miquel Mulero, Begona Muguerza, Manuel Suarez, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: This study evaluates the influence of different photoperiod exposures on the bioavailability of grape seed proanthocyanidins (GSPEs) extract and found that photoperiods affect its bioavailability. Moreover, photoperiods also influence the gut microbiota composition and the bioavailability of polyphenols in the body, which in turn affects the health effects of obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Elia Navarro-Masip, Marina Colom-Pellicer, Francesca Manocchio, Anna Arola-Arnal, Francisca Isabel Bravo, Begona Muguerza, Gerard Aragones
Summary: Seasonal rhythms and photoperiod can influence metabolism and adipose tissue functionality. Supplementation with grape-seed proanthocyanidins extract (GSPE) has shown potential in preventing obesity-related alterations. In this study, GSPE supplementation was found to prevent excessive body weight gain and restore serum cholesterol and non-esterified fatty acids (NEFAs) concentrations depending on the photoperiod. GSPE also helped combat obesity-induced adipocyte hypertrophy and upregulated adiponectin mRNA levels. Overall, GSPE administration reduced the impact of obesity on adipose tissue depending on the photoperiod and type of adipose depots.
Article
Multidisciplinary Sciences
Anne-Sophie Delbes, Mar Quinones, Cedric Gobet, Julien Castel, Raphael G. P. Denis, Jeremy Berthelet, Benjamin D. Weger, Etienne Challet, Aline Charpagne, Sylviane Metairon, Julie Piccand, Marine Kraus, Bettina H. Rohde, John Bial, Elizabeth M. Wilson, Lise-Lotte Vedin, Mirko E. Minniti, Matteo Pedrelli, Paolo Parini, Frederic Gachon, Serge Luquet
Summary: Peripheral organ circadian clocks, such as the liver clock, can affect the central pacemaker and the overall circadian physiology, offering potential insights into disorders related to altered circadian rhythms.
Article
Biochemistry & Molecular Biology
Miguel Lopez-Moreno, Estefania Jimenez-Moreno, Antonio Marquez Gallego, Gema Vera Pasamontes, Jose Antonio Uranga Ocio, Marta Garces-Rimon, Marta Miguel-Castro
Summary: In recent years, quinoa has been proposed as an emerging crop for functional food production. Quinoa hydrolysates obtained from the crop have shown in vitro biological activity. This study aimed to evaluate the beneficial effects of red quinoa hydrolysate on oxidative stress and cardiovascular health in an in vivo experimental model of hypertension. The results revealed that oral administration of red quinoa hydrolysate significantly reduced blood pressure and exhibited antioxidant effects, thereby ameliorating hypertension and its associated complications.
Article
Food Science & Technology
Elia Navarro-Masip, Francesca Manocchio, Romina M. M. Rodriguez, Francisca Isabel Bravo, Cristina Torres-Fuentes, Begona Muguerza, Gerard Aragones
Summary: Grape-seed proanthocyanidin extract (GSPE) affects the expression of metabolic markers in white adipose tissue (WAT) and brown adipose tissue (BAT) in a photoperiod-dependent manner.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Elia Navarro-Masip, Francesca Manocchio, Marina Colom-Pellicer, Xavier Escote, Lisard Iglesias-Carres, Enrique Calvo, Francisca Bravo, Begona Muguerza, Yves Desjardins, Gerard Aragones
Summary: This study examines the seasonal effects of red grapes on metabolic markers of adipose tissue in healthy rats. The results show that consuming organic red grapes can increase energy expenditure and enhance UCP1 protein expression in brown adipose tissue. Furthermore, red grape consumption affects the gene expression profile of white adipose tissue, regulating browning markers and adipogenic/lipolytic markers in a photoperiod-dependent manner.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Miguel Lopez-Moreno, Marta Garces-Rimon, Marta Miguel-Castro, Elia Fernandez-Martinez, Maria Teresa Iglesias Lopez
Summary: This study aimed to evaluate the effect of a one-year nutrition education course on cardiometabolic parameters in undergraduate health science students. The findings suggest that the nutrition intervention resulted in changes in dietary patterns, with increased consumption of vegetables, nuts and legumes, as well as improvements in HDL-cholesterol levels.
Editorial Material
Endocrinology & Metabolism
Mar Quinones, Luisa Maria Seoane, Omar Al-Massadi
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorge R. Soliz-Rueda, Raul Lopez-Fernandez-Sobrino, Cristina Torres-Fuentes, Francisca I. Bravo, Manuel Suarez, Miquel Mulero, Begona Muguerza
Summary: Changes in light/dark cycles and obesogenic diets are related to the disruption of circadian rhythms and metabolic disorders. Grape seed flavanols have shown beneficial effects on metabolic diseases and recently a circadian system modulation has been suggested to mediate their health-enhancing properties.
Article
Endocrinology & Metabolism
V. Pena-Leon, R. Perez-Lois, M. Villalon, C. Folgueira, S. Barja-Fernandez, E. Prida, J. Baltar, F. Santos, J. Ferno, T. Garcia-Caballero, R. Nogueiras, M. Quinones, O. Al-Massadi, L. M. Seoane
Summary: The study found that gastric GDF15 is significantly regulated by fasting in rodents, an increase in gastric GDF15 secretion in obesity can lead to elevated circulating GDF15 levels in rats and humans. In addition, gastric GDF15 levels increase with age in both rodents and humans, displaying sexual dimorphism.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)