Article
Oncology
Xiangwan Miao, Zeyi Deng, Siqi Wang, Huanhuan Weng, Xinting Zhang, Hailiang Li, Huifen Xie, Juan Zhang, Ying Zhong, Bohui Zhang, Quanming Li, Minqiang Xie
Summary: The study identified IAP-1 as a key player in cisplatin resistance in nasopharyngeal carcinoma, regulating apoptosis induced by caspase and affecting the anti-proliferative and pro-apoptotic effects of cisplatin. High IAP-1 expression was associated with a worse survival status, suggesting its potential as a therapeutic target and prognostic indicator for advanced NPC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Fangrui Zhao, Dashuai Yang, Xiangpan Li
Summary: Nasopharyngeal carcinoma is a malignant tumor mainly found in East and Southeast Asia. Radical radiotherapy is the primary treatment for this type of cancer. However, interruptions in radiotherapy can lead to reduced effectiveness and potential tumor progression. This review examines the effects of radiotherapy interruption and explores possible measures to address this issue.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Yuxun Ding, Xiaohui Xiao, Lingli Zeng, Qiuping Shang, Wei Jiang, Sha Xiong, Xiaohui Duan, Jun Shen, Ruibing Wang, Jinshan Guo, Yue Pan
Summary: By developing RGD-targeted platinum-based nanoparticles, targeted chemoradiotherapy for NPC can be achieved with improved delivery efficiency of cisplatin. RPNs act as radiotherapy sensitizer and chemotherapy agents, leading to remarkable therapeutic outcome in synergistic chemoradiotherapy for NPC.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu, Fangyun Xie
Summary: This study reveals that FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma (NPC) through the TIE1-mediated PI3K/AKT signaling pathway, suggesting that targeting the FLI1/TIE1 signaling pathway could be a potential therapeutic strategy to enhance the efficacy of radiotherapy in NPC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jianbin Zhang, Yan Jiang, Ye Yu, Jiangping Li
Summary: This study evaluated the combination of TORC1/2 inhibitor sapanisertib and chemotherapy drug cisplatin for nasopharyngeal carcinoma (NPC) treatment. The results showed that sapanisertib effectively decreased NPC cell viability and proliferation, and acted synergistically with cisplatin to induce cell arrest and apoptosis. Sapanisertib had minimal effects on normal cells and also reduced NPC cell migration. These findings were evident in both in vitro and in vivo models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Oncology
Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, E. A. R. Engku Nur Syafirah, Yusuf Wada, Zaidah Abdul Rahman, Suhana Ahmad, Rohimah Mohamud, Norhafiza Mat Lazim, Chan Yean Yean
Summary: This study found that the prevalence of nasopharyngeal carcinoma in dermatomyositis patients is 3.3%, with higher rates in certain regions like Hong Kong, Malaysia, and Singapore. There is a higher incidence among male patients aged 40 and above, with many cases of NPC being diagnosed after the onset of dermatomyositis. Screening for NPC in older dermatomyositis patients, especially in the Asian region, is therefore essential.
Article
Oncology
Xin-Bin Pan, Yang Liu, Shi-Ting Huang, Su Pei, Kai-Hua Chen, Song Qu, Ling Li, Xiao-Dong Zhu
Summary: The study found that V30 of the parotid glands is a major predictive factor for grades 2-3 xerostomia in nasopharyngeal carcinoma patients, while the dose and volume of the submandibular glands are not independent predictive factors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Chen Xu, Shuai He, Ya-Qing Zhou, Chu-Jun Liu, Shu-Qiang Liu, Wan Peng, Yu-Xiang Liu, Pan-Pan Wei, Jin-Xin Bei, Chun-Ling Luo
Summary: The study reveals that RBM47 is frequently upregulated in nasopharyngeal carcinoma (NPC) specimens and associated with poor prognosis, acting as a transcriptional factor and modulator of alternative splicing in cooperation with hnRNPM to promote NPC progression. This suggests that RBM47 and hnRNPM could serve as prognostic factors and potential therapeutic targets for NPC.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Oncology
Tiancong Liu, Chao Ji, Yang Sun, Weiliang Bai
Summary: High expression of HOXA9 is significantly associated with advanced tumor stage and poorer survival in nasopharyngeal carcinoma patients, serving as an independent prognostic factor.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Dan Li, Hai-Ke Lei, Xiao-Lei Shu, Xin Zhang, Hong-Lei Tu, Feng Wang, Yu-Wei Wang, Ying Wang, Jiang-Dong Sui
Summary: Health insurance programs are effective in preventing financial hardship in cancer patients. However, little is known about how health insurance policies influence the prognosis of patients with nasopharyngeal carcinoma in Southwest China. This study investigated the association of insurance types and self-paying rates with NPC-specific mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Yunlai Liang, Yating Ma, Kun Wang, Manglin Xiang, Bin Yi
Summary: The association of NUCB-2/Nesfatin-1 with nasopharyngeal carcinoma was unclear, so this study aimed to clarify its role in the development, progression, and diagnosis of NPC. The results showed that NUCB-2 level was higher in NPC tissue than in rhinitis tissue, and suppression of NUCB-2 inhibited NPC cell proliferation while improvement of NUCB-2 promoted cell propagation. Moreover, serum NUCB-2 level could potentially be a serological marker for the early diagnosis of nasopharyngeal carcinoma.
CANCER CELL INTERNATIONAL
(2023)
Review
Immunology
Tingting Yang, Chanping You, Shuhui Meng, Zhengquan Lai, Weipeng Ai, Jun Zhang
Summary: Viral oncogenes can modulate cellular metabolic reprogramming to drive malignant transformation of normal epithelia cells. Understanding the dysregulation of viral oncogene-mediated signaling transduction in metabolic reprogramming may offer new therapeutic targets for virus-associated cancer treatment. This review focuses on elucidating how EBV infection and its encoded oncoproteins alter metabolic reprogramming to promote malignancy, and provides a new perspective on the interplay between EBV infection and metabolic pathways, offering a potential therapeutic intervention strategy for EBV-associated malignant diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Suming Pan, Xiangguo Zhang, Yugan Guo, Yin Li
Summary: This study reveals the inhibitory effects of DPCPX on nasopharyngeal carcinoma (NPC). By inhibiting the PI3K/AKT pathway, DPCPX induces Bim-dependent apoptosis and suppresses NPC cell growth. Additionally, DPCPX enhances the antitumor effects of chemotherapy drugs such as cisplatin, 5-FU, and Paclitaxel.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Oncology
Xiao Wang, Linxin Chen, Kaichun Huang, Yinbing Lin, Yingji Hong, Zhixiong Lin
Summary: Metastasis is a major challenge in treating nasopharyngeal carcinoma (NPC). This study identified carboxypeptidase vitellogenic-like protein (CPVL) as a tumor suppressor and a prognostic biomarker for evaluating metastasis risk in NPC. CPVL inhibits epithelial-mesenchymal transition (EMT), migration, and invasion of NPC cells, suggesting its role in suppressing tumor metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Kitson Liew, Gibson Qi Sheng Yu, Lesley Jia Wei Pua, Li Zhe Wong, Shiau Ying Tham, Ling-Wei Hii, Wei-Meng Lim, Brian Ming OuYong, Chin King Looi, Chun-Wai Mai, Felicia Fei-Lei Chung, Lu Ping Tan, Munirah Ahmad, Alan Soo-Beng Khoo, Chee-Onn Leong
Summary: Through genome-wide functional screens, LCK was identified as a key factor in NPC cell proliferation and cisplatin resistance. Depletion of LCK or treatment with LCK inhibitor induced tumor-specific cell death and enhanced cisplatin sensitivity in cells.
Article
Cell Biology
Ming-Jenn Chen, An-Ching Cheng, Ming-Fen Lee, Yi-Chiang Hsu
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Genetics & Heredity
Yu-Tsai Lin, Hung-Chen Wang, Hui-Ching Chuang, Yi-Chiang Hsu, Ming-Yu Yang, Chih-Yen Chien
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Article
Cell Biology
An-Chin Cheng, Yi-Chiang Hsu, Chiang-Chin Tsai
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Chemistry, Medicinal
An-Chin Cheng, Ching-Ju Shen, Chao-Ming Hung, Yi-Chiang Hsu
JOURNAL OF MEDICINAL FOOD
(2019)
Article
Biotechnology & Applied Microbiology
Tai-Hsin Tsai, Ann-Shung Lieu, Yi-Wen Wang, Sheau-Fang Yang, Yi-Chiang Hsu, Chih-Lung Lin
Summary: RTA 404 can significantly inhibit the proliferation, cell motility, cell cycle progression, and induce apoptosis in GBM cells in vitro. Furthermore, it may exert its effects by inhibiting N-cadherin and E-cadherin expression.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Chien-Ching Lee, Chao-Ming Hung, Chung-Hwan Chen, Yi-Chiang Hsu, Yuan-Pin Huang, Tsung-Bin Huang, Mon-Juan Lee
Summary: A novel aptamer-based competitive drug screening platform was developed for osteoporosis, facilitating high-throughput screening for potential small-molecule sclerostin inhibitors and offering a reliable strategy for target-specific new drug discovery. The potential sclerostin inhibitors obtained in this study showed promising effects on decreasing sclerostin levels and increasing alkaline phosphatase activity in osteocyte and mesenchymal stem cells, suggesting their potential as new therapeutics for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tai-Hsin Tsai, Ann-Shung Lieu, Tzuu-Yuan Huang, Aij-Lie Kwan, Chih-Lung Lin, Yi-Chiang Hsu
Summary: CDDO-TFEA can inhibit proliferation, cell cycle progression, and induce apoptosis in GBM cells, possibly through its inhibition of Cyclin B1, CDK1 expression, and Cyclin B1/CDK1 association, as well as the promotion of CHK1 and CHK2 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Tai-Hsin Tsai, Ann-Shung Lieu, Tzuu-Yuan Huang, Aij-Lie Kwan, Chih-Lung Lin, Yi-Chiang Hsu
Summary: RTA404 significantly inhibited cell viability and induced apoptosis in the U87MG cell line. Flow cytometry analysis revealed a significant decrease in mitochondrial membrane potential and an increase in apoptotic cell percentage with RTA404 treatment. Additionally, RTA404 may activate the DNA damage checkpoint system and induce apoptosis in established U87MG cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bi-He Cai, Zhi-Yu Bai, Ching-Feng Lien, Si-Jie Yu, Rui-Yu Lu, Ming-Han Wu, Wei-Chen Wu, Chia-Chi Chen, Yi-Chiang Hsu
Summary: The aggregation of mutant p53 induces its gain-of-function in head and neck squamous cell carcinoma. A combination therapy involving an NAMPT inhibitor and a p73 activator effectively suppresses the growth of cells with p53 gain-of-function mutants.
Article
Biochemistry & Molecular Biology
Ming-Han Wu, Rui-Yu Lu, Si-Jie Yu, Yi-Zhen Tsai, Ying-Chen Lin, Zhi-Yu Bai, Ruo-Yu Liao, Yi-Chiang Hsu, Chia-Chi Chen, Bi-He Cai
Summary: This study found that PTC124 can induce the expression of tumor suppressor genes NOTCH1 and FAT1 in head and neck squamous cell carcinoma, inhibiting cell proliferation and showing therapeutic potential.
Article
Biochemistry & Molecular Biology
Tai-Hsin Tsai, Yu-Feng Su, Cheng-Yu Tsai, Chieh-Hsin Wu, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: RTA dh404 is a novel synthetic oleanolic acid derivative with various properties and therapeutic effects on cancers. It reduces glioma cell viability and induces apoptosis, autophagy, and cell cycle arrest in glioblastoma cells. These effects are mediated by the regulation of associated genes, indicating the potential of RTA dh404 as a drug candidate for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chao-Ming Hung, Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: Our research shows that sulforaphane (SFN) has chemopreventive and potential chemotherapeutic effects on breast adenocarcinoma. Further studies are needed to understand the mechanisms behind SFN's antitumor activity. Our experiments demonstrate that SFN inhibits the growth of cancer cells and induces apoptosis, suggesting it could be used as an anticancer agent.
Article
Chemistry, Medicinal
Tai-Hsin Tsai, Cheng-Yu Tsai, Sin-Hua Moi, Chieh-Hsin Wu, Kuan-Ting Lee, Yi-Chiang Hsu, Yu-Feng Su
Summary: CDDO-dhTFEA has anticancer effects on glioblastoma cells by reducing cell proliferation and regulating cell cycle proteins. It induces G2/M cell cycle arrest and inhibits proliferation in U87MG and GBM8401 cells.
Article
Cell Biology
Chao-Ming Hung, Yi-Chiang Hsu, Tzu-Yu Chen, Chi-Chang Chang, Mon-Juan Lee
CELL BIOLOGY INTERNATIONAL
(2017)
Article
Cell Biology
Ya-Min Cheng, Ching-Ju Shen, Chi-Chang Chang, Cheng-Yang Chou, Ching-Chou Tsai, Yi-Chiang Hsu
CELL DEATH DISCOVERY
(2017)