Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 56, Issue 21, Pages 10092-10098Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf801010j
Keywords
Nitric oxide; quercetin; nitrite; EPR; rat; iron
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This study investigated whether reducing agents such as quercetin and iron(II) facilitate formation of nitric oxide (NO) gas from orally ingested nitrite in an vivo study. When 3 mg/kg (NaNO2)-N-15 was orally administered to rats with or without iron(II) or quercetin, Hb(15)NO, which is indicative of systemic (NO)-N-15, was detected in the blood, with the maximum blood concentration of Hb(15)NO at 15 min after nitrite or nitrite plus quercetin treatment, whereas after administration of nitrite plus iron(II) or nitrite plus iron(II) and quercetin, the time was shortened to 10 min. Interestingly, iron(II), quercetin, or iron(II) plus quercetin did not affect the total amount of Hb(15)NO generated from orally administered Nal(15)NO(2). However, the systemic nitrite concentration was significantly decreased in the presence of iron(II) or iron(II) plus quercetin. These results may indicate that iron(II) is critical to the generation of NO gas from nitrite, whereas quercetin contributed little under the in vivo experimental conditions.
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