Article
Polymer Science
Ahmad Arar, Assi Al Mousawi, Fabrice Morlet-Savary, Jacques Lalevee
Summary: Redox free radical polymerization (RFRP) is a cost-effective technique for producing polymers quickly and without energy consumption. By blending metal salts as oxidizing agents and reducing agents, a process with economic, low toxicity, and high stability is achieved under mild conditions. This method also allows for good control of gel time and an original chemical mechanism for the redox initiators is provided based on electron spin resonance experiments.
Article
Polymer Science
Ahmad Arar, Lilian Wisson, Jacques Lalevee
Summary: The study introduces a pure organic and peroxide-free redox initiating system for polymerization, which enables full control of work time and high reactivity under mild conditions.
Article
Chemistry, Applied
Lijuan Yu, Yang Wang, Hua Wen, Ming Jiang, Fan Wu, Juan Tian
Summary: Acetylferulic paeonol ester (APE) and ferulic paeonol ester (FPE) were synthesized and their structures were confirmed using various techniques. The results showed that APE was more effective in inhibiting fish oil oxidation compared to FPE, indicating that novel compounds with enhanced antioxidant activities can be obtained by covalently bonding two antioxidant active molecules.
Article
Biochemistry & Molecular Biology
Yuqi Shi, Xuelian Chen, Shaojia Qiang, Jie Su, Jiazhong Li
Summary: The study explored FA derivatives by utilizing the FA structural skeleton and conducted various experiments to evaluate their antioxidant and anti-inflammatory properties. Among the compounds tested, S-52372 showed promising scavenging effects on free radicals, anti-inflammatory properties, and lower toxicity compared to FA. Further research is warranted to explore its potential as an ideal FA derivative.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Alejandro Aragon-Gutierrez, Estela Rosa, Miriam Gallur, Daniel Lopez, Pilar Hernandez-Munoz, Rafael Gavara
Summary: In this study, antimicrobial and antioxidant films based on EVOH copolymer containing low amounts of ferulic acid were successfully developed by melt extrusion. The films exhibited UV blocking effect, improved thermal stability, increased water vapor and oxygen transmission rates, and showed significant antioxidant and antimicrobial activity. This suggests the potential applications of ferulic acid in active packaging for food products.
Article
Chemistry, Multidisciplinary
Yang Lu, Wei Wang, Dandan Wang, Xiujie Bian, Hui Zhang, Peng Shi
Summary: A theoretical study using density functional theory (DFT) method investigated the reaction mechanism of ferulic acid (FA) scavenging damaging radicals center dot OH and center dot NO2. The most active site for FA scavenging center dot OH was found to be the -OH group in the benzene ring, while the dominant channel for scavenging center dot NO2 was the RAF reaction on the C = C double bond in the aqueous phase.
STRUCTURAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sarah M. Zeitler, Progyateg Chakma, Matthew R. Golder
Summary: Mechanically-induced redox processes offer a promising alternative to conventional thermal and photochemical synthetic methods and provide exquisite control over the synthesis of high molecular weight polymers.
Article
Polymer Science
Devid Hero, Gergely Kali
Summary: The synthesis of linear polyisobutylene by free radical polymerization in aqueous medium using cyclodextrin solubilizer is reported. This method also led to the formation of new poly(isobutylene-co-acrylamide) amphiphilic copolymers. Additionally, reversible addition-fragmentation chain transfer radical polymerization of isobutylene using a PEG-based symmetric macro chain transfer agent resulted in the formation of Poly(PEG-b-isobutylene-b-PEG) block-copolymer. This novel polymerization method offers environmentally benign routes for producing novel copolymers.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Environmental Sciences
Hsin-Lin Cheng, Shan-Chih Lee, Ju Chang-Chien, Tzu-Rong Su, Jiann-Jou Yang, Ching-Chyuan Su
Summary: Ferulic acid (FA) pretreatment protected zebrafish hair cells from neomycin-induced damage and restored their mechanosensory behavior. By preventing neomycin from entering the cytoplasm of hair cells, FA pretreatment reduced reactive oxygen species production and prevented DNA damage. These findings reveal FA as an effective agent in preventing neomycin-induced ototoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Polymer Science
Stefan Frech, Edgar Molle, Andreas J. Butzelaar, Patrick Theato
Summary: A new and innovative post-polymerization modification procedure has been developed for the ethylene-free synthesis of polyethylene copolymers and block copolymers. By utilizing reversible-deactivation radical polymerization, poly[N-(acryloyloxy)phthalimide] statistical and block copolymers are subjected to thermally and photochemically induced metal-catalyzed decarboxylation, resulting in the formation of polyethylenes through the generation of secondary radicals at the polymer backbone. This approach presents a novel synthetic method in polymer chemistry for the efficient synthesis of different polyethylene block copolymers.
Article
Chemistry, Applied
Xingyue Xiao, Jinli Qiao, Jing Wang, Ji Kang, Li He, Juan Li, Qingbin Guo, Steve W. Cui
Summary: Ferulic acid was successfully tagged onto arabinoxylan molecule by CDI radical grafting reaction, which resulted in decreased water solubility and molecular weight of AX, but increased apparent viscosity and antioxidant activity. These changes were positively correlated with the degree of attached FA. The study highlights the critical role of phenolic compounds in affecting the functional and bioactive properties of non-starch polysaccharides.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Xiuxiu Qi, Hongmei Yan, Yingxue Li
Summary: This study successfully prepared a pH-sensitive fluorescent polymer using ATRP method, and developed pH-sensitive core-shell nanoparticles as carriers for anticancer drug loading and controlled release by adding hollow mesoporous silicon. The nanocomposites showed high drug loading capacity and fluorescence properties, selectively inhibiting melanoma cells.
Article
Materials Science, Multidisciplinary
Shuo Li, Ruchira Colaco, Anne Staubitz
Summary: Diazocine-functionalized initiators were synthesized for controlled radical polymerizations, and their efficiency in polymerizations of methyl acrylate and methacrylate was tested. The initiation of the reactions required high amounts of reducing agents and catalysts. Additionally, violet light irradiation during the reactions caused retardation or termination of the anilide compound.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Xing Huang, Mengquan Shi, Haoqi Zhai, Yuxi Zhang, Yunlong Zhang, Yuxia Zhao
Summary: In this study, nitrogen-doped carbon dots with certain water solubility were developed for photopolymerization applications. The carbon dots exhibited excellent visible light photoinitiation activity and biocompatibility, making them promising for 3D printing and biomedicine. CD-2, with a higher nitrogen content and mainly in pyridinic and pyrrolic forms, showed enhanced photoinitiation efficiency compared to CD-1.
Article
Chemistry, Multidisciplinary
Yang Zeng, Qinzhi Quan, Peng Wen, Zexi Zhang, Mao Chen
Summary: In this work, a light-driven organocatalyzed copolymerization method using TFVB was reported for the controlled synthesis of a variety of hybrid fluorine/boron polymers with low dispersities and good chain-end fidelity. The combination of fluorine and boron was shown to provide high-performance copolymer electrolytes with a high lithium-ion transference number, offering new opportunities for engineering high-performance materials for energy storage.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Lorenzo Francesco Madeo, Patrizia Sarogni, Giuseppe Cirillo, Orazio Vittorio, Valerio Voliani, Manuela Curcio, Tyler Shai-Hee, Bernd Buechner, Michael Mertig, Silke Hampel
Summary: A hybrid hydrogel was developed by loading curcumin onto graphene oxide nanosheets and blending them into an alginate hydrogel. The resulting system showed improved stability and exhibited strong anticancer effects.
Article
Biochemistry & Molecular Biology
Manuela Curcio, Matteo Brindisi, Giuseppe Cirillo, Luca Frattaruolo, Antonella Leggio, Vittoria Rago, Fiore Pasquale Nicoletta, Anna Rita Cappello, Francesca Iemma
Summary: In this study, actively-targeted and dual stimuli-responsive lipid-polymer nanoparticles were used to deliver doxorubicin hydrochloride in triple negative breast cancer cell lines. The nanoparticles were efficiently internalized in cancer cells and modulated drug release based on the surrounding pH and redox potential. In vitro experiments demonstrated the safety and efficacy of the nanoparticles in enhancing the cytotoxic effect of the anticancer drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Rocco Malivindi, Francesco Patitucci, Sabrina Prete, Marco Dattilo, Adele Elisabetta Leonetti, Norma Scigliano, Ortensia Ilaria Parisi, Francesco Puoci
Summary: This study developed a safe and effective medical device called PIMIN050, using Citrus sinensis hydrolyzed powder and Crassostrea gigas shell powder as main components, to manage gastroesophageal reflux disease (GERD). The developed raft system showed strong characteristics such as strength, resilience, and neutralization profile, and demonstrated significant mucoadhesive and film-forming behavior, as well as the ability to inhibit pepsin diffusion in vitro. Safety studies confirmed the biocompatibility of the formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Fiore Pasquale Nicoletta, Francesca Iemma
Review
Engineering, Biomedical
Marco Dattilo, Francesco Patitucci, Sabrina Prete, Ortensia Ilaria Parisi, Francesco Puoci
Summary: Hydrogels are versatile materials that can mimic the mechanical properties of native tissues and are used for various biological applications. Polysaccharide-based hydrogels, such as chitosan, alginate, hyaluronic acid, cellulose, and carrageenan, have gained attention for their biocompatibility, biodegradability, non-toxicity, and excellent mechanical properties. These hydrogels can be used as drug delivery systems in cancer treatment to enhance therapeutic efficacy and minimize side effects. This review provides an overview of hydrogels' classification, properties, synthesis methods, and the application of natural polysaccharides in drug delivery for cancer treatment.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mariafrancesca Baratta, Aleksey Nezhdanov, Alexander I. Mashin, Manuela Curcio, Giuseppe Cirillo, Fiore P. Nicoletta, Giovanni De Filpo
Summary: The reduction of energy consumption is considered one of the most important measures to combat climate change. Smart windows, particularly PDLCs, provide an easy solution to increase energy efficiency and promote energy saving in various fields such as interior design, architecture, and automotive. This study focuses on the preparation and characterization of a reverse mode PDLC that allows the on-demand modification of both transmittance and color.
Article
Materials Science, Multidisciplinary
Mariagrazia Di Luca, Ensieh Poursani, Manuela Curcio, Giuseppe Cirillo, Antonietta Salerno, Sara Bolognini, Giovanni De Filpo, Sara Filippi, Orazio Vittorio, Francesca Iemma, Fiore Pasquale Nicoletta
Summary: In this study, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) was designed as an electro-responsive and antimicrobial device for delivering Rose Bengal (RB) to the skin. The hybrid system showed uniform surface, high biocompatibility and biodegradability. Drug loading and release experiments demonstrated the enhanced binding efficiency and electro-responsive behavior of the hybrid hydrogel, which also exhibited the ability to prevent the adhesion of methicillin-resistant Staphylococcus aureus and kill bacterial cells through sustained release of antimicrobial RB.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Cirillo, Manuela Curcio, Cesare Oliviero Rossi, Giovanni De Filpo, Mariafrancesca Baratta, Michele De Luca, Francesca Iemma, Fiore Pasquale Nicoletta
Summary: The conjugation of polyphenols is an effective method to modify the properties of biomedical materials. In this study, curcumin (CUR) was conjugated to sodium alginate (CA) and chitosan (CS) to increase the viscosity of the conjugates and control the release of loaded therapeutics. Calorimetric and rheological analyses confirmed the enhanced rigidity and interconnection between polymer chains in the conjugates. The evaluation of drug delivery performance showed sustained release profiles, indicating the potential for the development of controlled delivery systems.
Review
Engineering, Biomedical
Sabrina Prete, Marco Dattilo, Francesco Patitucci, Giuseppe Pezzi, Ortensia Ilaria Parisi, Francesco Puoci
Summary: Biomaterials have diverse applications in the biomedical field, particularly in wound healing. The combination of biopolymers with wound healing properties can stimulate and trigger cell responses crucial to the healing process. This review focuses on optimal management and care for wound treatment, highlighting the use of biopolymers, drug delivery systems, and nanotechnologies in enhancing wound healing applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Lorenzo Francesco Madeo, Manuela Curcio, Francesca Iemma, Fiore Pasquale Nicoletta, Silke Hampel, Giuseppe Cirillo
Summary: In this study, two hybrid hydrogel systems were synthesized using two crosslinking methods: physical (ionic gelation) and chemical (radical polymerization). The chemical method (H-A-GO(C)) resulted in hydrogels with higher swelling degree and pronounced pH responsivity, while the physical method (H-A-GO(P)) led to degradation under external voltages. The release profiles of the hybrid hydrogels, extensively analyzed using mathematical models, showed sustained drug release and the ability to modulate the release amount and rate by electro-stimulation of H-A-GO(C).
C-JOURNAL OF CARBON RESEARCH
(2023)
Article
Engineering, Biomedical
Ortensia Ilaria Parisi, Fabrizio Francomano, Marco Dattilo, Francesco Patitucci, Sabrina Prete, Fabio Amone, Francesco Puoci
Summary: Molecular recognition is a useful property shared by various molecules, allowing them to play important roles in biological and pharmaceutical research, diagnostics, theranostics, therapy, and drug delivery. While antibodies have been widely used, their high production cost and time limitations have led to research on alternative molecules such as MIPs. However, further investigations are needed to address the lack of toxicity studies and limited practical applications of MIPs.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
