Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 146, Issue 2, Pages 220-223Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2012.09.008
Keywords
Histaminergic system; Depression; Tuberomamillary nucleus; Postmortem prefrontal cortex
Categories
Funding
- China Scholarship Council for State Scholarship Fund [(2007) 3020]
- China Exchange Program of the Royal Netherlands Academy of Arts and Sciences (KNAW) [10CDP037]
Ask authors/readers for more resources
Background: Rodent experiments suggested that the neuronal histaminergic system may be involved in symptoms of depression. Methods: We determined, therefore, in postmortem tissue of 12 mood disorder patients (8 major depression disorder (MDD) and 4 bipolar disorder (BD)) and 12 well matched controls the expression of the rate-limiting enzyme for histamine production and histidine decarboxylase in the tuberomamillaiy nucleus (TMN) by quantitative in situ hybridization. In addition we used qPCR to determine the expression of the 4 histamine receptors and of the enzyme breaking down histamine, histamine N-methyltransferase (HMT), in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulated cortex (ACC). Results: No changes were observed in the expression of these molecules, except for a significant lower HMT mRNA expression in the ACC of MDD subjects. Limitations: Several inherent and potentially confounding factors of a postmortem study, such as medication and cause of death, did not seem to affect the conclusions. The group size was relatively small but well documented, both clinically and neuropathologically. Conclusion: Except for a lower HMT mRNA expression in the ACC of MDD subjects, the neuronal histaminergic system did not show significant changes, either in the rate limiting enzyme involved in its production or in its receptors in 2 main projection sites, the ACC/DLPFC. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available