Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Joseigla Pinto de Oliveira, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: The study aimed to assess the role of childhood trauma in differentiating MDD and BD, as well as to describe the conversion rate from MDD to BD and its predictors. Findings indicated that predictors of conversion to BD included lower education, substance abuse, younger age of onset, and family history, while childhood trauma was not a significant risk factor for conversion.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: This study characterized the common and specific alterations in the dynamic local functional connectivity pattern in patients with bipolar depressive disorder (BDD) and major depressive disorder (MDD) using a newly developed method called dynamic regional phase synchrony (DRePS). The findings provided new insight into the neural mechanism of BDD and MDD patients and could potentially inform the diagnosis and treatment of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Wen Liu, Xiaowei Jiang, Yide Xin, Zijing Deng, Yu Xie, Yifang Zhou, Yifan Wu, Qikun Sun, Lingtao Kong, Feng Wu, Yanqing Tang
Summary: This study identified differences in dynamic amplitude low-frequency fluctuations (dALFF) between patients with major depressive disorder (MDD) and those who converted to bipolar disorder (BD), and described the role of sex effects in differentiating the two disorders. A positive correlation was found between dALFF values and WCST scores in MDD patients, and this correlation was observed only in female MDD patients in the occipital gyrus.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
J. Lumikukka Socada, John J. Soderholm, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: This study investigated the prevalence, severity, co-occurrence, and overlap of manic symptoms and borderline personality features in unipolar and bipolar major depressive episodes. The results showed that the presence of mixed and borderline features in MDEs is common, with differences in diagnosis-specific features among different subcohorts. The study highlighted the impact of hypomania on perceived BPD features and the correlation between manic symptoms and borderline features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Alessio Simonetti, Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Emiliana Mancuso, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Andrea Fiorillo, Gabriele Sani
Summary: This multicentric observational study aimed to investigate the relationship between affective temperaments and bipolar disorder (BD) or major depressive disorder (MDD), as well as their influence on the severity and course of the diseases. The results revealed that specific affective temperaments were associated with certain disease characteristics. Evaluating affective temperaments may contribute to a better understanding of mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Hyeyoung Kim, Sang Jin Rhee, Hyunju Lee, Dohyun Han, Tae Young Lee, Minah Kim, Eun Young Kim, Jun Soo Kwon, Hyunsuk Shin, Hyeyoon Kim, Yong Min Ahn, Kyooseob Ha
Summary: High-throughput proteomic technologies were used to identify dysregulated proteins in the plasma of patients with major depressive disorder (MDD) and bipolar disorder (BD). Several proteins were found to be altered in both disorders, with higher fold changes observed in MDD patients. These findings may aid in identifying candidate biomarkers for mood disorders.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Mehmet Utku Kucuker, Aysegul Ozerdem, Deniz Ceylan, Alejandra Cabello-Arreola, Ada M. C. Ho, Boney Joseph, Lauren M. Webb, Paul E. Croarkin, Mark A. Frye, Marin Veldic
Summary: This systematic review examined the role of DNA repair enzymes, particularly base excision repair (BER), in mood disorders. The study found that SNPs of several BER genes are associated with MDD and BD, but conflicting findings and limited studies make it difficult to draw definitive conclusions about BER gene expression. Further research comparing DNA repair during episodes of mood disorders to remission may provide valuable insights into the role of DNA repair in these conditions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
David T. Liebers, Mehdi Pirooznia, Andrea Ganna, Fernando S. Goes
Summary: The study demonstrates that psychiatric polygenic risk scores can modestly improve the distinction between BD and MDD cases based on clinical grounds, potentially providing utility for subjects at the extremes of the distribution or those with poorly measured clinical symptoms.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Clinical Neurology
Kody G. Kennedy, Megan Mio, Benjamin I. Goldstein, Paolo Brambilla, Giuseppe Delvecchio
Summary: This review and meta-analysis found that individuals with severe mental illness, especially schizophrenia, have wider retinal venules compared to controls, indicating a potential connection between cerebrovascular health and mental illness.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Zongchang Li, David Li, Xiaogang Chen
Summary: This study shows differences in genetic association between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) with schizophrenia (SCZ) and major depressive disorder (MDD). The study finds that BD-II is more polygenic compared to BD-I, SCZ, and MDD, and there is substantial polygenic overlap between BD-I and SCZ, as well as between BD-I and MDD. The study also identifies specific shared genetic loci between BD subtypes and SCZ or MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Jian Zhou, Xiaowei Jiang, Yifang Zhou, Yue Zhu, Linna Jia, Ting Sun, Linzi Liu, Qikun Sun, Luyu Ren, Yanan Guo, Feng Wu, Lingtao Kong, Yanqing Tang
Summary: This study compared white matter network alterations between patients with remitted major depressive disorder (rMDD) and remitted bipolar disorder (rBD). The findings showed specific changes in certain brain regions that could potentially distinguish between these two affective disorders during remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Substance Abuse
Scott Veldhuizen, Anjali Behal, Laurie Zawertailo, Peter Selby
Summary: This study analyzed the effectiveness and dosage issue of nicotine replacement therapy (NRT) for smoking cessation, and found that patient reluctance to use higher doses may contribute to poorer treatment outcomes.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Neurosciences
Scott Veldhuizen, Chloe Bedard, Sara King-Dowling, Jaime Barratt, Matthew Kwan, John Cairney
Summary: This study examined the measurement stability of motor functioning in 589 children aged 4-5 years. The results suggest that the observed improvements in motor functioning may be influenced by measurement error, and the stability of motor functioning may be greater than what previous research indicates.
HUMAN MOVEMENT SCIENCE
(2023)
Article
Psychiatry
Scott Veldhuizen, Anjali Behal, Laurie Zawertailo, Osnat Melamed, Mahavir Agarwal, Peter Selby
Summary: People with schizophrenia are more likely to smoke and less likely to quit successfully after treatment. This study examines outcomes and service use in a large sample of people with schizophrenia treated in a general-population cessation program. Results show that cessation rates are lower for people with schizophrenia, but still better than unaided quit attempts.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Alene Toulany, Paul Kurdyak, Therese A. Stukel, Rachel Strauss, Longdi Fu, Jun Guan, Lisa Fiksenbaum, Eyal Cohen, Astrid Guttmann, Simone Vigod, Maria Chiu, Charlotte Moore Hepburn, Kimberly Moran, William Gardner, Mario Cappelli, Purnima Sundar, Natasha Saunders
Summary: This study aimed to investigate the relationship between social determinants of health and physician-based mental healthcare utilization and virtual care use among children and adolescents in Ontario, Canada, during the COVID-19 pandemic. Using linked health and demographic administrative data from 2017 to 2021, multivariable Poisson regressions compared rates of outpatient physician-based mental healthcare use during the pandemic with pre-COVID rates. The study found that utilization rates were lower among children and adolescents in the most deprived areas and higher among immigrants. Refugees had the lowest use of virtual care.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Bryan Tanner, Paul Kurdyak, Claire de Oliveira
Summary: The objective of this study was to examine the impacts of the COVID-19 pandemic on psychiatric hospitalizations in Ontario. The authors conducted a time series analysis using data from July 2017 to September 2021 and found that hospitalization volumes initially decreased during the pandemic but returned to pre-pandemic levels by May 2020. However, hospitalizations for psychotic disorders increased by approximately 9%, and short stays and involuntary admissions also experienced an increase before trending downwards.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
James A. G. Crispo, Lisa Liu, Paxton Bach, Dominique R. Ansell, Branavan Sivapathasundaram, Francis Nguyen, Paul Kurdyak, Dallas P. Seitz, Michael Conlon, Jacquelyn J. Cragg
Summary: Despite an increase in unregulated amphetamine use, there is limited data on associated emergency department visits in Canada. The study aimed to examine trends in amphetamine-related ED visits over time in Ontario, as well as factors associated with ED revisits within 6 months.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
M. Ishrat Husain, David J. Rodie, Athina Perivolaris, Marcos Sanches, Allison Crawford, Kyle P. Fitzgibbon, Andrea Levinson, Rose Geist, Paul Kurdyak, Brian Mitchell, David Oslin, Nadiya Sunderji, Benoit H. Mulsant, PARTNERs Study Grp
Summary: Telephone-based collaborative care (tCC) delivered by lay providers can improve outcomes for primary care patients with common mental conditions. This study found that tCC was more effective than enhanced usual care (eUC) in reducing anxiety symptoms and the number of weekly drinks in those with at-risk drinking, but did not have a significant effect on depression symptoms.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Alex Abramovich, W. Ariel Gould, Nelson Pang, Claire de Oliveira, Tomisin Iwajomo, Myriam Vigny-Pau, Kinnon MacKinnon, June Sing Hong Lam, Paul Kurdyak
Summary: This retrospective cohort study from Ontario found that neighbourhood-level marginalization does not clinically mediate mental health service use among transgender individuals. However, transgender individuals are more likely to be exposed to various forms of marginalization and have higher rates of health service utilization across all outcomes.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Natasha Saunders, Rachel Strauss, Sarah Swayze, Alex Kopp, Paul Kurdyak, Zainab Furqan, Arfeen Malick, Muhammad Ishrat Husain, Mark Sinyor, Juveria Zaheer
Summary: This study examines the association between Muslim religious affiliation and suicide and self-harm presentations among first- and second-generation immigrant youth. The study found that males from Muslim-majority countries had lower suicide rates compared to males from Muslim-minority countries. There was no significant difference in suicide and self-harm presentations among female Muslim youth.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Medicine, General & Internal
Natasha Ruth Saunders, Therese A. Stukel, Rachel Strauss, Longdi Fu, Eyal Cohen, Simone Vigod, Astrid Guttmann, Paul Kurdyak, Alene Toulany
Summary: A study found that the proportion of physicians providing exclusively virtual care for children and adolescents in outpatient mental healthcare in a single-payer health system in Ontario, Canada is associated with physician factors such as gender, training, specialty, and practice size.
Article
Medicine, General & Internal
David Rudoler, M. Ruth Lavergne, Emily Gard Marshall, Juveria Zaheer, Selene Etches, Kimberley P. Good, Agnes Grudniewicz, Alan Katz, Paul Kurdyak, James Bolton, Ridhwana Kaoser, Catherine Moravac, Jason Morrison, Benoit Mulsant, Sandra Peterson, Phil G. Tibbo
Summary: Despite a steady per-capita supply of psychiatrists in most provinces, the Canadian population has poor and inequitable access to psychiatric care. This study aims to improve access to psychiatric care by developing comparable indicators of supply, analyzing variations in the characteristics and practice style of the psychiatrist workforce, and studying psychiatrist practice choices and intentions.
Article
Sport Sciences
Otavio Amaral de Andrade Leao, Thayna Ramos Flores, Jaime Barratt, Andrea Damaso Bertoldi, Marlos Rodrigues Domingues, John Cairney, Ulf Ekelund, Inacio Crochemore-Silva, Gregore Iven Mielke, Pedro Curi Hallal
Summary: Physical activity has a negative association with weight-related growth indicators, and weight-related growth indicators also have a negative impact on physical activity in children under five years of age.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Psychology, Developmental
Maeghan E. James, John Cairney, Nikoleta Odorico, Tracia Finlay-Watson, Kelly P. Arbour-Nicitopoulos
Summary: This study developed and evaluated a web-based platform for parents to support the physical and social-emotional development of preschoolers. The platform was found to be acceptable and feasible, with parents indicating high satisfaction and identifying factors that may influence their engagement at home.
JOURNAL OF MOTOR LEARNING AND DEVELOPMENT
(2023)
Letter
Anthropology
Sara King-Dowling, Kathryn Fortnum, Matthew Y. W. Kwan, John Cairney
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Stephanie Babij, Maeghan E. James, Scott Veldhuizen, Christine Rodriguez, David Price, Matthew Kwan, John Cairney
Summary: This study examines the impact of cumulative prenatal risk factors on the presence of Developmental Coordination Disorder (DCD) in young children. The results show that there is a significant increase in the odds of a child having DCD when there are more prenatal risk factors. Further investigation is needed to explore the cumulative impact of multiple prenatal risk factors and their specific combinations in relation to DCD.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)