Review
Pharmacology & Pharmacy
Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Summary: Pulmonary drug delivery is focused on directing drugs to lung disease sites for maximum therapeutic benefit, with capsule-based dry powder inhalers (cDPIs) being a popular and convenient option for treating a variety of diseases. cDPI technology is relatively simple, cost-effective, and has a lower carbon footprint compared to other inhaler devices.
Review
Pharmacology & Pharmacy
Anne Haaije de Boer, Paul Hagedoorn, Floris Grasmeijer
Summary: In this article, examples of ancient inhalation therapy and the development of early dry powder inhalers are discussed. The use of databases and personal communication with historians and custodians of historic manuscripts and artifacts were used to verify information. The article suggests that inhalation therapy may have a longer and more widespread history than currently known.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Li Ding, Ashlee D. Brunaugh, Sven Stegemann, Scott V. Jermain, Matthew J. Herpin, Justin Kalafat, Hugh D. C. Smyth
Summary: This review aims to provide information on critical factors to be considered for the development of capsule-based dry powder inhalers (cDPIs) using a quality by design (QbD) approach. Defining critical quality attributes is essential in order to understand critical material attributes and critical process parameters.
Review
Pharmacology & Pharmacy
Nashwa El-Gendy, Craig M. Bertha, Mohammed Abd El-Shafy, Dhaval K. Gaglani, Andrew Babiskin, Elizabeth Bielski, Susan Boc, Sneha Dhapare, Lanyan Fang, Katharine Feibus, Anubhav Kaviratna, Bing V. Li, Markham C. Luke, Tian Ma, Bryan Newman, Michael Spagnola, Ross L. Walenga, Liang Zhao
Summary: This review examines the regulatory science for generic dry powder inhalation products worldwide, highlighting the revised guidance issued by the FDA that emphasizes the principles of quality by design and elements of pharmaceutical development. It also provides recommendations to expedite generic approvals for abbreviated new drug applications.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Gajendra Singh, Albyn Lowe, Athiya Azeem, Shaokoon Cheng, Hak-Kim Chan, Ross Walenga, Agisilaos Kourmatzis
Summary: This study investigated the transport of pharmaceutical dry powder inside an inhaler-like device using high-speed imaging, focusing on the effect of inflow modifications on the dispersion characteristics of agglomerates inside the device. By strategically perturbing airflow conditions, the research observed complete fluidisation of the powder bed and various behaviors such as local turbulence, bimodal fragment size behavior, and flow separation induced by changes in flow behavior. The study's findings provide valuable data for understanding the impact of inflow conditions on a dry powder inhaler-like device and validating computational models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Zhanying Zheng, Sharon Shui Yee Leung, Raghvendra Gupta
Summary: This article focuses on the development of modelling methodologies for flow and particle behaviors in DPI devices and their applications to device design in several emerging fields. Various modelling methods, including the most recent multi-scale approaches, are covered and the latest simulation studies of different devices are summarised and critically assessed.
Review
Pharmacology & Pharmacy
Rachel Yoon Kyung Chang, Michael Y. T. Chow, Dipesh Khanal, Donghao Chen, Hak-Kim Chan
Summary: Therapeutic biologics delivered through pulmonary route offer safe and effective treatment options for respiratory diseases, but require careful formulation strategies, manufacturing processes, and stability considerations.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Hana Douafer, Veronique Andrieu, Emmanuel Wafo, Michelle Sergent, Jean Michel Brunel
Summary: The global increase of multidrug resistant bacteria and the lack of new classes of antibiotics are challenging clinicians in treating bacterial infections. A new adjuvant has been identified to enhance antibiotic activity against resistant P. aeruginosa strains. An experimental protocol was developed to optimize a dry powder for inhalation delivering antibiotic and adjuvant simultaneously.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Benedict Benque, Johannes G. Khinast
Summary: Drug delivery from a capsule-based dry powder inhaler is influenced by the inhaler's design, the drug's formulation, and the inhalation maneuver. Patient variability poses a challenge in designing new inhaler types. Simulation studies show that different inhalation profiles can affect carrier powder motion and acceleration events.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Takaaki Ito, Eriko Yamazoe, Kohei Tahara
Summary: This study demonstrates a method for preparing drugs for dry powder inhalers by cryo-milling nanofiber mats. The method maintains the enzymatic activity of the drugs and provides good inhalation properties for fine particles.
Article
Cardiac & Cardiovascular Systems
Sakurako Tajiri, Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Kohichiro Asano
Summary: The study found that inhalation flow profiles measured in real-world settings differ from those measured in the laboratory, showing weaker and shorter characteristics. The results emphasize the importance of rapid inhalation when using a dry powder inhaler.
RESPIRATORY MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jiawei Wang, Xiangjun Kong, Linfeng Hu, Yuanjia Hu
Summary: This article provides a comprehensive review of patents related to dry powder inhalers (DPIs), including disease indications, medicaments, milestone patents, and small molecule inhibitors. The study identifies popular technologies in the DPI field and explores emerging development directions to assist researchers in making relevant R&D decisions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Richard Pasteka, Lara Alina Schoellbauer, Joao Pedro Santos da Costa, Radim Kolar, Mathias Forjan
Summary: This study investigates the changes in aerosol particle diameter and particle number concentration of pharmaceutical aerosols generated by four dry powder inhalers under realistic inhalation and exhalation conditions. Through the use of the xPULM(TM) active respiratory system model, the study found significant differences in mean particle diameter between inhaled and exhaled particles, with most particles depositing in the lung. The mechanical upper airway model acts as a filter for larger particles and increases the resistance of the overall system.
Review
Pharmacology & Pharmacy
Sabine Haeussermann, Laura J. Arendsen, John N. Pritchard
Summary: Adherence to inhaled treatments is a complex challenge for patients with COPD and asthma. Monitoring tools, such as smart inhalers, can provide real-world data on patient behavior.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Alex Wilkinson, Ashley Woodcock
Summary: The choice of asthma treatment options has significant impact on reducing greenhouse gas emissions, with strategies that replace overuse of reliever MDIs with inhaled corticosteroids having the potential to improve asthma control and reduce carbon emissions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Correction
Pharmacology & Pharmacy
Gunther Hochhaus, Mong-Jen Chen, Abhinav Kurumaddali, Uta Schilling, Yuanyuan Jiao, Stefanie K. Drescher, Elham Amini, Simon M. Berger, Bhargava Kandala, Christine Tabulov, Jie Shao, Brandon Seay, Mutasim N. Abu-Hasan, Sandra M. Baumstein, Lawrence Winner, Jagdeep Shur, Robert Price, Michael Hindle, Xiangyin Wei, Cynthia Carrasco, Dennis Sandell, Oluwamurewa Oguntimein, Minori Kinjo, Renishkumar Delvadia, Bhawana Saluja, Sau L. Lee, Denise S. Conti, Jurgen B. Bulitta
Article
Engineering, Chemical
Arun Kolanjiyil, Sana Hosseini, Ali Alfaifi, Dale Farkas, Ross Walenga, Andrew Babiskin, Michael Hindle, Laleh Golshahi, P. Worth Longest
Summary: A verified computational fluid dynamics (CFD) model was developed to simulate nasal spray deposition for different spray-pump designs, incorporating cloud motion effects. The accuracy of the CFD model was confirmed by comparing predictions with in vitro measurements, demonstrating the importance of two-way coupling for most nasal spray pumps.
AEROSOL SCIENCE AND TECHNOLOGY
(2022)
Article
Respiratory System
Connor Howe, Mohammad A. M. Momin, Karl Bass, Ghali Aladwani, Serena Bonasera, Michael Hindle, Philip Worth Longest
Summary: Modifications to the nasal interface of an infant air-jet DPI were found to improve aerosol delivery performance, particularly in preterm nasal-throat models. By using a rigid curved prong and adding a metal mesh to dissipate turbulent jet, lung delivery efficiency was increased while nasal-throat deposition was reduced. The platform performed similarly in two different preterm airway models, with no statistically significant difference observed in performance metrics.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Worth Longest, Amr Hassan, Dale Farkas, Michael Hindle
Summary: The study aimed to determine the best spray drying conditions for a tobramycin excipient enhanced growth (Tobi-EEG) formulation in a pediatric air-jet dry powder inhaler (DPI) through computational fluid dynamics (CFD) simulations and aerosol characterization experiments. The newly recommended spray dryer conditions improved delivery performance of the lead Tobi-EEG formulation in pediatric inhalers.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Karl Bass, Mohammad A. M. Momin, Connor Howe, Ghali Aladwani, Sarah Strickler, Arun Kolanjiyil, Michael Hindle, Robert M. DiBlasi, Worth Longest
Summary: The objective of this study was to investigate the effects of different nasal prong configurations on nostril deposition of pharmaceutical aerosols in preterm infants. The results showed that the use of nasal prongs significantly affected the deposition of aerosols in the infant nasal cavity, calling for design alterations to improve lung delivery efficiency.
Article
Pharmacology & Pharmacy
Ali Alfaifi, Sana Hosseini, Amir R. Esmaeili, Ross Walenga, Andrew Babiskin, Theodore Schuman, Worth Longest, Michael Hindle, Laleh Golshahi
Summary: This study developed a set of in vitro adult nasal geometries to improve the relationships between commonly conducted in vitro studies for locally-acting nasal spray drug products with in vivo regional deposition. By statistically analyzing and validating the performance of the models, this research aims to facilitate the development of locally-acting nasal sprays and provide a better understanding of how in vitro metrics relate to in vivo regional nasal deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Dale Farkas, Morgan L. Thomas, Amr Hassan, Serena Bonasera, Michael Hindle, Worth Longest
Summary: This study evaluated the in vitro aerosol performance of a dry powder antibiotic product in pediatric subjects aged 2-10 years. The results showed that the product nearly eliminated extrathoracic depositional loss, demonstrated high efficiency nose-to-lung antibiotic aerosol delivery, and had little variability across subject age and administered air volume.
PHARMACEUTICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Michael Hindle, P. Worth Longest
Summary: The study successfully incorporated a passive cyclic loading strategy into the infant air-jet dry powder inhaler (DPI) platform and demonstrated high efficiency aerosol lung delivery under various conditions.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Benjamin M. M. Spence, Worth Longest, Rabijit Dutta, Mohammad A. M. Momin, Sarah Strickler, Michael Hindle
Summary: The objective of this study was to develop a new heated dryer system for efficient lung delivery of nebulized aerosol and demonstrate its performance through in vitro testing. The results showed that the system had high lung delivery efficiency and reduced drug loss.
Article
Pharmacology & Pharmacy
Rudra Pangeni, Tuo Meng, Sagun Poudel, Divya Sharma, Hallie Hutsell, Jonathan Ma, Bruce K. Rubin, Worth Longest, Michael Hindle, Qingguo Xu
Summary: Airway mucus is a complex gel that acts as a barrier against foreign pathogens and assists in their removal through mucociliary clearance. In respiratory diseases, changes in mucus properties lead to decreased pathogen capture and lung function decline. Designing aerosol delivery systems, such as muco-adhesive particles and muco-penetrating particles, can improve drug retention and absorption in the lungs. This review provides insight into airway mucus composition, rheological characteristics, techniques to study flow dynamics and particle diffusion, and advancements in engineering muco-penetrating particles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Sana Hosseini, Ali Alfaifi, Amir Reza Esmaeili, David Edwards, Theodore Schuman, Worth Longest, Michael Hindle, Laleh Golshahi
Summary: This study investigated the relationship between nasal anatomical characteristics and drug deposition. The results showed no clear correlation between nasal anatomical characteristics and drug deposition, but a combination of specific variables can predict the range of drug deposition.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Arun Kolanjiyil, Ross Walenga, Andrew Babiskin, Laleh Golshahi, Michael Hindle, Worth Longest
Summary: This study analyzed the effects of changes in spray cone angle, spray velocity, spray ovality, and droplet size distribution on regional nasal deposition using a computational fluid dynamics model. The results showed that spray cone angle had the greatest impact on nasal deposition, followed by plume ovality and characteristic droplet size. Spray velocity and droplet size distribution uniformity had only minimal influence. The study established quantitative relationships for predicting changes in nasal deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ghali Aladwani, Mohammad A. M. Momin, Benjamin Spence, Dale R. Farkas, Serena Bonasera, Amr Hassan, Michael Hindle, Worth Longest
Summary: The objective of this study was to investigate the spray performance of powders produced by different mesh nebulizers in the initial design of a new small-particle spray dryer system. Various mesh sources were used to spray dry an aqueous excipient enhanced growth (EEG) model formulation and the resulting powders were characterized. The medical-grade Aerogen Solo and Aerogen Pro mesh sources were selected as lead candidates for their superior aerosolization performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Rudra Pangeni, Amr Ali Mohamed Hassan, Dale Farkas, Hadi Sudarjat, Worth Longest, Michael Hindle, Qingguo Xu
Summary: This study investigated the aerosol performance of a novel small animal air-jet dry powder insufflator (Rat AJ DPI) for delivering albuterol EEG aerosol to rat lungs. The Rat AJ DPI showed narrower aerosol size distribution profiles compared to the Penn-Century Insufflator. It also delivered significantly larger doses to rat lungs at a higher loaded mass and had a higher delivery efficiency compared to the manual actuation of the same dose.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Sarah Strickler, Michael Hindle, Worth Longest
Summary: This study focused on the development of an infant air-jet dry powder inhaler (DPI) that could be actuated multiple times with minimal user interaction. The metering system, consisting of a powder delivery tube (PDT) and a powder supporting shelf, could be tuned for individual powder formulations to maintain high efficiency lung delivery. The optimized infant air-jet DPI provided efficient and consistent lung delivery of aerosols based on in vitro testing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Francisco J. Higuera, Juan Fernandez de la Mora
Summary: This study investigates a particle condensation device that uses cold and warm humid air streams to achieve water vapor condensation. Compared to existing water condensation particle counters, this configuration offers advantages such as variable saturation ratio, accelerated penetration of water vapor, and a relatively uniform saturation field.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Brijal Prajapati, Vishal Dharaiya, Manoranjan Sahu, Chandra Venkatraman, Pratim Biswas, Kajal Yadav, Delwin Pullokaran, Ramya Sunder Raman, Ruqia Bhat, Tanveer Ahmad Najar, Arshid Jehangir
Summary: This study evaluated the performance of a low-cost particulate matter sensor and proposed a physics-based calibration method. The results showed that the physics-based calibration approach performed better compared to statistical models at both observation sites.
JOURNAL OF AEROSOL SCIENCE
(2024)
Correction
Engineering, Chemical
N. Searle, K. Kaur, K. Kelly
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Tianyu Cen, Laura Torrent, Andrea Testino, Christian Ludwig
Summary: In this study, a hyphenated setup consisting of a rotating disk diluter (RDD) with spICP-MS (RDDspICP-MS) was used for online sampling and characterization of metallic nanoparticles (NPs) in ambient pressure aerosols. The RDD allowed for constant flow rate sampling of aerosols and adjusting the dilution ratio for different particle number concentrations (PNCs). The feasibility of this setup was tested with different sizes of AuNPs in argon-based and air-based aerosols, and the results showed a lower limit of detection for number concentration. The capability of the setup to accurately investigate multi-modal samples and the interference of ionic species was also demonstrated.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
A. Valenzuela, E. Bazo, R. A. Rica, L. Alados-Arboledas, F. J. Olmo-Reyes
Summary: This article introduces a method to measure the extinction cross section of levitated particles using an electrodynamic trap and double-cavity ring down spectroscopy technique, and demonstrates the potential of this method in 1,2,6-hexanetriol particles through simulations and experiments. Unlike traditional methods, this technique provides crucial information about the extinction cross section of sodium chloride particles during dehydration and hydration processes.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Shadi Yaqoubi, Mohaddese Sokuti, Sahand Mazloum-Ravasan, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: In this study, a modified version of ultrasonic spray pyrolysis was used to prepare salbutamol sulfate dry powder. The engineered particles showed suitable characteristics for effective drug delivery to the lungs and demonstrated acceptable aerosolization performance. This newly introduced method appears to be capable of producing dry powder formulations of different drugs without the need for surfactants or stabilizers.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Ashley L. Nord, Patrice Dosset, Pierre Slangen, Manouk Abkarian
Summary: Phonation has been found to be a potent transmission route for the COVID-19 virus. To control transmission, it is important to measure the amount of aerosols produced by speech. Researchers used digital in-line holography to overcome experimental challenges and successfully imaged the formation and deformation of saliva filaments in the mouth during speech, as well as the resulting aerosolized droplets.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Yating Wang, Yiyang Zhang, Zhu Fang, Xinxin Wu
Summary: The research investigates the energy dissipation in particle-wall collision with roughness using the finite element method. The results show that the presence of surface roughness leads to lower viscoelastic dissipation and higher restitution coefficient compared to a smooth surface. The collision time is identified as a key factor in predicting the energy dissipation.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Shaamrit Balendra, Akshay Kale, Julie Pongetti, Mohsen Kazemimanesh, Molly Haugen, Lee Weller, Adam Boies
Summary: The measurement of airborne particles is important for detecting and characterising air pollution, emissions, fire detection, occupational and climate impacts. However, current optical particle counters (OPCs) cannot measure ultrafine particles. This study explores the limitations of miniaturising a condensation particle counter (CPC) growth chamber and provides a toolkit for optimising the design of miniaturised CPC-GCs.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Markus Snellman, Namsoon Eom, Maria E. Messing, Knut Deppert, Chris Hogan
Summary: Segregated bimetallic nanoparticles, such as core-shell nanoparticles, have attracted widespread interest in various fields like biomedicine, catalysis, and optoelectronics. Aerosol technology provides an optimal platform for controlling the size, structure, and composition of nanoparticles, which are crucial parameters for tuning the material performance for specific applications. In this study, researchers developed a novel evaporator design that allows on-line coating of core particles with a shell directly in the gas phase. By utilizing a local heater, the researchers were able to decouple the heating process of the evaporating material from the aerosol particles, thereby limiting core-shell alloying. The resulting core-shell particle formation with controllable shell thickness was demonstrated using evaporation of zinc onto core particles of gold, tin, and bismuth. Simple models were also discussed to explain the observed growth process inside the evaporator and the formation of the shell.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Kentaro Misawa, Yuto Kasai
Summary: In this study, the laser-induced fluorescence technique was used to observe scattered and fluorescent signals from fluorescent polystyrene latex particles. The ratio of fluorescence to scattered signal intensities was found to be almost equal for particles of the same size, allowing for the separate observation of mixed-size fluorescent particles. Relative fluorescence intensities were obtained by incorporating ratios of fluorescence to scattered signal and relative scattered signal intensities.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Sripriya Nannu Shankar, William B. Vass, John A. Lednicky, Tracey Logan, Rebeccah L. Messcher, Arantzazu Eiguren-Fernandez, Stavros Amanatidis, Tara Sabo-Attwood, Chang-Yu Wu
Summary: This study introduces a testing system that allows for direct exposure of aerosolized viruses onto host cells. By collecting particles of different sizes and analyzing them, researchers obtained information on the concentration and viability of the virus at different particle sizes.
JOURNAL OF AEROSOL SCIENCE
(2024)