Review
Pharmacology & Pharmacy
Rachel Yoon Kyung Chang, Michael Y. T. Chow, Dipesh Khanal, Donghao Chen, Hak-Kim Chan
Summary: Therapeutic biologics delivered through pulmonary route offer safe and effective treatment options for respiratory diseases, but require careful formulation strategies, manufacturing processes, and stability considerations.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Kahori Miyamoto, Tomomi Akita, Chikamasa Yamashita
Summary: This study reported the development of a radiolabeling method for lyophilizate for dry powder inhalation (LDPI) formulations, which may be useful for the quantification of drug deposition in human lungs.
Article
Pharmacology & Pharmacy
Nicholas Bungert, Mirjam Kobler, Regina Scherliess
Summary: The study compared two established dry particle coating options and found that using magnesium stearate can reduce surface energy of carrier particles and significantly enhance the aerodynamic performance of carrier-based blends. High-shear mixer coating offers significant benefits, including lower drug-carrier adhesion and higher efficiency in the coating process.
Review
Pharmacology & Pharmacy
Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Summary: Pulmonary drug delivery is focused on directing drugs to lung disease sites for maximum therapeutic benefit, with capsule-based dry powder inhalers (cDPIs) being a popular and convenient option for treating a variety of diseases. cDPI technology is relatively simple, cost-effective, and has a lower carbon footprint compared to other inhaler devices.
Article
Pharmacology & Pharmacy
Mengyu Li, Rachel Yoon Kyung Chang, Yu Lin, Sandra Morales, Elizabeth Kutter, Hak-Kim Chan
Summary: The spray-dried phage cocktail powder demonstrated stability, inhalability, and efficacy against various MDR P. aeruginosa strains causing pulmonary infections, broadening the bactericidal spectrum and reducing resistance emergence compared to single-phage formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Wing-Hin Lee, Ching-Yee Loo, Daniela Traini, Paul M. Young
Summary: This study aimed to develop a simple dry powder inhalation (DPI) formulation containing paclitaxel (PTX) and curcumin (CUR) to achieve preferential cytotoxicity towards lung cancer cells.
Review
Pharmacology & Pharmacy
Li Ding, Ashlee D. Brunaugh, Sven Stegemann, Scott V. Jermain, Matthew J. Herpin, Justin Kalafat, Hugh D. C. Smyth
Summary: This review aims to provide information on critical factors to be considered for the development of capsule-based dry powder inhalers (cDPIs) using a quality by design (QbD) approach. Defining critical quality attributes is essential in order to understand critical material attributes and critical process parameters.
Review
Medicine, Research & Experimental
Hao Lou, Li Ding, Tian Wu, Weikun Li, Ryan Khalaf, Hugh D. C. Smyth, Darren L. Reid
Summary: This review provides an overview of the critical process parameters in the manufacturing of dry powder inhaler (DPI) products and discusses the application of models and simulations in DPI process development. The authors emphasize the increasing importance of models and simulations in evaluating the impact of material attributes and process parameters on process performance, and expect that advancements in computational power will enable more accurate modeling and simulation of real-world DPI process operations.
MOLECULAR PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of mouthpiece designs in carrier-based dry powder inhalation on aerosol particle characteristics. It is found that a mouthpiece with a spiral channel and mixing chamber is effective in delivering drug particles uniformly to the peripheral target regions of the respiratory system under low flow velocities.
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of adding bypass holes in a dry powder inhaler on aerosol particle characteristics. The direction, size, and position of the bypass holes in the inhaler passage were found to significantly influence the spray output. Adding bypass holes decreased the mean penetration length of drug particles by 12%, but simultaneously increased the spray angle by 35%, resulting in a significant decrease in forward particle momentum.
Article
Pharmacology & Pharmacy
Stephanie Hufnagel, Haiyue Xu, Sawittree Sahakijpijarn, Chaeho Moon, Zhengrong Cui, Laura Q. M. Chow, Robert O. Williams
Summary: Thin-film freeze-drying (TFFD) is an effective technique for preparing inhalable dry powders of monoclonal antibodies (mAbs) for pulmonary drug delivery. This study investigated the formulation and aerosol performance of TFFD dry powders prepared with different excipients. The results showed that TFFD dry powders had desirable aerosol properties and improved stability compared to liquid formulations. The addition of polyvinylpyrrolidone K40 further enhanced the storage stability of the mAbs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Amanpreet Kaur, Arvind K. Bansal
Summary: This study employed a one-step spray drying process to generate ready-to-use nanocrystalline solid dispersion dry powder for inhalation of voriconazole. Various formulation and process related parameters were screened to optimize the particle size. The powders were extensively characterized, and the addition of Aerosil(R) 200 was found to improve aerosolization performance.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Rick Heida, Paul Hagedoorn, Melle C. van Meel, Jurrie E. R. Prins, Frederike S. Simonis, Renate Akkerman, Anke L. W. Huckriede, Henderik W. Frijlink, Anne H. de Boer, Wouter L. J. Hinrichs
Summary: A challenge in developing dry powder formulations for inhalation is the poor reproducibility of administration to small laboratory animals. Current devices for delivering dry powder formulations to small rodents often fail to function optimally due to the use of the same puff of air for both powder dispersion and aerosol delivery. A novel aerosol generator was introduced, allowing the administration of a pre-generated aerosol to mice lungs, with controlled powder delivery. Although the emitted aerosol showed favorable size range for lung deposition and reproducibility, in vivo fluorescent imaging revealed significant differences in dose deposition and powder distribution among mice, suggesting inevitable biological variation in lung deposition.
Article
Pharmacology & Pharmacy
Jong-Ju Lee, Linh Dinh, Juhyun Park, Rama Khraisat, Jun Woo Park, Jae Kwan Jeong, Juseung Lee, Hyun Sil Kim, Moo Suk Park, Jun-Hyun Ahn, Sung-Joo Hwang
Summary: This study prepared lysozyme-loaded liposomal dry powder inhalers using various non-ionic surfactants and characterized their properties. The results showed that the formulation with a drug to PS 80 ratio of 1:0.5 w/w maintained protein activity while demonstrating good aerosol performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Tuangrat Praphawatvet, Zhengrong Cui, Robert O. Williams III
Summary: This paper provides a comprehensive review of the pharmaceutical applications of thin-film freeze-drying (TFF) powders of small molecule drugs. The unique physical properties of TFF powders facilitate efficient pulmonary delivery and improve dissolution and bioavailability after oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
Jieqing Gan, Zongyan Zhou, Aibing Yu, Dean Ellis, Reece Attwood, Wei Chen
Summary: Multibody dynamics (MBD) simulation is a useful tool for analyzing the kinematic function of multibody systems, while discrete element method (DEM) is commonly used for simulating particle flows and overall processes. Combining MBD and DEM methods through functional mock-up interface (FMI) co-simulation can predict equipment performance by considering both material and equipment behavior. This study utilized Dymola software to perform MBD and FMI co-simulations, developing MBD models for a hydraulic excavator system and GPU-based DEM models for excavator digging cycles. The results demonstrated the significant impact of solid materials on excavator movement.
Article
Engineering, Chemical
Lingling Liu, Shibo Kuang, Baoyu Guo, Aibing Yu
Summary: Optimization of ironmaking blast furnaces involves considering bottom and top operations. A recently developed integrated BF model and numerical orthogonal experiments are used to predict BF performance indicators and conduct multi-objective optimization and operatable zone identification.
CHEMIE INGENIEUR TECHNIK
(2023)
Review
Infectious Diseases
Sue C. Nang, Yu-Wei Lin, Aleksandra Petrovic Fabijan, Rachel Y. K. Chang, Gauri G. Rao, Jonathan Iredell, Hak-Kim Chan, Jian Li
Summary: This review examines the current literature on phage pharmacology and highlights major pharmacological challenges for phage therapy. The lack of PK/PD information represents a major challenge for phage therapy, as therapeutic phages are biological entities with complex PK/PD.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Yuncheng Wang, Dipesh Khanal, Adit B. Alreja, Hang Yang, Rachel Y. K. Chang, Waiting Tai, Mengyu Li, Daniel C. Nelson, Warwick J. Britton, Hak-Kim Chan
Summary: This study investigated the feasibility of producing inhalable powders of endolysins Cpl-1 and ClyJ-3 using spray drying method with excipients. The results showed that ClyJ-3 lost its bioactivity before the drying process, while Cpl-1 maintained its bioactivity in the spray-dried powders. Cpl-1 formulations with leucine and either lactose or trehalose exhibited promising physico-chemical properties and aerosol performances. These findings suggest that endolysin Cpl-1 can be formulated as spray dry powders for potential treatment of pulmonary infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Dipesh Khanal, Jinhee Kim, Jing Zhang, Wei-Ren Ke, Mark M. Banaszak Holl, Hak Kim Chan
Summary: The aim of this research was to use optical photothermal infrared spectroscopy (OPTIR) to analyse the chemical composition of pharmaceutical dry powder inhalation (DPI) aerosol particles. The study confirmed the presence of specific chemical peaks related to the drugs and excipients in the size-segregated particles of DPI formulations. It also found that the drug to excipient distribution ratio varied in different formulations, indicating heterogeneity. The results showed that OPTIR can serve as a valuable analytical platform for screening the physicochemical properties of DPI aerosols in solid state.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Athiya Azeem, Gajendra Singh, Lunjian Li, Hak-Kim Chan, Runyu Yang, Shaokoon Cheng, Agisilaos Kourmatzis
Summary: This study quantified the probability of agglomerate-to-wall collision using a unique image processing technique. The purpose was to investigate the effects of flow rate and particle size on the percentage of colliding agglomerates within a powder dispersion device.
PHARMACEUTICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Grace Tsz Yan Yau, Waiting Tai, Jonathon Carl Arnold, Hak-Kim Chan, Philip Chi Lip Kwok
Summary: The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. This review examines the preclinical and clinical evidence on the therapeutic use of CBD in treating various brain disorders, as well as different drug delivery approaches for CBD.
PHARMACEUTICAL RESEARCH
(2023)
Article
Engineering, Chemical
Yifan Qin, Xiao Dong Chen, Aibing Yu, Jie Xiao
Summary: Mathematical modeling of mass transfer and absorption in the small intestine is challenging and requires a reliable and computationally efficient predictive model. This study derives an absorption model that considers the 3D intestinal inner wall structure and can be used in a 1D distributed model. Computational fluid dynamics simulations are used to quantify the mass-transfer coefficient. The model provides insights into the influence of intestinal morphology and motility on mass transfer and absorption.
Article
Energy & Fuels
E. Dianyu, Peng Zhou, Langyong Ji, Jiaxin Cui, Qiang Xu, Liejin Guo, Aibing Yu
Summary: In this study, a validated CFD-DEM model is used to investigate the dynamics, microstructure, and thermochemical behaviors in the raceway of a blast furnace with hydrogen injection operations. The effects of hydrogen injection concentration on raceway size, gas temperature, and components are studied.
Article
Pharmacology & Pharmacy
Hao Miao, Ke Huang, Yingwen Li, Renjie Li, Xudong Zhou, Jingyu Shi, Zhenbo Tong, Zhenhua Sun, Aibing Yu
Summary: In this study, the LNP formulation, atomization methods, and buffer system were optimized to maintain stability and efficiency of mRNA encapsulated LNPs during the atomization process. A suitable LNP formulation for atomization, AX4, DSPC, cholesterol, and DMG-PEG2K at a 35/16/46.5/2.5 (%) molar ratio, was identified based on in vitro experiments. Soft mist inhaler (SMI) was found to be the most suitable method for pulmonary delivery of mRNA encapsulated LNPs. The physico-chemical properties of the LNPs, such as size and entrapment efficiency, were further improved by adjusting the buffer system with trehalose. In vivo fluorescence imaging of mice demonstrated the potential of SMI with proper LNPs design and buffer system for inhaled mRNA-LNP therapies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Dazhao Gou, Hak-Kim Chan, Agisilaos Kourmatzis, Runyu Yang
Summary: This study conducted a numerical investigation using coupled computational fluid dynamics (CFD) and discrete element method (DEM) to evaluate the impact of design changes in a commercial dry powder inhaler (DPI) device on the aerosolization of an API-only formulation. Six different designs were proposed by modifying the mouthpiece and chamber of the original geometry. The performances of these designs were evaluated in terms of powder deposition and fine powder fraction (FPF) in the device. The study found that the resistance and FPF emitted varied with different designs, highlighting the importance of the mouthpiece and chamber design on powder dispersion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Zhiwei Shen, Jingliang Dong, Liam Milton-McGurk, Xinyu Cai, Hanieh Gholizadeh, Hak-Kim Chan, Ann Lee, Agisilaos Kourmatzis, Shaokoon Cheng
Summary: Understanding the effects of anatomical structures on nasal flow and particle deposition is important for drug delivery optimization and assessing the impact of pollutants and toxins inhalation. This study found that simplifying the geometry of the nasal cavity had minimal effect on airflow but influenced the location and quantity of particle deposition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Maziar Kakhi, Chandana Jayasundara, Ross Walenga, Srinivas Ravindra Babu Behara, Hak-Kim Chan, Runyu Yang
Summary: This study develops a numerical model to investigate the effect of aperture size on powder dispersion in dry powder inhalers. The results show that larger apertures can reduce the emptying time of the capsule and increase the particle evacuation velocity. However, the impact energy of collisions is not significantly affected by aperture size. It is also found that inside the capsule, particle-particle collisions are more frequent, while outside the capsule, particle-wall collisions are more frequent.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yue Cao, Dipesh Khanal, Jinhee Kim, Rachel Yoon Kyung Chang, Alex Seungyeon Byun, Sandra Morales, Mark M. Banaszak Holl, Hak-Kim Chan
Summary: This study investigates the effect of common organic solvents on the stability of bacteriophages. The results show that the bacteriophages are more stable in alcohols and DMSO, and myoviruses tend to be more stable than podoviruses. The choice of solvents for phage formulation depends on the specific phage and solvent types.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Cell Biology
Rohan Flint, Daniel R. Laucirica, Hak-Kim Chan, Barbara J. Chang, Stephen M. Stick, Anthony Kicic
Summary: Pulmonary bacterial infections pose a significant health risk to individuals with chronic respiratory diseases, and the emergence of antimicrobial resistance has necessitated the development of alternative therapies. Phage therapy, which targets antimicrobial-resistant pathogens, shows promise as an adjunct or alternative to antibiotics. Delivery of phages to the lungs is crucial for respiratory infections, and nebulization has been identified as a potential method. However, the factors that affect phage stability during nebulized delivery have not been fully characterized.
Article
Engineering, Chemical
Francisco J. Higuera, Juan Fernandez de la Mora
Summary: This study investigates a particle condensation device that uses cold and warm humid air streams to achieve water vapor condensation. Compared to existing water condensation particle counters, this configuration offers advantages such as variable saturation ratio, accelerated penetration of water vapor, and a relatively uniform saturation field.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Brijal Prajapati, Vishal Dharaiya, Manoranjan Sahu, Chandra Venkatraman, Pratim Biswas, Kajal Yadav, Delwin Pullokaran, Ramya Sunder Raman, Ruqia Bhat, Tanveer Ahmad Najar, Arshid Jehangir
Summary: This study evaluated the performance of a low-cost particulate matter sensor and proposed a physics-based calibration method. The results showed that the physics-based calibration approach performed better compared to statistical models at both observation sites.
JOURNAL OF AEROSOL SCIENCE
(2024)
Correction
Engineering, Chemical
N. Searle, K. Kaur, K. Kelly
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Tianyu Cen, Laura Torrent, Andrea Testino, Christian Ludwig
Summary: In this study, a hyphenated setup consisting of a rotating disk diluter (RDD) with spICP-MS (RDDspICP-MS) was used for online sampling and characterization of metallic nanoparticles (NPs) in ambient pressure aerosols. The RDD allowed for constant flow rate sampling of aerosols and adjusting the dilution ratio for different particle number concentrations (PNCs). The feasibility of this setup was tested with different sizes of AuNPs in argon-based and air-based aerosols, and the results showed a lower limit of detection for number concentration. The capability of the setup to accurately investigate multi-modal samples and the interference of ionic species was also demonstrated.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
A. Valenzuela, E. Bazo, R. A. Rica, L. Alados-Arboledas, F. J. Olmo-Reyes
Summary: This article introduces a method to measure the extinction cross section of levitated particles using an electrodynamic trap and double-cavity ring down spectroscopy technique, and demonstrates the potential of this method in 1,2,6-hexanetriol particles through simulations and experiments. Unlike traditional methods, this technique provides crucial information about the extinction cross section of sodium chloride particles during dehydration and hydration processes.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Shadi Yaqoubi, Mohaddese Sokuti, Sahand Mazloum-Ravasan, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: In this study, a modified version of ultrasonic spray pyrolysis was used to prepare salbutamol sulfate dry powder. The engineered particles showed suitable characteristics for effective drug delivery to the lungs and demonstrated acceptable aerosolization performance. This newly introduced method appears to be capable of producing dry powder formulations of different drugs without the need for surfactants or stabilizers.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Ashley L. Nord, Patrice Dosset, Pierre Slangen, Manouk Abkarian
Summary: Phonation has been found to be a potent transmission route for the COVID-19 virus. To control transmission, it is important to measure the amount of aerosols produced by speech. Researchers used digital in-line holography to overcome experimental challenges and successfully imaged the formation and deformation of saliva filaments in the mouth during speech, as well as the resulting aerosolized droplets.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Yating Wang, Yiyang Zhang, Zhu Fang, Xinxin Wu
Summary: The research investigates the energy dissipation in particle-wall collision with roughness using the finite element method. The results show that the presence of surface roughness leads to lower viscoelastic dissipation and higher restitution coefficient compared to a smooth surface. The collision time is identified as a key factor in predicting the energy dissipation.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Shaamrit Balendra, Akshay Kale, Julie Pongetti, Mohsen Kazemimanesh, Molly Haugen, Lee Weller, Adam Boies
Summary: The measurement of airborne particles is important for detecting and characterising air pollution, emissions, fire detection, occupational and climate impacts. However, current optical particle counters (OPCs) cannot measure ultrafine particles. This study explores the limitations of miniaturising a condensation particle counter (CPC) growth chamber and provides a toolkit for optimising the design of miniaturised CPC-GCs.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Markus Snellman, Namsoon Eom, Maria E. Messing, Knut Deppert, Chris Hogan
Summary: Segregated bimetallic nanoparticles, such as core-shell nanoparticles, have attracted widespread interest in various fields like biomedicine, catalysis, and optoelectronics. Aerosol technology provides an optimal platform for controlling the size, structure, and composition of nanoparticles, which are crucial parameters for tuning the material performance for specific applications. In this study, researchers developed a novel evaporator design that allows on-line coating of core particles with a shell directly in the gas phase. By utilizing a local heater, the researchers were able to decouple the heating process of the evaporating material from the aerosol particles, thereby limiting core-shell alloying. The resulting core-shell particle formation with controllable shell thickness was demonstrated using evaporation of zinc onto core particles of gold, tin, and bismuth. Simple models were also discussed to explain the observed growth process inside the evaporator and the formation of the shell.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Kentaro Misawa, Yuto Kasai
Summary: In this study, the laser-induced fluorescence technique was used to observe scattered and fluorescent signals from fluorescent polystyrene latex particles. The ratio of fluorescence to scattered signal intensities was found to be almost equal for particles of the same size, allowing for the separate observation of mixed-size fluorescent particles. Relative fluorescence intensities were obtained by incorporating ratios of fluorescence to scattered signal and relative scattered signal intensities.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Sripriya Nannu Shankar, William B. Vass, John A. Lednicky, Tracey Logan, Rebeccah L. Messcher, Arantzazu Eiguren-Fernandez, Stavros Amanatidis, Tara Sabo-Attwood, Chang-Yu Wu
Summary: This study introduces a testing system that allows for direct exposure of aerosolized viruses onto host cells. By collecting particles of different sizes and analyzing them, researchers obtained information on the concentration and viability of the virus at different particle sizes.
JOURNAL OF AEROSOL SCIENCE
(2024)
