Article
Clinical Neurology
Bin Gao, Hongqiu Gu, Wengui Yu, Shimeng Liu, Qi Zhou, Kaijiang Kang, Jia Zhang, Zixiao Li, Xingquan Zhao, Yongjun Wang
Summary: The study revealed that a considerable number of patients with intracerebral hemorrhage presented with dehydration upon admission. Patients with dehydration had significantly lower risks of in-hospital mortality, especially among younger patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Adrian D. Wood, Gillian D. Edward, Kirsten Cumming, Mohannad W. Kafri, Roy L. Soiza, Lee Hooper, John F. Potter, Phyo K. Myint
Summary: Dehydration in hospitalized patients, particularly the elderly, is associated with higher morbidity and mortality. A study comparing ICW/ECW ratio and BUN/Cr ratio in predicting poor outcomes found that a low ICW/ECW ratio was associated with unfavorable discharge destination, while the BUN/Cr ratio did not show significant relationship with prolonged hospitalization or discharge destination. Utilizing BIA in conjunction with biochemical measurements could provide valuable information for patient prognosis.
Article
Integrative & Complementary Medicine
Cui Xie, Yu Zhan, You Wu, Zhixin Zhang, Yang Xiang, Lin Wang, Dan Chen
Summary: This study investigated the expression and clinical significance of serum-soluble sST2, BDNF, CTnI, and BUN/Cr in patients with heart failure. The results showed that the levels of sST2, CTnI, and BUN/Cr were significantly elevated, while the level of BDNF was decreased in patients with heart failure. The findings highlight the importance of these biomarkers in the diagnosis and prognosis of heart failure.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Emergency Medicine
Sung Jin Bae, Sun Hwa Lee, Seong Jong Yun, Keon Kim
Summary: This study evaluated the performance of BUN/Cr ratio, IVC diameter ratio, and BUN/Albumin ratio as predictive markers for in-hospital mortality and ICU admission among various diseases in the emergency department. The results showed that the BUN/Albumin ratio was the only significant predictor of in-hospital mortality and ICU admission. The BUN/Albumin ratio is a simple and useful tool for predicting outcomes of patients in the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Virology
Fesih Ok, Omer Erdogan, Emrullah Durmus, Serkan Carkci, Aggul Canik
Summary: The study identified that the blood urea nitrogen/creatinine ratio and neutrophil to lymphocyte ratio are independent predictors for the severity and survival of COVID-19. Routine evaluation of these parameters can help in identifying high-risk cases with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Clinical Neurology
Wei-Feng Jiang, Meng-Ling Deng
Summary: This study investigated the association between changes in BUN/Cr and stroke outcomes during hospitalization after acute ischemic stroke (AIS). The results demonstrated that the decrease in BUN/Cr is positively correlated with better early neurological improvement in AIS patients.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Ha-Jin Lim, Seung-Yeob Lee, Hyun-Jung Choi
Summary: The accuracy of ABL90 FLEX PLUS in measuring creatinine and blood urea nitrogen was evaluated, and suitable candidate specimens were identified. The results showed that ABL90 FLEX PLUS had mean differences of -0.10 and -3.51 mg/dL for creatinine and blood urea nitrogen, respectively, compared to other analyzers. Serum was found to be suitable for creatinine testing using ABL90 FLEX PLUS, while citrated whole-blood did not meet the acceptance criteria.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Mehdi Sadeghian, Sepideh Rahmani, Arash Jafarieh, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: A meta-analysis was conducted to evaluate the effect of oral curcumin on serum levels of creatinine and blood urea nitrogen (BUN). The results showed that oral curcumin supplementation significantly improved creatinine levels but increased BUN levels. Subgroup analysis indicated that longer duration of curcumin intervention had a more favorable effect on serum BUN levels. This suggests that oral curcumin with high bioavailability can positively impact creatinine and BUN levels in patients with inflammatory diseases when supplemented for > 8 weeks.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Saidah Rauf, Irhamdi Achmad M. Kep, Santi Aprilian Lestaluhu
Summary: This study found that water supplementation increased water and total fluid intake in elderly individuals, regardless of dehydration status. Serum BDNF levels increased during dehydration and returned to normal levels after appropriate rehydration.
Article
Geriatrics & Gerontology
Anton De Spiegeleer, Jordi Van Migerode, Antoon Bronselaer, Evelien Wynendaele, Milan Peelman, Filip Vandaele, Geert Byttebier, Guy De Tre, Luc Belmans, Christophe Van de Wiele, Mike Sathekge, Diemer Van Dijck, Bo Saxberg, Myriam Alexander, David Fedson, Dirk Elewaut, Nele Van den Noortgate, Bart De Spiegeleer
Summary: This study suggests that the use of statins in nursing home residents can reduce all-cause mortality, indicating the potential geroprotector effect of statins in this population. More research is needed to further investigate this effect.
Article
Cardiac & Cardiovascular Systems
Norihiro Nishioka, Daisuke Kobayashi, Junichi Izawa, Taro Irisawa, Tomoki Yamada, Kazuhisa Yoshiya, Changhwi Park, Tetsuro Nishimura, Takuya Ishibe, Hitoshi Kobata, Takeyuki Kiguchi, Masafumi Kishimoto, Sung-Ho Kim, Yusuke Ito, Taku Sogabe, Takaya Morooka, Haruko Sakamoto, Keitaro Suzuki, Atsunori Onoe, Tasuku Matsuyama, Yohei Okada, Satoshi Matsui, Satoshi Yoshimura, Shunsuke Kimata, Shunsuke Kawai, Yuto Makino, Ling Zha, Kosuke Kiyohara, Tetsuhisa Kitamura, Taku Iwami
Summary: This study investigated the association between blood urea nitrogen to creatinine ratio (BCR) and survival with favourable neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients. The results showed that both higher and lower BCR were associated with poorer neurological outcomes compared to normal BCR, especially in cardiogenic OHCA patients.
JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Woo Rhim Park, Hye Rim Kim, Jin Young Park, Hesun Erin Kim, Jaehwa Cho, Jooyoung Oh
Summary: The study found that a high blood urea nitrogen to creatinine ratio (BCR) could predict the occurrence of hypoactive delirium in ICU patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Connie S. S. Cole, Janet S. S. Carpenter, Justin Blackburn, Chen X. X. Chen, Bobby L. L. Jones, Susan E. E. Hickman
Summary: By conducting a retrospective longitudinal analysis of nursing home resident pain scores, researchers identified and characterized four pain trajectories, including persistent pain presence, decreasing-increasing pain presence, increasing-decreasing pain presence, and consistent pain absence. Demographic characteristics such as younger age, female gender, living in a rural area, as well as clinical factors like obesity and intact cognition, were associated with specific pain trajectories. Residents diagnosed with Alzheimer's disease or dementia were less likely to be in trajectories with pain, highlighting the challenges of evaluating pain in this population. Staff in nursing homes should understand and respond to these factors to improve pain management and assessment for residents.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Environmental Sciences
Adam W. Stern, Daliana Roig, Courtney Valerio, Thomas Denagamage
Summary: Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) is a useful indicator of azotemia in human postmortem examinations. This study aimed to evaluate differences in VUN, CREA, and magnesium (MG) concentrations in vitreous humor collected postmortem from cats with and without renal or post-renal disease. Statistically significant differences were found for VUN, CREA, and MG between the two groups.
Article
Urology & Nephrology
Song Shen, Xudong Yan, Biao Xu
Summary: This study aimed to explore the relationship between blood urea nitrogen/creatinine (BUN/Cre) ratio and all-cause or cause-specific mortality in the general population. The study found a U-shaped relationship between BUN/Cre ratio and all-cause mortality, with the lowest mortality observed in the range of 11.43 to 14.64. The highest BUN/Cre ratio quartile was associated with the lowest risk of cancer mortality.
