Journal
MUSCLE & NERVE
Volume 52, Issue 4, Pages 631-639Publisher
WILEY-BLACKWELL
DOI: 10.1002/mus.24572
Keywords
cross-sectional area; maximal shortening velocity; myosin; specific force; steroid myopathy
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Funding
- Fondazione CARIPLO of Milan, Italy [2010.0764]
- Ministry of Health [RF-2011-02350228]
- University of Turin
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Introduction: The aim of this study was to understand the effects of short-term glucocorticoid administration in healthy subjects. Methods: Five healthy men received dexamethasone (8 mg/day) for 7 days. Vastus lateralis muscle biopsy and knee extension torque measurement were performed before and after administration. A large number of individual muscle fibers were dissected from the biopsy samples (pre-administration: n = 165, post-administration: n = 177). Results: Maximal knee extension torque increased after administration (similar to 13%), whereas both type 1 and type 2A fibers had decreased cross-sectional area (type 1: similar to 11%, type 2A: similar to 17%), myosin loss (type 1: similar to 18%, type 2A: similar to 32%), and loss of specific force (type 1: similar to 24%, type 2A: similar to 33%), which were preferential for fast fibers. Conclusion: Short-term dexamethasone administration in healthy subjects elicits quantitative and qualitative adaptations of muscle fibers that precede (and may predict) the clinical appearance of myopathy in glucocorticoid-treated subjects.
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