Review
Pharmacology & Pharmacy
Kwadwo Mfoafo, Rahul Mittal, Adrien Eshraghi, Yadollah Omidi, Hossein Omidian
Summary: Thiolated polymers, known as thiomers, have unique mucoadhesive properties and can form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins. This makes them suitable for drug delivery systems (DDSs) for dry mucosal surface diseases. Thiomers offer higher adhesion and retention time compared to non-thiolated polymers, leading to increased bioavailability and reduced patient noncompliance. They can also inhibit enzymes, increase permeability, and protect protein and peptide drugs from digestive enzymes. Thiolated polymers have potential applications in adhesion, controlled drug release, and tissue engineering.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mai Bay Stie, Johan Ring Gatke, Ioannis S. Chronakis, Jette Jacobsen, Hanne Morck Nielsen
Summary: Sublingual drug delivery is an attractive approach, but it faces challenges due to saliva flow. In this study, a two-layered hybrid drug delivery system was developed for the sublingual delivery of a therapeutic peptide. The system consisted of peptide-loaded mucoadhesive electrospun chitosan/polyethylene oxide-based nanofibers and a saliva-repelling backing film, which achieved unidirectional release and protected the peptide from wash-out.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Mai Bay Stie, Heidi Oblom, Anders Christian Norgaard Hansen, Jette Jacobsen, Ioannis S. Chronakis, Jukka Rantanen, Hanne Morck Nielsen, Natalja Genina
Summary: The study designed a multi-layered nanofiber-on-foam-on-film (NFF) drug delivery system with mucoadhesive properties and saliva-repelling ability, which improved drug absorption and permeability through oral mucosa. This system has great potential for non-invasive drug administration.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Chaiyakarn Pornpitchanarong, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat, Mark Bradley, Prasopchai Patrojanasophon
Summary: The objective of this research was to develop a novel mucoadhesive polymer for drug delivery applications based on N-(2-aminoethyl) maleimide-functionalized carboxymethyl cellulose. The weight ratios of the materials were tuned to explore the condition providing the highest maleimide content on the polymer. The synthesized polymer exhibited superior mucoadhesive capability and the ability to control drug release.
CARBOHYDRATE POLYMERS
(2022)
Review
Dentistry, Oral Surgery & Medicine
K. Mokabari, M. Iriti, E. M. Varoni
Summary: Vaccine technology has continuously evolved, and mucosal vaccination, such as oral administration, has gained scientific interest. The oral mucosa provides a promising route for antigen delivery, promoting an effective immune response. Mucoadhesive biomaterial-based delivery systems, including nanoparticles, films, liposomes, microneedles, and gels, have shown controlled release and enhanced immunological responses. These systems are stable, easy to produce, and can be used for mass vaccination during outbreaks.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Hasan Afzaal, Shahiq-uz-Zaman, Adil Saeed, Syed Damin Abbas Hamdani, Amir Raza, Alvina Gul, Mustafeez Mujtaba Babar, Jayakumar Rajadas
Summary: A mucoadhesive formulation has been developed to improve the absorption of drugs through the intravaginal route, and an efficient assay method has been established for quantification of the drug molecule.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Nanoscience & Nanotechnology
Mariia S. Saveleva, Mikhail E. Lobanov, Olga I. Gusliakova, Valentina O. Plastun, Ekaterina S. Prikhozhdenko, Olga A. Sindeeva, Dmitry A. Gorin, Oksana A. Mayorova
Summary: The study proposes the use of microsized mucoadhesive macromolecular carriers based on whey protein isolate as a drug delivery system to improve the therapeutic efficiency and reduce the painfulness of intravesical instillation procedure for bladder diseases. The emulsion microgels showed sufficient mucoadhesion and prolonged drug release, and were able to accumulate in the bladder more efficiently compared to systemic injection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Olga Cegielska, Maciej Sierakowski, Pawel Sajkiewicz, Kairi Lorenz, Karin Kogermann
Summary: This study designed a nanofibrous drug delivery system as an alternative for eye drops, which could achieve more accurate dosing and improve drug residence time and bioavailability in the eye. Permeation experiments through sheep corneas indicated that the system could release the drug almost linearly in time and achieve therapeutic concentrations in the receptor medium.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Engineering, Biomedical
Sony Priyanka Bandi, Shubhmita Bhatnagar, Venkata Vamsi Krishna Venuganti
Summary: Mucus is a viscoelastic gel that traps pathogens and foreign particles, while also being essential for drug carriers to access underlying epithelial tissues. Various strategies have been developed to achieve mucoadhesion and mucus penetration in drug delivery systems. Advances in materials chemistry have led to the expansion of materials available for mucosal drug delivery applications.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Manisha Pandey, Hira Choudhury, Jenifer Ngu Shao Ying, Jessica Foo Sze Ling, Jong Ting, Jocelyn Su Szhiou Ting, Ivory Kuek Zhia Hwen, Ho Wan Suen, Hazimah Syazwani Samsul Kamar, Bapi Gorain, Neha Jain, Mohd Cairul Iqbal Mohd Amin
Summary: Oral cancer, especially SCC, is a significant global health challenge with traditional treatments having drawbacks. The oral mucosa can serve as a drug administration route, with mucoadhesive nanocarriers showing promise for targeted drug delivery in the oral cavity.
Article
Engineering, Biomedical
Soheil Haddadzadegan, Patrick Knoll, Richard Wibel, Gergely Kali, Andreas Bernkop-Schnuerch
Summary: This study compared the mucus permeating and mucoadhesive properties of three generations of thiolated cyclodextrins. Thiolated CDs were protected with different compounds, leading to improved viscosity, mucus diffusion, and mucoadhesion. The results suggest that S-protection of thiolated CDs can enhance their mucus penetrating and mucoadhesive properties.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Nitjawan Sahatsapan, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit, Prasopchai Patrojanasophon
Summary: This study synthesized dual-functional mucoadhesive nanoparticles for intravesical chemotherapy, demonstrating effective drug delivery and potent inhibitory effects against cancer cells, showing potential clinical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Julian David Friedl, Marcel Walther, Pia Katharina Vestweber, Jana Wachter, Patrick Knoll, Arne Matteo Joergensen, Andreas Bernkop-Schnuerch, Maike Windbergs
Summary: To date, buccal administration of lipophilic drugs remains challenging due to poor solubility and limited penetration. In this study, researchers developed mucoadhesive electrospun SEDDS patches to overcome these limitations. The patches showed high encapsulation efficiency, improved drug penetration, and enhanced therapeutic effects, making them a promising approach for oromucosal delivery of lipophilic drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Ritu Rathi, Sukhanpreet Kaur, Inderbir Singh
Summary: Co-crystallization is a promising method for enhancing the physical properties of API and herbal bioactives, improving solubility, taste masking, and bioavailability. However, toxicological, stability, regulatory, and scaleup issues need to be addressed before commercial viability.
CRYSTAL GROWTH & DESIGN
(2022)
Editorial Material
Pharmacology & Pharmacy
Ritu Rathi, Inderbir Singh
Summary: The co-crystallization of drugs can enhance their properties, but some issues need to be addressed before exploring commercial viability.
PHARMACEUTICAL PATENT ANALYST
(2022)
Article
Polymer Science
Vivek Puri, Ameya Sharma, Pradeep Kumar, Kamal Dua, Kampanart Huanbutta, Inderbir Singh, Tanikan Sangnim
Summary: Modified gum ghatti is a suitable approach for developing controlled drug delivery systems, and the toxicological study on animals showed no adverse effects after oral administration of pure and thiolated gum ghatti, suggesting their safety as potential candidates for drug formulation.
Review
Pharmacology & Pharmacy
Ritu Rathi, Sanshita, Alpesh Kumar, Vivekanand Vishvakarma, Kampanart Huanbutta, Inderbir Singh, Tanikan Sangnim
Summary: The rectal route is an effective method for delivering active pharmaceutical ingredients locally and systemically. This review discusses rectal physiology, diseases, pharmaceutical factors, and various drug delivery systems. Clinical trials and novel drug delivery carriers for rectal administration are presented, along with opportunities, challenges, advancements, and patented formulations for rectal drug delivery.
Article
Pharmacology & Pharmacy
Kittipat Suwanpitak, Lee-Yong Lim, Inderbir Singh, Pornsak Sriamornsak, Thanongsak Thepsonthi, Kampanart Huanbutta, Tanikan Sangnim
Summary: This study aimed to develop an add-on device for dry powder inhalers (Accuhaler) using 3D printing technology to improve drug administration efficiency in patients with limited inspiratory capacity. The effectiveness and operating mechanism of the add-on device were evaluated by quantifying active pharmaceutical ingredients using HPLC assay and simulating air and particle flow in the device.
Article
Pharmacology & Pharmacy
Ritu Rathi, Renu Kushwaha, Ayushi Goyal, Inderbir Singh
Summary: Co-crystallization is a technique used to modify physicochemical properties of pharmaceutical ingredients, aiming to enhance therapeutic efficacy and reduce toxicity. This patent describes the development of oxaliplatin co-crystals using flavonoids, such as baicalein and naringenin, through solvent volatilization technique. The co-crystals improve solubility and stability in the GI tract, leading to reduced side effects and toxicity. They show slow drug release, delayed hydrolysis, low cytotoxicity, and enhanced therapeutic activity on gastric adenocarcinoma cells.
PHARMACEUTICAL PATENT ANALYST
(2022)
Editorial Material
Pharmacology & Pharmacy
Shristhi Sohan Rawat, Arya Rai, Ritu Rathi, Akshay Sharma, Kampanart Huanbutta, Tanikan Sangnim, Inderbir Singh
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Nutrition & Dietetics
Vivek Puri, Manju Nagpal, Inderbir Singh, Manjinder Singh, Gitika Arora Dhingra, Kampanart Huanbutta, Divya Dheer, Ameya Sharma, Tanikan Sangnim
Summary: Nutraceuticals, the nourishing components with nutritional benefits and therapeutic effects, play a significant role in human health care and future therapeutic development. This article discusses the applications of nutraceuticals in health promotion, disease reduction, and support therapy. Nanotechnology can improve the health benefits of nutraceuticals, and prior knowledge of their interactions with drugs helps prevent side effects.
Article
Pharmacology & Pharmacy
Kampanart Huanbutta, Napapat Rattanachitthawat, Kunlathida Luangpraditkun, Pornsak Sriamornsak, Vivek Puri, Inderbir Singh, Tanikan Sangnim
Summary: Skin fungal infection remains a serious public health problem, with drug resistance and limited access to medicines. This study developed an ethosome formulation loaded with Zingiber zerumbet (L.) rhizome extract to enhance antifungal activity in deep layer skin. The ethosome system showed improved skin penetration and retention of the active compound compared to liquid extract. Further in vivo tests are needed for clinical application.
Article
Pharmacology & Pharmacy
Sajal Jain, Ritu Rathi, Upendra Nagaich, Inderbir Singh
Summary: Co-processing involves incorporating microcrystalline cellulose and mannitol together to limit the use of lubricant in tablet composition. The co-processed excipients have smaller particle size and lactose coated particles compared to the physical blend excipients.
PHARMACEUTICAL PATENT ANALYST
(2023)
Article
Polymer Science
Hitesh Chopra, Shabana Bibi, Yugal Kishore Mohanta, Tapan Kumar Mohanta, Sandeep Kumar, Inderbir Singh, Muhammad Saad Khan, Pradipta Ranjan Rauta, Abdulrahman Alshammari, Metab Alharbi, Abdullah F. Alasmari
Summary: Curcumin-based hydrogel system with antimicrobial activity and wound healing potential was developed and evaluated in vitro and in silico. The hydrogel showed antimicrobial activity against both gram-positive and gram-negative microorganisms. In silico studies revealed good binding energy scores and significant interaction of curcumin components with key residues of inflammatory proteins, indicating its potential for wound healing. Further in vivo experiments are needed to assess the clinical efficacy of the hydrogel films.
Review
Chemistry, Medicinal
Snigdha Chakraborty, Inderbir Singh
Summary: Enormous research has been conducted and is still ongoing to find the best possible novel drug delivery system for onychomycosis management. Approaches like incorporation of herbal constituents in nano-formulations, inkjet printing, laser devices, iontophoretic techniques, etc. can be employed to make safe and effective drug delivery systems which are regulatory compliant.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2023)
Article
Chemistry, Multidisciplinary
Kittipat Suwanpitak, Pornsak Sriamornsak, Inderbir Singh, Tanikan Sangnim, Kampanart Huanbutta
Summary: Polyglycolic acid (PGA) nanoparticles were continuously synthesized using a 3D-printed vortex tube reactor. The reactor design was optimized using computer-aided design (CAD) and design of experiments (DoE), and the mixing efficiency was evaluated using computational fluid dynamics simulations (CFD). The results showed that the optimized reactor design achieved homogeneous mixing and improved productivity compared to traditional tubular reactors. The study also identified the impact of flow parameters on PGA nanoparticle size and polydispersity index.
Review
Nanoscience & Nanotechnology
Arya Rai, Simrandeep Kaur, Shristhi Sohan Rawat, Inderbir Singh
Summary: Gastric cancer, caused by various risk factors such as age, H. pylori infection, excessive salt intake, and poor diet, can be diagnosed through ultrasound, CT scan, endoscopic biopsy, and biomarker detection. Conventional treatments like radiation, surgery, and chemotherapy have limitations including high risk of tumor recurrence and drug resistance. Herbal bio-actives and nano-formulations show promise in overcoming these limitations and improving targeted delivery, solubility, efficacy, and reducing toxicity. Future prospects include multifunctional nanoparticles and theragnostic strategies. This review provides comprehensive insights into gastric cancer, its diagnosis, treatment approaches, and the potential of herbal bioactives encapsulated in nano-formulations.
Review
Biology
Inderbir Singh, Jaswinder Kaur, Sukhanpreet Kaur, Bibhuti Ranjan Barik, Rakesh Pahwa
Summary: Pharmaceutical product development is a challenging and costly process, but computational methods such as artificial neural networks and neuro-fuzzy models can assist in speeding up the industrial process, enhancing productivity, quality, and consistency. This review discusses the working principles, types, advantages, and disadvantages of these computational tools, as well as their applications in developing various pharmaceutical products.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2023)