Article
Medicine, General & Internal
Shirley V. Wang, Sebastian Schneeweiss, RCT-DUPLICATE Initiative
Summary: Nonrandomized studies using insurance claims databases can provide real-world evidence on the effectiveness of medical products. By emulating the design parameters of randomized clinical trials and quantifying the agreement between database studies and RCTs, this study highlights the importance of closely replicating trial design and measurements for reliable conclusions.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Tobias Zellner, Christian Rabe, Jens von der Wellen-Pawlowski, Dagmar Hansen, Harald John, Franz Worek, Florian Eyer
Summary: A 63-year-old male was admitted to the hospital after ingesting ethanol and pirimiphos-methyl with suicidal intentions. The patient had a complex medical history and received medical treatment and monitoring. He eventually recovered and was transferred to a neurological rehabilitation facility for further treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Kenneth B. Gordon, Richard G. Langley, Richard B. Warren, Yukari Okubo, Linda Stein Gold, Joseph F. Merola, Luke Peterson, Krista Wixted, Nancy Cross, Delphine Deherder, Diamant Thaci
Summary: The study aimed to evaluate the 2-year safety profile of bimekizumab in patients with moderate to severe plaque psoriasis. Pooled analysis of data from 8 clinical trials showed that bimekizumab was well tolerated with an increased incidence of mild to moderate oral candidiasis. No safety signals were observed, and there was no increased risk of adverse events with longer duration of bimekizumab exposure.
Article
Medicine, General & Internal
Takahiro Itaya, Yotsuha Isobe, Sayoko Suzuki, Kanako Koike, Masakazu Nishigaki, Yosuke Yamamoto
Summary: This study assessed the robustness of statistically significant findings from COVID-19 RCTs and found that a relatively small number of events could change the results of these trials. Therefore, individual results of COVID-19 RCTs should not be heavily relied upon.
Article
Ophthalmology
Qi Tan, Alex L. K. Ng, George P. M. Cheng, Victor C. P. Woo, Pauline Cho
Summary: This study found that combining 0.01% atropine with orthokeratology (AOK) has a better effect in retarding axial elongation compared to orthokeratology alone (OK). The study included 96 Chinese children aged 6 to 11 years with myopia and showed that the AOK group had significantly slower axial elongation compared to the OK group. The AOK group also exhibited larger pupil dilation and choroidal thickening.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Pediatrics
Manon Tauzin, Laetitia Marchand-Martin, Cecile Lebeaux, Sophie Breinig, Olivier Claris, Pierre Tourneux, Ceneric Alexandre, Corinne Levy, Camille Jung, Agnes Dechartres, Xavier Durrmeyer
Summary: The study found no significant difference in death or risk of neurodevelopmental delay between the atropine-propofol group and the atropine-atracurium-sufentanil group in premedication before nonemergency intubation at 2 years of corrected age.
JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Michael M. Hammond, Lu Tian, Lihui Zhao, Dongxue Zhang, Mary M. McDermott
Summary: This study found that participation in supervised exercise therapy is significantly associated with improved walking performance in patients with peripheral artery disease (PAD). Higher attendance rates at exercise sessions are associated with greater improvement in 6-minute walk distance, while even relatively low attendance rates still result in significant improvement in walking performance.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Thomas Perneger, Angele Gayet-Ageron
Summary: This study aims to estimate the strength of evidence for the null hypothesis vs the effectiveness hypothesis in statistically nonsignificant primary outcome results of randomized clinical trials. The results demonstrate that many trials provide strong support for the null hypothesis of no effect.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biology
Xin Huang, Huika Xia, Qi Zhang, Colin Blakemore, Yan Nan, Wenyao Wang, Jie Gao, Spencer S. Ng, Jing Wen, Tiejun Huang, Xiaoqing Li, Mingliang Pu
Summary: Asynchronous stimulation can rebalance input to the visual cortex and improve amblyopia. Clinical studies have shown that asynchronous binocular training is a fast and effective treatment for anisometropic amblyopia, with long-lasting effects of at least 2 years.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Medicine, General & Internal
Hazael Ramiro Ceja-Galvez, Francisco Israel Renteria-Flores, Ferdinando Nicoletti, Jorge Hernandez-Bello, Gabriela Macedo-Ojeda, Jose Francisco Munoz-Valle
Summary: By January of 2023, the COVID-19 pandemic had resulted in 6,700,883 deaths and 662,631,114 cases worldwide, with no effective therapies or standardized treatment schemes available. This review aims to analyze the most efficient and promising therapies and drugs for prevention and treatment of severe COVID-19, providing support for healthcare professionals in choosing the best pharmacological approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Deborah A. Theodore, Angela R. Branche, Lily Zhang, Daniel S. Graciaa, Madhu Choudhary, Timothy J. Hatlen, Raadhiya Osman, Tara M. Babu, Samuel T. Robinson, Peter B. Gilbert, Dean Follmann, Holly Janes, James G. Kublin, Lindsey R. Baden, Paul Goepfert, Glenda E. Gray, Beatriz Grinsztejn, Karen L. Kotloff, Cynthia L. Gay, Brett Leav, Jacqueline Miller, Ian Hirsch, Jerald Sadoff, Lisa M. Dunkle, Kathleen M. Neuzil, Lawrence Corey, Ann R. Falsey, Hana M. El Sahly, Magdalena E. Sobieszczyk, Yunda Huang
Summary: This study identified risk factors associated with COVID-19, severe COVID-19, and SARS-CoV-2 infection through the analysis of data from four COVID-19 vaccine trials. The results showed that workplace exposure and living condition risk were associated with increased rates of COVID-19, while age ≥65 years and Black or African American race were associated with decreased rates of COVID-19. Factors such as race, diabetes, and comorbidities were associated with increased rates of severe COVID-19.
Article
Ophthalmology
Hannan Xu, Luyao Ye, Yajun Peng, Tao Yu, Shanshan Li, Shijun Weng, Yelin Huang, Yuzhong Chen, Ying Fan, Haidong Zou, Jiangnan He, Jianfeng Zhu, Xun Xu
Summary: This study investigated the involvement of choroidal vascularity in the antimyopia and rebound mechanisms of high-dose atropine. The results showed that 1% atropine induced choroidal thickening, while 0.01% atropine had little effect on the choroid. Total choroidal area partially explained the antimyopic and rebound effects of atropine.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica M. Franklin, Elisabetta Patorno, Rishi J. Desai, Robert J. Glynn, David Martin, Kenneth Quinto, Ajinkya Pawar, Lily G. Bessette, Hemin Lee, Elizabeth M. Garry, Nileesa Gautam, Sebastian Schneeweiss
Summary: The study found differences between RCT and corresponding RWE study populations, but showed that selecting active comparator therapies with similar indications and use patterns can enhance the validity of RWE. Despite efforts to closely emulate RCT design, agreement between RCT and RWE findings varied depending on the agreement metric used, indicating the need for further research to understand the frequency and contexts in which RWE findings match RCTs.
Article
Pediatrics
Stephanie M. Cho, Stylianos Serghiou, John Pa Ioannidis, Terry P. Klassen, Despina G. Contopoulos-Ioannidis
Summary: The study found that a small proportion of large pediatric RCTs had industry funding, with most participants coming from lower-middle-income countries. Few trials targeted mortality as an outcome, and a significant number of trials completed for over 12 months remained unpublished. The number of trials correlated well with pediatric GBD, highlighting the importance of incentive collaborations, timely publication, and alignment with pediatric GBD for improving child health globally.
Article
Dermatology
Brett King, Arash Mostaghimi, Yutaka Shimomura, Abraham Zlotogorski, Gwang-Seong Choi, Ulrike Blume-Peytavi, Thierry Passeron, Katrin Holzwarth, Yves Dutronc, Jill McCollam, Fan Emily Yang, Sarah Stanley, Wen-Shuo Wu, Rodney Sinclair
Summary: This study analyzed the safety data of baricitinib in patients with severe alopecia areata from two clinical trials. The results showed that the safety profile of baricitinib was consistent and no deaths were reported.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Ophthalmology
Laura Liebermann, Sarah R. Hatt, David A. Leske, Jonathan M. Holmes
Article
Ophthalmology
Katherine K. Weise, Brett Kaminski, Michele Melia, Michael X. Repka, Yasmin S. Bradfield, Bradley V. Davitt, David A. Johnson, Raymond T. Kraker, Ruth E. Manny, Noelle S. Matta, Susan Schloff
Article
Ophthalmology
Graham E. Quinn, Velma Dobson, Bradley V. Davitt, David K. Wallace, Robert J. Hardy, Betty Tung, Dejian Lai, William V. Good
Article
Ophthalmology
Sarah R. Hatt, David A. Leske, Laura Liebermann, Jonathan M. Holmes
Article
Ophthalmology
Stephen J. Smith, David A. Leske, Sarah R. Hatt, Jonathan M. Holmes
Editorial Material
Ophthalmology
Michael X. Repka, Jonathan M. Holmes
Article
Ophthalmology
Susan A. Cotter, Nicole C. Foster, Jonathan M. Holmes, B. Michele Melia, David K. Wallace, Michael X. Repka, Susanna M. Tamkins, Raymond T. Kraker, Roy W. Beck, L. Hoover Darren, Eric R. Crouch, Aaron M. Miller, Christie L. Morse, Donny W. Suh
Article
Ophthalmology
Jonathan M. Holmes, Laura Liebermann, Sarah R. Hatt, Stephen J. Smith, David A. Leske
Letter
Ophthalmology
Michael X. Repka, Jonathan M. Holmes
Article
Ophthalmology
David K. Wallace, Elizabeth L. Lazar, Jonathan M. Holmes, Michael X. Repka, Susan A. Cotter, Angela M. Chen, Raymond T. Kraker, Roy W. Beck, Michael P. Clarke, Ingryd J. Lorenzana, David B. Petersen, Joan T. Roberts, Donny W. Suh
Article
Ophthalmology
Carmen Barnhardt, Susan A. Cotter, G. Lynn Mitchell, Mitchell Scheiman, Marjean T. Kulp
OPTOMETRY AND VISION SCIENCE
(2012)
Article
Ophthalmology
Don W. Lyon, Kristine Hopkins, Raymond H. Chu, Susanna M. Tamkins, Susan A. Cotter, B. Michele Melia, Jonathan M. Holmes, Michael X. Repka, David T. Wheeler, Nicholas A. Sala, Janette Dumas, David I. Silbert
OPTOMETRY AND VISION SCIENCE
(2013)
Article
Ophthalmology
David A. Leske, Sarah R. Hatt, Laura Liebermann, Jonathan M. Holmes
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2012)
Article
Ophthalmology
Tomohiko Yamada, Sarah R. Hatt, David A. Leske, Jonathan M. Holmes
Article
Ophthalmology
Laura Liebermann, Sarah Hatt, David Leske, Tomohiko Yamada, Brian Mohney, Michael Brodsky, Jonathan Holmes
