Article
Neurosciences
Luana Gilio, Diego Fresegna, Antonietta Gentile, Livia Guadalupi, Krizia Sanna, Francesca De Vito, Sara Balletta, Silvia Caioli, Francesca Romana Rizzo, Alessandra Musella, Ennio Iezzi, Alessandro Moscatelli, Giovanni Galifi, Roberta Fantozzi, Paolo Bellantonio, Roberto Furlan, Annamaria Finardi, Valentina Vanni, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi
Summary: Exercise has an immunomodulatory effect in MS patients, reducing levels of proinflammatory cytokines and improving mood disorders. IL-2 plays a causal role in mood disorders and synaptic dysfunction in MS. Further studies are needed to investigate the long-term effects of exercise as a disease-modifying therapy in MS.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Psychology, Multidisciplinary
Ana Jerkovic, Ana Prorokovic, Meri Matijaca, Jelena Vuko, Ana Poljicanin, Angela Mastelic, Ana Curkovic Katic, Vana Kosta, Lea Kustura, Kresimir Dolic, Zoran Dogas, Maja Rogic Vidakovic
Summary: The study examined the factor structure and correlates of the Hospital Anxiety and Depression Scale (HADS) in multiple sclerosis patients, finding it to be a reliable and valid self-assessment scale for monitoring the psychiatric and psychological status of patients with MS. The HADS subscales showed good internal consistencies and convergent validity, suggesting its use in clinical monitoring.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Julia Baldt, Niklas Frahm, Michael Hecker, Barbara Streckenbach, Silvan Elias Langhorst, Pegah Mashhadiakbar, Katja Burian, Janina Meissner, Felicita Heidler, Jorg Richter, Uwe Klaus Zettl
Summary: Polypharmacy is a significant issue in patients with multiple sclerosis, and it is associated with depression severity and comorbidities. A study on 374 MS patients found that patients with higher depression severity were more likely to be taking multiple medications, while anxiety was not correlated with polypharmacy. Furthermore, the frequency of comorbidities showed a positive correlation with anxiety and depression scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Stephanie L. Silveira, Katie L. J. Cederberg, Brenda Jeng, E. Morghen Sikes, Brian M. Sandroff, Catherine D. Jones, Robert W. Motl
Summary: This study found that symptom clusters among patients with multiple sclerosis were correlated with quality of life, with three distinct clusters identified based on the severity of symptoms. Patterns of symptom clusters varied among different age groups, particularly with the presence of severe sleep problem clusters in older adults. The severity of symptom clusters was significantly associated with worse quality of life, highlighting the importance of addressing co-occurring symptoms in MS patients.
QUALITY OF LIFE RESEARCH
(2021)
Review
Clinical Neurology
Arman Shafiee, Hedieh Soltani, Mohammad Mobin Teymouri Athar, Kyana Jafarabady, Parham Mardi
Summary: This study conducted a comprehensive analysis on the prevalence of depression and anxiety among multiple sclerosis patients in Iran, showing a significant proportion of people with MS in Iran are affected by depression and anxiety.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Antonio Carotenuto, Cristiano Scandurra, Teresa Costabile, Luigi Lavorgna, Giovanna Borriello, Lucia Moiola, Matilde Inglese, Francesca Trojsi, Martina Petruzzo, Antonio Ianniello, Agostino Nozzolillo, Maria Cellerino, Giacomo Boffa, Laura Rosa, Alessandro Chiodi, Giuseppe Servillo, Marcello Moccia, Simona Bonavita, Massimo Filippi, Maria Petracca, Vincenzo Brescia Morra, Roberta Lanzillo
Summary: This study examined the relationship between physical disability, physical exercise, and mental health in multiple sclerosis (MS) patients. The results showed that physical disability significantly impacted depression during the COVID-19 pandemic, with physical activity playing a moderating role. Our findings suggest that promoting exercise in MS patients may improve psychological wellbeing regardless of the level of physical disability.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yao-Ching Huang, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Fang-Jung Wan, Shi-Hao Huang, Ren-Jei Chung, Richard S. Wang, Bing-Long Wang, Nian-Sheng Tzeng, Chien-An Sun
Summary: The study found that patients with multiple sclerosis (MS) have a higher risk of developing a wide range of psychiatric disorders, including depression, anxiety, bipolar disorder, etc. Some disease-modifying drugs were associated with a lower risk of anxiety or depression.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Nutrition & Dietetics
Jose Enrique de la Rubia Orti, Maria Cuerda-Ballester, Claudia Emmanuela Sanchis-Sanchis, Jose Maria Lajara Romance, Esther Navarro-Illana, Maria Pilar Garcia Pardo
Summary: This article discusses the impact of ketogenic diet (KD) on emotional symptoms in patients with multiple sclerosis (MS). The study found that KD can improve glutamate activity and reduce central inflammation by reducing obesity, improving insulin resistance, and dyslipidemia. This improvement may alleviate functional disability and emotional disorders such as anxiety and depression by reducing extrasynaptic glutamate activity.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
C. B. Tauil, A. D. Rocha-Lima, B. B. Ferrari, F. M. Silva, L. A. Machado, C. Ramari, C. O. Brandao, L. M. B. dos Santos, L. L. dos Santos-Neto
Summary: NF-L levels are elevated in patients with MS and psychiatric disorders, but the relationship between depression and anxiety in RRMS-Fingo patients and NF-L levels is not statistically significant. MS events such as anxiety and depression may contribute to the onset of clinical relapses, subclinical cases, and neurodegeneration.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Immunology
Patricia J. McLaughlin, Laura B. Odom, Peter A. Arnett, Shannon Orehek, Gary A. Thomas, Ian S. Zagon
Summary: This study investigated the effects of low-dose naltrexone (LDN) therapy on anxiety and depression levels in persons with multiple sclerosis (PwMS) during the early months of COVID-19. The results showed that PwMS who were prescribed LDN, either alone or as an adjuvant therapy, had significantly lower self-reported anxiety and depression scores compared to those on oral disease-modifying therapies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Rehabilitation
Areum Han
Summary: This study examined the effects of mindfulness-and acceptance-based interventions (MABIs) on reducing symptoms in individuals with multiple sclerosis (MS). The results showed significant effects of MABIs in reducing symptoms of depression, anxiety, stress, and pain, but a moderate effect on fatigue symptoms. Future high-quality studies with follow-up evaluations are needed to further support these findings and explore intervention features that enhance and sustain effects.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Clinical Neurology
Di Cara Marcella, Grezzo Denise, Palmeri Rosanna, Lo Buono Viviana, Cartella Emanuele, Micchia Katia, Formica Caterina, Rifici Carmela, Sessa Edoardo, D. 'Aleo Giangaetano, Maresca Giuseppa, Bramanti Placido, Corallo Francesco
Summary: Multiple sclerosis causes various psychosocial problems, with common symptoms being anxiety, depression, stress, fatigue, and pain. Studies have shown that mindfulness treatment can reduce depressive symptoms, improve quality of life, and decrease fatigue.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Nancy D. Chiaravalloti, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Ulrik Dalgas, John DeLuca, Cecilia Meza, Nancy B. Moore, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Rob Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter, Gary Cutter, Anthony Feinstein
Summary: Overall, there was little change in symptoms of depression or anxiety, as well as overall quality of life for individuals with Progressive Multiple Sclerosis during the COVID-19 pandemic.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Afagh Garjani, Rodden M. Middleton, Richard Nicholas, Nikos Evangelou
Summary: This study aims to understand the recovery process from COVID-19 among patients with MS and identify predictors, including patients' pre-COVID-19 physical and mental health status. The findings suggest that patients with preexisting severe neurologic impairment or mental health problems are less likely to recover from COVID-19.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Elizabeth S. Gromisch, Lindsay O. Neto, Jessica Sloan, Tuula Tyry, Frederick W. Foley
Summary: This study found that the MSRS can relatively accurately identify individuals with MS experiencing mental health difficulties, particularly those who may have symptoms of depression or anxiety, with good classification accuracy. This can assist clinicians in triaging patients who need additional help or support.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Kristoffer Romero, Nancy J. Lobaugh, Sandra E. Black, Lisa Ehrlich, Anthony Feinstein
PSYCHIATRY RESEARCH-NEUROIMAGING
(2015)
Article
Clinical Neurology
Marie Theaudin, Kristoffer Romero, Anthony Feinstein
MULTIPLE SCLEROSIS JOURNAL
(2016)
Article
Clinical Neurology
Kristoffer Romero, Prathiba Shammi, Anthony Feinstein
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2015)
Article
Neuroimaging
Kristoffer Romero, Bennis Pavisian, William R. Staines, Anthony Feinstein
NEUROIMAGE-CLINICAL
(2015)
Article
Neurosciences
Signy Sheldon, Kristoffer Romero, Morris Moscovitch
Article
Linguistics
Kristoffer Romero, Morris Moscovitch
JOURNAL OF MEMORY AND LANGUAGE
(2012)
Article
Clinical Neurology
Kristoffer Romero, Sandra E. Black, Anthony Feinstein
FRONTIERS IN NEUROLOGY
(2014)
Article
Neurosciences
Kristoffer Romero, Morgan D. Barense, Morris Moscovitch
Article
Geriatrics & Gerontology
Carina L. Fan, Kristoffer Romero, Brian Levine
Article
Psychology, Experimental
Kaitlyn Abeare, Kristoffer Romero, Laura Cutler, Christina D. Sirianni, Laszlo A. Erdodi
Summary: The study validated the use of RCFTFCR as a PVT in a clinical sample and supported its role in measuring cognitive ability. Results indicated that RCFTFCR could more accurately reflect the natural variability of examinees' visual perception and verbal memory skills. Despite the need for further studies with different samples and accuracy, RCFT has the potential to be a useful tool in clinical settings for measuring visual memory.
PERCEPTUAL AND MOTOR SKILLS
(2021)
Article
Psychology, Clinical
Kristoffer Romero, Astrid Coleman, Arjan Heir, Larry Leach, Guy B. Proulx
Summary: Understanding the multivariate base rates (MVBRs) of low scores on neuropsychological tests is crucial to avoid misdiagnosing mild cognitive impairment (MCI). This study calculated the MVBRs of low or high cognitive scores in older adults presenting to a memory clinic, and found a higher probability of obtaining low cognitive test scores in this clinically referred sample compared to normative samples.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Psychology, Clinical
Kristoffer Romero, Natalia Ladyka-Wojcik, Arjan Heir, Buddhika Bellana, Larry Leach, Guy B. Proulx
Summary: This study used cluster analysis to identify 4 subgroups within MCI patients: cognitively intact, globally impaired, amnestic/visuospatial impairment, and mild, mixed-domain. Interestingly, differences in self-reported multilingualism were found within these clusters. Including patients with cerebrovascular disease led to subtle differences in subgroup classification and revealed new insights into shared cognitive features beyond diagnostic categories.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Andree-Ann Cyr, Kristoffer Romero, Laura Galin-Corini
Summary: The study aimed to compare the performance of healthy older adults on computerized cognitive tasks completed at home and in the laboratory, finding no significant effect of the testing environment or correlation with computer familiarity or attitudes. Performance on computerized tasks positively correlated with their paper-and-pencil equivalents.
Article
Gerontology
Nicholas B. Diamond, Kristoffer Romero, Nivethika Jeyakumar, Brian Levine
PSYCHOLOGY AND AGING
(2018)