Journal
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
Volume 9, Issue 9, Pages 670-676Publisher
WILEY
DOI: 10.1111/j.1610-0387.2011.07656.x
Keywords
atopic dermatitis; genetics; filaggrin; epidermal barrier; polymorphisms
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Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of loss of function mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.
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