Article
Multidisciplinary Sciences
Rafael Mamede, Florbela Pereira, Joao Aires-de-Sousa
Summary: Machine learning algorithms were used to classify UV-Vis absorption spectra of organic molecules, and the models were validated for accuracy and sensitivity with external test sets. The ML output was explored as a predictor for 3T3 NRU in vitro phototoxicity assay results.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Taeseong Woo, Hye Yun Kim, Su Yeon Kim, Byungjae Hwang, Cheolwoo Ahn, Seok-Kyu Kwon, Jae-Ick Kim, Jung-Hoon Park
Summary: Recent advances in biochemistry and optics have made it possible to observe faint signals from single molecules. However, the detection range is limited by the dynamic range of current detectors. To overcome this limitation, structured illumination high dynamic range (SI-HDR) imaging is introduced, enabling real-time HDR imaging with a single measurement. The method demonstrates wide applicability in various applications.
Article
Biochemical Research Methods
Dora Mahecic, Willi L. Stepp, Chen Zhang, Juliette Griffie, Martin Weigert, Suliana Manley
Summary: Event-driven acquisition is a method that uses neural network recognition of specific biological events to switch between slow and fast super-resolution imaging, improving the spatiotemporal resolution of capturing interesting events. It allows the microscope to respond specifically to complex biological events, acquiring data enriched in relevant content.
Article
Nanoscience & Nanotechnology
Vytas Reipa, Nam Wong Song, Minjeong Kwak, Min Beom Heo, Tae Geol Lee, Paul Westerhoff, Yuqiang Bi, Blaza Toman, Vincent A. Hackley, Haruhisa Kato, Yosuke Tabei, Kanokwan Nontapot, Yonghyun Choi, Jonghun Choi
Summary: A new International Standard for testing nanomaterial photocatalytic activity under physiological conditions has been issued, providing a high throughput assay using a bio-compatible indicator NAD. This standard offers a screening tool to determine nanomaterial potency for phototoxicity and has been validated through an interlaboratory comparison study.
Article
Cell Biology
Justyna Kowalska, Klaudia Banach, Zuzanna Rzepka, Jakub Rok, Marta Karkoszka, Dorota Wrzesniok
Summary: Phototoxicity induced by antibiotics is a real problem in health care. This study focused on lomefloxacin, a fluoroquinolone antibiotic with strong phototoxic activity. The results showed that lomefloxacin affected the cell cycle and caused oxidative stress and cytotoxicity in human dermal fibroblasts exposed to UVA radiation.
Article
Engineering, Environmental
Sze-Mun Lam, Man-Kit Choong, Jin-Chung Sin, Honghu Zeng, Liangliang Huang, Lin Hua, Haixiang Li, Zeeshan Haider Jaffari, Kyung Hwa Cho
Summary: This study successfully decomposed Rhodamine B dye, Staphylococcus aureus, and Bacillus cereus using a novel composite material. The composite showed improved photoactivity and the Ti3C2 MXene acted as an outstanding co-catalyst. Experimental evidence revealed that hydroxyl and superoxide anion radicals played pivotal roles in the photodegradation of RhB dye. Furthermore, the real-world viability of the composite material was demonstrated.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Simona Codruta Heghes, Oliviu Vostinaru, Cristina Mogosan, Doina Miere, Cristina Adela Iuga, Lorena Filip
Summary: Coumarins, a family of benzopyrones, are widely distributed in nature and can be found in seeds, fruits, flowers, or roots of various plant species. They are present in significant concentrations in certain herbs or spices used as nutraceuticals, but can also be found in cosmetics or household products due to their pleasant odor. Accidental exposure to high doses of coumarins can lead to harmful effects in patients. This review provides a summary of the latest published data on preclinical and clinical studies with natural coumarins, focusing on the investigation of general and specific toxicity, to better understand the safety profile of these valuable compounds. Regulatory aspects regarding the use of natural coumarins in different regions of the world are also reviewed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Saba Qureshi, Sonam Chandra, Deepti Chopra, Divya Dubey, Veena Jain, Somendu Kumar Roy, Ratan Singh Ray
Summary: This study showed that nabumetone can induce phototoxicity and photogenotoxicity, leading to cell damage and death. Additionally, it was found to cause UV-induced genotoxicity. Therefore, patients using this drug should avoid sunlight exposure, and healthcare providers should provide proper guidance on drug photosensitivity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sung-Won Kim, Gwang-Bum Im, Yeong Hwan Kim, Suk Ho Bhang
Summary: This study demonstrates the use of bOLED to enhance the paracrine secretion of hADSCs, resulting in improved therapeutic effects. The bOLED promotes angiogenesis through a cell-signaling mechanism and does not induce phototoxicity. This method effectively overcomes the barriers of toxicity and low yield in stem cell therapies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Agricultural Engineering
Xinying Hou, Yan Li, Xiaoyu Zhang, Shijian Ge, Yang Mu, Jinyou Shen
Summary: A bottleneck for microalgae-based wastewater bioremediation is the inhibition of microalgae activity caused by toxic pollutants. This study investigated the defense strategies of Chlorella sorokinana against toxic pyridine. The results showed that pyridine caused photoinhibition and reactive oxygen species overproduction in a concentration-dependent manner. The understanding of intracellular and extracellular self-defense mechanisms of microalgae against pyridine stress can facilitate the development of microalgae-based technology in wastewater bioremediation.
BIORESOURCE TECHNOLOGY
(2023)
Article
Peripheral Vascular Disease
Felix Goetzinger, Thomas Wilke, Faence Hardtstock, Julia Krieger, Ulf Maywald, Michael Kunz, Lucas Lauder, Martin Schulz, Felix Mahfoud, Michael Boehm
Summary: This study compared the cancer risk associated with hydrochlorothiazide (HCT) versus other diuretics. The results showed that HCT treatment was associated with a lower overall cancer risk but a slightly increased risk of skin cancer compared to non-HCT diuretics.
JOURNAL OF HYPERTENSION
(2023)
Article
Chemistry, Applied
Alejandro Vignoni, Carla Layana, Helena C. Junqueira, Andres H. Thomas, Rosangela Itri, Mauricio S. Baptista, Mariana Vignoni
Summary: Lipophilic photosensitizers like O-decyl-Ptr can efficiently induce lipid oxidation through the type I mechanism, leading to the generation of alcohols, ketones, and hydroperoxides in biomembranes. The binding and photosensitizing properties of O-decyl-Ptr make it a promising candidate for photodynamic therapy in cellular experiments.
Article
Biochemistry & Molecular Biology
Jakub Rok, Zuzanna Rzepka, Klaudia Banach, Justyna Kowalska, Dorota Wrzesniok
Summary: Melanoma is a dangerous cancer with aggressive properties and low effectiveness of current therapies. Tetracyclines have shown anticancer activity, and this study analyzes their phototoxic effect on melanoma cells. The results demonstrate that tetracycline-induced phototoxicity significantly reduces the number of live cells by cell cycle arrest and decreased cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Michal Gackowski, Tomasz Osmalek, Anna Froelich, Filip Otto, Raphael Schneider, Janina Lulek
Summary: The widespread use of titanium (IV) oxide (TiO2) in various industries has attracted significant scientific attention. TiO2 can serve as both a photoprotector and a photocatalyst, with enhanced potential in nanometer-sized crystals. Its ability to scatter sunlight is extensively utilized in sunscreens, and efforts have been made to incorporate TiO2 into dermal formulations of photosensitive drugs. However, its tendency to generate reactive oxygen species (ROS), which can be cytotoxic, hinders its full potential. Therefore, modifications of TiO2 nanoparticles such as polymorphic form, size, shape, and surface modifications are explored to minimize its photocatalytic effects. This review provides an overview of the potential risks and opportunities associated with the use of TiO2 in skin care formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Mei Wen, Nuo Yu, Zhigao Yi, Pu Qiu, Cheng Tao, Daniel K. Macharia, Meifang Zhu, Zhigang Chen, Xiaogang Liu
Summary: Conventional photo/sonosensitizers lack selectivity and cause severe skin and retina phototoxicity. The use of a copper-hematoporphyrin monomethyl ether nanoframework (CuHF) can suppress fluorescence on healthy tissues and prevent phototoxicity to the skin and eyes. In addition, this nanoframework can react with endogenous hydrogen sulfide in colon cancer cells, enabling simultaneous photothermal and sonodynamic therapies.
Article
Dermatology
Kathleen F. O'Brien, Sonal D. Shah, Elena Pope, Roderic J. Phillips, Francine Blei, Eulalia Baselga, Maria C. Garzon, Catherine McCuaig, Anita N. Haggstrom, Peter H. Hoeger, James R. Treat, Marissa J. Perman, Jane S. Bellet, Xavier Cubiro, Jeffrey Poole, Ilona J. Frieden
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Article
Dermatology
D. Thaci, K. Papp, D. Marcoux, L. Weibel, A. Pinter, P. -D. Ghislain, I. Landells, P. H. Hoeger, K. Unnebrink, M. M. B. Seyger, D. A. Williams, S. Rubant, S. Philipp
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Article
Immunology
Sudhir Venkatesan, Puja R. Myles, Kirsty J. Bolton, Stella G. Muthuri, Tarig Al Khuwaitir, Ashish P. Anovadiya, Eduardo Azziz-Baumgartner, Tahar Bajjou, Matteo Bassetti, Bojana Beovic, Barbara Bertisch, Isabelle Bonmarin, Robert Booy, Victor H. Borja-Aburto, Heinz Burgmann, Bin Cao, Jordi Carratala, Tserendorj Chinbayar, Catia Cilloniz, Justin T. Denholm, Samuel R. Dominguez, Pericles A. D. Duarte, Gal Dubnov-Raz, Sergio Fanella, Zhancheng Gao, Patrick Gerardin, Maddalena Giannella, Sophie Gubbels, Jethro Herberg, Anjarath Lorena Higuera Iglesias, Peter H. Hoeger, Xiao Yun Hu, Quazi T. Islam, Mirela F. Jimenez, Gerben Keijzers, Hossein Khalili, Gabriela Kusznierz, Ilija Kuzman, Eduard Langenegger, Kamran B. Lankarani, Yee-Sin Leo, Romina P. Libster, Rita Linko, Faris Madanat, Efstratios Maltezos, Abdullah Mamun, Toshie Manabe, Gokhan Metan, Aukse Mickiene, Dragan Mikic, Kristin G. Mohn, Maria E. Oliva, Mehpare Ozkan, Dhruv Parekh, Mical Paul, Barbara A. Rath, Samir Refaey, Alejandro H. Rodriguez, Bunyamin Sertogullarindan, Joanna Skret-Magierlo, Ayper Somer, Ewa Talarek, Julian W. Tang, Kelvin To, Dat Tran, Timothy M. Uyeki, Wendy Vaudry, Tjasa Vidmar, Paul Zarogoulidis, Jonathan S. Nguyen-Van-Tam
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Dermatology
Peter Mayser, Pietro Nenoff, Dieter Reinel, Dietrich Abeck, Jochen Brasch, Georg Daeschlein, Isaak Effendy, Gabriele Ginter-Hanselmayer, Yvonne Graeser, Uta-Christina Hipler, Peter Hoeger, Annette Kolb-Maeurer, Hagen Ott, Martin Schaller, Miriam Zidane
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2020)
Review
Dermatology
P. H. Hoeger
Summary: Vascular malformations are caused by localized defects in vascular development and are influenced by various factors, leading to complex genotype-phenotype correlations. The differential diagnosis of VM is challenging, except for diseases with pathognomonic phenotypes, but increasing sequencing techniques will facilitate this process. Targeted pharmacotherapy shows promise for the treatment of VM patients.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Letter
Dermatology
Mina Saleva-Stateva, Maria Hess, Kristin Technau-Hafsi, Lisa Weibel, Mihai-Alexandru Badea, Maria del Carmen Boente, Martin Theiler, Maria Jose Fiandrino, Peter Hoeger, Andreas Zimmer, David Rafei-Shamsabadi, Maria Balabanova, Judith Fischer, Melanie Boerries, Cristina Has
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Dermatology
Doris Weiss, Anne Teichler, Peter H. Hoeger
Summary: Blue rubber bleb nevus syndrome is a rare vascular syndrome characterized by continuous eruption of vascular nodules, which may be complicated by acute life-threatening hemorrhage and localized intravascular coagulation. Sirolimus therapy for children with this syndrome has shown promising results and deserves further investigation.
PEDIATRIC DERMATOLOGY
(2021)
Article
Dermatology
Tatjana D. Wahjudi, Heinz Kutzner, Matthias Bleeke, Peter H. Hoeger
Summary: This case study demonstrates the development of multiple dermatofibrosarcoma protuberans in a 4-year-old boy post-human stem cell transplantation for severe combined immunodeficiency due to adenosine deaminase deficiency. It suggests a potential role of chimerism in toxic metabolite accumulation and DNA damage leading to DFSP. Lifelong dermatologic surveillance is essential for ADA-SCID patients due to the inconspicuous nature of DFSP lesions.
PEDIATRIC DERMATOLOGY
(2021)
Biographical-Item
Medicine, General & Internal
Peter H. Hoeger, Veronica A. Kinsler
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Biographical-Item
Dermatology
P. H. Hoeger, V. A. Kinsler
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Biographical-Item
Dermatology
Peter H. Hoeger, Veronica A. Kinsler
PEDIATRIC DERMATOLOGY
(2021)
Letter
Dermatology
Florian Schmid, Peter H. Hoeger
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Cristina Has, Moritz Hess, Waltraud Anemueller, Ulrike Blume-Peytavi, Steffen Emmert, Regina Foelster-Holst, Jorge Frank, Kathrin Giehl, Claudia Guenther, Johanna Hammersen, Kathrin Hillmann, Bettina Hoeflein, Peter H. Hoeger, Alrun Hotz, Thuy Anh Mai, Vinzenz Oji, Holm Schneider, Kira Suessmuth, Iliana Tantcheva-Poor, Frederieke Thielking, Birgit Zirn, Judith Fischer, Antonia Reimer-Taschenbrecker
Summary: This study reports the epidemiological data of EB in Germany, showing the incidence and prevalence of different types of EB. The findings are important for informing national policies, drug development, and improving the quality of life for EB patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Peter H. Hoeger, Lisa M. Koehler, Maria Reipschlaeger, Sandra Mercier
Summary: Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP) is a genetic skin disease with marked age-dependent clinical expressivity caused by mutations in the FAM111B gene. FAM111B encodes a nuclear protein involved in impaired DNA repair, affecting multiple systems. Currently, there is no effective treatment available, but specific inhibition of catalytic activity may be a future strategy. Early imaging of relevant organ systems is necessary to start treatment as early as possible.
PEDIATRIC DERMATOLOGY
(2023)
Article
Dermatology
Tatjana Braun, Maria Wehner, Anne Teichler, Regina C. Betz, Peter H. Hoeger
Summary: Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal dominant hair loss disorder. We report a sporadic case of a 4-year-old boy with clinical features suggestive of MUHH, in whom we identified a new pathogenic variant in U2HR. This finding expands the known spectrum of U2HR variants underlying MUHH and provides further genetic information for genotype-phenotype correlation.
PEDIATRIC DERMATOLOGY
(2023)
