Article
Immunology
Joseph P. McGinley, Gu Lung Lin, Deniz Oner, Tanya Golubchik, Daniel O'Connor, Matthew D. Snape, Olivier Gruselle, Annefleur C. Langedijk, Joanne Wildenbeest, Peter Openshaw, Harish Nair, Jeroen Aerssens, Louis Bont, Federico Martinon-Torres, Simon B. Drysdale, Andrew J. Pollard
Summary: The study evaluated the association between the severity of RSV disease and host age, viral load, and RSV subtypes. Younger infants were more likely to have severe RSV disease, while older infants, higher viral load, and RSV-A were associated with fever. RSV-A and RSV-B caused similar disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Pierluigi Marzuillo, Anna Di Sessa, Raffaella Golino, Paola Tirelli, Maeva De Lucia, Giulio Rivetti, Emanuele Miraglia del Giudice, Stefano Guarino, Felice Nunziata
Summary: We investigated the prevalence and associated factors of acute kidney injury (AKI) in hospitalized patients with viral bronchiolitis. Among the retrospective enrollment of 139 children, AKI was found in 15 patients. Respiratory syncytial virus (RSV) infection, preterm birth, low birth weight, and high hematocrit levels were significantly associated with AKI. This study highlights the importance of monitoring kidney function in viral bronchiolitis patients and identifying risk factors for AKI.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Diego Rodriguez-Alvarez, Cristina Rodriguez-De Tembleque, Emilio Cendejas-Bueno, Elena Perez-Costa, Jesus Diez-Sebastian, Pedro De la Oliva
Summary: This study found that exposure to secondhand smoke increases the risk of pulmonary bacterial superinfection and the need for invasive mechanical ventilation in severely ill infants with acute bronchiolitis. Tobacco smoke significantly impacts the risk of lower respiratory tract infections in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Xinxian Guan, Shasha Gao, He Zhao, Huiting Zhou, Yan Yang, Shenglin Yu, Jian Wang
Summary: This study investigates the clinical characteristics of community-acquired viral pneumonia in hospitalized term and preterm infants. It found that bacterial coinfection can worsen the disease and preterm infants are more susceptible to such coinfection.
Article
Medicine, General & Internal
Milena De Paulis, Danielle Bruna Leal Oliveira, Luciano Matsumiya Thomazelli, Alexandre Archanjo Ferraro, Edison Luiz Durigon, Sandra E. Vieira
Summary: The study of 70 hospitalized infants found that higher HRSV viral load in isolated infections was associated with prolonged ventilatory support, oxygen therapy, and hospitalization days. In co-infection groups, a longer duration of oxygen therapy was observed when the HRSV viral load was predominant.
Article
Virology
Guohong Zhu, Dan Xu, Yuanyuan Zhang, Tianlin Wang, Lingyan Zhang, Weizhong Gu, Meiping Shen
Summary: The study found that the rates of viral infection in children vary by different ages and seasons, with the highest positivity rate of adenovirus appearing in the preschool period, respiratory syncytial virus being highest in infants, and influenza virus increasing with age. The total positive rate of viral infection in different seasons is highest in winter, with influenza positivity rate also being highest in winter.
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Jessica Santiago Cruz, Luciano Kleber de Souza Luna, Vitoria Rodrigues Guimaraes Alves, Danielle Dias Conte, Nancy Cristina Junqueira Bellei
Summary: RSV plays a significant role in acute respiratory infections among children. Viral load may impact disease severity and clinical presentation. Age and coinfection with other pathogens can also influence RSV infection outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Mohammad Hussain Alqahtani, Mohammad Faraj Alqahtani, Mohammed Asiri, Saad Alghamdi, Ziyad Alshagawi, Saleh Alzahrani
Summary: The study aims to determine the clinical presentation, past medical history, hospitalization course, and prognosis in children below two years of age who have been hospitalized in the past five years. The results show a significant increase in the length of ICU and ventilator use among females compared to males. Furthermore, infants younger than 12 months account for the majority of ICU admissions.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Kim Stobbelaar, Thomas C. Mangodt, Winke Van der Gucht, Lise Delhaise, Jasmine Andries, Valerie Gille, Cyril Barbezange, Annemieke Smet, Benedicte Y. De Winter, Jozef J. De Dooy, Tom Schepens, Els L. I. M. Duval, Paul Cos, Philippe G. Jorens, Stijn Verhulst, Peter L. Delputte
Summary: The respiratory syncytial virus (RSV) is the leading cause of viral lower respiratory tract infections (LRTI) in children worldwide, and is associated with significant morbidity and mortality rates. This study found that patients with a single RSV infection had higher disease severity compared to patients with RSV co-infections, suggesting that the presence of viral co-infections could influence the course of RSV bronchiolitis. Further investigation is needed to guide physicians in early treatment decisions for patients who may benefit from current or future treatment options.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Sara Debes, Jon Birger Haug, Birgitte Freiesleben de Blasio, Jonas Christoffer Lindstrom, Christine Monceyron Jonassen, Susanne Gjeruldsen Dudman
Summary: The clinical features and outcomes of viral respiratory tract infections (RTIs) in adults, particularly respiratory syncytial virus (RSV) infections, have not been thoroughly studied. This study found that patients with RSV infections had higher levels of inflammation markers and disease severity compared to patients with other common respiratory viruses, but there were no differences in the need for intensive care unit (ICU) admission or mortality.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Laura L. Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir A. Madhi, William J. Muller, Heather J. Zar, Dennis Brooks, Amy Grenham, Ulrika Wahlby Hamren, Vaishali S. Mankad, Pin Ren, Therese Takas, Michael E. Abram, Amanda Leach, M. Pamela Griffin, Tonya Villafana
Summary: A single injection of nirsevimab administered before the RSV season protected healthy late-preterm and term infants from medically attended RSV-associated lower respiratory tract infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Shoko Ozeki, Makoto Oshiro, Daichi Fukumi, Tomoya Takeuchi, Sayaka Mii, Yuichi Nishikado
Summary: This study retrospectively analyzed the seasonal variation of respiratory syncytial virus (RSV)-associated hospitalizations over the past decade and found that the seasonal peak of RSV epidemic shifted from autumn and winter to summer before 2016. The study also revealed an association between seasonality and disease severity, with younger children being hospitalized and requiring more oxygen during autumn and winter, although this difference disappeared after 2016.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Marco Maglione, Antonia Pascarella, Chiara Botti, Giuseppe Ricci, Fiorella Morelli, Fabiana Camelia, Alberto Micillo, Camilla Cali, Fabio Savoia, Vincenzo Tipo, Antonietta Giannattasio
Summary: This study evaluated the epidemiology of acute respiratory infections in hospitalized children during the third year of the COVID-19 pandemic and found that public health measures aimed at limiting SARS-CoV-2 circulation may have contributed to reducing the circulation of other respiratory viruses. Respiratory syncytial virus (RSV) was the most detected pathogen in positive panels.
Article
Infectious Diseases
Ainara Mira-Iglesias, Clarisse Demont, F. Xavier Lopez-Labrador, Beatriz Mengual-Chulia, Javier Garcia-Rubio, Mario Carballido-Fernandez, Miguel Tortajada-Girbes, Juan Mollar-Maseres, German Schwarz-Chavarri, Joan Puig-Barbera, Javier Diez-Domingo
Summary: This study conducted in the Valencia Region, Spain from 2014 to 2018, revealed that the incidence rates of RSV-associated hospitalization varied by season and hospital, with factors such as age and being born before or at the beginning of the RSV season playing a critical role. The data suggests the importance of better characterization of the population driving the healthcare burden for the development of future immunization strategies against RSV.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
