Review
Pharmacology & Pharmacy
Ziwei Hu, Jinhong Lin, Jintao Chen, Tengxi Cai, Lixin Xia, Ying Liu, Xun Song, Zhendan He
Summary: Viral pneumonia poses a serious threat to global health, with millions of cases requiring hospitalization annually. Current treatments focus on antiviral medications and herbal remedies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Guohong Zhu, Dan Xu, Yuanyuan Zhang, Tianlin Wang, Lingyan Zhang, Weizhong Gu, Meiping Shen
Summary: The study found that the rates of viral infection in children vary by different ages and seasons, with the highest positivity rate of adenovirus appearing in the preschool period, respiratory syncytial virus being highest in infants, and influenza virus increasing with age. The total positive rate of viral infection in different seasons is highest in winter, with influenza positivity rate also being highest in winter.
Article
Immunology
Meghana Nadiger, Prithvi Sendi, Paul A. Martinez, Balagangadhar R. Totapally
Summary: In hospitalized children in the United States, HMPV infection is less common than RSV infection. Complex chronic conditions are more prevalent in children hospitalized with HMPV infection. Hospitalization with HMPV is associated with longer length of stay and higher hospital charges. The adjusted mortality is similar with both infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Review
Virology
Justine Oliva, Olivier Terrier
Summary: Respiratory tract infections pose a significant public health problem, with viral-bacterial co-infections playing a key role in the severity of these infections. Understanding the mechanisms of these co-infections at physiological and immunological levels is crucial, as well as exploring the importance of the microbiome and pathological context in the evolution of co-infections.
Article
Virology
Chantal J. Snoeck, Konstantin Evdokimov, Kinnaly Xaydalasouk, Sodaly Mongkhoune, Aurelie Sausy, Keoudomphone Vilivong, Maude Pauly, Judith M. Hubschen, Somxay Billamay, Claude P. Muller, Antony P. Black
Summary: Respiratory infections are a common reason for medical consultations in children, with human rhinoviruses being the most frequently detected pathogen in Lao children. Influenza A and B viruses combined infection is also common. The study provides recommendations for vaccination and further research.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Y. Mandelia, G. W. Procop, S. S. Richter, S. Worley, W. Liu, F. Esper
Summary: This study evaluated the dynamics of respiratory viral co-infections in children and adults, finding that co-infections are more common in children, especially those under the age of 5. Specific pairings of viral pathogens occurred at altered rates compared to predictions, suggesting potential direct or indirect interactions between specific viruses.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, Research & Experimental
Tal Levinson, Asaf Wasserman, Shani Shenhar-Tsarfaty, Ora Halutz, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Tomer Ziv-Baran
Summary: This study compared the levels of C-reactive protein (CRP) as an indicator of inflammation severity between SARS-CoV-2 and other common respiratory viral infections. The results showed that SARS-CoV-2 patients had higher CRP levels compared to other viral infections, indicating a higher intensity of inflammation caused by SARS-CoV-2.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Anthony Bosco
Summary: Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Recent findings highlight novel aspects of the interferon response in sLRI pathogenesis and provide new directions for mechanistic studies and drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Yuki Furuse, Raita Tamaki, Akira Suzuki, Taro Kamigaki, Michiko Okamoto, Mariko Saito-Obata, Emiko Nakagawa, Mayuko Saito, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani
Summary: This study examined the prevalence of respiratory viruses among children with acute respiratory infections in the Philippines. The research found that the prevalence of respiratory viruses in healthcare facilities was significantly higher than in households, with respiratory syncytial virus and rhinovirus being the most common.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Immunology
Cecilia Johansson, Freja C. M. Kirsebom
Summary: Viral respiratory infections can cause severe diseases, especially in vulnerable populations like infants and the elderly. Neutrophils are important immune cells that play a role in host defense, but their exact role in viral infections, which replicate intracellularly, is still unclear. Tight regulation of neutrophils is necessary in the lungs to prevent damage to host tissues.
MUCOSAL IMMUNOLOGY
(2021)
Article
Infectious Diseases
Liang Chen, Xiudi Han, YanLi Li, Chunxiao Zhang, Xiqian Xing
Summary: This study aimed to compare the clinical characteristics and severity between adults with respiratory syncytial virus (RSV-p) and influenza-related pneumonia (Flu-p). The findings showed that severe outcomes, such as invasive ventilation, ICU admission, and 30-day mortality, were significantly higher in FluA-p compared to RSV-p, while FluB-p was comparable to RSV-p in terms of risk.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Abderrahman Bimouhen, Zakia Regragui, Fatima El Falaki, Hassan Ihazmade, Samira Benkerroum, Imad Cherkaoui, Ahmed Rguig, Hind Ezzine, Touria Benamar, Soumia Triki, Youssef Bakri, Hicham Oumzil
Summary: The study found that RSV was the most common virus among III and SARI patients in Morocco, particularly in children under 5 years of age. Influenza viruses were also common and frequently detected in adults. Other respiratory viruses did not display clear seasonal patterns.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Immunology
Pontus Hedberg, John Karlsson Valik, Lina Abdel-Halim, Tobias Alfven, Pontus Naucler
Summary: This study compared the outcomes of adults attending the emergency department with Omicron, influenza, or respiratory syncytial virus (RSV) infections. The findings showed that Omicron infections were more common and associated with more severe outcomes compared to influenza and RSV, particularly among unvaccinated patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Benjamas Chuaychoo, Kanokwan Rattanasaengloet, Run Banlengchit, Navin Horthongkham, Niracha Athipanyasilp, Kanyarat Totanarungroj, Nisa Muangman
Summary: This retrospective study analyzed hospitalized adult RSV and influenza patients in Thailand, revealing that RSV is less common but similar to influenza in terms of complications and mortality. Clinical manifestations are not reliable in distinguishing between RSV and influenza, necessitating laboratory-confirmed diagnosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Marco Maglione, Antonia Pascarella, Chiara Botti, Giuseppe Ricci, Fiorella Morelli, Fabiana Camelia, Alberto Micillo, Camilla Cali, Fabio Savoia, Vincenzo Tipo, Antonietta Giannattasio
Summary: This study evaluated the epidemiology of acute respiratory infections in hospitalized children during the third year of the COVID-19 pandemic and found that public health measures aimed at limiting SARS-CoV-2 circulation may have contributed to reducing the circulation of other respiratory viruses. Respiratory syncytial virus (RSV) was the most detected pathogen in positive panels.
