Review
Engineering, Biomedical
Xiaojie Lin, Ching Ting Tsao, Masayuki Kyomoto, Miqin Zhang
Summary: Osteoarthritis (OA) is a prevalent chronic disease in the elderly population, with current clinical treatments limited to symptom relief. Injectable natural polymer hydrogels are considered highly promising for controlled drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Orthopedics
Alice Baroncini, Pedro Berjano, Filippo Migliorini, Claudio Lamartina, Daniele Vanni, Stefano Boriani
Summary: This article presents a case of spinal RDOA that underwent multiple revisions for implant failure, resulting in coronal and sagittal imbalance. The disease is characterized by rapidly developing vertebral endplate edema and destruction of the disk space, requiring careful surgical planning.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Liang Wen, Yang Yu, Desi Ma, Zhiwei Wang
Summary: This study aimed to investigate the effect of joint line orientation on the initial bone resection in mechanically aligned total knee arthroplasty (MA-TKA). The results showed that for varus knees with valgus femurs, the initial bone resection was positively correlated with the mechanical lateral distal femoral angle (mLDFA), and the intraoperative bone resection adjustment was significantly correlated with both mLDFA and medial proximal tibial angle (MPTA) in all varus knees.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Gillian A. Hawker, Eric Bohm, Michael J. Dunbar, Peter Faris, C. Allyson Jones, Tom Noseworthy, Bheeshma Ravi, Linda J. Woodhouse, Deborah A. Marshall, BEST Knee Study Team
Summary: This study aimed to determine the discriminant ability of preoperative measures of TKA need, readiness/willingness, and expectations, in order to improve the outcomes of TKA surgery. The study found that incorporating patients' readiness, willingness, and expectations can enhance the success rate of the surgery.
Article
Nutrition & Dietetics
Chun-De Liao, Shih-Wei Huang, Yu-Yun Huang, Che-Li Lin
Summary: The study found a strong association between sarcopenic obesity and knee osteoarthritis (KOA), which may impact the recovery outcomes of older patients undergoing total knee replacement (TKR). Furthermore, patients with sarcopenic obesity had a higher risk of poor range of motion (ROM) recovery following TKR surgery.
Review
Pharmacology & Pharmacy
Juntao Zhang, Fangyang Fan, Aifeng Liu, Chao Zhang, Qi Li, Chenglong Zhang, Feng He, Man Shang
Summary: In this study, the molecular mechanism of ICA for the treatment of KOA was investigated using network pharmacology, molecular docking, and literature research. Core targets for KOA treatment include TNF, IGF1, MMP9, PTGS2, ESR1, MMP2, among others, with main biological processes involving regulation of inflammatory response and collagen catabolic process. The most likely pathways involved were the IL-17 signaling pathway, TNF signaling pathway, and Estrogen signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Chemistry, Medicinal
Ashim Gupta
Summary: Amniotic tissue, as a new alternative treatment for knee and hip osteoarthritis, shows potential safety and effectiveness in clinical studies. However, further multi-center, prospective, double-blinded, randomized controlled trials are needed to establish its efficacy and justify its clinical use.
Review
Biochemistry & Molecular Biology
Francisco Javier Martin-Vega, David Lucena-Anton, Alejandro Galan-Mercant, Veronica Perez-Cabezas, Carlos Luque-Moreno, Maria Jesus Vinolo-Gil, Gloria Gonzalez-Medina
Summary: The application of NSAIDs by phonophoresis is effective in relieving symptoms and improving physical function in patients with knee osteoarthritis. Further long-term studies are recommended to validate the treatment effects.
Article
Medicine, General & Internal
Jaromir Jarecki, Magdalena Sobiech, Karolina Turzanska, Agnieszka Tomczyk-Warunek, Miroslaw Jablonski
Summary: This study found that KT is an effective method for improving subcutaneous drainage and decreasing subcutaneous tissue after total knee arthroplasty, but it does not affect postoperative pain and range of motion.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Computer Science, Hardware & Architecture
Shih-Chin Tan, Chun-Liang Lai, Jia-Jeng Hou
Summary: Osteoarthritis has become one of the most severe disability diseases in developed countries, causing pain, disability, and financial burdens. In this study, scenario and incident models are used to analyze different patient groups and identify key factors affecting treatment outcomes.
JOURNAL OF SUPERCOMPUTING
(2022)
Article
Biochemistry & Molecular Biology
Luz Herrero-Manley, Ana Alabajos-Cea, Luis Suso-Marti, Enrique Viosca-Herrero, Isabel Vazquez-Arce
Summary: The study aimed to test the practicality of the existing diagnostic criteria for early knee osteoarthritis (EKOA) and evaluate the clinical progression of both healthy subjects at risk and patients diagnosed with EKOA. The participants were classified into EKOA and healthy subjects based on disability, pain, and self-reported variables. Most participants remained in their original classification, although some were reclassified during the follow-ups. The current diagnostic criteria could lead to misdiagnosis due to fluctuations in patients' conditions.
Article
Rheumatology
Priyanka Ballal, Christine Peloquin, Cindy Germaine Boer, Tuhina Neogi
Summary: This study suggests that warfarin use is associated with a higher risk of knee and hip replacements compared to DOAC use. Furthermore, longer duration of warfarin use is linked to an increased risk of joint replacement.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Instruments & Instrumentation
Jun Xiao, Yong Hu, Lin Huang, Zhi-Fa Huang, Wei-Zhou Jiang, Yu-Qiang Luo, Meng-Yan Jia, Di Chen, Zhan-Jun Shi
Summary: Hyaluronic acid coverage on the impaired cartilage is crucial for its beneficial effect on knee osteoarthritis, with distribution in different joints affected by the route of drug delivery. Intra-articular injection of HA through the medial midpatellar route showed superior clinical efficacy and cartilage coverage compared to the anteromedial route in treating mild-to-moderate KOA.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Clodagh M. Toomey, Jackie L. Whittaker, Luz Palacios-Derflingher, Carolyn A. Emery
Summary: This study shows that individuals with youth sport knee injuries, beyond ACL or meniscus injury, may also experience significant pain and symptoms 3-12 years following injury. Further replication and follow-up are needed to identify potential clinical trajectory towards osteoarthritis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Said A. Ibrahim
Summary: An algorithm developed through machine learning on existing radiological data from diverse people has the potential to improve the diagnosis and management of knee pain from osteoarthritis and reduce racial disparities in the assessment of knee pain.
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.