Article
Endocrinology & Metabolism
Neil Binkley, Brian Nickel, Paul A. A. Anderson
Summary: Total joint replacement is common and increasing, but it can lead to bone loss and periprosthetic fractures, which are often overlooked by osteoporosis clinicians. This clinical review aims to raise awareness about these fractures, which are related to osteoporosis, and suggest approaches to reduce their occurrence. It emphasizes the importance of bone health evaluation after a periprosthetic fracture and the need for primary prevention through bone health assessment and optimization prior to elective orthopedic procedures.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Fabio Massimo Ulivieri, Luca Rinaudo
Summary: A proper assessment of osteoporotic fragility fracture prediction requires consideration of factors like bone density, texture, geometry, and strength, obtained through methods like dual X-ray absorptiometry (DXA). The Bone Strain Index (BSI) is a new DXA-derived index designed to evaluate bone resistance to strain by incorporating information on density distribution, bone geometry, and loadings.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Heenam Goel, Neil Binkley, Didier Hans, William D. Leslie
Summary: This registry-based study showed that low bone mineral density (BMD), but not low trabecular bone score (TBS), predicted fracture in younger adults. Routine clinical TBS measurement is not recommended for young adults, and further study is needed.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wentao Lin, Chaoqin He, Faqin Xie, Tao Chen, Guanghao Zheng, Houjie Yin, Haixiong Chen, Zhiyun Wang
Summary: In this study, the authors assessed the diagnostic discordance between lumbar osteoporosis detected by QCT and DXA, and evaluated their predictive performance for prevalent vertebral fracture. The results showed that in older patients undergoing spinal surgery, QCT-vBMD is more helpful than DXA in terms of osteoporosis detection rate and prediction of patients with prevalent VFs.
Article
Endocrinology & Metabolism
Hyun Woo Park, Hyojung Jung, Kyoung Yeon Back, Hyeon Ju Choi, Kwang Sun Ryu, Hyo Soung Cha, Eun Kyung Lee, A. Ram Hong, Yul Hwangbo
Summary: In individuals under the recommended age for DXA examination, the XGBoost model demonstrated reliable performance in predicting osteoporosis, surpassing conventional risk assessment tools.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Jia-Liang Chen, Yao Liu, Yu-Fei Bi, Xian-Bo Wang
Summary: This study assessed the prevalence and clinical characteristics of osteoporosis in Chinese patients with PBC. The results showed that osteoporosis is very common in PBC patients, with older age, lower BMI, previous steroid therapy, and advanced liver disease being the main independent risk factors.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Clinical Neurology
Matthias Pumberger, Yannick Palmowski, Patrick Strube, Christin Schwemmer, Stephanie Roll, Timo Zippelius, Michael Putzier
Summary: This study aimed to evaluate the correlation between lumbar DXA measurements and parameters of bone architecture in patients with osteoporosis. The results suggest that lumbar DXA does not accurately represent microstructural bone architecture and is not a reliable tool for evaluating bone quality in the spine.
Review
Obstetrics & Gynecology
S. Cerdas Perez, L. E. Herrera, E. Gonzalez
Summary: Osteoporosis is a prevalent skeletal disorder that decreases bone strength and increases the risk of fragility fractures. Dual-energy X-ray absorptiometry (DXA) is the preferred method for evaluating bone mineral density, but clinical and technical considerations must be taken into account to avoid misdiagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andre Euler, Tristan Nowak, Brian Bucher, Matthias Eberhard, Bernhard Schmidt, Thomas G. Flohr, Diana Frey, Oliver Distler, Hatem Alkadhi
Summary: The study assessed the accuracy and impact of different sizes and tube voltages on bone mineral density (BMD) using a photon-counting detector CT system in an ex vivo animal spine. Results showed that neither size nor tube voltage had significant effect on BMD measurements.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ferdinand Roski, Johannes Hammel, Kai Mei, Bernhard Haller, Thomas Baum, Jan S. Kirschke, Daniela Pfeiffer, Klaus Woertler, Franz Pfeiffer, Peter B. Noel, Alexandra S. Gersing, Benedikt J. Schwaiger
Summary: The study assessed the diagnostic accuracy of iodine-corrected vertebral BMD measurements derived from non-dedicated contrast-enhanced phantomless dual-layer spectral CT examinations. Converted BMD values adjusted for individual vessel iodine concentrations showed a high agreement with non-enhanced DLCT-BMD, suggesting that opportunistic BMD measurements are feasible even in non-dedicated contrast-enhanced DLCT examinations.
EUROPEAN RADIOLOGY
(2021)
Review
Endocrinology & Metabolism
Dilki Madhuchani, Sumudu Nimali Seneviratne, Leanne M. Ward
Summary: Bone accrual in childhood affects bone health later in life. Early loss of bone strength can lead to health issues and lower quality of life in childhood and adolescence. Improved assessment tools and treatment options, along with awareness of fracture history and risk factors, have enhanced the detection and management of bone fragility in children globally.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Ma, Xinmeng Hou, Chenglin Zhao, Yuanyuan Yan, Xiaoyue Cheng, Jianying Li, Daqing Ma, Zhenghan Yang
Summary: Using vertebral hydroxyapatite concentration measurements in unenhanced and contrast-enhanced spectral CT can accurately detect and predict the risk of osteoporosis-associated fractures.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, General & Internal
Abulfaz Isayev, Nigiar Velieva, Luljeta Isedisha, Zhala Isayeva, Kivanc Kamburoglu, Fatih Kuyumcu
Summary: This literature review examined the capability of cone-beam computed tomography (CBCT) to accurately identify low bone mass density in women. Ten studies were analyzed and the results showed that CBCT has good sensitivity and specificity in predicting osteoporosis. CBCT grayscale values were compared with dual energy X-ray absorptiometry scores, which strengthened the accuracy of CBCT's diagnostic capability. It is considered a feasible predictive tool for detecting patients at risk of osteoporosis.
Article
Gastroenterology & Hepatology
Phil A. Hart, Dhiraj Yadav, Liang Li, Savi Appana, William Fisher, Evan Fogel, Chris E. Forsmark, Walter G. Park, Stephen Pandol, Mark D. Topazian, Stephen K. Van den Eden, Santhi Swaroop Vege, David Bradley, Jose Serrano, Darwin L. Conwell
Summary: Chronic pancreatitis patients have a high prevalence of osteopathy, with older age, female sex, white race, and underweight body mass index category being associated with a higher probability of osteopathy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Clinical Neurology
Wentao Lin, Chaoqin He, Faqin Xie, Tao Chen, Guanghao Zheng, Houjie Yin, Haixiong Chen, Zhiyun Wang
Summary: This study compared the diagnostic accuracy of quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) in detecting lumbar osteoporosis, and found that QCT provided more accurate evaluation of bone density than DXA. QCT measurements at specific vertebral levels showed high diagnostic performance for osteoporotic vertebral compression fractures (OVCF).
Article
Rheumatology
Karine Briot, Christian Roux, Thierry Thomas, Hubert Blain, Daniel Buchon, Roland Chapurlat, Francoise Debiais, Jean Marc Feron, Jean Bernard Gauvain, Pascal Guggenbuhl, Eric Legrand, Anne Marie Lehr-Drylewicz, Eric Lespessailles, Florence Tremollieres, Georges Weryha, Bernard Cortet
Article
Rheumatology
Anthony Chapron, Typhaine Chopin, Maxime Esvan, Hang-Korng Ea, Frederic Liote, Pascal Guggenbuhl
Article
Rheumatology
Tristan Pascart, Laurene Norberciak, Hang-Korng Ea, Pascal Guggenbuhl, Frederic Liote
ARTHRITIS CARE & RESEARCH
(2019)
Letter
Rheumatology
Julia Goossens, Sylvie Lancrenon, Sabine Lanz, Hang-Korng Ea, Charles Lambert, Pascal Guggenbuhl, Alain Saraux, Catherine Delva, Samy Sahbane, Frederic Liote
Review
Rheumatology
Simon Cadiou, Omar Al Tabaa, Chi-Duc Nguyen, Marine Faccin, Raphael Guillin, Matthieu Revest, Pascal Guggenbuhl, Eric Houvenagel, Edouard Pertuiset, Guillaume Coiffier
CLINICAL RHEUMATOLOGY
(2019)
Article
Rheumatology
G. Coiffier, C. David, P. Gauthier, H. Le Bars, P. Guggenbuhl, A. Jolivet-Gougeon, J. D. Albert
CLINICAL RHEUMATOLOGY
(2019)
Review
Rheumatology
Jean-Claude Souberbielle, Catherine Cormier, Etienne Cavalier, Veronique Breuil, Francoise Debiais, Patrice Fardellone, Pascal Guggenbuhl, Rose-Marie Javier, Erick Legrand, Eric Lespessailles, Julien Paccou, Thierry Thomas, Bernard Cortet
Article
Biochemistry & Molecular Biology
Thibault Cavey, Chloe Latour, Marie-Laure Island, Patricia Leroyer, Pascal Guggenbuhl, Helene Coppin, Marie-Paule Roth, Claude Bendavid, Pierre Brissot, Martine Ropert, Olivier Loreal
Article
Rheumatology
Tristan Pascart, Laurene Norberciak, Hang-Korng Ea, Sahara Graf, Pascal Guggenbuhl, Frederic Liote
Letter
Rheumatology
Francois Robin, Guillaume Coiffier, Jean-David Albert, Christelle Darrieutort-Laffite, Simon Rio, Benoit Le Goff, Pascal Guggenbuhl
Article
Rheumatology
Olivia Berthoud, Guillaume Coiffier, Jean-David Albert, Anne Gougeon-Jolivet, Claire Goussault, Claude Bendavid, Pascal Guggenbuhl
Review
Rheumatology
Simon Cadiou, Francois Robin, Raphael Guillin, Aleth Perdriger, Stephane Jouneau, Nicolas Belhomme, Guillaume Coiffier, Pascal Guggenbuhl
Article
Rheumatology
Marion Couderc, Geraldine Bart, Guillaume Coiffier, Sophie Godot, Raphaele Seror, Jean-Marc Ziza, Pascal Coquerelle, Christelle Darrieutort-Laffite, Christian Lormeau, Carine Salliot, Eric Veillard, Louis Bernard, Marion Baldeyrou, Thomas Bauer, Beate Hyem, Robert Touitou, Bernard Fouquet, Denis Mulleman, Rene-Marc Flipo, Pascal Guggenbuhl
Article
Rheumatology
F. Robin, O. Berthoud, J. D. Albert, S. Cadiou, A. Gougeon-Jolivet, C. Bendavid, P. Guggenbuhl, Guillaume Coiffier
Summary: The study evaluated the performance of the Gout-calculator in patients with consecutive acute arthritis affecting large and intermediate joints, finding that while the calculator showed relatively good diagnostic performance for gout, it was not sufficient to rule out the differential diagnosis of septic arthritis in the SYNOLACTATE cohort.
CLINICAL RHEUMATOLOGY
(2021)
Review
Endocrinology & Metabolism
F. Robin, S. Cadiou, J-D Albert, G. Bart, G. Coiffier, P. Guggenbuhl
Summary: Methotrexate (MTX)-related osteopathy, characterized by pain, osteoporosis, and atypical fractures, is a rare condition that has been reported in patients treated with low doses of MTX for inflammatory diseases. Pathophysiological studies suggest a possible dose-dependent residual effect of MTX on osteo-forming bone cells.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.