Article
Immunology
Min Chen, Pei Yang, Zixuan Xin, Jiating Chen, Weihao Zou, Lijuan Zhou, Lili Yang, Jiao Peng, Hongjuan Peng
Summary: Toxoplasma gondii is a pathogen causing toxoplasmosis and has similarities with immunotherapy for cancers. The knockout of GRA5 gene in T. gondii resulted in an avirulent strain that stimulated immune responses. ME49 & UDelta;gra5 vaccination provided protection against T. gondii infection and breast cancer by boosting anti-tumor responses. The vaccine upregulated Th1 cytokines and tumor-infiltrating T cells, and increased the number of immune cells in the spleen.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Parasitology
Rajshekhar Y. Gaji, Amanda K. Sharp, Anne M. Brown
Summary: Toxoplasma gondii is a life-threatening intracellular pathogen that depends on protein kinases for its life cycle. Research on Toxoplasma kinases aims to understand their functions and potentially develop therapeutics against this parasite.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Parasitology
Anamaria Ioana Pastiu, Viorica Mircean, Aurelien Mercier, Karine Passebosc-Faure, Nicolas Plault, Marie-Laure Darde, Radu Blaga, Isabelle Villena, Dana Liana Pusta, Anamaria Cozma-Petrut, Adriana Gyoerke
Summary: This study investigated the epidemiology of Toxoplasma gondii infection in sheep in Romania and successfully isolated the infective strains. The results showed a high prevalence of T. gondii infection in sheep and lambs, highlighting the significant risk of human infection through consuming raw or undercooked sheep/lamb meat.
PARASITES & VECTORS
(2023)
Article
Engineering, Multidisciplinary
Wen Jiang, Mengyue Wang
Summary: Through studying the genotype of Toxoplasma gondii, it was found that there are genetic differences in Central and South America. From the perspective of pathogen virulence evolution, it is discovered that transmission route is a key factor causing global genetic differences in Toxoplasma gondii, and the diversity of hosts does not always increase its virulence differences. The reproductive mode of Toxoplasma gondii and frequent human trades are prerequisites for the development of its virulence.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Microbiology
Cristiana Luiza Radoi, Ovidiu Mircea Zlatian, Maria Balasoiu, Lucian Giubelan, Andreea Cristina Stoian, Livia Dragonu, Alexandru Neacsu, Dominic Gabriel Iliescu
Summary: This study examined the prevalence of anti-T. gondii IgM and IgG antibodies in two groups of childbearing age women. The results showed a decrease in the overall positivity rate of anti-T. gondii IgM antibodies, indicating improved public health interventions. However, there were variations among different age groups and between rural and urban environments, with a significant decrease in urban areas.
Article
Microbiology
Farlen J. B. Miranda, Bruno C. Rocha, Milton C. A. Pereira, Larissa M. N. Pereira, Erikson H. M. de Souza, Ana P. Marino, Pedro A. C. Costa, Daniel V. Vasconcelos-Santos, Lis R. Antonelli, Ricardo T. Gazzinelli
Summary: Toxoplasmosis affects a significant portion of the global population, with humans becoming accidental hosts through consumption of undercooked meat and contaminated water. Neutrophils play a crucial role in controlling T. gondii infections, with their activation and formation of NETs amplifying both innate and adaptive immune responses.
Review
Immunology
Chanjin Yoon, Yu Seong Ham, Woo Jin Gil, Chul-Su Yang
Summary: This review article provides an overview of the activation and specific role of the NLRP3 inflammasome in Toxoplasma gondii infection. It points out that the role of NLRP3 inflammasome in T. gondii infection is still uncertain and the mechanisms of its activation in different cell types are still unknown.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Pablo-Jesus Marin-Garcia, Nuria Planas, Lola Llobat
Summary: This article reviews the detection methods, prevalence, and control measures of Toxoplasma gondii in the food industry. T. gondii is a common parasite that causes infection through food contamination, but standardized detection methods are currently lacking in the industry. The main detection methods include bioassays, cell culture, molecular and microscopic techniques, and serological methods. Due to the high prevalence of T. gondii in many food products, standardized detection methods and control measures are necessary.
Article
Immunology
Hong-chao Sun, Pu-ming Deng, Yuan Fu, Jin-hua Deng, Rong-hui Xie, Jing Huang, Meng Qi, Tuan-yuan Shi
Summary: In this study, PLGA nanoparticles were used as a delivery system for T. gondii GRA12 and GRA7 antigens. Mice immunized with PLGA+GRA12 showed higher levels of IgG antibodies, increased lymphocyte proliferation, and a predominant Th1 immune response. Immunization with PLGA+GRA12 vaccine resulted in significantly reduced parasite loads and longer survival times compared to other vaccinated groups. However, PLGA was ineffective in enhancing the immune response induced by T. gondii GRA7.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Tadakimi Tomita, Debanjan Mukhopadhyay, Bing Han, Rama Yakubu, Vincent Tu, Joshua Mayoral, Tatsuki Sugi, Yanfen Ma, Jeroen P. J. Saeij, Louis M. Weiss
Summary: The study reveals that the cyst matrix protein MAG1 functions as a secreted immunomodulatory effector, regulating parasite virulence and dissemination by suppressing inflammasome activation. The balance between GRA15-induced inflammasome activation and MAG1-mediated suppression plays a crucial role in host-parasite interactions and the establishment of chronic infection.
Article
Cell Biology
Lidia Weglinska, Adrian Bekier, Katarzyna Dzitko, Barbara Pacholczyk-Sienicka, Lukasz Albrecht, Tomasz Plech, Piotr Paneth, Agata Paneth
Summary: This study showed that a series of 1,3,4-thiadiazole-2-halophenylamines compounds could effectively inhibit the invasion and proliferation of Toxoplasma gondii in host cells, with para-iodo derivative 12b being the most effective.
Review
Biology
Olivia L. McGovern, Yolanda Rivera-Cuevas, Vern B. Carruthers
Summary: Research on endocytosis in protozoan parasites, including malaria parasites and Toxoplasma gondii, is still in early stages. Malaria parasites acquire nutrients by internalizing hemoglobin from infected red blood cells, while the active endocytic system of Toxoplasma gondii was recently discovered. Future studies will help uncover the molecular basis and biological significance of endocytosis in Toxoplasma gondii.
Article
Microbiology
Mercedes Fernandez-Escobar, Federica Giorda, Virgina Mattioda, Tania Audino, Fabio Di Nocera, Giuseppe Lucifora, Katia Varello, Carla Grattarola, Luis Miguel Ortega-Mora, Cristina Casalone, Rafael Calero-Bernal
Summary: This study investigated the genetic diversity of Toxoplasma gondii strains in stranded dolphins found in the Mediterranean coastlines of Italy. The results showed that dolphins were mainly infected with ToxoDB#3 and #2 genotypes.
Article
Microbiology
Laura Alejandra Mendoza-Larios, Fernando Garcia-Dolores, Luis Francisco Sanchez-Anguiano, Jesus Hernandez-Tinoco, Cosme Alvarado-Esquivel
Summary: This study found no association between suicide and Toxoplasma gondii seropositivity, but further research is needed to confirm this lack of association.
Article
Rheumatology
Hassene Attout, Stephane Guez, Julien Durand, Florent Dubois, Arte Rughoobur, Claire Series
Letter
Medicine, General & Internal
H Attout, F Rahmeh, F Ziegler
REVUE DE MEDECINE INTERNE
(2000)
Article
Clinical Neurology
F Rahmeh, P Labouret, H Attout, F Ziegler
REVUE NEUROLOGIQUE
(2000)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.
