Evaluation of 25-Hydroxyvitamin D Serum Levels in Patients With Fibromyalgia

Background: Fibromyalgia (FM) is a condition characterized by chronic widespread musculoskeletal pain often associated with sleep disorders and mood and whose pathophysiology is still not clearly defined. In recent years, some studies have hinted at a possible association between different types of pain, including the pain present in FM, with vitamin D deficiency. Objective and Methods: The present work consisted of a cross-sectional study aimed at evaluating 25-hydroxyvitamin D (25(OH) D) serum levels in 87 patients with FM, as compared with a control group composed of 92 age- and sex-matched subjects with no chronic musculoskeletal pain. Clinical and laboratory variables that could affect the status of vitamin D were also considered. Results: There was no statistically significant difference between groups either with respect to mean serum concentration of 25(OH) D or as to the classification of levels as deficient, insufficient, or sufficient. There was no correlation of 25(OH) D levels with pain intensity. Conclusion: This study showed that light to moderate deficient and insufficient 25(OH) D levels are not found more commonly in patients with FM.