Article
Infectious Diseases
Dhelya Widasmara, Fitri Firdausiya
Summary: The case study involves a 14-year-old girl with SLE and lupus nephritis who developed DHZ and received acyclovir treatment, showing clinical improvement.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Rheumatology
Alexis Mathian, Paul Breillat, Karim Dorgham, Paul Bastard, Caroline Charre, Raphael Lhote, Paul Quentric, Quentin Moyon, Alice-Andree Mariaggi, Suzanne Mouries-Martin, Clara Mellot, Francois Anna, Julien Haroche, Fleur Cohen-Aubart, Delphine Sterlin, Noel Zahr, Adrian Gervais, Tom Le Voyer, Lucy Bizien, Quentin Amiot, Micheline Pha, Miguel Hie, Francois Chasset, Hans Yssel, Makoto Miyara, Pierre Charneau, Pascale Ghillani-Dalbin, Jean-Laurent Casanova, Flore Rozenberg, Zahir Amoura, Guy Gorochov
Summary: This study finds that neutralizing and non-neutralizing autoantibodies against type-I interferons (IFNs-I) are present in patients with systemic lupus erythematosus (SLE). Neutralizing anti-IFN-alpha antibodies are associated with reduced IFN-alpha levels and a decreased likelihood of developing active disease, but they increase the risk of herpes zoster and severe COVID-19 pneumonia. Severe COVID-19 pneumonia in SLE patients is mainly associated with combined neutralization of different IFNs-I.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Francesco Reggiani, Silvia Cardi, Fabio Tumminello, Marta Calatroni, Laura Locatelli, Maria Gerosa, Nicoletta Del Papa, Gabriella Moroni
Summary: This study evaluated the prevalence, incidence, and predictors of herpes zoster in lupus nephritis patients. The results showed that herpes zoster occurs unpredictably throughout the course of lupus nephritis, and its incidence seems to have increased in recent decades. Induction therapy with azathioprine and methylprednisolone pulses may provide protection, while higher cumulative doses of glucocorticoids, cyclophosphamide, and mycophenolate mofetil increase susceptibility.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ming-Han Chen, Chien-Sheng Wu, Ming-Huang Chen, Chang-Youh Tsai, Fa-Yauh Lee, Yi-Hsiang Huang
Summary: The incidence of HBV reactivation in patients with systemic lupus erythematosus is associated with the use of glucocorticoids, particularly in patients aged 40 and above receiving high doses. Antiviral prophylaxis is necessary for these high-risk SLE patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jinxia Chen, Limin Zhang, Liutao Huang, Shuxian Chen, Yongzhi Xu, Huafeng Liu
Summary: This study reveals the characteristics and risk factors for frequent readmission in patients with systemic lupus erythematosus (SLE), including age, serum markers, and their association with readmission. The main causes of readmission were infections and disease activity or recurrence.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Rheumatology
Andrew Kwan, Hanan Al Rayes, Tijana Lazova, Nicole Anderson, Dennisse Bonilla, Jiandong Su, Zahi Touma
Summary: This study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in patients with SLE. The results showed that HZ is highly prevalent in SLE and may be linked to disease-related and treatment-related effects on cellular immunity. The study also found that lymphopenia and glucocorticoid dosing were significantly associated with HZ events.
LUPUS SCIENCE & MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Sameh Bougatf, Faida Ajili, Sameh Sayhi
Summary: Due to improved management and reduced mortality from disease activity, infections have become the leading cause of morbidity and mortality in systemic lupus erythematosus patients. This study aimed to determine the prevalence and identify risk factors for severe infections in these patients. A retrospective study was conducted on 93 Tunisian lupus patients, revealing that the cumulative doses of corticosteroids, number of flares, pulmonary manifestations, pleuritis, and use of antimalarials were all associated with the risk of severe infections.
Article
Immunology
Marcia M. L. Kho, Stefan Roest, Dominique M. Bovee, Herold J. Metselaar, Rogier A. S. Hoek, Annemiek A. van der Eijk, Olivier C. Manintveld, Joke I. Roodnat, Nicole M. van Besouw
Summary: The study shows that the incidence and severity of herpes zoster in solid organ transplant recipients are highest after heart and lung transplantation, in older patients, and when CMV prophylaxis is lacking. Major risk factors include age over 50 at transplantation, type of organ transplant, CMV prophylaxis, and type of anti-rejection therapy. Complications such as post-herpetic neuralgia, disseminated disease, and cranial nerve involvement were reported in a significant number of patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Jiaqian Zhang, Shengxiao Zhang, Jun Qiao, Mengting Qiu, Xiaofeng Li
Summary: This study analyzed the characteristics of peripheral blood lymphocyte subsets in systemic lupus erythematosus (SLE) patients with and without infection. A risk assessment model was established to predict the occurrence of co-infection in SLE patients. T cells, NK cells, and CD4(+)T cells were found to be helpful in differentiating lupus with infection from lupus alone.
Article
Immunology
Lifan Zhang, Xiaoqing Zou, Nan Jiang, Lantian Xie, Jianghao Liu, Zhengrong Yang, Qifei Cao, Chunlei Li, Xiaochuan Sun, Fengchun Zhang, Yan Zhao, Xiaofeng Zeng, Xiaochun Shi, Xiaoqing Liu
Summary: This study aimed to investigate the incidence of active tuberculosis (ATB) and explore the risk factors for developing ATB in SLE patients in China. A multi-center prospective cohort study was conducted, and data on demographic features, TB infection status, clinical information, and laboratory data were collected. The results showed that the risk factors for ATB development in SLE patients included the maximum daily dose of glucocorticoids (GCs) and TB infection. Therefore, TB preventive treatment should be considered in SLE patients with a high daily dose of GCs (>30 mg/d) or TB infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Nikolaos Koletsos, Eugenia Gkaliagkousi, Antonios Lazaridis, Areti Triantafyllou, Panagiota Anyfanti, Panagiotis Dolgyras, Konstantina Dipla, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
Summary: This study demonstrates that patients with SLE show reduced microvascular reactivity during reperfusion, even in the absence of overt cardiovascular disease or risk factors, compared to controls. These findings indicate that skin microvascular dysfunction is present in SLE independent of the cardiovascular burden these patients carry, suggesting it may serve as an early indicator of vascular damage.
Article
Rheumatology
Ibrahim Almaghlouth, Jiandong Su, Sindhu R. Johnson, Eleanor Pullenayegum, Dafna Gladman, Murray Urowitz
Summary: Acquired hypogammaglobulinaemia in adult SLE patients is mostly transient, with only low IgA levels associated with an increased risk of infection. Further research is needed to determine if immunoglobulin replacement therapy can provide additional protective effects.
Article
Microbiology
Lifan Zhang, Yanan Ma, Nan Jiang, Xiaoqing Zou, Yueqiu Zhang, Fengchun Zhang, Xiaofeng Zeng, Yan Zhao, Shengyun Liu, Xiaoxia Zuo, Huaxiang Wu, Lijun Wu, Hongbin Li, Zhiyi Zhang, Sheng Chen, Ping Zhu, Miaojia Zhang, Wencheng Qi, Yi Liu, Huaxiang Liu, Xiaochun Shi, Xiaoqing Liu
Summary: The study aimed to determine the prevalence of latent tuberculosis infection (LTBI) among systemic lupus erythematosus (SLE) patients using the T-SPOT.TB assay and identify factors influencing the assay results. A total of 2,229 SLE patients were screened, with a positivity rate of 15%. Factors such as age over 40, evidence of previous tuberculosis, and disease severity were associated with positive T-SPOT.TB results, while high-dose glucocorticoid treatment and some types of immunosuppressants were associated with negative results. The study highlights the importance of active LTBI screening and preventive intervention in SLE patients in China.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Rosa M. R. Pereira, Marilia A. Dagostin, Valeria F. Caparbo, Lucas P. Sales, Sandra G. Pasoto, Clovis A. Silva, Emily F. N. Yuki, Carla G. S. Saad, Ana C. Medeiros-Ribeiro, Leonard V. K. Kupa, Solange R. G. Fusco, Victor A. O. Martins, Carolina C. M. F. Martins, Carmen Valente Barbas, Samuel K. Shinjo, Nadia E. Aikawa, Eloisa Bonfa
Summary: This study evaluates the immunogenicity, antibody decay, booster dose, and safety of inactivated CoronaVac vaccination in patients with ANCA-associated vasculitis. The results show that CoronaVac vaccine exhibits good safety and moderate immunogenicity in AAV patients, with a mild decline in antibodies after six months but a good response to the booster dose. Overall, the vaccine has minimal adverse effects.
Article
Rheumatology
Gabriela A. Munhoz, Nadia E. Aikawa, Clovis A. Silva, Sandra G. Pasoto, Tatiana N. Pedrosa, Luciana P. C. Seguro, Eloisa Bonfa, Eduardo F. Borba
Summary: This study aimed to determine the impact of lupus nephritis at disease onset on short-term accrual of 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) domains. The study found that patients with renal involvement had higher disease activity and required more treatment at disease onset, while patients without renal involvement also experienced damage in the early stages of the disease. Therefore, close monitoring and tailored treatment for lupus patients without renal involvement are important.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Carla G. S. Saad, Matheus S. R. Silva, Percival D. Sampaio-Barros, Julio C. B. Moraes, Claudia G. Schainberg, Celio R. Goncalves, Andrea Y. Shimabuco, Nadia E. Aikawa, Emily F. N. Yuki, Sandra G. Pasoto, Leonard V. K. Kupa, Renato K. Aoyama, Carlo S. R. Araujo, Clovis A. Silva, Ana C. Medeiros-Ribeiro, Eloisa Bonfa
Summary: This study evaluated the humoral responses to the SARS-CoV-2 vaccine in patients with spondyloarthritis and found that therapy had an impact on the immune response. TNF inhibitors attenuated the immune response, while sulfasalazine had a positive impact on vaccine antibody production.
Article
Rheumatology
Epitacio D. S. Neto, Taurino S. R. Neto, Flavio Signorelli, Gustavo G. M. Balbi, Alex H. Higashi, Mario Luiz R. Monteiro, Eloisa Bonfa, Danieli C. O. Andrade, Leandro C. Zacharias
Summary: The objective of this study was to perform a multimodal ophthalmological evaluation, including OCTA, in asymptomatic APS secondary to SLE patients and compare them to SLE patients and a control group. Ophthalmologic abnormalities occurred in approximately one-third of APS/SLE patients and SLE patients, while none were found in the control group. The most common retinal finding was Drusen-like deposits (DLDs) in APS/SLE and SLE patients, with severe changes exclusively occurring in APS/SLE patients. There was a possible association between PAMM, aPL triple positivity, and high aGAPSS scores in APS/SLE patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Sandra Gofinet Pasoto, Eduardo Ferreira Borba, Francisco Fellipe Claudino Formiga, Tatiana do Nascimento Pedrosa, Nadia Emi Aikawa, Marilda Agudo Mendonca Teixeira de Siqueira, Artur Silva Vidal Capao, Adriana Coracini Tonacio de Proenca, Ricardo Fuller, Emily Figueiredo Neves Yuki, Elaine Pires Leon, Victor Adriano de Oliveira Martins, Marta Heloisa Lopes, Alberto Jose da Silva Duarte, Clovis Artur Almeida da Silva, Eloisa Bonfa
Summary: This study investigated the safety and immunogenicity of influenza A (H3N2) vaccine in patients with primary Sjogren syndrome (pSS). The results showed that the vaccine induced a different pattern of immune response in pSS patients compared to other influenza A constituents. This finding is important for understanding the role of cellular immunity in pSS.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Luis Alonso Gonzalez, Graciela S. Alarcon, Guillermina B. Harvey, Rosana Quintana, Guillermo J. Pons-Estel, Manuel F. Ugarte-Gil, Gloria Vasquez, Luis J. Catoggio, Mercedes A. Garcia, Eduardo F. Borba, Nilzio A. Da Silva, Joao C. Tavares Brenol, Marlene Guibert Toledano, Loreto Massardo, Oscar Neira, Virginia Pascual-Ramos, Mary-Carmen Amigo, Leonor A. Barile-Fabris, Ignacio Garcia De La Torre, Jose Alfaro-Lozano, Maria Segami, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Antonio Iglesias-Gamarra, Bernardo A. Pons-Estel
Summary: This study aimed to determine the predictors of severe autoimmune hemolytic anemia (AIHA) occurrence and its impact on damage accrual and mortality in patients with systemic lupus erythematosus (SLE). The study found that male sex and higher disease activity at diagnosis were associated with a shorter time to severe AIHA occurrence. Although not statistically significant, hematological abnormalities at SLE diagnosis showed a certain trend toward predicting the occurrence of severe AIHA in a shorter time. Severe AIHA did not seem to impact damage and mortality.
Article
Rheumatology
Ana P. Sakamoto, Clovis A. Silva, Ana C. Pita, Vitor C. Trindade, Aline G. Islabao, Fernanda J. Fiorot, Sandra R. M. Lopes, Rosa M. R. Pereira, Claudia Saad-Magalhaes, Gleice C. S. Russo, Claudio A. Len, Rogerio do Prado, Lucia M. A. Campos, Nadia E. Aikawa, Simone Appenzeller, Virginia P. L. Ferriani, Marco F. Silva, Marta Felix, Adriana R. Fonseca, Ana P. L. Assad, Flavio R. Sztajnbok, Maria C. Santos, Blanca E. Bica, Evaldo G. Sena, Ana J. Moraes, Melissa M. Fraga, Teresa C. Robazzi, Paulo F. Spelling, Iloite M. Scheibel, Andre S. Cavalcanti, Erica N. Matos, Luciano J. Guimaraes, Flavia P. Santos, Licia M. H. Mota, Eloisa Bonfa, Maria T. Terreri
Summary: The objective of this study was to explore the associations between mortality in cSLE patients and their characteristics, as well as to evaluate the risk factors and determine the main causes of death. The results showed that the mortality rate in cSLE patients in Brazil was low, but neuropsychiatric lupus and chronic kidney disease were found to be significant risk factors for mortality.
Article
Rheumatology
Clovis Artur Silva, Leonard de Vinci Kanda Kupa, Ana Cristina Medeiros-Ribeiro, Sandra Gofinet Pasoto, Carla Goncalves Schahin Saad, Emily Figueiredo Neves Yuki, Joaquim Ivo Vasques Dantas Landim, Victor Hugo Ferreira e Leda, Luisa Sacchi de Camargo Correia, Artur Fonseca Sartori, Carolina Campagnoli Machado Freire Martins, Carolina Torres Ribeiro, Filipe Waridel, Victor Adriano de Oliveira Martins, Samuel Katsuyuki Shinjo, Danieli Castro Oliveira Andrade, Percival Degrava Sampaio Barros, Eduardo Ferreira Borba Neto, Nadia Emi Aikawa, Eloisa Bonfa
Summary: The study aimed to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with autoimmune rheumatic diseases (ARD). The results showed that there was no significant difference in the frequency and symptoms of post-acute COVID-19 between ARD patients and non-ARD controls, suggesting that vaccination has a minimal impact on post-acute COVID-19 in ARD patients.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Karina Rossi Bonfiglioli, Ana Cristina de Medeiros Ribeiro, Ana Paula Carnieletto, Ivanio Pereira, Diogo Souza Domiciano, Henrique Carrico da Silva, Alisson Pugliesi, Leticia Rocha Pereira, Maria Fernanda Resende Guimaraes, Rina Dalva Neubarth Giorgi, Ana Paula Monteiro Gomides Reis, Claiton Viegas Brenol, Paulo Louzada-Junior, Maria de Fatima Lobato da Cunha Sauma, Sebastiao Cezar Radominski, Licia Maria Henrique da Mota, Geraldo da Rocha Castelar-Pinheiro
Summary: This study aimed to determine the prevalence of extra-articular manifestations (ExtRA) in rheumatoid arthritis (RA) patients and its association with demographic and clinical variables. The results showed that the overall prevalence of ExtRA in the cohort was 23.4%, and it was significantly associated with age, disease duration, serological markers, disease activity, and treatment options.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Nadia Emi Aikawa, Eduardo Ferreira Borba, Verena Andrade Balbi, Adriana Maluf Elias Sallum, Izabel Mantovani Buscatti, Lucia Maria Arruda Campos, Katia Tomie Kozu, Cristiana Couto Garcia, Artur Silva Vidal Capao, Adriana Coracini Tonacio de Proenca, Elaine Pires Leon, Alberto Jose da Silva Duarte, Marta Heloisa Lopes, Clovis Artur Silva, Eloisa Bonfa
Summary: This study aimed to evaluate the short-term immunogenicity and safety of influenza A/Singapore (H3N2) vaccine in juvenile systemic lupus erythematosus (JSLE) patients. The results showed that JSLE patients had similar immune response to the vaccine as the healthy control group, indicating that the vaccine provides adequate immune protection and has a good safety profile.
ADVANCES IN RHEUMATOLOGY
(2023)
Review
Rheumatology
Joaquim Ivo Vasques Dantas Landim, Andre Silva Franco, Percival Degrava Sampaio-Barros, Renata Miossi, Ana Cristina Medeiros-Ribeiro, Rosa Maria R. Pereira, Ana Paula Luppino Assad
Summary: In this report, we present a case of a 26-year-old female with previously undiagnosed systemic sclerosis (SSc) complicated by scleroderma renal crisis (SRC). The patient's condition improved after appropriate treatment.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Peripheral Vascular Disease
Tatiane Almeida de Luna, Diego Augusto Nunes Rezende, Leandro Campos de Brito, Rafael Yokoyama Fecchio, Fernanda Rodrigues Lima, Ana Lucia de Sa Pinto, Ana Cristina de Medeiros Ribeiro, Karina Rossi Bonfiglioli, Bruno Gualano, Hamilton Roschel, Tiago Pecanha
Summary: A single session of aerobic exercise can reduce resting and stress-induced systolic blood pressure in women with rheumatoid arthritis and hypertension, supporting exercise as a strategy for controlling hypertension and reducing cardiovascular risk.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Rheumatology
Jobson Lopes de Oliveira, Rafael Alves Cordeiro, Lissiane Karine Noronha Guedes, Sandra Gofinet Pasoto
Summary: Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that primarily affects the salivary and lacrimal glands, with potential lung involvement. Shrinking lung syndrome (SLS) is a rare respiratory complication associated with systemic lupus erythematosus, and its association with pSS is even rarer. This study describes a case of SLS in a patient with pSS and highlights the importance of considering SLS in patients with pSS and respiratory symptoms.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Surian Clarisse C. R. Ribeiro, Lucas P. Sales, Alan L. Fernandes, Mariana O. Perez, Liliam Takayama, Valeria F. Caparbo, Ana Paula L. Assad, Nadia E. Aiwaka, Claudia Goldenstein-Schainberg, Eduardo F. Borba, Diogo S. Domiciano, Camille P. Figueiredo, Rosa M. R. Pereira
Summary: This study analyzed the potential association between localized bone damage and systemic bone loss in patients with longstanding polyarticular juvenile idiopathic arthritis (pJIA). The results showed that bone erosions in pJIA women were associated with decreased cortical bone parameters, and these patients also exhibited systemic bone impairment compared to healthy controls.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)