Journal
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Volume 14, Issue 2, Pages 92-93Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RHU.0b013e31816b4487
Keywords
rituximab; Wegener granulomatosis; granulomatous disease
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Wegener granulomatosis is an autoimmune disorder with a double spectrum. Vasculitic manifestations are at one end of it , whereas granulomatous ones are at the other. Rituximab (RTX) is a chimeric monoclonal antibody that has been successfully used in this condition. However, the granulomatous forms have been reported to show a tendency to be less responsive to RTX than the vasculitic disease. We present 4 cases of predominantly Wegener granulomatosis that responded positively to RTX.
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