Article
Cell Biology
Rui Niu, Ze-Tong Nie, Lin Liu, Yu-Wen Chang, Jian-Qun Shen, Qiong Chen, Li-Jie Dong, Bo-Jie Hu
Summary: The study showed that in PDR patients, anti-VEGF treatment led to increased retinal fibrosis, while a dual-target treatment reduced fibrosis, indicating that FSTL1 may be involved in the pathogenesis of PDR and is associated with fibrosis caused by anti-VEGF treatment.
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Eva K. Langendorf, Pol M. Rommens, Philipp Drees, Ulrike Ritz
Summary: The study indicates that dexamethasone inhibits angiogenesis by suppressing VEGF release, impacting muscle atrophy and regeneration. In co-culture models, dexamethasone increases the expression of myogenic transcription factors while repressing angiogenic factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yaowu Qin, Jing Zhang, Savalan Babapoor-Farrokhran, Brooks Applewhite, Monika Deshpande, Haley Megarity, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Tao Ma, Yuan Rui, Stephany Y. Tzeng, Jordan J. Green, M. Valeria Canto-Soler, Silvia Montaner, Akrit Sodhi
Summary: For patients with proliferative diabetic retinopathy (PDR) who do not respond adequately to pan-retinal laser photocoagulation (PRP) or anti-vascular endothelial growth factor (VEGF) therapies, targeting the HIF-2 alpha/PAI-1 axis may be an effective adjunct therapy for the treatment of PDR patients.
Article
Biochemistry & Molecular Biology
Bente Juhl, Flemming Klein, Toke Bek, Line Petersen
Summary: Pregnancy is a risk factor for the development or aggravation of diabetic retinopathy. There may be a relationship between low plasma vitamin C (vitC) levels during pregnancy and the progression of diabetic retinopathy in women with type 1 diabetes.
Article
Medicine, Research & Experimental
Xue Dong, Yi Lei, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu, Mei Du, Haifang Yin, Xiaohong Wang, Hua Yan
Summary: The study utilized exosomes (EXOs) as carriers for delivering the anti-angiogenic peptide KV11 via retro-orbital injection, showing enhanced suppression of neovascularization and vascular leakage in the retina. This system has the potential to treat proliferative retinopathy in a less invasive manner compared to intravitreal injection.
Article
Oncology
Nahid Nafissi, Maryam Mohammadlou, Mohammad Esmaeil Akbari, Seyed Rabie Mahdavi, Maryam Sheikh, Mohammad Borji, Ebrahim Babaee, Rasoul Baharlou
Summary: This study compared the impact of intraoperative radiotherapy (IORT) on the levels of angiogenic factors in the blood and surgical wound fluids of breast cancer patients. The results showed significant differences in the levels of EGF, DLL4, and VEGF before and after surgery, and TGF-beta and DLL4 were able to differentiate between early-stage and late-stage disease. Interestingly, IORT also reduced the rate of death and recurrence in breast cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amit Joharapurkar, Vishal Patel, Samadhan Kshirsagar, Maulik S. Patel, Hardikkumar Savsani, Mukul Jain
Summary: Saroglitazar showed significant benefits in reducing retinal vascular damage in diabetic rats, as well as in decreasing neovascularization in oxygen-induced retinopathy and VEGF-induced angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Liyang Ji, Hong Tian, Keith A. Webster, Wei Li
Summary: Diabetic retinopathy is the leading cause of vision loss in working adults in developed countries, now recognized as a neurovascular disorder. Disturbance of the neurovascular unit can lead to vision-threatening clinical manifestations. While VEGF inhibitors are widely used to treat DR, their limited efficacy suggests the involvement of other signaling molecules in the pathogenesis of the disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mohammed Nadim Sardoiwala, Shakti Nagpal, Babita Bhatt, Subhasree Roy Choudhury, Surajit Karmakar
Summary: Oxidative stress, reactive oxygen species generation, and overexpression of VEGF are characteristic events in diabetic retinopathy. The downregulation of VEGF and anti-inflammatory action are important for DR therapy. In this study, melatonin-loaded polydopamine nanoparticles were synthesized using a reverse microemulsion method to improve melatonin delivery and replenish VEGF downregulation.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Irene Andres-Blasco, Alex Gallego-Martinez, Ximena Machado, Javier Cruz-Espinosa, Salvatore Di Lauro, Ricardo Casaroli-Marano, Victor Alegre-Ituarte, Jose Fernando Arevalo, Maria Dolores Pinazo-Duran
Summary: The study aimed to evaluate the molecules related to oxidative stress, inflammation, angiogenesis, and apoptosis in patients with proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). By investigating their correlation in the plasma and vitreous body, as well as examining ophthalmological examination data, the study found that oxidative stress and inflammation were increased in the plasma and vitreous samples from patients with PDR/DME, while antioxidant capacity was decreased. The study suggests that exploring the relationship between these potential biomarkers in the plasma and vitreous may help detect early molecular changes in PDR/DME and monitor therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Guanrong Wu, Baoyi Liu, Qiaowei Wu, Changting Tang, Zijing Du, Ying Fang, Yijun Hu, Honghua Yu
Summary: The study found that the expression of various angiogenesis and inflammation mediators in the vitreous fluid of eyes with proliferative diabetic retinopathy (PDR) was significantly increased, and there were correlations between these mediators. The levels of these mediators were also correlated with kidney damage, indicating potential common pathways in diabetic retinopathy and nephropathy.
FRONTIERS IN MEDICINE
(2021)
Review
Integrative & Complementary Medicine
Fatemeh Sanie-Jahromi, Zahra Zia, Mehrdad Afarid
Summary: This study reviews the effects of garlic on diabetes, VEGF, and BDNF, as well as its impact on diabetic retinopathy. The findings indicate that garlic has beneficial effects in treating diabetes, inhibiting angiogenesis, and protecting against neurodegeneration. Garlic can be considered as a complementary treatment option for diabetic retinopathy, supported by available clinical evidence.
Article
Chemistry, Multidisciplinary
Camila M. L. Machado, Magdalena Skubal, Katja Haedicke, Fabio P. Silva, Evan P. Stater, Thais L. A. de O. Silva, Erico T. Costa, Cibele Masotti, Andreia H. Otake, Luciana N. S. Andrade, Mara de S. Junqueira, Hsiao-Ting Hsu, Sudeep Das, Benedict Mc Larney, Edwin C. Pratt, Yevgeniy Romin, Ning Fan, Katia Manova-Todorova, Martin Pomper, Jan Grimm
Summary: Cell membrane-derived particles (Mp) shed from tumor cells have the potential to be used as drug delivery vehicles for targeted and immunotherapeutic treatments. Prostate-specific membrane antigen (PSMA) is highly expressed in Mp and extracellular vesicles (EV) from prostate cancer. It has been discovered that PSMA can be transferred to the tumor microenvironment through Mp and alter cellular characteristics, resulting in increased secretion of angiogenic factors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Abdelrahman Y. Fouda, Zhimin Xu, Jutamas Suwanpradid, Modesto Rojas, Esraa Shosha, Tahira Lemtalsi, Chintan Patel, Ji Xing, Syed A. Zaidi, Wenbo Zhi, Brain K. Stansfield, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Summary: Current therapies for proliferative retinopathy are often associated with adverse side-effects. This study proposes a new strategy for limiting neurovascular injury and promoting repair during early-stage disease. The treatment using pegylated A1 (A1 enzyme with polyethylene glycol modification) inhibits pathological retinal neovascularization, promotes angiogenic repair, and improves retinal function by decreasing expression of pro-inflammatory factors and increasing expression of growth factors. A1 is critically involved in reparative angiogenesis and neuroprotection, suggesting pegylated A1 as a potential therapy for retinal injury and proliferative retinopathy.
CELL DEATH & DISEASE
(2022)
Article
Obstetrics & Gynecology
Shakeel Waqqar, Salman Aziz, Rabia Shakeel, Anum Waheed, Syed S. Ahmed, Asad Ali, Ayyaz A. Khan, Muhammad Shoaib
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Muhammad Umair Hanif, Adnan Yaseen, Roquyya Gul, Muhammad Usman Mirza, Muhammad Hassan Nawaz, Sved Shoaib Ahmed, Selman Aziz, Saima Chatidhary, Ayyaz Ali Khan, Muhammad Shoaib
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2018)
Meeting Abstract
Biochemical Research Methods
M. U. Hanif, R. Gul, M. I. Hanif
Article
Medicine, General & Internal
Tayyaba Gul Malik, Syed Shoaib Ahmed, Roquyya Gul, Muhammad Khalil, Abrar Ahmed Malik, Masoom Khan
TURKISH JOURNAL OF MEDICAL SCIENCES
(2018)
Article
Zoology
Zahra Nazir, Saba Ijaz, Roquyya Gul, Mahjabeen Saleem
PAKISTAN JOURNAL OF ZOOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Faiza Gul Durrani, Roquyya Gul, Muhammad Usman Mirza, Naheed Nazly Kaderbhai, Matheus Froeyen, Mahjabeen Saleem
Article
Biochemistry & Molecular Biology
Asia Parveen, Sher Alam Khan, Muhammad Usman Mirza, Hina Bashir, Fatima Arshad, Maria Iqbal, Waseem Ahmad, Ahsan Wahab, Amal Fiaz, Sidra Naz, Fareeha Ashraf, Tayyaba Mobeen, Salman Aziz, Syed Shoaib Ahmed, Noor Muhammad, Nehal F. Hassib, Mostafa I. Mostafa, Nagwa E. Gaboon, Roquyya Gul, Saadullah Khan, Matheus Froeyen, Muhammad Shoaib, Naveed Wasif
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biology
Hafiz Muzzammel Rehman, Muhammad Usman Mirza, Mian Azhar Ahmad, Mahjabeen Saleem, Matheus Froeyen, Sarfraz Ahmad, Roquyya Gul, Huda Ahmed Alghamdi, Muhammad Shahbaz Aslam, Muhammad Sajjad, Munir Ahmad Bhinder
Editorial Material
Medicine, General & Internal
Tayyaba Gul Malik
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Roquyya Gul, Muhammad Umair Hanif, Faiza Gul, Hafiz Muzzammel Rehman, Mahjabeen Saleem, Muhammad Sarfaraz Ahmad, Muhammad Usman Mirza
Summary: This study focuses on the molecular cloning, expression, and structural characterization of growth hormone-receptor (GHR) and its extracellular domain as growth hormone binding protein (GHBP) in the liver of Nili-Ravi buffalo. The research provides sequence characterization of BbGHR in Nili-Ravi buffaloes and explores the molecular interactions between growth hormone and its receptor, as well as the stability of the proteins.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Maryam Shahid, Zubair Saleem, Tayyaba Gul Malik, Muhammad Fardaleet
Summary: This study compared the changes in Retinal Nerve Fiber Layer (RNFL) thickness and Intraocular Pressure (IOP) after phacoemulsification in glaucoma patients versus non-glaucoma patients. The results showed that after one month, glaucoma patients had an increase in RNFL thickness, while non-glaucoma patients had a smaller change in RNFL thickness. There was no significant difference in IOP changes between the two groups.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Immunology
Hafiz Muzzammel Rehman, Muhammad Sajjad, Muhammad Akhtar Ali, Roquyya Gul, Muhammad Irfan, Muhammad Naveed, Munir Ahmad Bhinder, Muhammad Usman Ghani, Nadia Hussain, Amira S. A. Said, Amal H. I. Al Haddad, Mahjabeen Saleem
Summary: Zika virus (ZIKV) pandemic has posed serious threats to global health, and the search for effective drugs against the viral infection is urgent. Using in silico drug exploration, three potential drug molecules were identified as potent inhibitors of Zika NS2B-NS3 protease.
Article
Biotechnology & Applied Microbiology
Rabia Nisar, Burarah Arooj, Bushra Muneer, Roquyya Gul, Mahjabeen Saleem
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)
