Article
Ophthalmology
Mohammad Refaat, Abdussalam M. Abdullatif, Mostafa M. Hamza, Tamer A. Macky, Mohamed-Sameh H. El-Agha, Gaafar Ragab, Mahmoud M. Soliman
Summary: The study on the safety and efficacy of extended monthly intravitreal infliximab injections in patients with active posterior uveitis in Behcet's disease revealed that the treatment was associated with a high complication rate and failure to control inflammation in most eyes, indicating that it should not be considered a substitute to systemic therapy.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Review
Medicine, General & Internal
Morgane Joubert, Anne-Claire Desbois, Fanny Domont, Amine Ghembaza, Alexandre Le Joncour, Adrien Mirouse, Georgina Maalouf, Mathilde Leclercq, Sarah Touhami, Patrice Cacoub, Bahram Bodaghi, David Saadoun
Summary: Uveitis is a common and significant complication in Behcet's disease, with a high risk of blindness. It commonly presents as panuveitis, with bilateral involvement occurring after 2 years on average. Prompt management is crucial to achieve remission and preserve vision. Biologic therapies have revolutionized the treatment of uveitis in Behcet's disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
Summary: IL33/ST2 gene polymorphisms are associated with the development of BDU, with specific alleles showing significant differences in BD patients with different clinical features, indicating the important role of IL33/ST2 in the pathogenesis of BDU.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Luca De Simone, Alessandro Invernizzi, Raffaella Aldigeri, Valentina Mastrofilippo, Chiara Marvisi, Fabrizio Gozzi, Elena Bolletta, Chantal Adani, Nicolo Pipitone, Francesco Muratore, Luigi Fontana, Carlo Salvarani, Luca Cimino
Summary: The study aimed to report the long-term results of biologic treatment for severe and refractory Behcet's uveitis, choosing a different biologic agent based on the uveitis clinical features. The study found that both IFN and IFX were effective and well tolerated in treating refractory BU.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Medicine, General & Internal
Masaru Takeuchi, Yoshihiko Usui, Kenichi Namba, Hiroshi Keino, Masaki Takeuchi, Hiroshi Takase, Koju Kamoi, Keitaro Hase, Takako Ito, Kei Nakai, Kazuichi Maruyama, Eri Kobayashi, Hisashi Mashimo, Tomohito Sato, Nobuyuki Ohguro, Junko Hori, Annabelle A. Okada, Koh-hei Sonoda, Nobuhisa Mizuki, Hiroshi Goto
Summary: This retrospective study evaluated the 10-year outcome of infliximab (IFX) treatment for uveitis in Behcet disease patients. The results showed that approximately 75% of patients continued IFX treatment for 10 years, and their visual acuity significantly improved and remained stable. Although half of the patients experienced recurrence of uveitis after treatment, there was no significant difference in visual acuity compared to those without recurrence.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Tianyu Tao, Shizhao Yang, Daquan He, Zhaohuai Li, Binyao Chen, Lei Zhu, Wenru Su
Summary: This cross-sectional study investigated the efficacy and safety of dexamethasone implant, Ozurdex(R), as an adjunctive treatment for refractory Behcet's uveitis (BU). The study included 61 patients (80 eyes) divided into non-DEX and DEX groups. After >12 months of treatment, the DEX group showed significantly higher improvement in fluorescein angiography score and vitritis score compared to the non-DEX group. Despite worsening posterior capsule opacification score, the DEX group had higher usage of low-dose systemic glucocorticoid and fewer relapse times. Therefore, Ozurdex(R) is an effective and safe option for refractory BU patients, providing control of vasculitis, stabilization of vitreous inflammation, prevention of recurrence, and reduction of daily glucocorticoid doses.
CLINICAL IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Hanna Zajac, Anna Turno-Krecicka
Summary: Behcet's disease is a systemic vasculitis that commonly affects the oral, genital, and ocular regions, potentially leading to blindness. The first line treatment is azathioprine, with alternative immunosuppressive and biological agents used in severe or refractory cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Suibin Lin, Zhirong Xu, Zhiming Lin, Baozhao Xie, Junmei Feng
Summary: Behcet's disease is a chronic multi-systemic disease characterized by oral ulcers, genital ulcers, ocular inflammatory involvements, and other systemic features. Ocular involvements are common and can cause severe tissue damage and potential blindness. The pathogenesis of the disease is not fully understood, but genetic factors, environmental triggers, and immunological abnormalities play important roles. Novel biotherapies targeting specific proteins have shown promise in recent years. This review focuses on ocular involvement, mechanisms, and advances in therapeutic approaches, particularly novel biologics. Management during pregnancy is also discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Gulen Hatemi, Nur Beyza Tukek, Sinem Nihal Esatoglu, Yesim Ozguler, Sitki Safa Taflan, Ugur Uygunoglu, Melike Melikoglu, Serdal Ugurlu, Izzet Fresko, Aksel Siva, Zekayi Kutlubay, Sebahattin Yurdakul, Hasan Yazici, Vedat Hamuryudan
Summary: The objective of the study was to investigate the efficacy and safety of infliximab in BS patients with vascular involvement. Among the 127 patients treated with infliximab, the remission rate was 73% at Month 6 and 63% at Month 12. Patients with pulmonary artery involvement and venous thrombosis had better remission rates compared to those with non-pulmonary artery involvement and venous ulcers.
CLINICAL IMMUNOLOGY
(2023)
Article
Ophthalmology
Satoshi Yamana, Eiichi Hasegawa, Atsunobu Takeda, Nobuyo Yawata, Koh-Hei Sonoda
Summary: Infliximab treatment is effective in controlling ocular inflammatory attacks and reducing ocular disease activities in patients with Behcet's disease-associated uveitis, while also maintaining their visual acuity.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Julie Gueudry, Mathilde Leclercq, David Saadoun, Bahram Bodaghi
Summary: Behcet's disease is a systemic vasculitis disease primarily affecting young individuals, characterized by ocular involvement, venous and arterial occlusion, and potential rapid and severe vision loss. Early therapeutic intervention is crucial, but diagnosis remains a challenge.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Yasutsugu Ida, Masaki Takeuchi, Mami Ishihara, Etsuko Shibuya, Takahiro Yamane, Yukiko Hasumi, Shigeru Kawano, Ikuko Kimura, Nobuhisa Mizuki
Summary: Although no ocular attacks were observed for at least 1 year after IFX withdrawal, this prospective study indicates that IFX withdrawal should be considered carefully, even for patients in long term remission of ocular and extraocular lesions.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Immunology
Yang Deng, Yinan Zhang, Tao Cai, Qingfeng Wang, Wanyun Zhang, Zhijun Chen, Xiang Luo, Guannan Su, Peizeng Yang
Summary: This study provides insights into the immunopathogenesis of Behcet's uveitis and reveals the potential therapeutic target of LCK signaling in intraocular immunopathology.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Rheumatology
Se Rim Choi, Joo Young Shin, Anna Shin, Hokyung Choung, Se Joon Woo, Sang Jun Park, You-Jung Ha, Yun Jong Lee, Eun Bong Lee, Jin Kyun Park, Eun Ha Kang
Summary: Patients with Behcet's disease have a higher risk of blindness and vision-threatening ocular comorbidities compared to the general population. Males are at a higher risk of blindness due to greater severity rather than a lower incidence of uveitis. The risk of uveitis and blindness decreases with higher age at BD diagnosis.
Article
Multidisciplinary Sciences
Mohammad Zarei, Hossein Pesarakli, Mehdi Yaseri, Hamed Etesali, Nazanin Ebrahimiadib
Summary: This study investigated the correlation of OCT parameters with fluorescein angiography in evaluating inflammatory activity in Behcet's retinal vasculitis. Results showed that parameters such as CSMT, PRT2.2, PRT3.45, and PNFLT had significant correlation with FA scores, with PRT3.45 and PNFLT showing the strongest correlation with angiographic inflammatory activity. These parameters may serve as non-invasive alternatives to FA for monitoring Behcet's retinal vasculitis.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Ichiro Yonese, Hiroshi Takase, Mayumi Yoshimori, Erika Onozawa, Akiho Tsuzura, Tohru Miki, Manabu Mochizuki, Osamu Miura, Ayako Arai
EUROPEAN JOURNAL OF HAEMATOLOGY
(2019)
Article
Ophthalmology
Manabu Mochizuki, Justine R. Smith, Hiroshi Takase, Toshikatsu Kaburaki, Nisha R. Acharya, Narsing A. Rao, Massimo Accorinti, Nisha R. Acharya, Fatma Asyari, Kalpana Babu, Soumyava Basu, Jyotirmay Biswas, Bahram Bodaghi, Soon-Phaik Chee, Ramandeep Chhabra, Claude L. Cowan, Debra A. Goldstein, Hiroshi Goto, Yih-Shiou Hwang, Mami Ishihara, Douglas A. Jabs, Nicholas P. Jones, Toshikatsu Kaburaki, Hidetoshi Kawashima, Moncef Khairallah, Phuc LeHoang, Kazuichi Maruyama, Peter McCluskey, Manabu Mochizuki, Philip I. Murray, Kenichi, Namba, Nobuyuki Ohguro, Shigeaki Ohno, Annabelle A. Okada, Narsing A. Rao, Tsutomu Sakai, Shwu-Jiuan Sheu, Justine R. Smith, Ko-hei Sonoda, Somsiri Sukavatcharin, Hiroshi Takase, Ilknur Tugal-Tutkun, Hyeong Gon Yu, Manfred Zierhut
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Hiroyuki Takahashi, Hiroshi Takase, Ayako Arai, Manabu Mochizuki, Kyoko Ohno-Matsui
Article
Ophthalmology
Kosei Shinohara, Noriaki Shimada, Hiroshi Takase, Kyoko Ohno-Matsui
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Article
Ophthalmology
Satoko Nakano, Yasuhiro Tomaru, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Norio Shimizu, Sunao Sugita
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Medicine, General & Internal
Miyuki Tanaka, Koju Kamoi, Natsuko Nagaoka, Tomoka Ishida, Hisako Karube, Hiroshi Takase, Kyoko Ohno-Matsui
Article
Oncology
Ayako Arai, Hiroshi Takase, Mayumi Yoshimori, Kouhei Yamamoto, Manabu Mochizuki, Osamu Miura
Review
Ophthalmology
Masaru Miyanaga, Hiroshi Takase, Kyoko Ohno-Matsui
Summary: This study investigated ocular manifestations in patients positive for serum anti-neutrophil cytoplasmic antibodies (ANCAs) in Japan. The results showed that optic nerve involvement, scleritis, and iritis were common ocular manifestations among these patients, with most optic nerve involvement patients being myeloperoxidase-ANCA positive, and most anterior segment involvement patients being proteinase-3-ANCA positive. Serum ANCA evaluation is helpful in identifying the etiology of ocular inflammation and diagnosing ANCA-associated vasculitis, a life-threatening disease.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
Mari Handa-Miyauchi, Hiroshi Takase, Miyuki Tanaka, Masako Akiyama, Kyoko Ohno-Matsui, Manabu Mochizuki
Summary: The revised IWOS criteria showed high diagnostic parameters in Japanese patients. The classification of presumed or probable OS may need further modification to improve diagnostic accuracy.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Pediatrics
Susumu Yamazaki, Asami Shimbo, Yuko Akutsu, Hiroshi Takase, Tomohiro Morio, Masaaki Mori
PEDIATRIC RHEUMATOLOGY
(2020)
Article
Ophthalmology
Hiroshi Takase, Hiroshi Goto, Kenichi Namba, Nobuhisa Mizuki, Annabelle A. Okada, Nobuyuki Ohguro, Koh-Hei Sonoda, Makoto Tomita, Hiroshi Keino, Takeshi Kezuka, Reo Kubono, Kazuomi Mizuuchi, Etsuko Shibuya, Hiroyuki Takahashi, Ryoji Yanai, Manabu Mochizuki
Summary: This study retrospectively reviewed the clinical characteristics of 149 consecutive ARN patients and investigated factors associated with poor visual prognosis. Anterior chamber cells or mutton-fat keratic precipitates, unilateral involvement, and yellow-white retinal lesions were commonly observed at initial presentation. Rapid circumferential expansion of retinal lesions, development of retinal break or retinal detachment, and optic atrophy were recorded during the clinical course. Four variables were identified as predictors of poor visual prognosis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Biology
Akira Meguro, Mami Ishihara, Martin Petrek, Ken Yamamoto, Masaki Takeuchi, Frantisek Mrazek, Vitezslav Kolek, Alzbeta Benicka, Takahiro Yamane, Etsuko Shibuya, Atsushi Yoshino, Akiko Isomoto, Masao Ota, Keisuke Yatsu, Noriharu Shijubo, Sonoko Nagai, Etsuro Yamaguchi, Tetsuo Yamaguchi, Kenichi Namba, Toshikatsu Kaburaki, Hiroshi Takase, Shin-ichiro Morimoto, Junko Hori, Keiko Kono, Hiroshi Goto, Takafumi Suda, Soichiro Ikushima, Yasutaka Ando, Shinobu Takenaka, Masaru Takeuchi, Takenosuke Yuasa, Katsunori Sugisaki, Nobuyuki Ohguro, Miki Hiraoka, Nobuyoshi Kitaichi, Yukihiko Sugiyama, Nobuyuki Horita, Yuri Asukata, Tatsukata Kawagoe, Ikuko Kimura, Mizuho Ishido, Hidetoshi Inoko, Manabu Mochizuki, Shigeaki Ohno, Seiamak Bahram, Elaine F. Remmers, Daniel L. Kastner, Nobuhisa Mizuki
COMMUNICATIONS BIOLOGY
(2020)
Meeting Abstract
Ophthalmology
Takashi Ono, Manabu Mochizuki, Hiroshi Goto, Tsutomu Sakai, Fumihiko Nitta, Nobuhisa Mizuki, Hiroshi Takase, Yutaka Kaneko, Junko Hori, Satoko Nakano, Nobuhisa Nao-i, Nobuyuki Ohguro
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Hiroshi Takase, Justine R. Smith, Nisha Acharya, Jennifer E. Thorne, Peter J. McCluskey, Bahram Bodaghi, Moncef Khairallah, Kalpana Babu, Nattaporn Tesavibul, Ilknur Tugal-Tutkun, Joyce H. Yamamoto, Narsing A. Rao, Manabu Mochizuki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Yukiko Terada, Toshikatsu Kaburaki, Hiroshi Takase, Satoko Nakano, Hiroshi Goto, Yoshitsugu Inoue, Kazuichi Maruyama, Kazunori Miyata, Kenichi Namba, Koh-hei Sonoda, Yutaka Kaneko, Jiro Numaga, Manabu Mochizuki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)