Journal
JAPANESE JOURNAL OF INFECTIOUS DISEASES
Volume 66, Issue 1, Pages 56-59Publisher
NATL INST INFECTIOUS DISEASES
DOI: 10.7883/yoken.66.56
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- Ministry of Health, Labour and Welfare of Japan
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To investigate the molecular epidemiology of human metapneumovirus (HMPV) infections in acute respiratory infections (ART), we performed genetic analysis of the F gene in HMPV from patients with ART in Fukui Prefecture from August 2005 to July 2011. HMPV was detected in 53 of 741 nasopharyngeal swabs (7.2%). Phylogenetic analysis helped us assign 31 strains to subgroup A2, 1 strain to subgroup B1, and 21 strains to subgroup B2. The prevalence of HMPV was peaked between January and June. A high degree of nucleotide identity was seen among subgroup A2 strains (95.6-100%) and subgroup B2 strains (97.5-100%). In addition, no positively selected sites (substitutions) were found in the F gene in these HMPV strains. The results suggest that the prevalent HMPV strains in Fukui were associated with various ART in Japan during the investigation period.
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