Journal
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Volume 42, Issue 10, Pages 912-918Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jjco/hys116
Keywords
radiology-PET; CT; orthopedics; sarcoma; prognostic factors
Categories
Funding
- Scientific Research Expenses for Health and Welfare Programs [17-12]
- promotion and standardization of diagnostic accuracy in PET/CT imaging
- Ministry of Health, Labour and Welfare
- Princess Takamatsu Cancer Research Fund
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The aim of this study was to investigate the prognostic implications of F-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in patients with chest wall sarcoma. Positron emission tomography/computed tomography scans of 42 patients (mean age: 46 years) with chest wall sarcomas were analyzed. Pathologic confirmation was obtained by surgical specimens in all patients. Tumor grade assessed by Ki-67 (MIB-1) immunohistochemical analysis and expression of glucose transporter protein 1 were compared with a maximum standardized uptake value. Univariate and multivariate analyses were conducted for estimates of overall and event-free survivals. The median maximum standardized uptake value of the tumor was 10.2 and the median MIB-1 index of the tumor was 32.5. Glucose transporter protein 1 expression was found in 29 patients (69). Univariate analyses revealed that surgery, chemotherapy, MIB-1 labeling index (cut-off 32.5), MIB-1 grade, glucose transporter protein 1 expression and maximum standardized uptake value were possible predictors for overall and event-free survival. Multivariate analysis revealed that surgery (hazard ratio, 4.852; P 0.017), maximum standardized uptake value (hazard ratio, 3.077; P 0.037) and MIB-1 labeling index (hazard ratio, 6.549; P 0.003) were independent predictors of event-free survival. In addition, surgery (hazard ratio, 4.092; P 0.021) and maximum standardized uptake value (hazard ratio, 2.968; P 0.027) were independent predictors of overall survival. F-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography allows the prediction of prognosis after treatment in patients with chest wall sarcoma and may be useful in selecting high-risk patients for more risk-adapted treatments.
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