Review
Biotechnology & Applied Microbiology
Xueliang Li, Shibin Liu, Jie Tan, Chunsheng Wu
Summary: The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor based on the field-effect principle of semiconductors. It has the unique ability to address specific areas of the sensor using movable light, enabling two-dimensional image distribution detection of chemical/biomass. This review summarizes the advantages of LAPS as a sensing unit in microelectrochemical analysis systems and discusses the recent advances in LAPS analysis system development, including research on ion diffusion, enzymatic reaction, microbial metabolism, and droplet microfluidics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Electrochemistry
Jiezhang Luo, Shibin Liu, Jie Tan, Yinghao Chen, Wenbo Zhao, Huijuan Li, Guifang Li, Yongqian Du
Summary: In this study, a differential light addressable potentiometric sensor (LAPS) with solid-state reference (SSR) is proposed for pH measurement. By controlling the illumination excitation of SSR, the amplitude and phase between LAPS output and SSR output are matched, achieving signal matching and significant reduction of background signal. SSR, as a reference signal source, can assist the differential LAPS to realize low-background pH measurement conveniently and flexibly.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Tatsuo Yoshinobu, Ko-ichiro Miyamoto
Summary: This study tested different waveforms of modulated illuminations for LAPS and found that a square wave with a low duty ratio was more efficient than a sine wave, maximizing the signal.
Review
Chemistry, Physical
Tatsuo Yoshinobu, Michael J. Schoening
Summary: The light-addressable potentiometric sensor (LAPS) is a versatile platform for chemical and biosensing, with the ability to divide its flat sensor surface into separate areas or pixels for independent sensing. It has been widely applied to cells and biological samples, with recent trends and applications focusing on advancements in technology and biomaterials.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Jie Tan, Shibin Liu, Jiezhang Luo, Yinghao Chen, Wenbo Zhao, Huijuan Li, Guifang Li, Xueliang Li
Summary: In this study, a light addressable potentiometric sensor (LAPS) was proposed to detect local potential changes caused by protonation and deprotonation between electrolyte and insulator using light pulse. The semiconductor of LAPS was fabricated by combining microsphere lithography with wet etching, resulting in well-ordered, tunable and low-cost pyramidal pits-patterned silicon. The experiment results and theoretical analyses showed that LAPS with pyramidal pits-patterned silicon demonstrated acceptable pH response, good long-term stability, and high performance in terms of photocurrent enhancement ratio, signal-to-noise ratio and pH imaging.
ANALYTICA CHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Yun-Chong Li, Bo Jiao, Yi-Jun Zhang, Jian Wang, Wei Ren, De-Wen Zhang, Xun Hou, Zhao-Xin Wu
Summary: The authors demonstrate the potential of fullerene (C-60) as a candidate material for the photosensitive layer of LAPS, and propose a unique bipolar photo-response phenomenon. They explain this phenomenon with an oxygen-trap-induced space-charge mechanism.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Analytical
Yinghao Chen, Shibin Liu, Jiezhang Luo, Wenbo Zhao, Guifang Li, Yongqian Du, Jie Tan, Yue Tan, Yun Zhang
Summary: In this study, a crack metallic network (CMN) is proposed to improve the spatial resolution of a chemical imaging system based on light-addressable potentiometric sensor (LAPS). The CMN, prepared on a colloidal film as a template, effectively reduces electrode coverage and enhances photoelectric conversion efficiency.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Metallurgy & Metallurgical Engineering
Ko-ichiro Miyamoto, Manato Kaneko, Mengyun Wang, Carl Frederik Werner, Tatsuo Yoshinobu
Summary: In this study, a novel method for detecting hydrogen permeation through metal using a combination of LAPS and micro-volume measurement cell was proposed. The results demonstrated the potential of applying LAPS to visualize hydrogen permeation sites on metal surfaces.
ISIJ INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Jintao Liang, Kaiteng Yan, Yutong Liu, Xiaoqing Yao, Fei Guo, Wen Xue, Guiyin Li, Jiejing Chen, Zhide Zhou
Summary: In this study, a high-performance light addressable potentiometric sensor (LAPS) based on reduced graphene oxide-polyacrylamide-ferrocene/gold nanoparticles (rGO-PAM-Fc/AuNPs) was constructed for the detection of 1,5-AG. The designed LAPS showed good linearity, sensitivity, specificity, reproducibility, and stability. This work provides a highly sensitive, portable, and low-cost assay for the detection of 1,5-AG.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jintao Liang, Xiaohang Shi, Huafu Feng, Min Chen, Wenzhan Li, Junxiang Lai, Weipeng Hu, Guiyin Li
Summary: A novel silicon-based light-addressable potentiometric sensor (LAPS) was designed for the detection of 1,5-anhydroglucitol (1,5-AG) in human serum, showing good sensitivity and specificity as a potential testing method for clinical samples.
BIOELECTROCHEMISTRY
(2021)
Review
Chemistry, Analytical
Yage Liu, Ping Zhu, Shuge Liu, Yating Chen, Dongxin Liang, Miaomiao Wang, Liping Du, Chunsheng Wu
Summary: This review introduces the basic principle and general configuration of the light-addressable potential sensor (LAPS), as well as its recent applications in chemical sensing, biosensing, and cell monitoring. The article outlines the development trends of LAPS from the aspects of material and optical improvement, aiming to provide research and application perspectives for chemical sensing, biosensing, and imaging technology.
Article
Chemistry, Analytical
Tao Liang, Nan Jiang, Shuqi Zhou, Xinyi Wang, Yingke Xu, Chunsheng Wu, Dmitry Kirsanov, Andrey Legin, Hao Wan, Ping Wang
Summary: This study combined LAPS with ionophore-doped all-solid-state silicone-rubber ISMs to establish a program-controlled multiplexed ISLAPS system for physiological ions detection. The silicone-rubber ISMs have better adhesion to silicon-based sensors without containing plasticizers, which can avoid the plasticizer pollution and improve the long-term stability. Pre-modifying a layer of P3OT on the sensor surface inhibit the formation of an aqueous layer and improve the sensor lifetime.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Fangming Chen, Qiaoyu Yang, MingRui Jiang, Yao Meng, Jian Wang
Summary: This study proposes a simple device that combines light-addressable potentiometric sensor (LAPS) imaging and microelectrodes for label-free sensing and imaging of electrochemical reactions. The device allows qualitative and quantitative observation and visualization of electrochemical reactions occurring on the microelectrodes.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Hsin-Yin Peng, Chia-Ming Yang, Yu-Ping Chen, Hui-Ling Liu, Tsung-Cheng Chen, Dorota G. Pijanowska, Po-Yu Chu, Chia-Hsun Hsieh, Min-Hsien Wu
Summary: A novel two-in-one system based on optical-driven manipulation and sensing in a microfluidics setup was realized, integrating sensor and actuator functions on a lab on a chip (LOC). LACE and LAPS operations successfully demonstrated the collection of magnetic beads and measurement of pH values, showing comparable performance to traditional setups. This provides strong support for future point-of-care testing applications.
Article
Chemistry, Analytical
Guiyin Li, Shengnan Li, Qing Huang, Xinhao Li, Zhengyu Zhang, Jintao Liang, Zhide Zhou
Summary: This study developed a LAPS for rapid detection of LDL, and achieved accurate detection of LDL concentration by using RGO-PANI-HNCs and LDLapt as the sensitive membrane material. The sensor showed good specificity, selectivity, reproducibility, and precision, providing a simple and effective method for early diagnosis of ASCVD.
MICROCHEMICAL JOURNAL
(2023)
