Article
Critical Care Medicine
Elizabeth A. Stokes, Michelle J. Lazaroo, Madeleine Clout, Stephen J. Brett, Sarah Black, Kim Kirby, Jerry P. Nolan, Barnaby C. Reeves, Maria Robinson, Chris A. Rogers, Lauren J. Scott, Helena Smartt, Adrian South, Jodi Taylor, Matthew Thomas, Sarah Voss, Jonathan R. Benger, Sarah Wordsworth
Summary: The study compared the cost-effectiveness of using i-gel and TI as the initial AAM strategy for non-traumatic OHCA patients, showing that there were minimal differences in QALYs and costs between the two methods.
Article
Anesthesiology
L. Q. Yang, L. Zhu, X. Shi, C. H. Miao, H. B. Yuan, Z. Q. Liu, W. D. Gu, F. Liu, X. X. Hu, D. P. Shi, H. W. Duan, C. Y. Wang, H. Weng, Z. L. Huang, L. Z. Li, Z. Z. He, J. Li, Y. P. Hu, L. Lin, S. T. Pan, S. H. Xu, D. Tang, D. I. Sessler, J. Liu, M. G. Irwin, W. F. Yu, POLMA-EP Investigators
Summary: In a clinical study, it was found that using a supraglottic airway device rather than a tracheal tube can reduce postoperative pulmonary complications in older patients undergoing non-cardiothoracic surgery under general anesthesia.
Article
Anesthesiology
Maximilian Hammer, Peter Santer, Maximilian S. Schaefer, Friederike C. Althoff, Karuna Wongtangman, Ulrich H. Frey, Xinling Xu, Matthias Eikermann, Philipp Fassbender
Summary: In adult noncardiac surgical cases under general anesthesia, the use of supraglottic airway devices (SGAs) was associated with a lower risk of emergent postoperative intubation, while the use of non-depolarizing neuromuscular blocking agents (NMBAs) appeared to increase the risk of emergent postoperative intubation in patients managed with an SGA.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Critical Care Medicine
Quentin Le Bastard, Jade Rouzioux, Emmanuel Montassier, Valentine Baert, Morgan Recher, Herve Hubert, Stephane Leteurtre, Francois Javaudin
Summary: This study found that in pediatric OHCA, patients who received endotracheal intubation had lower 30-day survival rates and poorer neurological outcomes compared to those who received supraglottic ventilation, without a significant association with return of spontaneous circulation.
Article
Emergency Medicine
Hubert Dufour-Neyron, Katherine Tanguay, Alexandra Nadeau, Marcel Emond, Jessica Harrisson, Sebastien Robert, Nicolas Capolla-Daneau, Mathieu Groulx, Pierre-Hugues Carmichael, Eric Mercier
Summary: This study investigated the proportion of successful ventilation and the number of attempts required for ETC insertion in prehospital airway management in the province of Quebec, Canada. The study found lower proportions of successful ventilation and first-pass success compared to reported literature, highlighting the need for further research on the reasons behind these lower rates and their impact on patient-centered outcomes.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Loric Stuby, Laurent Jampen, Julien Sierro, Maxime Bergeron, Erik Paus, Thierry Spichiger, Laurent Suppan, David Thurre
Summary: Early insertion of an i-gel(R) supraglottic airway device during out-of-hospital cardiac arrest simulation improves chest compression fraction and enhances ventilation parameters, but results in shallower compressions. Further resolution of this issue is required before conducting clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Pascal Laferriere-Langlois, Alexandre Dion, Eric Guimond, Fannie Nadeau, Veronique Gagnon, Frederick D'Aragon, Yanick Sansoucy, Marie-Jose Colas
Summary: This study compared the efficacy of three second-generation SGA devices as conduits for bronchoscopy-guided endotracheal intubation. The results showed similar intubation times among the three groups, with the i-gel device being faster and easier to insert, and the Air-Q Blocker device being easier to remove. The study suggests that clinicians should choose the appropriate SGA device based on their clinical experience.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Critical Care Medicine
Jason A. Bartos, Arianne Clare Agdamag, Rajat Kalra, Lindsay Nutting, R. J. Frascone, Aaron Burnett, Nik Vuljaj, Charles Lick, Peter Tanghe, Ryan Quinn, Nicholas Simpson, Bjorn Peterson, Kari Haley, Kevin Sipprell, Demetris Yannopoulos
Summary: This study compared the use of endotracheal intubation (ETI) and supraglottic airways (SGA) in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). The results showed that ETI was associated with improved oxygenation and ventilation, increased eligibility for ECPR, and higher neurologically favorable survival rates compared to SGA.
Article
Critical Care Medicine
David L. Murphy, Natalie E. Bulger, Brenna M. Harrington, Jillian A. Skerchak, Catherine R. Counts, Andrew J. Latimer, Betty Y. Yang, Charles Maynard, Thomas D. Rea, Michael R. Sayre
Summary: A study on the number of intubation attempts in non-traumatic OHCA patients found that increasing attempts were associated with a lower likelihood of favorable neurologic survival.
Article
Medicine, General & Internal
Joern Grensemann, Emma Moehlenkamp, Philipp Breitfeld, Pischtaz A. Tariparast, Tanja Peters, Mark A. Punke, Stefan Kluge, Martin Petzoldt
Summary: This study compared VST and VL for tracheal intubation in patients with expected difficult airways, finding that VST was non-inferior to VL in terms of oxygenation, provided better visualization but prolonged intubation.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Critical Care Medicine
Brendan Burke, William Tierney, Rachel Georgopoulos, Samir Q. Latifi, Hemant S. Agarwal
Summary: Involvement of the upper airway in the systemic lupus erythematosus (SLE) disease process is uncommon, but can lead to severe complications such as acute tracheal necrosis. Prompt airway evaluation and treatment are crucial for the recovery of SLE patients with rare upper airway involvement.
Article
Anesthesiology
Berthold Moser, Michael Kemper, Maren Kleine-Brueggeney, Lukas Gasteiger, Markus Weiss
Summary: This study demonstrates that clinically relevant combinations of adult-size TTs and SGAs can be incompatible, making flexible bronchoscope-guided tracheal intubation through an SGA impossible. Additional limitations exist regarding the removal of the SGA and the maneuverability of the flexible bronchoscope.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Critical Care Medicine
Henry E. Wang, Xabier Jaureguibeitia, Elisabete Aramendi, Jeffrey L. Jarvis, Jestin N. Carlson, Unai Irusta, Erik Alonso, Tom Aufderheide, Robert H. Schmicker, Matthew L. Hansen, Ryan M. Huebinger, M. Riccardo Colella, Richard Gordon, Robert Suchting, Ahamed H. Idris
Summary: In the PART trial, compared with ETI, LT was associated with shorter total CC interruption duration but not other CC quality measures. CC quality may be associated with OHCA airway management.
Review
Pediatrics
Nicole K. Yamada, Christopher Jd McKinlay, Bin Huey Quek, Georg M. Schmolzer, Myra H. Wyckoff, Helen G. Liley, Yacov Rabi, Gary M. Weiner
Summary: This study compared the use of supraglottic airway devices (SA) with face masks in newborn infants receiving positive pressure ventilation (PPV) after birth. The results showed that the use of SA decreased the probability of failure to improve with PPV and reduced the need for endotracheal intubation. The duration of PPV and time until heart rate recovery were also shorter with the use of SA.
Article
Anesthesiology
Sang-Hwan Ji, Sung-Ae Cho, Young-Eun Jang, Eun-Hee Kim, Jin-Tae Kim, Hee-Soo Kim, Ji-Hyun Lee
Summary: This study trained anesthesiology residents in fiberoptic-guided endotracheal intubation using a pediatric manikin and evaluated their learning curves. All 30 participants acquired proficiency after practicing 8 to 25 times. In the actual clinical setting, the success rate of the technique was 92.8% with an average procedure time of 71.3 seconds.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Economics
Simone Huygens, Heleen Vellekoop, Matthijs Versteegh, Irene Santi, Laszlo Szilberhorn, Tamas Zelei, Balzs Nagy, Apostolos Tsiachristas, Rositsa Koleva-Kolarova, Sarah Wordsworth, Maureen Rutten-van Molken, HEcoPerMed Consortium
Summary: This study addresses the challenges of evaluating histology-independent treatments using entrectinib as an example. It evaluates the cost-effectiveness of testing all patients for NTRK fusions and treating positive cases with entrectinib, compared to no testing and standard care. The results show that testing and treatment have higher costs and effects.
Article
Dermatology
Rhiannon C. Macefield, Jane M. Blazeby, Barnaby C. Reeves, Anni King, Jonathan Rees, Anne Pullyblank, Kerry Avery
Summary: This study developed and evaluated a method for patients to capture standardized wound images for remote wound assessment to detect surgical site infection (SSI). The results showed that the method is simple, standardized, and acceptable, and high-quality images can be used for remote assessment of SSI.
JOURNAL OF TISSUE VIABILITY
(2023)
Editorial Material
Critical Care Medicine
Jerry P. Nolan, Katherine M. Berg, Janet E. Bray
INTENSIVE CARE MEDICINE
(2023)
Review
Anesthesiology
James Penketh, Jerry P. Nolan
Summary: Post-cardiac arrest syndrome (PCAS) is a complex condition that affects survivors of cardiac arrest. This review explores strategies for managing PCAS, including oxygenation, blood pressure control, coronary reperfusion timing, temperature control, and seizure treatment. Despite ongoing research, many questions about the optimal interventions for PCAS remain unanswered, and the role of intracranial pressure monitoring is still unclear.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2023)
Article
Health Care Sciences & Services
Catherine Hyams, Robert Challen, Robin Marlow, Jennifer Nguyen, Elizabeth Begier, Jo Southern, Jade King, Anna Morley, Jane Kinney, Madeleine Clout, Jennifer Oliver, Sharon Gray, Gillian Ellsbury, Nick Maskell, Luis Jodar, Bradford Gessner, John McLaughlin, Leon Danon, Adam Finn
Summary: This study demonstrates that Omicron infection in hospitalized patients results in lower disease severity compared to the Delta variant. Despite being relatively lower, Omicron infection still imposes a significant burden on patients and public health.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Anesthesiology
A. J. Shrimpton, V. Brown, J. Vassallo, J. P. Nolan, J. Soar, F. Hamilton, T. M. Cook, B. R. Bzdek, J. P. Reid, C. H. Makepeace, J. Deutsch, R. Ascione, J. M. Brown, J. R. Benger, A. E. Pickering
Summary: Cardiopulmonary resuscitation generates high concentrations of respiratory aerosol, suggesting the need for airborne transmission precautions in high-risk pathogen settings.
Article
Health Care Sciences & Services
Jessica Harris, Koen B. Pouwels, Thomas Johnson, Jonathan Sterne, Christalla Pithara, Kalaivani Mahadevan, Barney Reeves, Umberto Benedetto, Yoon Loke, Daniel Lasserson, Brett Doble, Noreen Hopewell-Kelly, Sabi Redwood, Sarah Wordsworth, Andrew Mumford, Chris Rogers, Maria Pufulete
Summary: This study quantified the bleeding risk among patients undergoing different antiplatelet and triple therapy regimens for percutaneous coronary intervention or coronary artery bypass grafting, as well as conservatively managed acute coronary syndrome. The results suggest that more potent dual antiplatelet therapy may increase the risk of bleeding without reducing the incidence of major adverse cardiovascular events.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Pharmacology & Pharmacy
Laszlo Szilberhorn, Tamas Zelei, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Molken, Rositsa Koleva-Kolarova, Apostolos Tsiachristas, Sarah Wordsworth, Balazs Nagy
Summary: Correct diagnosis of MODY is important to provide appropriate treatment. Screening with the MODY calculator then genetic testing is considered cost-effective, and the addition of autoantibody testing can replace no screening. The budget impact ranges from 0.001% to 0.025% of annual public healthcare spending.
PERSONALIZED MEDICINE
(2023)
Editorial Material
Pharmacology & Pharmacy
Maureen Rutten-van Moelken, Matthijs Versteegh, Balazs Nagy, Sarah Wordsworth
PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Rositsa Koleva-Kolarova, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Molken, Laszlo Szilberhorn, Tamas Zelei, Balazs Nagy, Sarah Wordsworth, Apostolos Tsiachristas
Summary: The cost-effectiveness and budget impact of introducing extended DPYD testing with ToxNav prior to capecitabine/5-fluorouracil in metastatic breast cancer patients in the UK, The Netherlands, and Hungary were examined. ToxNav was cost-effective in all three countries and resulted in budget savings in the UK and The Netherlands.
PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Rositsa Koleva-Kolarova, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Moelken, Laszlo Szilberhorn, Tamas Zelei, Balazs Nagy, Sarah Wordsworth, Apostolos Tsiachristas
Summary: This study aimed to assess the cost-effectiveness of ToxNav (c), a multivariant genetic test, for screening DPYD and personalized chemotherapy dosing in metastatic breast cancer patients in the UK. Results showed that ToxNav (c) was dominant over standard of care, providing additional quality-adjusted life years and cost savings per patient. Sensitivity analysis further supported the effectiveness of the ToxNav (c) strategy.
PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Balazs Nagy, Tamas Zelei, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Moelken, Rositsa Koleva-Kolarova, Apostolos Tsiachristas, Sarah Wordsworth, Laszlo Szilberhorn
Summary: The HEcoPerMed consortium developed a methodological guidance for economic evaluations in personalized medicine, and health economic models were developed to analyze the recommendations. The models addressed most of the recommendations and identified essential recommendations in each study.
PERSONALIZED MEDICINE
(2023)
Article
Anesthesiology
J. P. Nolan, J. Soar, A. D. Kane, I. K. Moppett, R. A. Armstrong, E. Kursumovic, T. M. Cook
Summary: According to current guidance, cardiopulmonary resuscitation should be attempted when cardiac arrest occurs during anesthesia, and 'do not attempt cardiopulmonary resuscitation' recommendation should be suspended if a patient has it pre-operatively. However, how this guidance is implemented in everyday clinical practice in the UK is unknown. This study found that a small proportion of patients had a pre-existing 'do not attempt cardiopulmonary resuscitation' recommendation, and when cardiac arrest occurred, some patients achieved return of spontaneous circulation, but most of them died before discharge from the hospital.
Article
Anesthesiology
R. A. Armstrong, T. M. Cook, A. D. Kane, E. Kursumovic, J. P. Nolan, F. C. Oglesby, L. Cortes, C. Taylor, I. K. Moppett, S. Agarwal, J. Cordingley, M. T. Davies, J. Dorey, S. J. Finney, S. Kendall, G. Kunst, D. N. Lucas, R. Mouton, G. Nickols, V. J. Pappachan, B. Patel, F. Plaat, B. R. Scholefield, J. H. Smith, L. Varney, E. Wain, J. Soar
Summary: This study describes the management and outcomes of peri-operative cardiac arrest in UK practice, highlighting the impact of factors such as arrest rhythm, patient age, surgical priority, and the cause of cardiac arrest on patient survival and functional outcomes.
Article
Anesthesiology
A. D. Kane, T. M. Cook, R. A. Armstrong, E. Kursumovic, M. T. Davies, S. Agarwal, J. P. Nolan, J. H. Smith, I. K. Moppett, F. C. Oglesby, L. Cortes, C. Taylor, J. Cordingley, J. Dorey, S. J. Finney, G. Kunst, D. N. Lucas, G. Nickols, R. Mouton, B. Patel, V. J. Pappachan, F. Plaat, B. R. Scholefield, L. Varney, J. Soar
Summary: This study investigated the occurrence of complications during anesthesia in a national cohort. The results showed variations in the frequency of different types of complications, with higher rates in emergency surgeries. Factors such as age, ASA physical status, gender, urgency and extent of surgery, day of the week, and time of day were found to be associated with the occurrence of complications. These data can be valuable for risk assessment and obtaining patient consent.