Article
Toxicology
Pieter A. Cohen, Ross R. Ellison, John C. Travis, Slava V. Gaufberg, Roy Gerona
Summary: Phenibut is used for various conditions in Russia, but has abuse potential. Despite FDA warnings, all 4 brands of over-the-counter supplements analyzed in the study contained phenibut, with quantities increasing in 3 of 4 products post-warning. The presence of phenibut in these supplements poses potential risks to consumers.
CLINICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Pamela R. Pehrsson, Janet M. Roseland, Kristine Y. Patterson, Katherine M. Phillips, Judith H. Spungen, Karen W. Andrews, Pavel A. Gusev, Jaime J. Gahche, Carol J. Haggans, Joyce M. Merkel, Abby G. Ershow
Summary: Data on iodine content in foods and dietary supplements are crucial for developing dietary guidance and addressing iodine deficiency. Collaboration between USDA, FDA, and ODS-NIH provides iodine databases to monitor iodine status and develop dietary guidance for the general population and at-risk subgroups.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Biotechnology & Applied Microbiology
Ekaterina Khokhlova, Pyeongsug Kim, Joan Colom, Shaila Bhat, Aoife M. Curran, Najla Jouini, Kieran Rea, Christopher Phipps, John Deaton
Summary: This study investigated the gluten levels in commercially available dietary enzymes and their effect on inflammatory response in human cell culture assays. The results showed that all tested enzyme products had a gluten concentration equivalent to or below 20 ppm, and did not significantly differ in inflammatory response compared to gluten reference standards.
FERMENTATION-BASEL
(2022)
Article
Medicine, Legal
Nicolas Fabresse, Laurie Gheddar, Pascal Kintz, Adeline Knapp, Islam Amine Larabi, Jean-Claude Alvarez
Summary: Substandard and counterfeit drugs are a growing global problem. Analysis of pharmaceuticals and dietary supplements seized from the black market among bodybuilders in France revealed a significant proportion of products with quality issues.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Chemistry, Applied
Dasom Shin, Jeongeun Kwon, Hui-Seung Kang, Junghyuck Suh, Eunju Lee
Summary: The Ministry of Food and Drug Safety in South Korea has found that many dietary supplements contain unapproved ingredients, posing potential health risks to consumers. The most commonly found unapproved ingredients are in products marketed for sexual enhancement and weight loss. This study is important because it sheds light on the adulteration trends of unapproved ingredients in dietary supplements.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Food Science & Technology
Gabriela Pilarska, Magdalena Twaruzek, Iwona Altyn
Summary: This study aims to evaluate the contamination of molds and mycotoxins in dietary supplements based on purple coneflower in the Polish market. The results show that these supplements are commonly contaminated with molds and mycotoxins, with Aspergillus spp., Phoma spp., and Eurotium spp. being the most common molds, and ZEN, DON, and T-2 toxin being the most common mycotoxins.
Article
Nutrition & Dietetics
Desiree A. Lucassen, Elske M. Brouwer-Brolsma, Hendriek C. Boshuizen, Monica Mars, Johan de Vogel van den Bosch, Edith JM. Feskens
Summary: The smartphone-based 2-hour recall method (2hR) is a valid approach to assess dietary intake, as it shows similar results to traditional 24-hour recalls (24hR) and objective biomarkers, with slightly higher intake estimates.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Clinical Neurology
Leigh K. Sharpless, Aaron S. Kesselheim, Serena L. Orr, Jonathan Darrow
Summary: This study assessed the characteristics and variation of endpoints used in trials supporting FDA approval of medications for migraine treatment. The findings revealed inconsistent endpoint selection within the same indication, mechanistic class, and route of administration, making it difficult to directly compare these medications. Inconsistent definitions for episodic and chronic migraine were also observed.
Editorial Material
Clinical Neurology
Juliana H. Vanderpluym
Summary: Migraine management includes acute treatments for immediate relief and preventive treatments for long-term reduction of attacks. Individualized treatment decisions require consideration of factors such as efficacy, safety, characteristics, and patient preferences.
Review
Pharmacology & Pharmacy
Lulu Gao, Xudong Liu, Xiaoyan Luo, Xiaofan Lou, Pusen Li, Xian Li, Xiaomeng Liu
Summary: Aging is influenced by various factors and has led to an increase in aging-related diseases globally. Natural products have been used for a long time and have been proven to have antiaging effects through various cellular pathways. This article reviews several natural products with potential antiaging properties and highlights their cellular and molecular mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Utako Murai, Ryoko Tajima, Mai Matsumoto, Yoko Sato, Saki Horie, Aya Fujiwara, Emiko Koshida, Emiko Okada, Tomoko Sumikura, Tetsuji Yokoyama, Midori Ishikawa, Kayo Kurotani, Hidemi Takimoto
Summary: The accuracy of web-based dietary assessments compared to conventional methods was examined in this review. Mean differences and correlation coefficients for several dietary components were analyzed. The results showed acceptable differences and correlations for energy, macronutrients, sodium, vegetables, and fruits. Participants were generally favorable towards using web-based dietary assessments. These findings indicate the potential widespread use of web-based dietary assessments in the future.
Letter
Medicine, General & Internal
S. Sean Tu, Aaron S. Kesselheim, Kathrine Wetherbee, William B. Feldman
Summary: This study evaluates the frequency of continuation patents on brand-name drugs approved by the US Food and Drug Administration from 2000 to 2015.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biochemical Research Methods
Clarisse L. L. Torres, Felipe A. G. de Oliveira, Luis Felipe Jooris, Monica C. C. Padilha, Henrique M. G. Pereira
Summary: Dietary supplements are widely used by both the general population and athletes, but they can pose health risks and lead to adverse findings due to the potential contamination or adulteration with banned substances. The Brazilian Doping Control Laboratory found a significant number of tainted samples and different types of prohibited substances in these supplements, highlighting the importance of raising awareness in the sports community.
DRUG TESTING AND ANALYSIS
(2023)
Review
Oncology
Paul Gougis, Marc Hilmi, Arthur Geraud, Olivier Mir, Christian Funck-Brentano
Summary: Herbs, food, and dietary supplements can interact with anticancer drugs through cytochrome P450 isoforms, affecting drug metabolism. Among 261 HFDS studied, 21 were found to interact with CYP3A4, a key metabolic pathway for many anticancer drugs. This interaction can have implications for the efficacy and safety of cancer treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Davide Benedetto Tiz, Luana Bagnoli, Ornelio Rosati, Francesca Marini, Claudio Santi, Luca Sancineto
Summary: This review describes recently FDA-approved drugs, many of which contain active moieties that have not been previously approved by the FDA. These drugs provide important new therapies for patients with multiple unmet diseases.
