Article
Immunology
Barbara E. Mahon, Jakub Simon, Marc-Alain Widdowson, Mohamed Samai, Eric Rogier, Jennifer Legardy-Williams, Kenneth Liu, Jarad Schiffer, James Lange, Carolynn DeByle, Robert Pinner, Anne Schuchat, Laurence Slutsker, Susan Goldstein
Summary: Asymptomatic adults, with or without malaria infection, showed robust immune responses to the rVSV Delta G-ZEBOV-GP vaccine lasting for 9-12 months, although those with malaria infection had slightly lower responses.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Melanie J. Shears, Felicia N. Watson, Brad C. Stone, Irene Cruz Talavera, Chaitra Parthiban, Jokichi Matsubara, K. C. Natasha, B. Kim Lee Sim, Stephen L. Hoffman, Sean C. Murphy
Summary: The development of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many existing malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages, but they require multiple doses and have suboptimal efficacy against field-transmitted malaria.
Review
Immunology
Yi-Dan Ding, Lin-Zhen Shu, Rui-Shan He, Kai-Yun Chen, Yan-Juan Deng, Zhi-Bin Zhou, Ying Xiong, Huan Deng
Summary: Immunotherapy using Listeria monocytogenes vaccine shows promise in enhancing anti-tumor effects by reshaping the tumor microenvironment and activating immune cells, but it needs to be combined with other treatments for better efficacy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Pamela Rosa-Goncalves, Luciana Pereira de Sousa, Flavia Lima Ribeiro-Gomes, Leonardo Jose Moura Carvalho, Claudio Tadeu Daniel-Ribeiro
Summary: Malaria, caused by protozoa of the genus Plasmodium, is an ancient parasitic disease characterized by fever, headache, sweating, and chills. Neurological, neurocognitive, and behavioral alterations, as well as poor school performance, can develop in survivors. Neuroinflammation plays a crucial role in the cognitive dysfunctions associated with malaria. Vaccination with type 2 immune response elicitors, such as the tetanus-diphtheria vaccine, may have a beneficial effect in alleviating neuroinflammation and mitigating neurocognitive deficits.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Virology
Toufik Abdul-Rahman, Lukman Lawal, Emily Meale, Oyinbolaji A. Ajetunmobi, Soyemi Toluwalashe, Uthman Hassan Alao, Shankhaneel Ghosh, Neil Garg, Abdullahi Tunde Aborode, Andrew Awuah Wireko, Aashna Mehta, Kateryna Sikora
Summary: The Ebola virus has caused multiple outbreaks in Africa with high fatality rates. Social factors such as human mobility, behavior, and cultural norms contribute to the transmission risk. However, challenges including lagging vaccine production pose a risk of another outbreak.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Dilhan J. Perera, Momar Ndao
Summary: Helminths are a significant cause of disease globally, surpassing malaria and tuberculosis; however, they are considered neglected tropical diseases with no approved vaccines for human use. Due to their complexity and ability to evade traditional vaccine strategies, research is focusing on novel methods such as viral vectors and genetic elements to develop effective vaccines.Understanding helminth vaccine-induced immunity is crucial for the advancement of potent vaccine platforms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Daniela Manno, Catriona Patterson, Abdoulie Drammeh, Kevin Tetteh, Mattu Tehtor Kroma, Godfrey Tuda Otieno, Bolarinde Joseph Lawal, Seyi Soremekun, Philip Ayieko, Auguste Gaddah, Abu Bakarr Kamara, Frank Baiden, Muhammed Olanrewaju Afolabi, Daniel Tindanbil, Kwabena Owusu-Kyei, David Ishola, Gibrilla Fadlu Deen, Babajide Keshinro, Yusupha Njie, Mohamed Samai, Brett Lowe, Cynthia Robinson, Bailah Leigh, Chris Drakeley, Brian Greenwood, Deborah Watson-Jones, Junki Maruyama
Summary: We evaluated the immunogenicity of the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen in individuals with previous exposure to malaria and those who experienced clinical malaria after vaccination. We found that there was no difference in antibody responses to the Ebola virus glycoprotein between different categories of previous malaria exposure. We also found that the vaccine regimen was effective in individuals who experienced clinical malaria after vaccination.
Article
Medicine, General & Internal
Supriya Ravichandran, Surender Khurana
Summary: A serodiagnostic test has been developed to differentiate between individuals with EBOV infection-induced antibodies and those with EBOV vaccine-induced antibodies. This test can accurately detect Ebola virus infections and could be implemented as a robust diagnostic tool for epidemiology and surveillance during and after outbreaks, especially in countries with mass Ebola vaccinations.
Editorial Material
Microbiology
Nginache Nampota Nkomba, Cristiana Cairo, Miriam K. Laufer
Summary: The first malaria vaccine has been approved for children in malaria-endemic areas, but its modest efficacy highlights the need for further attention and research.
CELL HOST & MICROBE
(2022)
Review
Immunology
Si-Yuan Zhu, Ke-Da Yu
Summary: Breast cancer is the most commonly diagnosed cancer worldwide, with relapse and metastasis posing significant challenges. Innovative therapeutic strategies, such as cancer vaccines, are needed to address these challenges. Although current results have been disappointing, recent studies suggest the potential of combining vaccines with other treatments for breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Danielle Stanisic, Mei-Fong Ho, Reshma Nevagi, Emily Cooper, Maddison Walton, Md Tanjir Islam, Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth, Michael F. Good
Summary: Malaria vaccine research has shifted towards whole-parasite vaccines, which present a broad repertoire of antigens to the immune system to limit antigenic polymorphism. This study developed an enhanced liposomal vaccine that induced protective immune responses in mice and strong cellular immune responses, making significant progress towards evaluating the vaccine in clinical trials.
Review
Parasitology
Sakineh Pirahmadi, Sedigheh Zakeri, Navid D. Djadid, Akram A. Mehrizi
Summary: An efficient malaria vaccine is crucial for malaria eradication, and the use of multiple adjuvants in subunit vaccines may be key. Identifying the most effective combination adjuvants can enhance the efficacy of vaccines against malaria.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Infectious Diseases
Jane Grant, Thomas Gyan, Francis Agbokey, Jayne Webster, Brian Greenwood, Kwaku Poku Asante
Summary: This study identified 12 main challenges and lessons learned by health service managers and health workers during the planning and early implementation phases of the RTS,S/AS01(E) pilot introduction in Ghana. The findings highlight the need for longer, more intensive and sustained delivery of contextually-appropriate sensitization prior to implementation.
Article
Biotechnology & Applied Microbiology
Ekta Mukhopadhyay, Florian Brod, Philip Angell-Manning, Nicola Green, Richard D. Tarrant, Frank J. Detmers, Emma J. Bolam, Ioana N. Baleanu, Mark Hobson, Gary Whale, Susan J. Morris, Rebecca Ashfield, Sarah C. Gilbert, Jing Jin, Simon J. Draper, Sarah P. Moyle, Eleanor L. Berrie, Adrian V. S. Hill
Summary: This study presents a method for producing a VLP-based anti-malaria vaccine called R21 under cGMP regulations. The production process was modified to produce clinical-grade material for human clinical trials. The use of C-tag technology for purification of the vaccine candidate is a first in human clinical trials. The R21 vaccine has shown high efficacy in African clinical trials.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Review
Immunology
Yong Chiang Tan, Chandrajit Lahiri
Summary: In parallel with the uncontrolled use of antibiotics, the emergence of multidrug-resistant bacteria has posed a severe threat to human health. Recent research has shown that designing vaccines is a realistic alternative strategy to combat this threat. By utilizing methods such as pan-genomics and network analysis, potential antigens for anti-A. baumannii vaccines can be discovered. As conventional approaches have limitations, in silico techniques, particularly network analysis, have shown promise in uncovering novel vaccine candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
