Tetradentate hydrazone metal complexes derived from cefazolin and 2,6-diacetylpyridine hydrazide: synthesis, characterization, and antibacterial activity

Tetradentate metal(II) coordination compounds of cefazolin 2,6-diacetylpyridinehydrazone ligand HL derived from the condensation of cefazolin antibiotic with 2,6-diacetylpyridine hydrazide were synthesized. The ligand and mononuclear [ML(H2O)(2)][PF6] (M = Mn2+, Co2+, Ni2+, Zn2+) complexes were characterized by elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, H-1 NMR, and molecular modeling studies. The ligand behaves as a monoanionic tetradentate NNOO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar disk diffusion method.