Journal
MONATSHEFTE FUR CHEMIE
Volume 146, Issue 10, Pages 1621-1630Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-015-1482-z
Keywords
Formation; Spectroscopy; Fluorescence; Stability constants; Speciation
Categories
Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [172016]
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The formation of host-guest inclusion complex of levofloxacin with beta-cyclodextrin (beta-CD) was studied by fluorescence spectroscopy in buffer solution (pH 7.4) at 298 K. The experimental results confirmed the existence of 1:1 inclusion complex of levofloxacin with beta-CD. The association constant of the beta-CD inclusion complex was obtained from the Benesi-Hildebrand equation. The formation of the inclusion complex was confirmed by the IR and H-1 NMR technique. The complex formation equilibria between Gd(III) ion and levofloxacin were investigated in aqueous solutions without and in the presence of beta-cyclodextrin. The stoichiometry and stability constants of the formed complexes are reported, and the concentration distribution of the various complex species has been evaluated as a function of pH. The effect of beta-cyclodextrin on dissociation constants, K (a), of levofloxacin and stability constants of gadolinium(III)- levofloxacin complexes, beta (p,q,r), were examined. Furthermore, effect of levofloxacin on the speciation and distribution Gd(III) in human blood plasma was evaluated by computer simulation.
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