Review
Biochemistry & Molecular Biology
Silvio Borrelli, Ida Matarazzo, Eugenio Lembo, Laura Peccarino, Claudia Annoiato, Maria Rosaria Scognamiglio, Andrea Foderini, Chiara Ruotolo, Aldo Franculli, Federica Capozzi, Pavlo Yavorskiy, Fatme Merheb, Michele Provenzano, Gaetano La Manna, Luca De Nicola, Roberto Minutolo, Carlo Garofalo
Summary: Increasing potassium intake can improve blood pressure and cardiovascular outcomes, but hyperkalaemia is prevalent in CKD patients and associated with poor prognosis. The correct nutritional approach to hyperkalaemia is still controversial, but new K+-binder drugs offer a safe and effective option for controlling serum potassium levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Riaz Qureshi, Evan Mayo-Wilson, Tianjing Li
Summary: This paper outlines the challenges of researching harms in systematic reviews, emphasizing the importance of understanding terminology and not solely relying on published reports of clinical trials for conclusions about harms. Visualizations may enhance communication of harm information.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Hematology
Ghulam Rehman Mohyuddin, Rajshekhar Chakraborty, Edward R. Scheffer Cliff
Summary: This article discusses the potential benefits and drawbacks of screening for plasma cell dyscrasias, as well as the implications of using mass spectrometry for diagnosing monoclonal gammopathy of undetermined significance in routine practice.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Aruna Kamineni, V. Paul Doria-Rose, Jessica Chubak, John M. Inadomi, Douglas A. Corley, Jennifer S. Haas, Sarah C. Kobrin, Rachel L. Winer, Jennifer Elston Lafata, Elisabeth F. Beaber, Joshua S. Yudkin, Yingye Zheng, Celette Sugg Skinner, Joanne E. Schottinger, Debra P. Ritzwoller, Jennifer M. Croswell, Andrea N. Burnett-Hartman
Summary: This review evaluates the reporting of harms in U.S. cancer screening guidelines and identifies inconsistencies and opportunities for improvement. The guidelines do not fully report harms for any specific organ type or category across organ types. Reporting of harms is most complete for prostate cancer screening and least complete for colorectal cancer screening. Future work should consider nuances of each organ-specific screening process and explore optimal ways to determine net screening benefit. Improved harms reporting can aid decision making and improve cancer screening outcomes.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Environmental Sciences
Kai Song, Xinping Yang, Yunjing Wang, Zichao Wan, Junfang Wang, Yi Wen, Han Jiang, Ang Li, Jingshun Zhang, Sihua Lu, Baoming Fan, Song Guo, Yan Ding
Summary: This study sampled and analyzed indoor air pollutants and identified four new organic compounds. A three-step pipeline was proposed to screen and evaluate the contamination potential of these new compounds. Mintketone and sesquiterpenes may be derived from the use of volatile chemical products, while (5α)-androstane is probably human-emitted.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Psychology, Developmental
Brianna K. Hunter, Julie Markant
Summary: Developing attention skills is crucial for children as they are biased towards orienting to faces, especially caregiver faces, indicating a higher motivational salience.
DEVELOPMENTAL PSYCHOLOGY
(2023)
Review
Immunology
Francesca Matteini, Medhanie A. Mulaw, M. Carolina Florian
Summary: The aging of the bone marrow niche leads to declining HSC function, but certain niche structures and signals are crucial for maintaining HSC function. The use of new technical tools has revealed the impact of BM niche aging on HSCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Social Sciences, Interdisciplinary
Hong Liu
Summary: This paper presents the results of a retrospective study on the cognitive effects of learning a foreign language in late adulthood. The findings suggest that language learning can lead to improvements in attention and working memory abilities.
Editorial Material
Medicine, General & Internal
Mark A. Pallansch
Summary: The United States and the United Kingdom are facing outbreaks of imported poliovirus due to undervaccination.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Philippe Favre, Jeff Bischoff
Summary: The objective of this study is to propose a general method for determining which patient harms should be included in an in silico clinical trial (ISCT) for regulatory submission. The proposed method considers the risk, impact, and technical feasibility associated with the harms. With this method, it is hoped that a consistent approach to scoping an ISCT can be adopted, supporting investment in ISCT, enabling consistent review by regulators, and maximizing the impact of modeling technologies to improve patient outcomes.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Environmental Sciences
Kristin K. Isaacs, Jonathan T. Wall, Katie Paul Friedman, Jill A. Franzosa, Helen Goeden, Antony J. Williams, Kathie L. Dionisio, Jason C. Lambert, Monica Linnenbrink, Amar Singh, John F. Wambaugh, Alexander R. Bogdan, Christopher Greene
Summary: The Minnesota Department of Health has partnered with the U.S. Environmental Protection Agency to develop an automated workflow for screening potential drinking water contaminants. This workflow utilizes multiple data sources and quantitative algorithms to quickly evaluate the toxicity and exposure potential of chemicals, allowing for efficient prioritization of further assessments. This workflow is a valuable tool for resource-saving, expanding screening capabilities, and selecting candidates for contaminant assessment programs.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Review
Primary Health Care
Alison N. Huffstetler, Joseph Fraiman, Shannon Brownlee, Michael A. Stoto, Kenneth W. Lin
Summary: This study aims to comprehensively assess the direct, severe harms of screening colonoscopy in the United States. The primary outcome was the number of severe bleeding events and gastrointestinal (GI) perforations within 30 days of screening colonoscopy. The rate of severe bleeding ranged credibly from 16.4 to 36.18 per 10,000 colonoscopies; the rate of perforation ranged credibly from 7.62 to 8.50 per 10,000 colonoscopies. The risk of harm subsequent to screening colonoscopy is higher than previously reported and should be discussed with patients when engaging in shared decision making.
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Samuel M. Lockhart, Stephen O'Rahilly
Summary: Colchicine, an anti-inflammatory agent commonly used to treat gout, exerts its effects in mice by inducing the hormone GDF-15 in the liver, as demonstrated by Weng et al. in the latest issue of Nature Metabolism.
Editorial Material
Multidisciplinary Sciences
Joseph Bak-Coleman, Carl T. Bergstrom, Jennifer Jacquet, James Mickens, Zeynep Tufekci, Timmons Roberts
Summary: Emerging information technologies, such as ChatGPT, require appropriate management, and establishing an intergovernmental panel to synthesize evidence is the best way forward.
Article
Engineering, Environmental
Lei Huang, Peter Fantke, Amelie Ritscher, Olivier Jolliet
Summary: This study aims to evaluate the potential impact of chemicals in building materials on human health, proposing a model for predicting chemical emissions and identifying 55 high-risk substances in particular, highlighting the need for safer alternatives.
JOURNAL OF HAZARDOUS MATERIALS
(2022)