Article
Immunology
Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Summary: Immune function changes with age, and infection with CMV accelerates these changes, resulting in increased mortality and impaired responses in elderly individuals. Following organ transplantation, CMV+ recipients show accelerated aging of CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Verner Eerola, Ville Sallinen, Marko Lempinen, Ilkka Helantera
Summary: A longer procurement interval is associated with improved long-term outcomes in pancreas transplantation, as it is correlated with increased death-censored graft survival and decreased acute rejections. This study analyzed the association between procurement interval and pancreas graft outcomes using multivariable models. The results showed that a longer procurement interval is beneficial for pancreas transplantation.
TRANSPLANT INTERNATIONAL
(2023)
Article
Surgery
Jennie H. Kwon, Walker M. Blanding, Khaled Shorbaji, Joseph R. Scalea, Barry C. Gibney, Prabhakar K. Baliga, Arman Kilic
Summary: Organ donation after circulatory death (DCD) expands access to transplantation and improves waitlist outcomes for liver and heart transplant candidates. However, DCD transplant carries increased mortality risk for kidney, liver, and lung recipients.
Article
Surgery
Emily M. Eichenberger, Sarah Satola, David Neujahr, Vance G. Fowler Jr, Divya Gupta, Mandy Ford, Stephanie M. Pouch
Summary: This study investigates the risk factors and outcomes of candidemia in thoracic solid organ transplant recipients. It finds a low incidence of candidemia among heart and lung transplant recipients, but a higher mortality and morbidity rate in those who develop candidemia.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Meghan Aversa, Tereza Martinu, Christopher Patriquin, Marcelo Cypel, David Barth, Rasheed Ghany, Jin Ma, Shaf Keshavjee, Lianne G. Singer, Kathryn Tinckam
Summary: The Toronto Lung Transplant Program has been using a desensitization regimen since 2008 for DSA-positive lung transplants, and long-term follow-up showed that allograft survival and CLAD-free survival of these patients were not significantly different from other lung transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Irsa S. Hasan, James A. Brown, Derek Serna-Gallegos, Edgar Aranda-Michel, Sarah Yousef, Yisi Wang, Ibrahim Sultan
Summary: This observational study compared outcomes of patients undergoing thoracic endovascular aortic repair (TEVAR) for complicated type B aortic dissection (TBAD) or descending thoracic aortic (DTA) aneurysm using a nationwide readmissions database from 2010 to 2018. The results showed that patients with TBAD had higher rates of in-hospital mortality, postoperative complications, and readmissions compared to patients with DTA. TBAD was independently associated with mortality after adjusting for other variables.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Vanessa Granja A. Burbano, Teresa Woelfer, Naomi Vlegels, Fanny Quandt, Hanna Zimmermann, Johannes Wischmann, Lars Kellert, Thomas Liebig, Konstantinos L. Dimitriadis, Jeffrey Saver, Steffen Tiedt, GSR Investigators
Summary: Experimental and neuroimaging studies suggest that the time of day has an impact on acute infarct growth, but its relevance in patient selection for acute treatments is uncertain. In a study involving 9357 stroke patients receiving endovascular treatment, morning treatment was associated with the lowest 90-day mRS scores. Successful recanalization had a stronger effect on outcome in morning-treated patients, and the treatment benefit lasted longer compared to evening-treated patients, indicating that the time of day might have implications for patient selection in EVT.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Hematology
Zeinab Afify, Manuela Orjuela-Grimm, Christine Moore Smith, Mansi Dalal, James B. Ford, Pallavi Pillai, Joanna M. Robles, Sonika Reddy, Sarah McCormack, Matthew J. Ehrhardt, Tonya Ureda, Warren Alperstein, Holly Edington, Tamara P. Miller, Jeremy D. Rubinstein, Madison Kavanaugh, Andrew J. Bukowinski, Erika Friehling, Julie M. Rivers, Karen M. Chisholm, Lianna J. Marks, Clinton C. Mason
Summary: PSOT-BL is a clinically aggressive malignancy and a rare form of PTLD. Most patients developed PSOT-BL more than 2 years after transplantation. Heart and liver were the most frequently transplanted organs. The outcomes of intensive regimens for PSOT-BL patients are comparable to immunocompetent children with BL. Multi-institutional collaboration is important for collecting prospective data to determine the optimal treatment regimen.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Surgery
Belle Liew, David Nasralla, Satheesh Iype, Joerg-Matthias Pollok, Brian Davidson, Dimitri A. Raptis
Summary: Machine perfusion, especially hypothermic machine perfusion, showed advantages in reducing early allograft dysfunction and improving recipient outcomes in liver transplant surgeries. Normothermic machine perfusion was associated with reduced graft injury and major complication risks. Both techniques have the potential to lead to cost savings.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Franchin, Francesca Mauri, Federico Fontana, Filippo Piacentino, Luca Guzzetti, Matti Jubouri, Mohamad Bashir, Gabriele Piffaretti
Summary: The aim of this study was to evaluate the incidence and outcomes of ischaemic organ complications after thoracic endovascular aortic repair (TEVAR). The study found that aortic arch atherosclerotic overload and the presence of shaggy aorta are predictors of organ ischaemic complications following TEVAR, which are associated with perioperative mortality, prolonged hospitalization, and a negative impact on long-term survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Surgery
Adrian Diaz, Rachel O'Reggio, Marc Norman, Jyothi R. Thumma, Justin B. Dimick, Andrew M. Ibrahim
Summary: This study evaluated the association between historical racist housing policies and modern-day healthcare outcomes. Patients residing in neighborhoods previously redlined or labeled Hazardous were more likely to experience worse outcomes after inpatient hospitalization compared to those living in Best neighborhoods, even after taking into account modern day measures of neighborhood disadvantage.
Article
Medicine, General & Internal
S. Ali Husain, Kristen L. King, Navin Sanichar, R. John Crew, Jesse D. Schold, Sumit Mohan
Summary: The study found that living donor kidney transplants from donors biologically related to their recipients had higher rates of allograft failure than transplants from donors unrelated to their recipients after HLA matching was accounted for. This association was mainly observed in recipients without cystic kidney disease and transplants from African American donors. Further research is needed to explore the factors contributing to this finding.
Article
Rehabilitation
Alison M. Cogan, Jennifer A. Weaver, David A. Ganz, Leslie Davidson, Keith R. Cole, Trudy Mallinson
Summary: This study investigated the association between therapy minutes per length of stay (LOS) day and functional outcomes among older adults after elective hip or knee replacement surgery. It found that participants with high gain trajectories achieved better functional independence at discharge regardless of therapy duration. Factors such as postsurgical pain and older age were significantly associated with lower odds of being in the medium or high gain rate groups.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Surgery
Michael C. Madigan, Anthony J. Lewis, Nathan L. Liang, Robert Handzel, Eric Hager, Michel S. Makaroun, Rabih A. Chaer, Mohammad H. Eslami
Summary: Nonoperative management of low-grade blunt traumatic aortic injury does not result in long-term complications or the need for reintervention. Select grade 3 injuries with smaller pseudoaneurysms and minimal periaortic hematoma can be safely observed.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Immunology
Fabiana G. Marcondes-Braga, Ciro M. Murad, Deborah S. P. Belfort, Rafael C. T. Dantas, Maria Tereza S. S. Lira, Carlos A. S. Aragao, Rinaldo F. Siciliano, Sandrigo Mangini, Luis Fernando B. C. Seguro, Iascara W. Campos, Monica S. Avila, Mariana V. O. Bello, Fernanda B. A. dos Santos, Tania M. Strabelli, Fabio A. Gaiotto, Fernando Bacal
Summary: This study investigates the characteristics and outcomes of heart transplant recipients infected with SARS-CoV-2. The findings reveal a high hospitalization rate and mortality rate in these patients. A subset of patients experienced severe disease and had lower lymphocyte counts during follow-up. Longer follow-up also showed an increased mortality rate, with bacterial infections being the leading cause of death. Cardiac allograft rejection and ventricular dysfunction were also notable. Strict midterm surveillance is recommended for heart transplant recipients with COVID-19.
Article
Cardiac & Cardiovascular Systems
Joshua C. Grimm, Vicente Valero, Arman Kilic, Todd C. Crawford, John V. Conte, Christian A. Merlo, Pali D. Shah, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Joshua C. Grimm, Cecillia Lui, Arman Kilic, Vicente Valero, Christopher M. Sciortino, Glenn J. R. Whitman, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2015)
Editorial Material
Surgery
S. C. Sweet, A. S. Shah
AMERICAN JOURNAL OF TRANSPLANTATION
(2014)
Article
Anesthesiology
Charles H. Brown, Maura Grega, Ola A. Selnes, Guy M. McKhann, Ashish S. Shah, Andrew LaFlam, William J. Savage, Steven M. Frank, Charles W. Hogue, Rebecca F. Gottesman
ANESTHESIA AND ANALGESIA
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, John V. Conte, William A. Baumgartner, Stuart D. Russell, Christian A. Merlo, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2014)
Letter
Cardiac & Cardiovascular Systems
R. Scott Stephens, Ashish S. Shah, Glenn J. R. Whitman
ANNALS OF THORACIC SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Vasileios Karantalis, Darcy L. DiFede, Gary Gerstenblith, Si Pham, James Symes, Juan Pablo Zambrano, Joel Fishman, Pradip Pattany, Ian McNiece, John Conte, Steven Schulman, Katherine Wu, Ashish Shah, Elayne Breton, Janice Davis-Sproul, Richard Schwarz, Gary Feigenbaum, Muzammil Mushtaq, Viky Y. Suncion, Albert C. Lardo, Ivan Borrello, Adam Mendizabal, Tomer Z. Karas, John Byrnes, Maureen Lowery, Alan W. Heldman, Joshua M. Hare
CIRCULATION RESEARCH
(2014)
Article
Cardiac & Cardiovascular Systems
Josef Stehlik, Lynne W. Stevenson, Leah B. Edwards, Maria G. Crespo-Leiro, Juan F. Delgado, Richard Dorent, Maria Frigerio, Peter Macdonald, Guy A. MacGowan, Alessandro Nanni Costa, Joseph G. Rogers, Ashish S. Shah, Rhiannon Taylor, Rajaiyer V. Venkateswaran, Mandeep R. Mehra
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Jason O. Robertson, Maria V. Grau-Sepulveda, Shoichi Okada, Sean M. O'Brien, J. Matthew Brennan, Ashish S. Shah, Akinobu Itoh, Ralph J. Damiano, Sunil Prasad, Scott C. Silvestry
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Ryan J. Tedford, Claude A. Beaty, Stephen C. Mathai, Todd M. Kolb, Rachel Damico, Paul M. Hassoun, Peter J. Leary, David A. Kass, Ashish S. Shah
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Ashish S. Shah, John V. Conte, Kaushik Mandal, William A. Baumgartner, Duke E. Cameron, Glenn J. R. Whitman
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Joshua C. Grimm, Ashish S. Shah, John V. Conte, Glenn J. R. Whitman, Christopher M. Sciortino
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Ashish S. Shah, James H. Black, Glenn J. R. Whitman, David D. Yuh, Duke E. Cameron, John V. Conte
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Surgery
George J. Arnaoutakis, Gregory J. Bittle, Jeremiah G. Allen, Eric S. Weiss, Jennifer Alejo, William A. Baumgartner, Ashish S. Shah, Christopher L. Wolfgang, David T. Efron, John V. Conte
WORLD JOURNAL OF SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Clinton D. Kemp, George J. Arnaoutakis, Timothy J. George, Maurice A. Smith, Nishant D. Patel, Duke E. Cameron, Ashish S. Shah
JOURNAL OF HEART VALVE DISEASE
(2013)