Article
Oncology
Sophie H. H. Chung, Susanna W. L. de Geus, Grant Shewmaker, Kelsey S. S. Romatoski, Frederick T. T. Drake, Naomi Y. Y. Ko, Andrea L. L. Merrill, Ariel E. E. Hirsch, Jennifer F. F. Tseng, Teviah E. E. Sachs, Michael R. R. Cassidy
Summary: This study compared the survival outcomes of men with positive sentinel lymph nodes after either sentinel lymph node biopsy (SLNB) alone or complete axillary dissection (ALND) in breast cancer. The results showed that ALND was associated with superior survival compared to SLNB alone in early-stage male breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
Jing Si, Rong Guo, Huan Pan, Xiang Lu, Zhiqin Guo, Chao Han, Li Xue, Dan Xing, Wanxin Wu, Caiping Chen
Summary: The aim of this study was to determine whether breast cancer patients with mastectomy and false-negative frozen section in sentinel lymph node biopsy (SLNB) could forgo axillary lymph node dissection (ALND). The study found that SLNB and axillary radiation therapy could effectively replace ALND in selected patients who met specific criteria.
FRONTIERS IN ONCOLOGY
(2022)
Review
Obstetrics & Gynecology
Stamatios Petousis, Panagiotis Christidis, Chrysoula Margioula-Siarkou, Anastasios Liberis, Eleftherios Vavoulidis, Georgia Margioula-Siarkou, Anastasia Vatopoulou, Alexios Papanikolaou, George Mavromatidis, Konstantinos Dinas
Summary: This study compared the survival outcomes of systematic axillary lymph node dissection (ALND) with sentinel lymph node dissection (SLN +/- ALND) in early-stage clinically node-negative breast cancer patients. The results showed that there was no significant difference in survival outcomes between the two procedures.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Oncology
Amparo Garcia-Tejedor, Carlos Ortega-Exposito, Sira Salinas, Ana Luzardo-Gonzalez, Catalina Falo, Evelyn Martinez-Perez, Hector Perez-Montero, M. Teresa Soler-Monso, Maria-Teresa Bajen, Ana Benitez, Raul Ortega, Anna Petit, Anna Guma, Miriam Campos, Maria J. Pla, Sonia Pernas, Judith Penafiel, Carlos Yeste, Miguel Gil-Gil, Ferran Guedea, Jordi Ponce, Maria Laplana
Summary: This study aims to evaluate whether axillary radiotherapy (ART) is non-inferior to axillary lymph node dissection (ALND) in patients with limited lymphatic involvement after neoadjuvant systemic treatment (NST), and whether it reduces surgery-related adverse effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Vanessa Monteiro Sanvido, Simone Elias, Gil Facina, Silvio Eduardo Bromberg, Afonso Celso Pinto Nazario
Summary: The study evaluated the overall survival and locoregional recurrence of patients with invasive breast tumors and sentinel node metastasis who underwent sentinel lymph node dissection (SLND) alone versus complete axillary lymph node dissection (ALND). The results showed that there were similar outcomes in overall survival and locoregional recurrence between the two groups, supporting the feasibility of de-escalating ALND to SLND in certain cases.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ya Qiu, Xiang Zhang, Zhiyuan Wu, Shiji Wu, Zehong Yang, Dongye Wang, Hongbo Le, Jiaji Mao, Guochao Dai, Xuwei Tian, Renbing Zhou, Jiayi Huang, Lanxin Hu, Jun Shen
Summary: The MRI-clinical-radiomics nomograms developed in this study showed high predictive performance in determining axillary NSLN status in SLN-positive breast cancer patients, reducing overtreatment and optimizing personalized surgical strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lei Liu, Yaoxin Lin, Guozheng Li, Lei Zhang, Xin Zhang, Jiale Wu, Xinheng Wang, Yumei Yang, Shouping Xu
Summary: This study developed a preoperative prediction model based on a nomogram to assist in selecting proper surgical procedures for T1-2 breast cancer patients with only one sentinel lymph node (SLN) metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Nur Amalina Che Bakri, Richard M. Kwasnicki, Naairah Khan, Omar Ghandour, Alice Lee, Yasmin Grant, Aleksander Dawidziuk, Ara Darzi, Hutan Ashrafian, Daniel R. Leff
Summary: This study evaluated the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb morbidity in breast cancer patients. The results showed that ALND patients had higher prevalence of lymphedema, pain, reduced strength, and range of motion compared with SLNB patients. These findings support the continued de-escalation of axillary surgery.
Article
Medicine, General & Internal
Se Hyun Oh, Ju Hyeon Kim, Seung Tae Seong, Jun Young Park, Jae Hyun Lee, Ghi Chan Kim, Ho Joong Jeong, Young Joo Sim
Summary: This study investigated the impact of axillary site radiation therapy on lymphoscintigraphy in breast cancer-related lymphedema patients who underwent sentinel lymph node dissection. The results suggest that both SLND and aRTx affect the activity of axillary lymph nodes and adversely affect lymphatic flow, becoming risk factors for lymphedema. Additionally, lymphedema may develop even in patients with normal lymphoscintigraphy.
Article
Oncology
Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng, Gaosong Wu
Summary: ALND based on BLL can minimize surgical extent for node-positive breast cancer patients, potentially reducing the occurrence of BCRL.
Article
Oncology
Qiufan Zheng, Hanjia Luo, Wen Xia, Qianyi Lu, Kuikui Jiang, Ruoxi Hong, Fei Xu, Shusen Wang
Summary: This study found significant differences in overall survival and breast cancer-specific survival between SLNB and ALND, with SLNB showing a slight survival advantage.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Surgery
Y. Andersson, L. Bergkvist, J. Frisell, J. de Boniface
Summary: The SENOMIC trial found that omitting axillary lymph node dissection in patients with breast cancer and sentinel node micrometastases had excellent 3-year event-free survival rates. However, patients who underwent mastectomy had worse tumor characteristics and higher risk of recurrence, especially without adjuvant radiotherapy. Long-term follow-up and enrollment of mastectomy patients are crucial.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Arielle P. Stafford, Tanya L. Hoskin, Courtney N. Day, Stacy B. Sanders, Judy C. Boughey
Summary: Management strategies of axilla in breast cancer patients with one or two positive sentinel lymph nodes vary, with lower rates of axillary lymph node dissection after breast-conserving surgery and higher rates after mastectomy. Factors such as age, tumor grade, and tumor size play a role in determining the need for axillary lymph node dissection.
ANNALS OF SURGICAL ONCOLOGY
(2022)
