Journal
MOLECULES
Volume 20, Issue 8, Pages 14611-14620Publisher
MDPI
DOI: 10.3390/molecules200814611
Keywords
Paraconiothynium brasiliense; endophytic fungus; sesquiterpenoid
Funding
- National Natural Science Foundation of China [81273395]
- Key Program of National Hi-Tech Research and Development [2012AA021703]
- Program of the Excellent Youth Scientists of Chinese Academy of Sciences
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2011083]
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Brasilamides K-N (1-4), four new bergamotane sesquiterpenoids; with 4-oxatricyclo (3.3.1.0 (2,7))nonane (1)and 9-oxatricyclo(4.3.0.0 (4,7))nonane (2-4) skeletons; were isolated from the scale-up fermentation cultures of the plant endophytic fungus Paraconiothynium brasiliense Verkley. The previously identified sesquiterpenoids brasilamides A and C (5 and 6) were also reisolated in the current work. The structures of 1-4 were elucidated primarily by interpretation of NMR spectroscopic data. The absolute configurations of 1-3 were deduced by analogy to the co-isolated metabolites 5 and 6; whereas that of C-12 in 4 was assigned using the modified Mosher method. The cytotoxicity of all compounds against a panel of eight human tumor cell lines were assayed.
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