Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Environmental Sciences
Yun-Fei Su, Cheng Li, Jing-Jing Xu, Fang-Yue Zhou, Tao Li, Cong Liu, Yan-Ting Wu, He-Feng Huang
Summary: Despite previous research on the effect of air pollutants on preterm birth (PTB), this study investigated the impact of particulate matter (PM) on PTB subtypes in Shanghai. Short-term exposure to PM2.5 and PM10 was positively associated with PTB and spontaneous preterm birth (sPTB) at a lag of 2 days. Long-term exposure to PM2.5 and PM10 in the 3rd trimester and 3 months before conception was associated with greater odds of sPTB and medically indicated preterm birth (miPTB). The findings suggest that different underlying causes of PTB may influence the susceptibility windows of PM exposure.
Article
Endocrinology & Metabolism
Yiting Mao, Chen Zhang, Yinyu Wang, Yicong Meng, Lei Chen, Cindy-Lee Dennis, Jianzhong Sheng, Yanting Wu, Hefeng Huang
Summary: The study identified a relationship between paternal age and infant birth weight, with advanced paternal age increasing the risk of SGA among preterm infants and LGA among term infants. These findings suggest potential implications for preconception care and the need for antenatal monitoring.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: This study found that preterm delivery is associated with an increased risk of stroke, which remains elevated for at least 40 years after delivery and is independent of other factors and familial influences.
Article
Pediatrics
Carrie Townley Flores, Amy Gerstein, Ciaran S. Phibbs, Lee M. Sanders
Summary: The study found that moderate and late preterm birth is associated with increased risks of low performance in mathematics and English language arts, chronic absenteeism, and suspension in young children, with the impact being most significant in late elementary school but diminishing in later grades.
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Shiran Zer, Tamar Wainstock, Eyal Sheiner, Shayna Miodownik, Gali Pariente
Summary: This study investigated the relationship between gestational age at birth and long-term neurological morbidity in preterm infants, finding a critical threshold at delivery before 25 weeks gestation. Infants born before this threshold had significantly higher risks for neurological morbidity and cerebral palsy, as shown by Cox models and Kaplan-Meier survival curves.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: The study found a significant association between preterm delivery and future risk of chronic hypertension in women, with elevated risks remaining at least 40 years later and largely independent of other maternal and shared familial factors. Preterm delivery should be recognized as a lifelong risk factor for hypertension in women.
Article
Obstetrics & Gynecology
L. H. Theilen, I. Hammad, H. Meeks, A. Fraser, T. A. Manuck, M. W. Varner, K. R. Smith
Summary: A retrospective cohort study in Utah from 1939 to 1977 found that women with spontaneous preterm birth (PTB) may have increased risks for long-term mortality. The study showed that spontaneous PTB was associated with higher all-cause mortality and cause-specific mortality, including deaths from neoplasms, circulatory disease, respiratory disease, digestive disease, genitourinary disease, and external causes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Geriatrics & Gerontology
David D. Dore, Lonnita Myles, Amy Recker, Dustin Burns, Catherine Rogers Murray, David Gifford, Vincent Mor
Summary: Despite advances in connecting Medicare claims and Minimum Data Set (MDS) information, the data infrastructure for long-term care is insufficient for public health surveillance and clinical research. Electronic health records (EHRs) have the potential to improve representation of nursing home residents in clinical research and provide more timely and detailed clinical information. The National Institute on Aging has funded the Long-Term Care (LTC) Data Cooperative to address the data gap in nursing homes and facilitate the use of comprehensive patient records for healthcare operations, research, and public health surveillance.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Marina Sanches Montemor, Gabriella Ferreira Demarque, Agatha Sacramento Rodrigues, Rossana Pulcinelli Vieira Francisco, Mario Henrique Burlacchini de Carvalho
Summary: This study examines the association between development and equality indices with the incidence of preterm birth in Brazil. The results indicate that areas with lower education levels and unequal income distribution have a higher proportion of spontaneous preterm birth, while elective preterm birth is positively associated with more advantaged socioeconomic status.
Article
Surgery
Jorge I. Portuondo, Kamal M. F. Itani, Nader N. Massarweh
Summary: The objective of this study was to evaluate the relationship between postoperative complications and long-term survival. The results showed that postoperative complications have an adverse impact on the risk of death in the immediate postoperative period as well as on long-term survival. This suggests that further investigation is needed to understand the longer-term implications of complications in addition to their perioperative impact.
Article
Environmental Sciences
Jennifer J. Yland, Yu Zhang, Paige L. Williams, Vicente Mustieles, Stylianos Vagios, Irene Souter, Antonia M. Calafat, Russ Hauser, Carmen Messerlian
Summary: This study found that preconception and prenatal exposure to phthalates may increase the risk of preterm birth, particularly in late pregnancy, especially the DEHP metabolites. This suggests that these chemicals may have adverse effects on women's health and fetal development.
ENVIRONMENTAL POLLUTION
(2022)
Article
Oncology
A. K. Warps, R. A. E. M. Tollenaar, P. J. Tanis, J. W. T. Dekker
Summary: Complications after colorectal cancer surgery can have a significant impact on long-term survival. Non-surgical complications have a greater effect on survival than surgical complications. The impact of surgical complications on survival is still measurable in rectal cancer patients after surviving the first year, but not in colon cancer patients.
Article
Endocrinology & Metabolism
Tobias Ruzok, Benita Schmitz-Koep, Aurore Menegaux, Robert Eves, Marcel Daamen, Henning Boecker, Esther Rieger-Fackeldey, Josef Priller, Claus Zimmer, Peter Bartmann, Dieter Wolke, Christian Sorg, Dennis M. Hedderich
Summary: Premature birth is associated with an increased risk of impaired body weight gain, potentially due to altered structure of hypothalamic nuclei involved in body weight control.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anish S. Kolan, Julianne M. Hall
Summary: Several studies have shown that endocrine disrupting chemicals (EDCs) can have harmful effects on various systems of the human body. This review summarizes the investigations into the impact of EDC exposure on reproductive systems, specifically preterm birth (PTB), and the efforts of international organizations to reduce the harmful effects of EDC exposure. The studies examined the association between EDCs and PTB, and although the findings differed, they collectively provide sufficient evidence of a possible link between EDC exposure and the risk of PTB. Therefore, international organizations such as the United Nations Environmental Programme (UNEP) and World Health Organization (WHO) should continue to regulate EDC exposure globally and monitor levels among individuals of reproductive age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
