Article
Biochemistry & Molecular Biology
Qingqing Wang, Zihou Liu, Rui Wang, Run Li, Xiaoru Lian, Yanquan Yang, Jiao Yan, Zhiqi Yin, Guangji Wang, Jianguo Sun, Ying Peng
Summary: This study investigated the additional benefits of Ginkgo biloba extract (GBE) in combination with statins for the treatment of dyslipidaemia. The results showed that the combination therapy significantly improved blood lipid parameters, reduced liver fat content, and had additional liver protection. GBE also regulated abnormal lipid metabolism and increased the exposure of statins in plasma, providing important implications for disease progression and statin resistance.
Article
Pharmacology & Pharmacy
Li-Wei Liu, He-Ying Yue, Jing Zou, Meng Tang, Fan-Mei Zou, Zhuo-Lun Li, Qing-Quan Jia, Yu-Bo Li, Jian Kang, Li-Hua Zuo
Summary: This study explored the neuroprotective effects of Ginkgo biloba leaf extract (GBLE) on Alzheimer's disease (AD) and its potential mechanism. The results showed that GBLE significantly improved cognitive function and reduced amyloid beta deposition in AD mice. Metabolomic and lipidomic analysis revealed that lipid metabolism was perturbed in AD mice, and GBLE restored the lipid metabolic balance. This study provides insights into the potential pathogenesis of AD and the therapeutic mechanism of GBLE.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sandra Maria Barbalho, Rosa Direito, Lucas Fornari Laurindo, Ledyane Taynara Marton, Elen Landgraf Guiguer, Ricardo de Alvares Goulart, Ricardo Jose Tofano, Antonely C. A. Carvalho, Uri Adrian Prync Flato, Viviane Alessandra Capelluppi Tofano, Claudia Rucco Penteado Detregiachi, Patricia C. Santos Bueno, Raul S. J. Girio, Adriano Cressoni Araujo
Summary: Ginkgo biloba is associated with memory and cognitive improvement and has potential effects on preventing and treating aging-related diseases through its antiapoptotic, antioxidant, and anti-inflammatory actions.
Article
Chemistry, Medicinal
Yun Wang, Yuanyuan Xu, Xiaowei Xu, Hong Wang, Dong Wang, Wenchao Yan, Jiaying Zhu, Haiping Hao, Guangji Wang, Lijuan Cao, Jun Zhang
Summary: This study confirmed the beneficial effects of Ginkgo biloba leave extract (GbE) in alleviating hypercholesterolemia, inflammation, and atherosclerosis. GbE treatment reshaped the intestinal microbiota, downregulated proinflammatory cytokines, and enhanced the expression of tight junction proteins. It also reversed the dysfunction of microbial metabolic phenotypes and reduced atherosclerotic plaque areas. These findings provide important insights into the pharmacological mechanism underlying the antiatherogenic efficacy of GbE.
PHYTOTHERAPY RESEARCH
(2022)
Article
Nutrition & Dietetics
Tingting Chen, Yiqiang Chen, Kaiyuan Li, Zhuo Chen, Qingyu Zhao, Yimeng Fan, Ying Liu, Suxia Zhang, Zhihui Hao
Summary: Ginkgo biloba extract (GBE) can modulate intestinal microbiota, decrease pro-inflammatory factors, elevate intestinal integrity, and protect animals from Citrobacter rodentium (CR)-induced colitis. Therefore, GBE should be seriously considered in the preventive control of CR-induced colitis and the development of effective and safe therapeutic strategies for controlling IBD.
Article
Nutrition & Dietetics
Marta Sochocka, Michal Ochnik, Maciej Sobczynski, Katarzyna Gebura, Aleksandra Zambrowicz, Piotr Naporowski, Jerzy Leszek
Summary: This study investigated the effect of Ginkgo biloba extract (EGb) on the mechanisms of innate immune response in peripheral blood leukocytes (PBLs) of Alzheimer's disease (AD) patients. The results showed that EGb had a beneficial effect, especially in AD women, as it reduced the production of inflammatory cytokines and downregulated the expression of inflammatory-associated genes.
Article
Chemistry, Medicinal
Fernanda Malanconi Thomaz, Jussara de Jesus Simao, Viviane Simoes da Silva, Meira Maria Forcelini Machado, Lila Missae Oyama, Eliane Beraldi Ribeiro, Maria Isabel Cardoso Alonso Vale, Monica Marques Telles
Summary: The study found that Ginkgo biloba extract (GbE) can modulate adipocyte differentiation, increasing lipid content and gene expression of major adipogenesis markers. GbE can modify key proteins involved in the differentiation process and accelerate the expression of mature adipocyte proteins.
Article
Chemistry, Medicinal
Jia Ke, Meng-Ting Li, Ya-Jing Huo, Yan-Qiong Cheng, Shu-Fen Guo, Yang Wu, Lei Zhang, Jianpeng Ma, Ai-Jun Liu, Yan Han
Summary: Our study showed that the combination of GBE50 and aspirin could enhance the antiplatelet effects by synergistic and additive effects, with stronger inhibition of platelet aggregation. GBE50 interfered with platelet aggregation through cAMP pathway, AA metabolism and calcium signaling pathway, while aspirin regulated platelet aggregation through AA metabolism and platelet activation. Demonstrating the potential application of GBE50 as a supplementary therapy for thrombosis-related diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Plant Sciences
Han-Yang Lin, Wen-Hao Li, Chen-Feng Lin, Hao-Ran Wu, Yun-Peng Zhao
Summary: This article provides detailed information on the biology of Ginkgo biloba, covering its ecological characteristics, distribution, habitat, responses to environment and biotic factors, physiological structure, reproductive and seed characters, and the impact of diseases and pests. Ginkgo has a strong adaptability globally, with high tolerance to temperature variations, drought, and fire. Stem rot and leaf blight are common diseases in nursery seedlings and juvenile trees, which can be mitigated through shading and fertilization. Ginkgo biloba is one of the world's most distinctive trees, with significant importance in plant evolution and human society.
JOURNAL OF ECOLOGY
(2022)
Review
Cell Biology
Liming Xie, Qi Zhu, Jiahong Lu
Summary: The study shows that Ginkgo biloba extract (GBE) has the potential to improve symptoms associated with Alzheimer's disease (AD) and consistently displays anti-AD effects in both preclinical and clinical trials. However, the studies are limited by poor method quality and inadequate sample size calculations.
Article
Biochemistry & Molecular Biology
Ke Wang, Yuan Chen, Xue Zhu, Wenjun Zou, Fanfan Zhou
Summary: The study demonstrates the protective effect of Ginkgo biloba extract (GBE) on photoreceptors against white light-induced oxidative damage. This effect is mediated through the modulation of CAV-1-redoxosome signaling, showing potential therapeutic benefits in preventing retinal degenerative diseases.
Article
Chemistry, Physical
Shujun Chen, Hai Zhang, Yujie Qiang, Bochuan Tan, Yuanhui Wu, Siyi Chen
Summary: A self-assembled monolayer (SAM) based on Ginkgo biloba exocarp extract (GBEE) was successfully formed on a copper surface, exhibiting efficient inhibition behavior. Characterization of the GBEE SAM using Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and contact angle tests confirmed the hydrophobic nature of the SAM. Electrochemical measurements and scanning electron microscopy revealed that the SAM showed excellent anti-corrosion performance with a high inhibition efficiency of 97.86%. Theoretical calculations were also conducted to further understand the adsorption and inhibition mechanism of the GBEE SAM.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Shuang Su, Xue-Qiong Yang, Ya-Bin Yang, Zhong-Tao Ding
Summary: Five new terpenoids, including a polyketide-terpenoid hybrid paraphaone and four eremophilane sesquiterpenoids, were isolated from the endophytic fungus Paraphaeosphaeria sp. cultured with Ginkgo biloba extract. These compounds exhibited significant antifungal and antifeedant activities against various phytopathogens and entomopathogens. The culture of Paraphaeosphaeria sp. using Ginkgo biloba medium could be a potential source of agricultural antibiotics.
Article
Plant Sciences
Marija Kovac Tomas, Iva Jurcevic, Dunja Samec
Summary: In this study, a HPLC-DAD method was developed to separate and determine five major biflavonoids in ginkgo. Tissue-specific profiling revealed that biflavonoids were not detected in plant parts not in direct contact with the environment. Leaves had the highest total biflavonoids content, with sciadopitysin being the predominant compound, while amentoflavone was the predominant biflavonoid in the bark.
Review
Pharmacology & Pharmacy
Zarko Kulic, Martin D. Lehner, Gunnar P. H. Dietz
Summary: The phytochemical composition of extracts derived from the same plant can vary significantly, affecting their pharmacokinetic and pharmacodynamic properties, and ultimately their clinical efficacy and safety. Regulating active constituent levels and reducing undesired substances is vital for ensuring the quality and consistency of herbal extracts. The heterogeneity of extracts should be carefully considered when evaluating the efficacy and safety of plant-derived remedies.
FRONTIERS IN PHARMACOLOGY
(2022)