Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Miruna Nemecz, Diana Simona Stefan, Ioana Karla Comarita, Alina Constantin, Gabriela Tanko, Cristian Guja, Adriana Georgescu
Summary: In this study, miR-218, miR-132, and miR-143 were identified as significantly up-regulated miRNAs in both circulating MVs and plasma from diabetic patients with dyslipidemia. These miRNAs showed significant correlations with important plasma markers representative of this pathology.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Oncology
Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi, Yufeng Yao
Summary: Our study suggests that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222 may play important roles in the development of CIN or CC.
Article
Medicine, General & Internal
Aiste Kondrotiene, Albertas Dauksa, Daina Pamedytyte, Mintaute Kazokaite, Aurelija Zvirbliene, Dalia Dauksiene, Vaida Simanaviciene, Raimonda Klimaite, Ieva Golubickaite, Rytis Stakaitis, Valdas Sarauskas, Rasa Verkauskiene, Birute Zilaitiene
Summary: Expressions of miR-21, miR-221, miR-222, and miR-181b are associated with clinicopathological parameters and high expression levels are related to adverse outcomes. Gender and age are identified as independent prognostic factors for patients with papillary thyroid carcinoma.
Article
Biochemistry & Molecular Biology
Pelin Telkoparan-Akillilar, Dilek Cevik
Summary: The study aimed to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222, and CHOP in patients with atherosclerosis compared to healthy controls. It was found that miR-17 and miR-106b were significantly increased in patients, while miR-21, miR-27a, and miR-222 were significantly decreased. Additionally, CHOP gene was significantly induced in patient samples.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Immunology
Shun Yuan, Qi Wu, Zhiwei Wang, Yanjia Che, Sihao Zheng, Yuanyang Chen, Xiaohan Zhong, Feng Shi
Summary: miR-223 is a crucial microRNA that plays important regulatory roles in the immune response, with abnormal expression associated with various infectious diseases such as viral hepatitis, HIV-1, and tuberculosis. The understanding of miR-223 physiopathology and its molecular mechanism in regulating immune responses to infectious diseases could lead to targeted diagnosis and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shohei Kaneko, Katsunori Yanai, Hiroki Ishii, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
Summary: The role of exogenous miRNAs in renal fibrosis was investigated using a mouse model. miR-122-5p was found to be downregulated in the kidneys of mice with renal fibrosis. Overexpression of miR-122-5p promoted fibrosis, while inhibition of miR-122-5p suppressed fibrosis. miR-122-5p regulated the expression of fibrosis-related mRNAs, including pro-fibrotic TGFBR2 and anti-fibrotic FOXO3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ayman Mohamed Metwally, Ameera Abdel Hamed Mahmoud Kasem, Magda Ismail Youssif, Safia Mohammed Hassan, Abdel Hady A. Abdel Wahab, Lobna Ahmed Refaat
Summary: The study aimed to determine the prognostic significance of serum miR-222-3p, miR-26b-5p, EBV-miR-BHRF1-2-5p, and EBV-miR-BHRF1-2-3p in DLBCL and correlate their levels with clinical and haematological markers. The study also investigated the role of BM BMI1 and PIM2 proteins in predicting BM infiltration. It was found that all the studied miRNAs were dysregulated in DLBCL serum samples.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Review
Medicine, General & Internal
Mingyu Shi, Qianying Lu, Yanmei Zhao, Ziling Ding, Sifan Yu, Junfeng Li, Mengjun Ji, Haojun Fan, Shike Hou
Summary: Small noncoding RNAs, microRNAs (miRNAs), play a crucial role in regulating various biological processes. The miRNA miR-223, which is expressed in myeloid lineage cells, is conserved throughout evolution and involved in the regulation of monocyte-macrophage differentiation, proinflammatory responses, and neutrophil recruitment. This review outlines the regulatory role of miR-223 in different cell types and summarizes its potential role in pulmonary inflammatory diseases such as COPD, ALI, COVID-19, providing insights into the molecular regulatory networks in these diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Linyuan Shen, Tianci Liao, Jingyun Chen, Jianfeng Ma, Jinyong Wang, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Changjun Zeng, Mailin Gan, Li Zhu
Summary: The study identified miR-221 and miR-222 and their target genes MyoG and Tnnc1 as key regulators during skeletal muscle regeneration, both regulated by GEN. GEN promotes satellite cell differentiation during skeletal muscle regeneration by inhibiting the expression of miR-221/222.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Cardiac & Cardiovascular Systems
My-Anh Nguyen, Huy-Dung Hoang, Adil Rasheed, Anne-Claire Duchez, Hailey Wyatt, Mary Lynn Cottee, Tyson E. Graber, Leah Susser, Sabrina Robichaud, Ibrahim Berber, Michele Geoffrion, Mireille Ouimet, Hilal Kazan, Lars Maegdefessel, Erin E. Mulvihill, Tommy Alain, Katey J. Rayner
Summary: miR-223 acts as a key regulator in macrophages, protecting against atherosclerosis by modulating cholesterol metabolism and inflammation pathways.
CIRCULATION RESEARCH
(2022)
Article
Neurosciences
Li Wu, Qian Xu, Mengxi Zhou, Yajing Chen, Chunyan Jiang, Yuhan Jiang, Yin Lin, Qing He, Lei Zhao, Yourong Dong, Jianren Liu, Wei Chen
Summary: Plasma levels of miR-153 and miR-223 were found to be significantly decreased in Parkinson's disease patients. MiR-153 levels were closely associated with disease duration and clinical phenotype, while miR-223 levels were linked to the presence of rapid eye movement sleep behavior disorder. These miRNAs could potentially serve as biomarkers for Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Adam M. Collison, Leon A. Sokulsky, Elizabeth Kepreotes, Ana Pereira de Siqueira, Matthew Morten, Michael R. Edwards, Ross P. Walton, Nathan W. Bartlett, Ming Yang, Thi Hiep Nguyen, Sebastian L. Johnston, Paul S. Foster, Joerg Mattes
Summary: Virus-induced respiratory infections, particularly with rhinoviruses, have significant health impacts on children. Inhibition of miRNA 122 (miR-122) shows promise in reducing inflammation and airway hyperreactivity induced by RV infections, with potential implications for treating bronchiolitis and asthma exacerbations. High miR-122 levels are associated with poorer clinical outcomes, suggesting anti-miR-122 oligonucleotides could be a therapeutic option.
Letter
Immunology
Rebecca N. Kumar, En-Ling Wu, Valentina Stosor, William J. Moore, Chad Achenbach, Michael G. Ison, Michael P. Angarone
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Candice J. McNeil, Jennifer S. Lee, Stephen R. Cole, Shivani A. Patel, Jeffrey Martin, William C. Mathews, Richard D. Moore, Kenneth H. Mayer, Joseph J. Eron, Michael S. Saag, Mari M. Kitahata, Chad J. Achenbach
Summary: This clinical cohort study found that Black MSM were at significantly increased risk for anal cancer compared to non-Black MSM. Further studies are necessary to evaluate factors impacting anal cancer incidence and outcomes in Black men with HIV.
Article
Infectious Diseases
Sarah J. Willis, H. Nina Kim, Chad J. Achenbach, Edward R. Cachay, Katerina A. Christopoulos, Heidi M. Crane, Ricardo A. Franco, Christopher B. Hurt, Mari M. Kitahata, Richard D. Moore, Michael J. Silverberg, Phyllis C. Tien, Daniel Westreich, Julia L. Marcus
Summary: This study assessed the incidence of extrahepatic cancer among people with HIV/HCV coinfection and found that the risk of any extrahepatic cancer among patients with untreated HCV coinfection at baseline was similar to the risk if they had been successfully treated for HCV, but not statistically significant. Treating HCV coinfection with DAAs did not show evidence of reducing the incidence of extrahepatic cancers among people with HIV receiving ART.
Article
Infectious Diseases
Omar Al-Heeti, Rebecca N. Kumar, Kendall Kling, Michael Angarone, Chad Achenbach, Babafemi Taiwo
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Lacy M. Simons, Ramon Lorenzo-Redondo, Meg Gibson, Sarah L. Kinch, Jacob P. Vandervaart, Nina L. Reiser, Mesut Eren, Elizabeth Lux, Elizabeth M. McNally, Anat R. Tambur, Douglas E. Vaughan, Kelly E. R. Bachta, Alexis R. Demonbreun, Karla J. F. Satchell, Chad J. Achenbach, Egon A. Ozer, Michael G. Ison, Judd F. Hultquist
Summary: This study found that the outcome of COVID-19 is associated with factors such as gender, age, body mass index, 4C Mortality score, and lactate dehydrogenase levels. Only the retrospectively calculated median Deterioration Index score was significantly associated with death. Furthermore, viral load was not significantly associated with outcome, suggesting that immune dysfunction plays a more crucial role in disease severity.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
En-Ling Wu, Rebecca N. Kumar, W. Justin Moore, Gavin T. Hall, Indre Vysniauskaite, Kwang-Youn A. Kim, Michael P. Angarone, Valentina Stosor, Michael G. Ison, Adam Frink, Chad J. Achenbach, Khalilah L. Gates
Summary: This study aimed to explore the impact of race/ethnicity on monoclonal antibody therapy. The study found that in high-risk ambulatory adult COVID-19 patients, those who identified as Hispanic/Latinx or Black were less likely to receive monoclonal antibody therapy, with insurance status, language, and social vulnerability contributing to these racial disparities.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Oncology
Jessica L. Castilho, Aihua Bian, Cathy A. Jenkins, Bryan E. Shepherd, Keith Sigel, M. John Gill, Mari M. Kitahata, Michael J. Silverberg, Angel M. Mayor, Sally B. Coburn, Dorothy Wiley, Chad J. Achenbach, Vincent C. Marconi, Ronald J. Bosch, Michael A. Horberg, Charles S. Rabkin, Sonia Napravnik, Richard M. Novak, W. Christopher Mathews, Jennifer E. Thorne, Jing Sun, Keri N. Althoff, Richard D. Moore, Timothy R. Sterling, Staci L. Sudenga
Summary: Low CD4/CD8 ratio is associated with increased cancer risk in PWH in the USA and Canada.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Nutrition & Dietetics
Thanh-Huyen T. Vu, Linda Van Horn, Chad J. Achenbach, Kelsey J. Rydland, Marilyn C. Cornelis
Summary: In the UKB cohort study, increased consumption of coffee, tea, oily fish, and fruit were found to be favorably associated with incident pneumonia/influenza, while increased consumption of red meat was adversely associated. These associations were similar for influenza, with only associations with tea and oily fish meeting statistical significance. The association between fruit consumption and pneumonia risk was stronger in women than in men.
Article
Oncology
Maxwell O. Akanbi, Lucy A. Bilaver, Chad Achenbach, Lisa R. Hirschhorn, Adovich S. Rivera, Olugbenga A. Silas, Patricia A. Agaba, Oche Agbaji, Nathan Y. Shehu, Solomon A. Sagay, Lifang Hou, Robert L. Murphy
Summary: This study analyzed data from adults receiving outpatient HIV care in Nigeria from 2006 to 2017 and found that the prevalence of HIV-associated Kaposi Sarcoma (KS) at enrollment did not significantly decline despite the expansion of antiretroviral therapy (ART). The low CD4 cell count at entry indicated a delay in HIV care enrollment, which increased the risk of KS. Early HIV diagnosis and linkage to ART interventions are critical in reducing KS risk in this population.
INFECTIOUS AGENTS AND CANCER
(2022)
Article
Public, Environmental & Occupational Health
Jonah Musa, Kyeezu Kim, Yinan Zheng, Yishu Qu, Brian T. Joyce, Jun Wang, Drew R. Nannini, Demirkan B. Gursel, Olugbenga Silas, Fatimah B. Abdulkareem, Godwin Imade, Alani S. Akanmu, Jian-Jun Wei, Masha Kocherginsky, Kwang-Youn A. Kim, Firas Wehbe, Chad J. Achenbach, Rose Anorlu, Melissa A. Simon, Atiene Sagay, Folasade T. Ogunsola, Robert L. Murphy, Lifang Hou
Summary: PhenoAA is associated with ICC in HIV-infected women, suggesting its potential as a biomarker for risk stratification of HIV-associated ICC in resource-constrained settings.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Alexander L. Lundberg, Ramon Lorenzo-Redondo, Judd F. Hultquist, Claudia A. Hawkins, Egon A. Ozer, Sarah B. Welch, P. V. Vara Prasad, Chad J. Achenbach, Janine White, James F. Oehmke, Robert L. Murphy, Robert J. Havey, Lori A. Post
Summary: The study shows that countries already in a Delta outbreak when Omicron arrived took longer to reach peak infection rates and saw a significant increase in the average apex of the Omicron outbreak. This suggests that high levels of Delta community transmission did not provide protection at the time of Omicron detection, but rather led to larger outbreaks in those countries.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Public, Environmental & Occupational Health
Djeneba Dabitao, Amadou Somboro, Ibrahim Sanogo, Bassirou Diarra, Chad J. Achenbach, Jane L. Holl, Bocar Baya, Moumine Sanogo, Mamadou Wague, Nadie Coulibaly, Mahamadou Kone, Hawa Baye Drame, Mohamed Tolofoudie, Bourahima Kone, Ayouba Diarra, Mamadou D. Coulibaly, Kathryn Saliba-Shaw, Yacouba Toloba, Mahamadou Diakite, Seydou Doumbia, Sabra L. Klein, William R. Bishai, Souleymane Diallo, Robert L. Murphy
Summary: Men and women respond differently to tuberculosis, with men having a higher incidence rate and showing greater effects before treatment initiation and during the intensive phase of treatment.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Kendall D. Kling, Patrick Janulis, Alexis R. Demonbreun, Amelia Sancilio, Baiba Berzins, Karen Krueger, Chad Achenbach, Rachelle Price, Margaret Sullivan, Matthew Caputo, Sara Hockney, Teresa Zembower, Thomas W. McDade, Babafemi Taiwo
Summary: Little is known about antibody response following booster vaccination in people living with HIV (PLWH). This study found that PLWH and controls without HIV had similar antibody levels and viral neutralization responses after a single SARS-CoV-2 booster vaccination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Adovich S. Rivera, Omar Al-Heeti, Lucia C. Petito, Mathew J. Feinstein, Chad J. Achenbach, Janna Williams, Babafemi Taiwo
Summary: In this observational study, it was found that pre-hospital statin use in COVID-19 patients aged 40 and above was associated with slightly lower rates of intubation and ICU admission. However, there was no significant difference in inpatient mortality between statin users and non-users. Therefore, the current COVID-19 treatment guidelines do not support the use of statins for reducing severe inpatient outcomes.
BMC INFECTIOUS DISEASES
(2023)
Article
Microbiology
Jacob P. Vandervaart, Nicole L. Inniss, Ted Ling-Hu, George Minasov, Grant Wiersum, Monica Rosas-Lemus, Ludmilla Shuvalova, Chad J. Achenbach, Judd F. Hultquist, Karla J. F. Satchell, Kelly E. R. Bachta
Summary: This study defines the antigenic regions of the SARS-CoV-2 nucleocapsid protein using structural biology and epitope mapping. The protein is highly immunogenic and its antibodies are commonly used as markers for prior infection. The study identified several epitope regions and reported the X-ray structure of the protein. These findings contribute to the development of diagnostics and vaccines.
MICROBIOLOGY SPECTRUM
(2023)