Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Biochemistry & Molecular Biology
Dahae Lee, Ji-Youn Kim, Hae-Won Kim, Jeong-Eun Yoo, Ki Sung Kang
Summary: The combination of genistein and atorvastatin significantly suppresses preadipocyte differentiation and downregulates adipogenic marker proteins, suggesting a potential alternative treatment for menopause-associated lipid metabolic disorders and obesity.
Article
Food Science & Technology
Jinhee Song, Hana Lee, Huijin Heo, Junsoo Lee, Younghwa Kim
Summary: We investigated the effects of chrysoeriol on fat cell formation and breakdown and identified the underlying mechanisms. Chrysoeriol inhibited fat accumulation in adipocytes and downregulated the expression of key genes involved in fat synthesis. Furthermore, chrysoeriol activated a protein kinase that promotes fat breakdown and increased the levels of free glycerol and fatty acids. Overexpression of specific enzymes for fat breakdown contributed to the enhanced lipolysis induced by chrysoeriol. Overall, chrysoeriol exhibited anti-adipogenic and lipolytic properties in fat cells.
Article
Biochemistry & Molecular Biology
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Seung Hyun Kim, Dong-Wook Kim, Ki Sung Kang
Summary: The study investigated the anti-adipogenic effects of hispidulin and p-synephrine alone and in combination, with the combination showing greater inhibition of lipid droplet formation. It may be a potential alternative strategy for developing novel anti-obesity drugs.
Article
Agriculture, Multidisciplinary
Jianwei Cui, Chengping Li, Xiao Cui, Xueyan Liu, Chaoqun Meng, Guoli Zhou
Summary: The study investigates the role of HO1 in preadipocyte differentiation and finds that the HO1 3'UTR short variant, produced by APA, escapes microRNA inhibition and has a stronger inhibitory effect on preadipocyte differentiation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Melania Iara Funk, Melisa Ailen Conde, Graciela Piwien-Pilipuk, Romina Maria Uranga
Summary: Inhibition of adipocyte differentiation by menadione, a synthetic form of vitamin K, is mediated, at least in part, by increased ROS and lipid peroxidation, leading to decreased intracellular lipid accumulation and triglyceride content by inhibiting the PI3K/Akt pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Ji Soo Lee, In Kyung Hyun, Hye-Jin Seo, Dahyun Song, Min Young Kim, Seok-Seong Kang
Summary: The study demonstrated that whey biotransformed by Weissella cibaria can reduce lipid accumulation and intracellular triglycerides in adipocytes, by suppressing the expression of adipogenic-related transcription factors and target genes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Toxicology
Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez
Summary: Butyltins and phenyltins, widely used organometallic chemicals, have been found to stimulate adipogenic differentiation. Among them, tributyltin (TBT) is the most potent inducer, followed by triphenyltin (TPT) and dibutyltin (DBT). However, TPT and DBT can weaken the adipogenic effect of TBT. These findings indicate the antagonistic effects among organotins and the involvement of PPAR gamma signaling in their adipogenic outcomes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinsoo Kim, Dohee Ahn, Sang J. Chung
Summary: This study identified chebulinic acid as a potential therapeutic agent for treating obesity by inhibiting PPP1CB activity and suppressing adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Beth A. Griesel, Satoshi Matsuzaki, Albert Batushansky, Timothy M. Griffin, Kenneth M. Humphries, Ann Louise Olson
Summary: This study using 3T3-L1 adipocytes as a model system found that an increase in glucose uptake during the first 3 days of differentiation promoted the expansion of the adipocyte metabolome and proteome. The positive effects were specifically due to increased expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), highlighting its critical role in regulating cellular metabolic remodeling for adipocyte differentiation and maturation.
Article
Biochemistry & Molecular Biology
Leo Man-Yuen Lee, Zhi-Qiang Lin, Lu-Xi Zheng, Yi-Fan Tu, Yik-Hing So, Xiu-Hua Zheng, Tie-Jun Feng, Xi-Yue Wang, Wai-Ting Wong, Yun-Chung Leung
Summary: Growing evidence shows that restricting amino acid intake can reverse obesity by reducing adipose tissue mass. Amino acids not only serve as building blocks for proteins but also play a role as signaling molecules in various biological processes. Understanding how adipocytes respond to changes in amino acid levels is crucial for studying obesity and developing potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Aina Lluch, Jessica Latorre, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: Substantial levels of lysozyme in adipose tissue have been found in association with obesity in mice and humans. This study investigates the role of lysozyme in adipogenesis, focusing on its expression and impact during 3T3-L1 adipocyte differentiation. The results suggest that lysozyme expression is important for the expression of adipogenic genes and adipocyte differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Czajka, Krzysztof Sawicki, Magdalena Matysiak-Kucharek, Marcin Kruszewski, Jacek Kurzepa, Paulina Wojtyla-Buciora, Lucyna Kapka-Skrzypczak
Summary: Chlorpyrifos, a representative of organophosphorus pesticides, has effects on the viability, proliferation, differentiation, and fatty acid uptake in 3T3-L1 cells. Exposure to chlorpyrifos decreases cell viability but increases it at low concentrations. It inhibits proliferation and differentiation of preadipocytes, reduces lipid accumulation, and down-regulates key transcription factors. In fully differentiated adipocytes, chlorpyrifos increases basal free fatty acid uptake. These findings suggest that chlorpyrifos may play a role in the development of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Food Science & Technology
Wenrui Liu, Lihua Wang, Jie Zhang
Summary: Peanut shells, as agricultural waste, contain luteolin (LUT) which has anti-obesity properties. The study found that the extract from peanut shells can inhibit adipogenesis, accelerate lipolysis, and promote lipid browning, making it a potential dietary supplement for weight management.
Article
Chemistry, Analytical
Gill-Woong Jang, Sun-Il Choi, Xionggao Han, Xiao Men, Hee-Yeon Kwon, Ye-Eun Choi, Mi-Hye Park, Ok-Hwan Lee
Article
Biochemistry & Molecular Biology
Min Woo Baek, Han Ryul Choi, Tifsehit Solomon, Cheon Soon Jeong, Ok-Hwan Lee, Shimeles Tilahun
Summary: The research findings demonstrate that preharvest MeJA treatment can significantly enhance the phytochemical composition and antioxidant activities of hydroponically grown pak choi. Hydroponically grown MeJA-treated pak choi shows higher levels of chlorophylls, total phenolics, GSLs, total flavonoids, and stronger antioxidant capacities compared to soil-grown counterparts.
Article
Biochemistry & Molecular Biology
Hee-Yeon Kwon, Sun-Il Choi, Xionggao Han, Xiao Men, Gill-Woong Jang, Ye-Eun Choi, Ok-Hwan Lee
Summary: This study established an extraction method to optimize the sinigrin content in Brassica juncea and confirmed the antiobesity mechanism of the extract. In the study, lipid accumulation and ROS production were significantly suppressed in both the BJJ extract and sinigrin-treated groups. It was also found that the expression of proteins regulating lipid accumulation, fatty acid oxidation, heat generation, and energy metabolism was effectively controlled by the BJJ extract and sinigrin, indicating their potential as a health functional food material for obesity.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hee-Do Hong, Sun-Il Choi, Ok-Hwan Lee, Young-Cheul Kim
Summary: The study demonstrates that ginsenosides Rb1 and Rg3 found in red ginseng have positive effects on adipocyte differentiation and the insulin signaling pathway, with the combination of Rb1 and Rg3 showing superior results.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Sun-Il Choi, Hee-Yeon Kwon, Im-Joung La, Yeon-Hui Jo, Xionggao Han, Xiao Men, Se-Jeong Lee, Yong-Deok Kim, Geum-Su Seong, Ok-Hwan Lee
Summary: The study demonstrated changes in bioactive compounds in Morinda citrifolia L. through fermentation, while also developing an HPLC analysis method for measuring these compounds, with validation in terms of precision and accuracy.
Article
Biochemical Research Methods
Yiwu Yan, Bo Zhou, Yeon-Joo Lee, Sungyong You, Michael R. Freeman, Wei Yang
Summary: This study identified UBR5 as a key E3 ubiquitin ligase in prostate cancer progression, with its expression levels strongly associated with disease aggressiveness. The research revealed that UBR5 influences PC cell sensitivity to the PARP inhibitor olaparib, suggesting potential benefits for patients with UBR5-high tumors in PARP inhibitor treatment.
Article
Multidisciplinary Sciences
Yiwu Yan, Bo Zhou, Chen Qian, Alex Vasquez, Mohini Kamra, Avradip Chatterjee, Yeon-Joo Lee, Xiaopu Yuan, Leigh Ellis, Dolores Di Vizio, Edwin M. Posadas, Natasha Kyprianou, Beatrice S. Knudsen, Kavita Shah, Ramachandran Murali, Arkadiusz Gertych, Sungyong You, Michael R. Freeman, Wei Yang
Summary: RIPK2 is identified as a potential therapeutic target for inhibiting prostate cancer metastasis. It is amplified/gained in about 65% of lethal metastatic castration-resistant prostate cancer cases. RIPK2 regulates the stability and activity of c-Myc by activating MKK7, and inhibiting RIPK2 signaling effectively impairs prostate cancer metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Agronomy
Min Woo Baek, Han Ryul Choi, Lee Yun Jae, Ho-Min Kang, Ok-Hwan Lee, Cheon Soon Jeong, Shimeles Tilahun
Summary: The preharvest treatment of 0.25 mM methyl jasmonate (MeJA) and 0.5 mM salicylic acid (SA) had significant positive effects on the yield and quality parameters of 'Kumato' tomatoes, including increasing important secondary metabolites, amino acids, and antioxidant activities. MeJA treatment was found to be more effective than SA in improving the yield and nutritional quality of 'Kumato' tomatoes.
Article
Chemistry, Multidisciplinary
Xionggao Han, Sun-Il Choi, Xiao Men, Se-Jeong Lee, Heegu Jin, Hyun-Ji Oh, Eunjin Kim, Jongwook Kim, Boo-Yong Lee, Ok-Hwan Lee
Summary: The study evaluated the anti-obesity effect of ESETM extract and found that it can inhibit adipogenesis and lipid accumulation, reducing weight change. The results suggest that ESETM may regulate weight through adipogenesis, lipogenesis, lipolysis, and thermogenesis pathways.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Sun-Il Choi, Xionggao Han, Se-Jeong Lee, Xiao Men, Geon Oh, Doo-Sik Lee, Ok-Hwan Lee
Summary: In this study, a simple analytical method using HPLC-PDA was developed to detect thiabendazole in frequently consumed foods in South Korea. The method showed good sensitivity and precision, and was applicable for both solid and liquid food samples.
Article
Nutrition & Dietetics
Xiao Men, Xionggao Han, Se-Jeong Lee, Geon Oh, Keun-Tae Park, Jong-Kwon Han, Sun-Il Choi, Ok-Hwan Lee
Summary: It was found that broccoli sprout powder, mustard seed powder, and sulforaphane-rich mixture powder have anti-obesogenic effects by inhibiting adipocyte differentiation and adipogenesis, and by increasing the expression of proteins related to lipid metabolism and lipolysis.
Article
Cell Biology
Hyun-Ji Oh, Heegu Jin, Byung-Yong Kim, Ok-Hwan Lee, Boo-Yong Lee
Summary: A natural compound CHDT, made from Angelica gigas and Artemisia dracunculus, has been found to potentially prevent muscle atrophy by regulating the Akt/mTOR signaling pathway and reducing the production of inflammatory cytokines.
Article
Chemistry, Multidisciplinary
Sun-Il Choi, Xionggao Han, Xiao Men, Se-Jeong Lee, Geon Oh, Ye-Eun Choi, Jung-Mo Yang, Ju-Hyun Cho, Ok-Hwan Lee
Summary: This study aimed to determine the anti-osteoporosis effect of Benincasa hispida extract and 2-furoic acid in ovariectomy-induced osteoporosis in mice. The results showed that bone density and bone formation markers were significantly recovered in the supplementation groups of 2-furoic acid and high-dose Benincasa hispida extract. Furthermore, bone resorption markers were significantly decreased in these supplementation groups. These findings suggest that Benincasa hispida extract could be used to prevent ovariectomy-induced osteoporosis and bone metabolic diseases.
APPLIED SCIENCES-BASEL
(2023)
Review
Food Science & Technology
Xiao Men, Xionggao Han, Geon Oh, Ji-Hyun Im, June Seok Lim, Geun Hee Cho, Sun-Il Choi, Ok-Hwan Lee
Summary: Sulforaphane (SFN) is a commonly found isothiocyanate in cruciferous vegetables. It has various biological effects and is widely used in functional foods and clinical medicine. However, its unstable structure and degradability limit its application. Therefore, studying its properties, stability, and finding methods to increase its content are of great importance.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Xiao Men, Sun-Il Choi, Xionggao Han, Hee-Yeon Kwon, Gill-Woong Jang, Ye-Eun Choi, Sung-Min Park, Ok-Hwan Lee
Summary: Pumpkin is widely planted and rich in nutrients, with potential anti-obesity, anti-diabetic, antibacterial, and anticancer effects, attracting attention in the medical field. Further research is needed to understand its mechanisms and potential benefits.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)