Article
Immunology
Monisha Sharma, Edinah Mudimu, Kate Simeon, Anna Bershteyn, Jienchi Dorward, Lauren R. Violette, Adam Akullian, Salim S. Abdool Karim, Connie Celum, Nigel Garrett, Paul K. Drain
Summary: Based on data from the STREAM trial in South Africa, point-of-care (POC) testing is a promising strategy to improve patient outcomes in moderately sized clinics in South Africa. Results are most sensitive to changes in the intervention impact on enrollment into community-based ART delivery.
Article
Multidisciplinary Sciences
Melanie Plazy, Adama Diallo, Thabile Hlabisa, Nonhlanhla Okesola, Collins Iwuji, Kobus Herbst, Sylvie Boyer, France Lert, Nuala McGrath, Deenan Pillay, Francois Dabis, Joseph Larmarange, Joanna Orne-Gliemann
Summary: This study reports on the implementation and effectiveness of a linkage-to-care intervention in rural South Africa, which involved tracking HIV-positive individuals through phone calls and home visits. The results showed that this intervention was effective in improving the linkage-to-care rate among patients.
Article
Immunology
Brian Arthur Sekiziyivu, Elizabeth Bancroft, Evelyn M. Rodriguez, Samuel Sendagala, Muniina Pamela Nasirumbi, Marjorie Sserunga Najjengo, Agnes N. Kiragga, Joseph Musaazi, Joshua Musinguzi, Enos Sande, Bartholow Brad, Shona Dalal, Tusiime Byakika-Jayne, Andrew Kambugu
Summary: The study showed that in Uganda, nurse-initiated and monitored ART is noninferior to clinician-initiated and monitored ART in treating HIV-infected patients. Future research should evaluate NIMART for other populations such as children, adolescents, and unstable patients.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Multidisciplinary Sciences
Adam Akullian, Alain Vandormael, Joel C. Miller, Anna Bershteyn, Edward Wenger, Diego Cuadros, Dickman Gareta, Till Barnighausen, Kobus Herbst, Frank Tanser
Summary: In a hyper-epidemic region of KwaZulu-Natal, South Africa, the median age of HIV seroconversion increased in both men and women, suggesting a changing demographic of HIV risk with a focus on younger age groups. The decline in HIV incidence was more pronounced in young men and women, while older individuals showed stable or even lagging declines in incidence. These results provide direct epidemiological evidence of the impact of large-scale treatment and prevention interventions on the age distribution of HIV incidence in sub-Saharan Africa.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Infectious Diseases
Barbara Rossetti, Massimiliano Fabbiani, Domenico Di Carlo, Francesca Incardona, Ana Abecasis, Perpetua Gomes, Anna Maria Geretti, Carole Seguin-Devaux, Federico Garcia, Rolf Kaiser, Sara Modica, Adrian Shallvari, Anders Sonnerborg, Maurizio Zazzi
Summary: This large multi-cohort study indicates high effectiveness of elvitegravir- or dolutegravir-based first-line ART in routine practice across Europe. Factors such as baseline viral load and CD4 cell count can affect the treatment outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Yann Ruffieux, Tafadzwa Dhokotera, Mazvita Muchengeti, Lina Bartels, Victor Olago, Julia Bohlius, Elvira Singh, Matthias Egger, Eliane Rohner
Summary: This study examined cancer incidence in adolescents and young adults living with HIV in South Africa from 2004 to 2014. The results showed that infection-related cancers were the most common types of cancer in this population, and their occurrence rates were higher with lower CD4 cell counts.
Review
Virology
Abdulhammed O. Babatunde, Oluwawapelumi D. Akin-Ajani, Ridwanullah O. Abdullateef, Taofeeq O. Togunwa, Haroun O. Isah
Summary: Africa accounts for two-thirds of global new HIV infections. Ten countries, including South Africa, Nigeria, Mozambique, and Kenya, were responsible for 80% of HIV cases in Africa in 2014. This study evaluates the antiretroviral therapy (ART) coverage strategies implemented by these countries and highlights the importance of community-based and digital health approaches in increasing ART coverage and retention. Challenges such as funding shortages and cultural/religious beliefs need to be addressed to achieve the 95-95-95 goal by 2030.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Kimesha Pillay, Lara Lewis, Santhuri Rambaran, Nonhlanhla Yende-Zuma, Derseree Archary, Santhanalakshmi Gengiah, Dhineshree Govender, Razia Hassan-Moosa, Natasha Samsunder, Salim S. Abdool Karim, Lyle R. McKinnon, Nesri Padayatchi, Kogieleum Naidoo, Aida Sivro
Summary: The study suggests that increased risk of TB recurrence in HIV infected individuals on ART is likely associated with HIV mediated translocation of microbial products and resulting chronic immune activation. This indicates that immunological markers play an important role in the risk of TB recurrence.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Health Care Sciences & Services
Sunny C. Okoroafor, Christmal Dela Christmals
Summary: A scoping review was conducted to synthesize evidence on task shifting and task sharing in Africa. The review identified 61 studies, with 53 providing insights on the rationale and scope of task shifting and task sharing. The rationales included health worker shortages, optimal utilization of existing health workers, and expanding access to health services. The scope of services shifted or shared in 23 countries included HIV/AIDS, tuberculosis, hypertension, diabetes, mental health, eyecare, maternal and child health, sexual and reproductive health, surgical care, medicines' management, and emergency care.
Article
Multidisciplinary Sciences
Ines Mendoza, Alicia Lazaro, Alfredo Espinosa, Lorenzo Sanchez, Ana Maria Horta, Miguel Torralba
Summary: This study shows that dolutegravir plus lamivudine (2-DR) is not as effective as bictegravir/emtricitabine/tenofovir alafenamide (3-DR) in treating HIV-1. However, the durability and safety of 2-DR are similar to 3-DR.
Article
Multidisciplinary Sciences
Nolwenn Conan, Erica Simons, Menard L. Chihana, Liesbet Ohler, Ellie FordKamara, Mduduzi Mbatha, Gilles VanCutsem, Helena Huerga
Summary: The viral suppression among people living with HIV in Eshowe/Mbongolwane, South Africa has significantly improved from 2013 to 2018, but young men have a lower suppression rate and women and older adults have a higher rate of unsuppressed viral load. Specific strategies are needed to increase viral suppression in these groups.
Review
Multidisciplinary Sciences
Marijanatu Abdulai, David Owiredu, Isaac Boadu, Philip Teg-Nefaah Tabong, Bismark Sarfo, Harriet Affran Bonful, Adolphina Addo- Lartey, Kwadwo Owusu Akuffo, Anthony Danso-Appiah
Summary: This study aims to explore the types and effectiveness of psychosocial interventions for improving the quality of life of elderly people living with HIV in Sub-Saharan Africa. By conducting a systematic review, researchers will collect and analyze relevant research data, providing reliable evidence for improving HIV care for this vulnerable population.
Article
Infectious Diseases
Guillaume Breton, Oumou Hawa Diallo, Mohamed Cisse, Oumou Hawa Diallo, Nene Aissatou Diallo, Seny Agnes Soumaoro, Yalikhatou Camara, Alice Montoye, Christine Rouzioux, Youssouf Koita, Gilles Peytavin, Roland Tubiana, Pierre Prange
Summary: This study investigated the feasibility of reinforced antiretroviral prophylaxis and early infant diagnosis in high-risk infants. The study found that reinforced antiretroviral prophylaxis and early infant diagnosis at birth are widely feasible. However, the lack of maternal disclosure of HIV status and the stigma associated with it affect the assessment of mother-to-child transmission risk and follow-up.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Ranjeeta Thomas, William J. M. Probert, Rafael Sauter, Lawrence Mwenge, Surya Singh, Sarah Kanema, Nosivuyile Vanqa, Abigail Harper, Ronelle Burger, Anne Cori, Michael Pickles, Nomtha Bell-Mandla, Blia Yang, Justin Bwalya, Mwelwa Phiri, Kwame Shanaube, Sian Floyd, Deborah Donnell, Peter Bock, Helen Ayles, Sarah Fidler, Richard J. Hayes, Christophe Fraser, Katharina Hauck
Summary: The HPTN 071 (PopART) trial showed that a combination HIV prevention package including universal HIV testing and treatment (UTT) reduced population-level incidence of HIV compared with standard care. The study simulated the costs and cost-effectiveness of the PopART intervention in Zambia and South Africa, showing that combination prevention with universal home-based testing can be delivered at low annual cost per person and is cost-effective in reducing HIV incidence in high-prevalence settings.
LANCET GLOBAL HEALTH
(2021)
Review
Multidisciplinary Sciences
Mulugeta Melku, Hailay Abrha Gesesew, Paul R. Ward
Summary: HIV drug resistance (HIVDR) is becoming a global concern, particularly in Africa. This systematic review aims to estimate the prevalence of HIVDR and its mutations among people living with HIV/AIDS (PLWH) in Africa. The study will also identify factors associated with HIVDR. The findings from this review will provide important insights for improving HIV treatment outcomes in Africa and globally.
Article
Infectious Diseases
Caroline Lions, Helene Laroche, Marion Mora, Gilles Pialoux, Laurent Cotte, Eric Cua, Lionel Piroth, Jean Michel Molina, Maria Salnikova, Gwenaelle Maradan, Isabelle Poizot-Martin, Bruno Spire
Summary: This study aimed to investigate missed opportunities for the use of Pre-Exposure Prophylaxis (PrEP) in people recently diagnosed with HIV, factors associated with PrEP knowledge, and reasons for not using PrEP. The results showed that there were gaps in the provision of PrEP information by healthcare providers and low acceptability of PrEP among eligible patients. Therefore, it is necessary to involve more diverse healthcare providers in prescribing PrEP and raise awareness among at-risk populations about the risk of HIV infection.
Article
Infectious Diseases
Antoine Bachelard, Valentina Isernia, Charlotte Charpentier, Aida Benalycherif, Marion Mora, Cecile Donadille, Claudine Duvivier, Karine Lacombe, Mayssam El Mouhebb, Bruno Spire, Roland Landman, Diane Descamps, Gilles Peytavin, Lambert Assoumou, Jade Ghosn, FAST sty grp
Summary: Initiating same-day ART for newly HIV-diagnosed individuals reduces transmission risk and improves treatment adherence. The BIC/FTC/TAF regimen has been shown to be safe, effective, and well accepted for same-day initiation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Paul Le Turnier, Isabelle Charreau, Audrey Gabassi, Diane Carette, Laurent Cotte, Gilles Pialoux, Cecile Tremblay, Bruno Spire, Marie-Laure Chaix, Laurence Meyer, Catherine Capitant, Constance Delaugerre, Francois Raffi, Jean-Michel Molina
Summary: Vaccination against hepatitis A virus (HAV) and hepatitis B virus (HBV) is recommended in men who have sex with men (MSM). This study assessed the uptake of HAV and HBV vaccines in non-immune participants and their immunisation during follow-up in the ANRS IPERGAY pre-exposure prophylaxis (PrEP) trial.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Immunology
Christian Laurent, Issifou Yaya, Benjamin Cuer, Luis Sagaon-Teyssier, Ephrem Mensah, Ter Tiero Elias Dah, Alou Coulibaly, Malan Jean-Baptiste Kouame, Gilles Peytavin, Laetitia Serrano, August Eubanks, Issa Traore, Fodie Diallo, Lucas Riegel, Daniela Rojas Castro, Claver A. Dagnra, Camille Anoma, Bea Vuylsteke, Bintou Dembele Keita, Bruno Spire
Summary: This study aimed to investigate HIV seroconversion, PrEP adherence, plasma drug concentrations, and HIV drug resistance among men who have sex with men (MSM) using event-driven or daily PrEP in West Africa. The results showed that participants who chose event-driven PrEP had higher HIV incidence and lower adherence. Improving adherence to event-driven PrEP is a major research and public health priority in this context.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
C. Protiere, L. Sagaon-Teyssier, C. Donadille, A. Sow, G. Gaubert, G. Girard, M. Mora, L. Assoumou, L. Beniguel, D. Michels, J. Ghosn, D. Costagliola, D. Rojas Castro, J. -M. Molina, B. Spire
Summary: Since the introduction of HIV pre-exposure prophylaxis (PrEP), stigma has been a significant barrier to its acceptance and adherence. This study aimed to determine the proportion of PrEP users who believe that taking PrEP can negatively affect their image and identify the factors associated with this perception.
Article
Medicine, General & Internal
Elisa Ruiz-Burga, Shema Tariq, Giota Touloumi, John Gill, Emily Jay Nicholls, Caroline Sabin, Cristina Mussini, Laurence Meyer, Alain Volny Anne, Christina Carlander, Sophie Grabar, Inma Jarrin, Marc Van der Valk, Linda Wittkop, Bruno Spire, Nikos Pantazis, Fiona M. Burns, Kholoud Porter
Summary: This study aims to understand the current drivers of the HIV epidemic in Europe, factors associated with access to, and uptake of prevention methods and ART initiation, and the experiences, needs, and outcomes of people with recently acquired HIV.
Article
Public, Environmental & Occupational Health
Thijs Reyniers, Stephane Alain Yoro Babo, Mamadou Ouedraogo, Ibrahima Kanta, Laurette Ekon Agbegnigan, Daniela Rojas, August Eubanks, Camille Anoma, Ter Tiero Elias Dah, Ephrem Mensah, Bintou Dembele Keita, Bruno Spire, Bea Vuylsteke, Christian Laurent
Summary: This study aimed to explore the perceptions of West African men who have sex with men (MSM) toward pre-exposure prophylaxis (PrEP) and their proposed strategies to overcome barriers to PrEP uptake. The results showed that participants were generally positive toward PrEP and suggested three main strategies for increasing its uptake, including raising awareness and improving knowledge of HIV, improving the dissemination of PrEP, and strategies to avoid stigmatization.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Policy & Services
Marion Fiorentino, Abdouramane Coulibaly, Aliou Kamissoko, Souleymane Drame, Aichata Kone, Sokona Traore, Mariam Kone, Sitan Fofana, Fatoumata Kanicomo, Gname Bagayoko, Mamadou Cisse, Gabriel Girard, Bruno Spire, Bintou Dembele Keita, Luis Sagaon-Teyssier
Summary: Most domestic servants in Mali are young female migrants living in precarious conditions. The attitudes of their employers greatly impact their physical and mental health, as well as the type of healthcare they receive. Violence, poor HIV/STI prevention knowledge, and unwanted pregnancies are significant risks for domestic servants. They express interest in receiving healthcare from community organizations due to fear of discrimination in healthcare facilities.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Health Policy & Services
M. Perray, D. Traore, L. Riegel, D. Rojas Castro, B. Spire, M. Mora, A. Yattassaye, M. Preau
Summary: Gundo-So is a community-based programme developed in Mali to support women living with HIV (WLHIV) in deciding whether to disclose their status. The ANRS-12373 research aims to evaluate the short and medium-term impact of this programme. Interviews with participants (14) were analyzed thematically, revealing positive feedback regarding emotional and financial support provided by the programme, the creation of new social connections, and improved disease management and psychosocial resources. Overall, the programme empowered participants and enhanced social support for WLHIV.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Review
Public, Environmental & Occupational Health
Victoire Sawras, Sylvie Deuffic-Burban, Marie Preau, Bruno Spire, Yazdan Yazdanpanah, Karen Champenois
Summary: This review explores the effectiveness of partner notification interventions for STIs and HIV, and identifies the need for more comprehensive outcomes and data to better understand the impact of these interventions.
Article
Immunology
Liem Binh Luong Nguyen, Jeanne Goupil de Bouille, Lola Menant, Marion Noret, Audrey Dumas, Maud Salmona, Jerome Le Goff, Constance Delaugerre, Pascal Crepey, Jeremy Zeggagh, ITOC Study Grp
Summary: In the context of low circulation of the Delta variant, there was no evidence of SARS-CoV-2 transmission among fully vaccinated participants in an indoor clubbing event. However, there was an increased risk of other respiratory virus infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Tangui Barre, David Zucman, Fabienne Marcellin, Clemence Ramier, Camelia Protopopescu, Raphaelle Tardieu, Karine Ory, Dominique Salmon-Ceron, Patrizia Carrieri
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Virology
Martine Peeters, Maeliss Champagne, Innocent Ndong Bass, Souana Goumou, Simon-Pierre Ndimbo Kumugo, Audrey Lacroix, Amandine Esteban, Dowbiss Meta Djomsi, Abdoul Karim Soumah, Placide Mbala Kingebeni, Flaubert Auguste Mba Djonzo, Guy Lempu, Guillaume Thaurignac, Eitel Mpoudi Ngole, Charles Kouanfack, Daniel Mukadi Bamuleka, Jacques Likofata, Jean-Jacques Muyembe Tamfum, Helene De Nys, Julien Capelle, Abdoulaye Toure, Eric Delaporte, Alpha Kabinet Keita, Steve Ahuka Mundeke, Ahidjo Ayouba
Summary: The seroprevalence of orthoebolaviruses was studied in bats from Cameroon, the Democratic Republic of Congo, and Guinea. The results showed that frugivorous bats had a higher seroprevalence compared to insectivorous bats. Gender and age had a minor impact on seroprevalence, but subadult bats had a higher seroprevalence. Further research is needed to determine the birthing pulses of bats and to detect viral RNA in order to understand the genetic diversity of filoviruses in bats and their potential pathogenicity to humans.
Article
Health Care Sciences & Services
Emilie Mosnier, Fernanda Artigas, Elodie Richard, Maxime Hoyer, David Michels, Stephanie Vandentorren, Gabriel Girard, Nicolas Nagot, Hippolyte Regnault, Marine Mosnier, Grace Inegbeze, Perrine Roux, Bruno Spire, Carole Eldin
Summary: The FASSETS study aims to improve knowledge of and access to sexual health care and PrEP among migrant women sex workers through targeted empowerment strategies.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Psychology, Clinical
Marion Fiorentino, Bakary Coulibaly, Clotilde Couderc, Bintou Dembele Keita, Camille Anoma, Elias Dah, Ephrem Mensah, Thomas Niamkey Aka, Juste Rodrigue Toure, Drissa Camara, Anouwarsadat Rodolphe Kokouba, Gwenaelle Maradan, Marion Mora, Michel Bourrelly, Lucas Riegel, Daniela Rojas-Castro, Bruno Spire, Christian Laurent, Luis Sagaon-Teyssier
Summary: HIV is highly prevalent in men who have sex with men (MSM) in West Africa. Many MSM in the region also have sex with women (MSMW), which increases the risk of HIV transmission to female partners. A study conducted in Burkina Faso, Cote d'Ivoire, Mali, and Togo found that nearly half of the MSMW participants were at a high behavioral risk of acquiring HIV from male partners and transmitting it to female partners. Factors associated with this high risk behavior included young age, exclusive attraction to men, feelings of loneliness, and homonegative violence. The study highlights the need for tailored HIV research and prevention strategies for MSMW and their female partners.
ARCHIVES OF SEXUAL BEHAVIOR
(2023)