Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 48, Issue 5, Pages 577-580Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e31817bbea5
Keywords
T-regulatory cells; CD4+; T cells; HIV-specific immunity; Candida-specific immunity; immune activation; HIV
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Background: Human immunodeficiency virus (HIV) infection is associated with abnormalities in T-regulatory (T-reg) cells, but the effect of HIV on the naive (CD45RO(-)) and memory (CD45RO(+)) CD25(+)CD127(lo)CD4(+) T-reg cell subsets has not been defined. Methods: We measured the absolute number and relative percentage of total, naive, and memory T-reg cells in HIV-infected subjects and compared these parameters with their CD4(+) T cells, viral load, levels of immune activation, and pathogen-specific immunity. Methods: We measured the absolute number and relative percentage of total, naive, and memory T-reg cells in HIV-infected subjects and compared these parameters with their CD4(+) T cells, viral load, levels of immune activation, and pathogen-specific immunity. Results: HIV infection was associated with an increased percentage of memory CD25(+)CD127(lo)CD4(+) T-reg cells and a decreased percentage of naive CD25(+)CD127(lo)CD4(+) T-reg cells as CD4(+) T cells declined. The level of HIV viremia inversely correlated with total, memory and naive CD25(+)CD127(lo)CD4(+) T-reg cell numbers and percentage of naive CD25(+)CD127(lo)CD4(+) T-reg cells. Lower total, memory, and naive CD25(+)CD127(lo)CD4(+) T-cell numbers were associated with higher levels of immune activation, whereas a higher percentage of CD25(+)CD127(lo)CD4(+) T-reg cells was associated with lower Candida- and HIV-specific immune responses. Conclusions: These observations suggest that CD25(+)CD127(lo)CD4(+) T-reg cells contribute to the immunodeficiency seen in HIV disease.
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