Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Ho Moon, Jong Woo Kim, Jun Ho Yang, Dong Hoon Kang, Sung Hwan Kim, Jae Jun Jung, Jong Hwa Ahn, Sung Eun Park, Kyung Nyeo Jeon, Joung Hun Byun
Summary: This study aimed to evaluate proximal left anterior descending coronary artery (LAD) disease using two factors: coronary artery tortuosity and bifurcation angle. The results showed that as the tortuosity and LM-LAD angle increased, the chances of proximal LAD lesions formation also increased. Therefore, d20*cos0 might be a useful predictor of proximal LAD stenosis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Edward L. Hannan, Ye Zhong, Kimberly Cozzens, David H. Adams, Leonard Girardi, Joanna Chikwe, Andrew Wechsler, Thoralf M. Sundt, Craig R. Smith, Jeffrey P. Gold, Stephen J. Lahey, Desmond Jordan
Summary: This study found that among patients with isolated PLAD disease, undergoing PCI, conventional CABG surgery, or minimally invasive CABG surgery showed no significant differences in mortality or composite outcomes over a 7-year follow-up period. However, conventional CABG surgery was associated with lower rates of subsequent revascularization compared to PCI and minimally invasive CABG surgery.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroto Tamaru, Kenichi Fujii, Masashi Fukunaga, Takahiro Imanaka, Kenji Kawai, Kojiro Miki, Tetsuo Horimatsu, Machiko Nishimura, Ten Saita, Akinori Sumiyoshi, Masahiko Shibuya, Tohru Masuyama, Masaharu Ishihara
Summary: This study evaluated the mechanism of decline in coronary pressure from the proximal to the distal part of the coronary arteries in the left anterior descending (LAD) versus the right coronary artery (RCA) using wave intensity analysis (WIA). The results showed that the pressure drop in the LAD was related to the distance from the ostium, while no such relationship was observed in the RCA. This may lead to gradual intracoronary pressure drop in the angiographically normal LAD.
JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Hironori Hara, Chao Gao, Hideyuki Kawashima, Rutao Wang, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, Michael J. Mack, David Holmes, Marie-Claude Morice, Stuart Head, Arie Pieter Kappetein, Thilo Noack, Piroze M. Davierwala, Friedrich W. Mohr, Scot Garg, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study investigated whether there are differences in long-term clinical outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with three-vessel disease and lesions in the proximal left anterior descending artery. The results showed that regardless of the presence or absence of lesions in the proximal left anterior descending artery, the incidence of major adverse cardiac or cerebrovascular events was significantly higher with PCI compared to CABG. However, there was no significant difference in 10-year mortality between the two procedures.
Article
Multidisciplinary Sciences
Masahiro Hada, Masahiro Hoshino, Nobutaka Wakasa, Tomoyo Sugiyama, Yoshihisa Kanaji, Masao Yamaguchi, Toru Misawa, Tatsuhiro Nagamine, Kai Nogami, Yumi Yasui, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Summary: Limited data are available regarding the influence of non-totally occluded lesions percutaneous coronary intervention (PCI) on non-target vessel coronary flow. In this study, 50 patients who underwent successful non-left anterior descending artery (non-LAD) PCI were consecutively studied, revealing a significant decrease in left anterior descending artery coronary flow velocity reserve (LAD-CFVR) after the procedure, primarily due to a reduction in LAD coronary flow velocity.
Article
Cardiac & Cardiovascular Systems
Konrad A. J. van Beek, Gijs J. van Steenbergen, Fabienne E. Vervaat, Bram C. J. H. Mulders, Bart H. van Straten, Lokien X. van Nunen, Inge F. Wijnbergen
Summary: In this retrospective study, the clinical outcomes of patients with symptomatic single-vessel coronary artery disease and hemodynamically significant diffuse left anterior descending disease treated with CABG or OMT were assessed. After a 2-year follow-up, there were no significant differences in the primary or secondary endpoints between OMT and CABG.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmed Shawky Shereef, Suaad Abdallah Ali Mosbah, Salwa Mohamed Ghoniem, Islam Elsayed Shehata
Summary: This study investigated the diagnostic performance of non-invasive resting myocardial deformation indices in identifying the functional significance of intermediate stenosis of the left anterior descending artery (LAD). The results demonstrated that the Post-systolic strain index (PSI) and the duration between Aortic valve closure (AVC) and regional peak longitudinal strain (PLS) can accurately identify functionally significant lesions.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Fay M. A. Nous, Tobias Geisler, Mariusz B. P. Kruk, Hatem Alkadhi, Kakuya Kitagawa, Rozemarijn Vliegenthart, Michaela M. Hell, Jorg Hausleiter, Patricia K. Nguyen, Ricardo P. J. Budde, Konstantin Nikolaou, Cezary Kepka, Robert Manka, Hajime Sakuma, Sachin B. Malik, Adriaan Coenen, Felix Zijlstra, Ernst Klotz, Pim van der Harst, Christoph Artzner, Admir Dedic, Francesca Pugliese, Fabian Bamberg, Koen Nieman
Summary: In this multicenter study, the combination of dynamic stress CT myocardial perfusion imaging (CT-MPI) with coronary CT angiography (CTA) showed incremental diagnostic value for the identification of hemodynamically significant coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Demosthenes G. Katritsis, Ioannis Pantos, Theodoros Zografos, Aferdita Spahillari, Antoinette de Waha, Anastasios Kopanidis, Stephanos Foussas, Peter H. Stone, Adnan Kastrati, Donald Cutlip
Summary: This study investigated the impact of anatomic and flow characteristics of left anterior descending (LAD) coronary artery stenoses on myocardial infarction development. It found that culprit lesions were located closer to the ostium, more stenosed, longer, and had a higher frequency of bifurcations, leading to flow recirculation and increased risk of coronary thrombosis. A logistic regression model using specific characteristics accurately predicted the development of culprit lesions.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ryuhei Saito, Kohei Koyama, Ken Kongoji, Kyoko Soejima
Summary: Simultaneous thrombosis in multiple coronary arteries is a rare finding in patients with acute ST-segment elevation myocardial infarction. It is difficult to detect using 12-lead electrocardiography and often leads to cardiogenic shock and fatal outcomes. Immediate revascularization and mechanical circulatory support are necessary.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Endocrinology & Metabolism
L. Wang, F. Wang, G. Su, G-H. Su
Summary: This case report summarizes the treatment experience of an acute myocardial infarction (MI) caused by a coronary artery aneurysm (CAA). The patient was successfully treated with percutaneous transluminal coronary angioplasty (PTCA) and anticoagulation therapy, and intravascular ultrasound (IVUS) assessment played a crucial role in guiding the diagnosis and treatment.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuihua Cheng, Jiong Ni, Weiwei Deng, Peijun Wang
Summary: This study investigated the association between perivascular fat attenuation index (FAI) and atherosclerotic plaque formation in the proximal region of the left anterior descending artery (LAD) within 3 years. The results showed that the length and stenosis of the myocardial bridge, as well as the perivascular FAI, were significant predictors of plaque formation. The combined predictive model incorporating these factors had higher diagnostic performance. Additionally, dynamic changes in the perivascular FAI were associated with plaque vulnerability.
ACADEMIC RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Raffaele Piccolo, Kaare H. Bonaa, Orestis Efthimiou, Olivier Varenne, Philip Urban, Christoph Kaiser, Lorenz Raeber, Adam de Belder, Wouter Remkes, Arnoud W. J. van't Hof, Goran Stankovic, Pedro A. Lemos, Tom Wilsgaard, Joerg Reifart, Alfredo E. Rodriguez, Expedito E. Ribeiro, Patrick W. J. C. Serruys, Alex Abizaid, Manel Sabate, Robert A. Byrne, Jose M. de la Torre Hernandez, William Wijns, Giovanni Esposito, Peter Jueni, Stephan Windecker, Marco Valgimigli
Summary: The study showed that compared to bare-metal stents, new-generation drug-eluting stents were associated with sustained reduction in the composite of cardiac death or myocardial infarction when used for the treatment of left anterior descending or left main coronary stenoses.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Carlo Caiati, Paolo Pollice, Fortunato Iacovelli, Francesca Sturda, Mario Erminio Lepera
Summary: E-Doppler TTE is highly feasible and reliable in detecting and assessing the severity of coronary stenosis, distinguishing between microcirculatory and epicardial causes of reduced coronary flow reserve. The method demonstrates high sensitivity and specificity in diagnosing coronary artery stenosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Ioannis Skalidis, Stephane Fournier, Nathalie Noirclerc, Olivier Muller, Emmanouil Skalidis, Niccolo Maurizi
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ioannis Skalidis, David Meier, Bernard De Bruyne, Carlos Collet, Jeroen Sonck, Thabo Mahendiran, David Rotzinger, Salah Dine Qanadli, Eric Eeckhout, Olivier Muller, Stephane Fournier
Summary: Noninvasive methods of estimating invasively measured fractional flow reserve (FFRinvasive) are actively being explored, aiming to avoid invasive procedures and drugs. This study evaluates the diagnostic performance of coronary angiography-derived FFR (FFRangio) in NSTEMI patients, demonstrating its sensitivity, specificity, and accuracy. FFRangio can precisely estimate FFRinvasive in NSTEMI patients and guide treatment decisions for coronary artery lesions without invasive procedures or drugs.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Matthieu Dietz, Christel H. Kamani, Gilles Allenbach, Vladimir Rubimbura, Stephane Fournier, Vincent Dunet, Giorgio Treglia, Marie Nicod Lalonde, Niklaus Schaefer, Eric Eeckhout, Olivier Muller, John O. Prior
Summary: Using low-dose silicon photomultipliers (SiPM) technology with Rb-82 cardiac PET/CT, impaired global stress MBF, global MFR, and regional MFC were found to be powerful predictors of major adverse cardiovascular events (MACE), outperforming traditional risk factors. However, only reduced global stress MBF independently predicted MACE.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Roxane de La Harpe, Christian W. Thorball, Claire Redin, Stephane Fournier, Olivier Mueller, Davide Strambo, Patrik Michel, Peter Vollenweider, Pedro Marques-Vidal, Jacques Fellay, Julien Vaucher
Summary: This study aimed to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores. The results showed that combining a polygenic risk score with clinical risk scores significantly improved risk reclassification for patients with intermediate risk for cardiovascular disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Juan F. Iglesias, Olivier Muller, Sylvain Losdat, Marco Roffi, David J. Kurz, Daniel Weilenmann, Christoph Kaiser, Dik Heg, Stephan Windecker, Thomas Pilgrim
Summary: In a randomized trial, ultrathin-strut biodegradable polymer sirolimus-eluting stents (BP-SES) were found to be superior to thin-strut durable polymer everolimus-eluting stents (DP-EES) in terms of target lesion failure (TLF) at 2 years among patients with ST-segment elevation myocardial infarction (STEMI). The study also revealed that regardless of whether patients underwent complex or noncomplex primary percutaneous coronary intervention (pPCI), BP-SES were superior to DP-EES.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Durig, Diego Arroyo, Marc Bedossa, Philippe Commeau, Stephane Fournier, Olivier Mueller, Paul Barragan, Herve Le Breton, Serban Puricel, Stephane Cook
Summary: This study provides data on patients presenting with acute coronary syndrome due to unprotected left main coronary artery (ULMCA) occlusion. The study found that ULMCA occlusion has a high short-term mortality rate, with 15% of patients dying in the cath lab and 42% dying in hospital. Patients who survived the index hospitalization had similar mortality rates as other st elevation myocardial infarction patients.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Farhang Aminfar, Vladimir Rubimbura, Luc Maillard, Stephane Noble, Gregoire Range, Loic Belle, Francois Derimay, Anne Bellemain-Appaix, Alexis Al Karaky, Jean-Francois Morelle, Georgios Sideris, Pascal Motreff, Olivier Muller, Julien Adjedj
Article
Pharmacology & Pharmacy
Aniek F. Markus, Victoria Y. Strauss, Edward Burn, Xintong Li, Antonella Delmestri, Christian Reich, Can Yin, Miguel A. Mayer, Juan-Manuel Ramirez-Anguita, Edelmira Marti, Katia M. C. Verhamme, Peter R. Rijnbeek, Daniel Prieto-Alhambra, Annika M. Joedicke
Summary: This study aimed to characterize the treatment of Thrombosis with thrombocytopenia syndrome (TTS) and other thromboembolic events after COVID-19 vaccination and compare them with pre-vaccination data. The results showed significant variability in the proportion of people treated across different databases before and after vaccination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Miklos Rohla, Fabrice Temperli, George C. M. Siontis, Roland Klingenberg, Baris Gencer, Nicolas Rodondi, Sarah Bar, David Nanchen, Francois Mach, Jonas D. Haner, Thomas Pilgrim, Olivier Muller, Christian M. Matter, Thomas Luscher, Marco Roffi, Dik Heg, Stephan Windecker, Lorenz Raber
Summary: This study compared the outcomes of STEMI patients undergoing PCI according to total ischemic time. The results showed that PCI performed within 12 hours of symptom onset had better outcomes, while PCI performed later than 12 hours was associated with higher mortality and target lesion failure rates. However, there was no significant difference in outcomes between PCI performed later than 48 hours and PCI performed between 12-48 hours.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Mattia Lunardi, Mamas A. Mamas, Josepa Mauri, Carmen Medina Molina, Oriol Rodriguez-Leor, Simon Eggington, Jan B. Pietzsch, Natalie L. Papo, Silke Walleser-Autiero, Andreas Baumbach, Francesco Maisano, Flavio L. Ribichini, Darren Mylotte, Emanuele Barbato, Jan J. Piek, William Wijns, Christoph K. Naber
Summary: The untimely or missed revascularization of STEMI patients during the COVID-19 pandemic has led to increased morbidity, mortality, and long-term adverse health outcomes. The analysis shows that the reduced treatment during lockdown led to a significant loss in survival and quality-adjusted life-years, as well as increased costs at the population level. The findings highlight the importance of timely revascularization and the potential long-term implications of delayed treatment for STEMI patients during a pandemic.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Niccolo Maurizi, Carlo Fumagalli, Ioannis Skalidis, Jacopo F. Imberti, Alessandro Faragli, Mattia Targetti, Henri Lu, Pierre Monney, Olivier Muller, Niccolo Marchionni, Franco Cecchi, Iacopo Olivotto
Summary: This study validated the accuracy of the D-Heart ECG device, a smartphone 8/12-Lead electrocardiograph with an image processing algorithm, for diagnosing ECG abnormalities in patients with hypertrophic cardiomyopathy. The results showed that the D-Heart ECG device had high accuracy and concordance with standard 12-Lead ECG, and the image processing algorithm provided accurate electrode placement, standardizing the quality of the examination.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Eng Hooi Tan, Danielle E. E. Robinson, Annika M. M. Joedicke, Mees Mosseveld, Katrine Bodkergaard, Carlen Reyes, Alireza Moayyeri, Annemarie Voss, Ettore Marconi, Francesco Lapi, Jonas Reinold, Katia M. C. Verhamme, Lars Pedersen, Malte Braitmaier, Marcel de Wilde, Marc Far Ruiz, Maria Aragon, Pauline Bosco-Levy, Regis Lassalle, Daniel Prieto-Alhambra, Maria T. T. Sanchez-Santos
Summary: The study examined patients prescribed osteoporosis medication and their usage patterns in European databases. Female, older patients with hypertension were the most common. Low persistence rates were observed for oral medications. These findings are important for healthcare providers to improve patient persistence with specific osteoporosis treatments.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Berta Raventos, Marti Catala, Mike Du, Yuchen Guo, Adam Black, Ger Inberg, Xintong Li, Kim Lopez-Guell, Danielle Newby, Maria de Ridder, Cesar Barboza, Talita Duarte-Salles, Katia Verhamme, Peter Rijnbeek, Daniel Prieto Alhambra, Edward Burn
Summary: The study developed an R package for calculating incidence rates and prevalence in OMOP CDM data, which was validated by comparing with published data and running benchmark analysis. The package can support descriptive epidemiological research and provide reliable estimations from large real-world datasets.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Review
Respiratory System
Delphine Vauterin, Frauke Van Vaerenbergh, Anna Vanoverschelde, Jennifer K. Quint, Katia Verhamme, Lies Lahousse
Summary: This article systematically reviews the existing methods for assessing adherence to COPD medication in healthcare databases and evaluates the reporting of influencing variables. The study finds significant variations in adherence assessment methods and recommends attention to transparency and reporting of variables.
EUROPEAN RESPIRATORY REVIEW
(2023)