Article
Multidisciplinary Sciences
Shinsuke Muraoka, Daiki Somiya, Aoi Ebata, Yuki Kumagai, Naoki Koketsu
Summary: This study investigated the prevalence of cerebrovascular events (CVEs) after PCI in the chronic phase, finding significant associations with the number of Coronary Artery Calcification (CAC) sites and post-PCI for chronic coronary syndrome. The study proposed a new and easy CAC evaluation method that accurately reflected future CVEs risk and may have clinical applicability.
Article
Materials Science, Multidisciplinary
Zakieh Alihemmati, Bahman Vahidi, Amirala Bakhshian Nik, Roza Vaez Ghaemi, Yasin Taghizadeh
Summary: The mechanical responses of endovascular stents play a crucial role in determining arterial homeostasis and vulnerability of atherosclerotic plaque. Stainless steel stents were found to apply higher stress to plaques and vessel walls, while magnesium alloy stents with similar design generated less stress. Minor improvements in magnesium alloy stents, such as increasing strut thickness, can enhance performance and reduce applied stresses, making them an optimal choice for stenting applications.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Valentino Bianco, Suresh Mulukutla, Edgar Aranda-Michel, Danny Chu, David Kaczorowski, Johannes Bonatti, Pyongsoo Yoon, Dustin Kliner, Catalin Toma, Yisi Wang, Steve Koscumb, Floyd Thoma, Forozan Navid, Derek Serna-Gallegos, Ibrahim Sultan
Summary: This study compares the outcomes of multiarterial grafting and percutaneous coronary intervention (PCI) in patients with multivessel coronary disease. It found that multiarterial grafting is associated with fewer adverse events, improved survival, and reduced hospital readmissions for appropriate patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Andrew M. Freeman, Subha Raman, Monica Aggarwal, David J. Maron, Deepak L. Bhatt, Purvi Parwani, John Osborne, James P. Earls, James K. Min, Jeroen J. Bax, Michael D. Shapiro
Summary: This article introduces a precision heart care approach that focuses on atherosclerosis as the primary target for evaluation and treatment. By directly quantifying and characterizing atherosclerosis, it aims to improve diagnosis, risk stratification, therapeutic decision-making, and personalized disease tracking. The American College of Cardiology has introduced the Atherosclerosis Treatment Algorithms, which personalize medical interventions based on coronary computed tomography angiography findings and cardiovascular risk factors, leveraging atherosclerosis burden and progression as primary targets for therapeutic intervention.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Engineering, Biomedical
Junsong Guo, Hao Wang, Ying Li, Shuang Zhu, Houxiang Hu, Zhanjun Gua
Summary: Coronary heart disease (CHD) is a leading cause of death and disability worldwide, particularly in low-income and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations, but nanotechnology offers promising alternatives for the diagnosis and treatment of CHD by utilizing the unique properties of nanomaterials. Nanomaterials can enhance early detection of CHD, facilitate targeted drug delivery and tissue engineering, and modulate inflammation and oxidative stress, addressing multiple aspects of CHD pathophysiology.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Multidisciplinary
Jia-Lu Hu, Zhi-Feng Yao, Min-Na Tang, Chun Tang, Xiao-Fan Zhao, Xi Su, Dan-Bo Lu, Qiu-Rong Li, Zhang-Sheng Wang, Yan Yan, Zeneng Wang
Summary: In this study, 78 human subjects were recruited and their gut microbiota compositions were analyzed. Specific microbial taxa associated with coronary artery disease (CAD) risks were identified, but the reproducibility of enriched taxa across different cohorts limited their use in early diagnosis and prevention of CAD. Only decreased Bacteroides abundance was found to be a reliable marker for indicating CAD progression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Changjing Feng, Rui Chen, Siting Dong, Wei Deng, Shushen Lin, Xiaomei Zhu, Wangyan Liu, Yi Xu, Xiaohu Li, Yinsu Zhu
Summary: By analyzing clinical data and CCTA images of 400 patients, it was found that FAI and NCPB were independent risk factors for coronary plaque progression. Combining conventional parameters with radiomics features derived from CCTA can better predict plaque progression.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Elias Bjornson, Dimitrios Samaras, Martin Adiels, Joel Kullberg, Fredrik Backhed, Goeran Bergstrom, Anders Gummesson
Summary: Non-alcoholic fatty liver disease (NAFLD) is associated with increased risk of coronary heart disease (CHD). ApoB-containing lipoproteins, including LDLs and TRLs, mediate a portion of the increased risk of atherosclerosis in people with NAFLD. Mediation analysis in a cohort of middle aged individuals showed that apoB, plasma triglycerides, and TRL-cholesterol mediate a significant proportion of the association between liver fat and coronary artery calcium score (CACS), with a higher degree of mediation observed for TRLs compared to LDLs. These results highlight the potential role of TRL-lowering in reducing NAFLD-associated coronary artery disease risk.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Xin-zheng Hou, En-qi Liu, Si-qi Liu, Hao Lv, Hua-feng Cui, Jing Han
Summary: This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. Multiple logistic regression and smooth curve fitting analysis were performed using the non-institutionalized US population from NHANES 2011-2018. The results showed an inverse association between serum albumin levels and CHD risk, with lower levels of serum albumin associated with a higher risk of CHD. Subgroup analysis indicated that this correlation was statistically significant in female patients over 60 years with hypertension but without diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Maria G. Hauge, Peter Damm, Klaus F. Kofoed, Anne S. Ersboll, Marianne Johansen, Per E. Sigvardsen, Mathias B. Moller, Andreas Fuchs, Jorgen T. Kuhl, Borge G. Nordestgaard, Lars Kober, Finn Gustafsson, Jesper J. Linde
Summary: This study found that younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared to women from the general population. Preeclampsia remained an independent risk factor for coronary atherosclerosis after adjusting for traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Masayuki Aoyama, Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kojiro Tanimoto, Masato Nakamura, Kazuo Kondo, Yukihiko Momiyama
Summary: This study found that plasma fortilin levels are elevated in patients with coronary artery disease (CAD), especially in those with severe disease involving multiple stenotic vessels. Fortilin levels were also found to be associated with the severity of CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Informatics
Tyler Hyungtaek Rim, Chan Joo Lee, Yih-Chung Tham, Ning Cheung, Marco Yu, Geunyoung Lee, Youngnam Kim, Daniel S. W. Ting, Crystal Chun Yuen Chong, Yoon Seong Choi, Tae Keun Yoo, Ik Hee Ryu, Su Jung Baik, Young Ah Kim, Sung Kyu Kim, Sang-Hak Lee, Byoung Kwon Lee, Seok-Min Kang, Edmund Yick Mun Wong, Hyeon Chang Kim, Sung Soo Kim, Sungha Park, Ching-Yu Cheng, Tien Yin Wong
Summary: This study developed a novel cardiovascular risk stratification system based on deep-learning-predicted coronary artery calcium (CAC) from retinal photographs, which showed promising results in predicting cardiovascular events and improving current risk stratification approaches.
LANCET DIGITAL HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Elisavet Karamanavi, David G. McVey, Sander W. van der Laan, Paulina J. Stanczyk, Gavin E. Morris, Yifan Wang, Wei Yang, Kenneth Chan, Robin N. Poston, Jun Luo, Xinmiao Zhou, Peng Gong, Peter D. Jones, Junjun Cao, Renata B. Kostogrys, Tom R. Webb, Gerard Pasterkamp, Haojie Yu, Qingzhong Xiao, Peter A. Greer, Emma J. Stringer, Nilesh J. Samani, Shu Ye
Summary: The study discovered that the CAD risk variants at the 15q26.1 locus reduce FES expression in monocytes, leading to larger atherosclerotic plaques with more monocytes/macrophages and smooth muscle cells. This finding suggests that enhancing FES activity could be a novel therapeutic approach for CAD intervention.
CIRCULATION RESEARCH
(2022)
Review
Endocrinology & Metabolism
Wen-Lu Ou-Yang, Bei Guo, Feng Xu, Xiao Lin, Fu-Xing-Zi Li, Su-Kang Shan, Feng Wu, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Ling-Qing Yuan
Summary: Despite the believed beneficial effects of irisin induced by exercise, methodological issues have raised doubts in recent studies, necessitating the use of new tools for reconfirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anantharaman Ramasamy, Ameer Hamid A. Khan, Jackie Cooper, Judit Simon, Pal Maurovich-Horvat, Retesh Bajaj, Pieter Kitslaar, Rajiv Amersey, Ajay Jain, Andrew Deaner, Johan H. C. Reiber, James C. Moon, Jouke Dijkstra, Patrick W. Serruys, Anthony Mathur, Andreas Baumbach, Ryo Torii, Francesca Pugliese, Christos Bourantas
Summary: This study evaluated the application of different coronary computed tomography angiography (CCTA) reconstruction methods in coronary atherosclerosis using intravascular ultrasound as the reference standard. The results showed that CCTA reconstruction with thinner slice thickness, smooth kernel, and highest strength advanced IR enabled more accurate quantification of the lumen and plaque in coronary atherosclerosis. Rating: 8/10
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Sant Kumar, Miao Chu, Jordi Sans-Rosello, Estefania Fernandez-Peregrina, Yirga Kahsay, Nieves Gonzalo, Carlos Hernando Salazar, Fernando Alfonso, Shengxian Tu, Hector M. Garcia-Garcia
Summary: This study used an artificial intelligence algorithm to analyze OCT findings and found that increased plaque volume is associated with the development of heart failure in TTS patients, suggesting the prognostic role of angiographically silent underlying coronary artery disease in these patients.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiayue Huang, Shengxian Tu, Shinichiro Masuda, Kai Ninomiya, Jouke Dijkstra, Miao Chu, Daixin Ding, Sean O. O. Hynes, Neil O'Leary, Yoshinobu Onuma, Patrick W. W. Serruys, William Wijns
Summary: Deep learning algorithm provides a feasible and reliable method to estimate plaque burden from OCT images, showing good concordance with IVUS and not affected by media visibility. OCT DL has a high diagnostic accuracy in identifying high plaque burden.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Letter
Cardiac & Cardiovascular Systems
Tsung-Ying Tsai, Yoshinobu Onuma, Patrick W. Serruys
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Capodanno, Roxana Mehran, Mitchell W. Krucoff, Usman Baber, Deepak L. Bhatt, Piera Capranzano, Jean-Philippe Collet, Thomas Cuisset, Giuseppe De Luca, Leonardo De Luca, Andrew Farb, Francesco Franchi, C. Michael Gibson, Joo-Yong Hahn, Myeong-Ki Hong, Stefan James, Adnan Kastrati, Takeshi Kimura, Pedro A. Lemos, Renato D. Lopes, Adrian Magee, Ryosuke Matsumura, Shuichi Mochizuki, Michelle L. O'Donoghue, Naveen L. Pereira, Sunil V. Rao, Fabiana Rollini, Yuko Shirai, Dirk Sibbing, Peter C. Smits, P. Gabriel Steg, Robert F. Storey, Jurrien ten Berg, Marco Valgimigli, Pascal Vranckx, Hirotoshi Watanabe, Stephan Windecker, Patrick W. Serruys, Robert W. Yeh, Marie-Claude Morice, Dominick J. Angiolillo
Summary: Antiplatelet therapy is the main pharmacologic treatment for preventing thrombotic or ischemic events in patients with coronary artery disease, but it also increases the risk of bleeding complications. Defining the optimal intensity of platelet inhibition based on clinical presentation and individual patient factors is challenging. Modulating antiplatelet therapy involves adjusting the type, dose, or number of drugs to balance the risks of thrombotic events and bleeding. To address confusion in terminology, this study provides an overview and definitions of different strategies of antiplatelet therapy modulation for patients with coronary artery disease.
Article
Cardiac & Cardiovascular Systems
Antonio Landi, Marco Valgimigli
Article
Multidisciplinary Sciences
Eric K. W. Poon, Masafumi Ono, Xinlei Wu, Jouke Dijkstra, Yu Sato, Matthew Kutyna, Ryo Torii, Johan H. C. Reiber, Christos V. Bourantas, Peter Barlis, Mohammed S. El-Kurdi, Martijn Cox, Renu Virmani, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study examined the effect of endothelial shear stress (ESS) on the morphological changes of a biorestorative coronary bypass graft using computational fluid dynamics (CFD) simulation. The results showed that the presence of an endoluminal flap compromised the flow and increased shear stress, potentially leading to tissue fatigue failure. This study provides important insights into the pathophysiology of biorestorative grafts.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pruthvi Chenniganahosahalli Revaiah, Bo Wang, Shinichiro Masuda, Kai Ninomiya, Shigetaka Kageyama, Nozomi Kotoku, He Xingqiang, Tsung-Ying Tsai, Yoshinobu Onuma, Adrian Wlodarczak, Shengxian Tu, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Shinichiro Masuda, Shigetaka Kageyama, Nozomi Kotoku, Kai Ninomiya, Ulrich Schneider, Ulf Teichgraber, Torsten Doenst, John D. Puskas, Jagat Narula, Kaoru Tanaka, Johan de May, Mark La Meir, Antonio L. Bartorelli, Saima Mushtaq, Giulio Pompilio, Daniele Andreini, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Shigetaka Kageyama, Kai Ninomiya, Neil O'Leary, Shinichiro Masuda, Nozomi Kotoku, Antonio Colombo, Robert-Jan van Geuns, Milan Milojevic, Michael J. Mack, Alan Soo, Scot Garg, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Pruthvi Chenniganahosahalli Revaiah, Kai Ninomiya, Nozomi Kotoku, Shinichiro Masuda, Shigetaka Kageyama, Marie Angele Morel, Bo Wang, He Xingqiang, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Xinlei Wu, Patrick W. Serruys, Xiaojie Yu, Yuanxue Sun, Yanru Chen, Daozhu Wu, Xinmin Zhang, Lianpin Wu
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yuki Ishibashi, Shinichiro Masuda, Takashi Muramatsu, Ken Kozuma, Hideyuki Kawashima, Gaku Nakazawa, Kuniaki Takahashi, Kengo Tanabe, Norihiro Kogame, Masato Nakamura, Taku Asano, Takayuki Okamura, Yosuke Miyazaki, Hiroki Tateishi, Yukio Ozaki, Shimpei Nakatani, Yuki Katagiri, Yoshihiro Morino, Kai Ninomiya, Shigetaka Kageyama, Nozomi Kotoku, Patricia O. Guimaraes, Pedro Lemos, Yoshinobu Onuma, Patrick W. Serruys
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick W. Serruys, Jiayue Huang, Shinichiro Masuda, Daixin Ding, Nozomi Kotoku, Shigetaka Kageyama, Shengxian Tu, William Wijns, Jouke Dijkstra, Sandeep Basavarajaiah, Antonio Colombo, Yoshinobu Onuma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Shinichiro Masuda, Shigetaka Kageyama, Kai Ninomiya, Nozomi Kotoku, Pruthvi Revaiah, Yoshinobu Onuma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)