Article
Multidisciplinary Sciences
Curtis Atkisson
Summary: Mentoring programs are commonly evaluated based on their impact on participants, but little is known about the variation in outcomes caused by different mentors. This study found that the choice of mentor accounts for a significant portion of variation in project success, with some mentors associated with positive outcomes and others with negative outcomes.
Article
Multidisciplinary Sciences
Yun Ting Ong, Chrystie Wan Ning Quek, Anushka Pisupati, Eleanor Kei Ying Loh, Vaishnavi Venktaramana, Min Chiam, Lalit Kumar Radha Krishna
Summary: This study evaluates the experiences of peer-mentors within a local research mentoring program and suggests that peer-mentoring not only fills the gaps in mentoring programs but also provides mentees with mentoring roles. The findings can guide the design and execution of peer-mentoring training and assessment programs for other organizations.
Article
Medicine, General & Internal
Carmen Tsang, Ahsan Huda, Max Norman, Carissa Dickerson, Vincenzo Leo, Jack Brownrigg, Mamas Mamas, Perry Elliott
Summary: This study evaluates the potential application of a machine learning algorithm in detecting undiagnosed wild type cardiac amyloidosis patients in the UK. The algorithm shows strong predictive ability when using both primary and secondary care data, and can aid in the identification of ATTRwt patients.
Article
Medicine, General & Internal
Xijie Wang, Bin Dong, Sizhe Huang, Zhaogeng Yang, Jun Ma, Jie Hu
Summary: A study in Guangdong, China identified four distinct systolic blood pressure trajectory groups in boys, with varying levels of hypertension risk in late adolescence. The research suggests that regular physical examinations could help identify individuals with higher risks for hypertension during puberty.
Article
Medicine, General & Internal
Zhuang Tian, Fang Wang, Wei Jin, Qing Zhang, Jingmin Zhou, Ping Yang, Geng Wang, Peiwen Hsu, Jing Sun, Shuyang Zhang, Yaling Han
Summary: The EXPLORER-CN trial aims to evaluate the efficacy and safety of Mavacamten in Chinese adults with symptomatic oHCM. The study will enroll 81 participants who will be randomly assigned to receive either Mavacamten or placebo. The primary efficacy endpoint is the change in Valsalva left ventricular outflow tract peak gradient determined by Doppler echocardiography.
Article
Medicine, General & Internal
Yasuo Okumura, Koichi Nagashima, Ryuta Watanabe, Katsuaki Yokoyama, Takeshi Kato, Hidehira Fukaya, Hidemori Hayashi, Shiro Nakahara, Wataru Shimizu, Yu-ki Iwasaki, Yuhi Fujimoto, Yasushi Mukai, Koichiro Ejima, Takayuki Otsuka, Shinya Suzuki, Masato Murakami, Masaomi Kimura, Masahide Harada, Junjiroh Koyama, Hideharu Okamatsu, Teiichi Yamane, Seigo Yamashita, Michifumi Tokuda, Ryohsuke Narui, Mitsuru Takami, Morio Shoda, Tomoo Harada, Ikutaro Nakajima, Katsuhito Fujiu, Kenichi Hiroshima, Kojiro Tanimoto, Tadashi Fujino, Keijiro Nakamura, Koji Kumagai, Ayako Okada, Hideki Kobayashi, Tatsuya Hayashi, Yuji Watari, Mina Hatsuno, Eizo Tachibana, Kazuki Iso, Kazumasa Sonoda, Yoshiyasu Aizawa, Akio Chikata, Satoru Sakagami, Masaru Inoue, Hitoshi Minamiguchi, Nobuhiko Makino, Kazuhiro Satomi, Yoshinao Yazaki, Hideshi Aoyagi, Makoto Ichikawa, Hironori Haruta, Takafumi Hiro, Kimie Okubo, Ken Arima, Taiki Tojo, Hajime Kihara, Satoru Miyanaga, Yoshiaki Fukuda, Koji Oiwa, Tamami Fujiishi, Masashi Akabane, Norikazu Ishikawa, Kengo Kusano, Koji Miyamoto, Haruna Tabuchi, Tomoyuki Shiozawa, Kenjiro Miyamoto, Hiroshi Mase, Kenta Murotani, REHEALTH AF study
Summary: This study aims to evaluate the benefits of ablation treatment in patients aged >= 80 years with non-valvular atrial fibrillation (AF), and to assess its impact on patients' quality of life (QoL) and long-term clinical outcomes.
Review
Medicine, General & Internal
Elli Tian, Celica Cosme, Justin Bauzon, Kavita Batra, Fadi Azar, Ariyon Schreiber
Summary: This study aims to determine the event rate of developing bradycardia while receiving remdesivir treatment compared with not receiving remdesivir in patients diagnosed with COVID-19. The analysis will be conducted by searching and screening relevant literature, and synthesizing the data qualitatively and quantitatively.
Article
Medicine, General & Internal
Ziwei Hou, Mao Xiang Zhao, Yizhen Sun, Sijing Zhang, Siyu Yao, Chi Wang, Miao Wang, Cuijuan Yun, Hao Xue, Shouling Wu
Summary: This study aimed to investigate the association between resting heart rate (RHR) and atrial fibrillation (AF) in the general population of China. The findings revealed a U-shaped relationship between RHR and incident AF, indicating that both lower and higher RHRs were associated with an increased risk of AF in the Chinese population.
Article
Medicine, General & Internal
Enoch Akowuah, Ayesha Mathias, Michelle Bardgett, Samantha Harrison, Adetayo S. Kasim, Kirsti Loughran, Emmanuel Ogundimu, Jason Trevis, Janelle Wagnild, Pasan Witharana, Helen C. Hancock, Rebecca H. Maier
Summary: Prehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impact of prehabilitation in patients undergoing cardiac surgery, despite the fact these patients are generally older and have more comorbidities and frailty. This trial will assess the feasibility and impact of a prehabilitation intervention consisting of exercise and inspiratory muscle training on preoperative functional exercise capacity in adult patients awaiting elective cardiac surgery, and determine any impact on clinical outcomes after surgery.
Article
Medicine, General & Internal
He Zhang, Xikun Han, Tuo Pan, Hai-Tao Zhang, Kai Zhong, Ze-Shi Li, Xinyi Jiang, Jun Pan, Dong-Jin Wang
Summary: This study aims to evaluate the effect of low-dose colchicine on myocardial protection during the perioperative period in patients undergoing cardiovascular surgery with CPB. A total of 132 patients will be recruited and randomized into the colchicine treatment group and control group. The primary outcome is the level of postoperative myocardial injury, and the secondary outcomes include biomarker levels for myocardial injury and inflammatory response markers, as well as poor postoperative outcomes.
Article
Medicine, General & Internal
Neda Khalilian Ekrami, Federico T. Magni, Vijay Dayalani, Isabelle C. van Gelder, Hessel F. Groenveld, Robert G. Tieleman, Ans C. P. Wiesfeld, Eng S. Tan, Michiel Rienstra, Yuri Blaauw, Bart A. Mulder
Summary: This study aimed to compare the effectiveness and safety of cryoballoon ablation in male and female patients and identify gender-related factors associated with clinical outcomes.
Article
Medicine, General & Internal
Anna Lisa Kunz, Anton Schonstein, Philipp Bahrmann, Evangelos Giannitsis, Hans-Werner Wahl, Hugo A. Katus, Norbert Frey, Anke Bahrmann
Summary: This study aims to estimate the association of commonly used biological age-related biomarkers high-sensitivity troponin-T (hs-TnT), C reactive protein (CRP), and haemoglobin (Hb) with all-cause mortality among older patients in the emergency department. The results showed that positive results in these biomarkers were associated with increased all-cause mortality, and the number of positive age-related biomarkers appeared to strongly indicate the risk of mortality.
Article
Medicine, General & Internal
Xiang Xiao, Xinyi Deng, Gaoyu Zhang, Mengru Liu, Dongliang Fu, Peng Yang, Xianlun Li, Hong Jiang
Summary: This study aims to find a new way to control blood pressure in hypertensive patients through respiratory feedback training based on cardiopulmonary resonance indices. The study will recruit 176 healthy individuals and 352 hypertensive patients, randomly dividing the hypertensive patients into a conventional treatment group and an experiment group. The experiment group will undergo additional daily respiratory training for 6 months. The primary outcome is the difference in clinical systolic blood pressure between the two groups after 6 months of intervention.
Article
Multidisciplinary Sciences
Shuo Li, Haomin Wang, Wei Ma, Lin Qiu, Kailun Xia, Yong Zhang, Haojie Lu, Mengjia Zhu, Xiaoping Liang, Xun-En Wu, Huarun Liang, Yingying Zhang
Summary: Continuous and reliable monitoring of blood pressure and cardiac function is achieved through an intelligent wearable system based on a conformal and flexible strain sensor array and deep learning neural networks. The sensor array acquires precise and feature-rich pulse waves from the wrist without precise positioning, allowing for high-quality monitoring of blood pressure and cardiac function parameters. This system has the potential to contribute to personalized health management, precise and early diagnosis, and remote treatment.
Article
Medicine, General & Internal
Cijun Luo, Wenhui Wu, Changwei Wu, Hongling Qiu, Ping Yuan, Rong Jiang, Qinhua Zhao, Sugang Gong, Rui Zhang, Jinling Li, Jing He, Jinming Liu, Lan Wang
Summary: The study revealed a high prevalence of abnormal liver function in IPAH patients with predominantly cholestatic enzyme profiles. Patients with mixed liver dysfunction had worse prognosis, and bilirubin and GGT levels were positively associated with all-cause mortality. A new Liver Function Predict Index (LFPI) was constructed as a simple predictor for IPAH prognosis, with an identified cut-off value of 2.729.
