Article
Ophthalmology
Johanna Rankenberg, Stefan Rakete, Brandie D. Wagner, Jennifer L. Patnaik, Christian Henning, Anne Lynch, Marcus A. Glomb, Ram H. Nagaraj
Summary: The levels of AGEs in human lens capsules during cataract surgery were found to be similar between diabetic and non-diabetic patients, except for significantly higher levels of glucosepane in diabetic patients, which may explain the similar incidence of posterior capsule opacification between the two groups.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Endocrinology & Metabolism
Xue-Meng Zhang, Yuan Gao, Meng-Xue Yang, Xiao-Di Zheng, Rui Zhang, Yue-Yue Wu, Miao Zeng, Qian Yang, Zhi-Yan Yu, Jun Liu, Bing-Bing Zha, Bo Yang
Summary: Diabetic kidney disease (DKD) is a complication of diabetes, and early detection is crucial. This study found that the noninvasive lens AGEs fluorescence detection method can be used to predict the occurrence of DKD, providing clinical value in diagnosing DKD in patients with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Nianjie Feng, Yang Shen, Chuanqin Hu, Jiangying Tan, Zhao Huang, Chao Wang, Zhiqiang Guo, Qian Wu, Juan Xiao
Summary: LSOPC demonstrates inhibitory effect on AGE formation in yogurt, positively affecting antioxidant activity and physicochemical properties.
FRONTIERS IN NUTRITION
(2021)
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Organic
Yudai Suwa, Emiko Yanase
Summary: This study clarified the chemical changes in procyanidins upon oxidation and determined the structures of four compounds using various oxidation methods, including enzymatic oxidation. The different ratios of oxidized products formed in water compared with organic solvents in the case of procyanidin B2 are attributed to the solvent-dependent conformational differences of procyanidin.
Article
Chemistry, Multidisciplinary
Belal Hanafy, Gareth W. Cave, Yvonne Barnett, Barbara K. Pierscionek
Summary: Nanoceria delays cataract progression through multiple mechanisms including mimicking catalase, improving cellular redox state, and inhibiting glucose-induced glycation of lens proteins.
Review
Dentistry, Oral Surgery & Medicine
Julie Toby Thomas, Betsy Joseph, Timo Sorsa, Matti Mauramo, Sukumaran Anil, Tuomas Waltimo
Summary: The systematic review aims to compare the levels of advanced glycation end products (AGEs) and RAGE expression in diabetic periodontitis patients with non-diabetic periodontitis patients and to identify the relationship of AGE and RAGE levels with periodontal disease severity.
Article
Agriculture, Multidisciplinary
Hong Sun, Juan Chen, Lili Sun, Bimin Shi, Jianzhong Li
Summary: Research found that silencing TXNIP can reduce renal lipid deposition, inhibit cholesterol uptake and synthesis through regulating SCAP, and may be a potential therapeutic target for treating a diabetic fatty kidney.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Chemistry, Multidisciplinary
Zhengwen Cai, Yong Li, Long Bai, Jiangshan Xu, Zhiqiang Liu, Tianxu Zhang, Shaojingya Gao, Yunfeng Lin
Summary: This study developed a novel nanomedicine that targets RAGE and suppresses AGE-induced inflammation. The nucleic acid drug effectively downregulates inflammation and inhibits the spread of cell death signals, providing a strategy for the treatment of diabetic complications and age-related diseases.
Article
Oncology
Yuri Doki, Yosuke Nakazawa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Hiroomi Tamura, Megumi Funakoshi-Tago
Summary: This study found that the levels of AGEs in lens proteins increase with age in mice, and the flavanone compound hesperetin (Hst) and its derivatives can prevent AGE formation and modification of lens proteins. These findings suggest that Hst and its derivatives may be good candidates for the prevention of presbyopia and cataracts.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Nutrition & Dietetics
Mieke Steenbeke, Ignace De Decker, Sophie Marchand, Griet Glorieux, Wim Van Biesen, Bruno Lapauw, Joris R. Delanghe, Marijn M. Speeckaert
Summary: The study found that a diet restricted in AGE consumption for two months did not affect AGE content in the body or sRAGE concentration in the blood. The impact of blood glucose levels appears to be more significant than the consumption of dAGEs.
Article
Endocrinology & Metabolism
Liu Gao, Chang Liu, Pan Hu, Na Wang, Xiaoxue Bao, Bin Wang, Ke Wang, Yukun Li, Peng Xue
Summary: The objective of this study was to analyze the quantitative association between advanced glycation end products (AGEs) and adjusted FRAX by rheumatoid arthritis (FRAX-RA) in postmenopausal type 2 diabetic (T2D) patients. The optimal cutoff value of AGEs was also explored, which was aimed at demonstrating the potential value of AGEs on evaluating osteoporotic fracture risk in postmenopausal T2D patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ch Uday Kumar, Udaykanth Suryavanshi, Vishwaraj Sontake, P. Yadagiri Reddy, Rajeshwer S. Sankhala, Musti J. Swamy, G. Bhanuprakash Reddy
Summary: Cataract caused by the aggregation of lens crystallins is a major cause of blindness worldwide. The chaperone-like activity of alpha-crystallin plays a crucial role in maintaining lens transparency. Increased sorbitol accumulation due to hyperglycemia is believed to be a mechanism for diabetic cataract, but its effect on alpha-crystallin structure and function is not yet understood. In this exploratory study, different concentrations of sorbitol were found to have contrasting effects on alpha-crystallin, with lower concentrations leading to decreased chaperone-like activity and subtle structural changes. Further research is needed to understand the mechanisms and implications of these effects on cataractogenesis.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Nutrition & Dietetics
Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, G. Bhanuprakash Reddy, Hemalatha Rajkumar, Umesh Kapil, Sila Deb, Anura Kurpad, Harshpal S. Sachdev
Summary: This study derived reference serum zinc concentration (SZC) cut-offs for apparently healthy Indian children and adolescents, and measured the prevalence of zinc deficiency. The findings showed that the present study's SZC cut-offs were lower than the international standards, indicating a lower prevalence of zinc deficiency in India.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Singareddy Sreenivasa Reddy, Utkarsh Reddy Addi, Raghu Pullakhandam, G. Bhanuprakash Reddy
Summary: The study found that zinc deficiency affects skeletal muscle proteostasis and mitochondrial biology in growing rats, leading to decreased cell size and increased cell death. It also activates the ubiquitin-proteasome system, declines autophagy, and affects mitochondrial fission, fusion, transcription, and oxidative phosphorylation components.
Review
Food Science & Technology
Shalini Rajagopal, Ayam Gupta, Rabia Parveen, Nidhi Shukla, Sanghati Bhattacharya, Jalaja Naravula, S. Anil Kumar, Praveen Mathur, Anita Simlot, Sudhir Mehta, Chhagan Bihari, Sumita Mehta, Ashwani Kumar Mishra, Bipin G. Nair, Krishna Mohan Medicherla, G. Bhanuprakash Reddy, Nese Sreenivasulu, P. B. Kavi Kishor, Prashanth Suravajhala
Summary: This review discusses the deficiency of vitamin K and its potential health impacts, highlighting the challenges in diagnosis and molecular physiology from a nutrigenomics perspective. It also mentions the use of foodomics technologies to study vitamin K deficiency and its effects on human health.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Chekkilla Uday Kumar, Singareddy Sreenivasa Reddy, Palla Suryanarayana, Madhoosudan A. Patil, Periketi Madhusudana Chary, Putcha Uday Kumar, Geereddy Bhanuprakash Reddy
Summary: This study investigated the preventive effect of cinnamon feeding on diabetic cardiomyopathy and its mechanisms. The results showed that cinnamon feeding can prevent oxidative stress and myocardial alterations in the heart of diabetic rats.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Utkarsh Reddy Addi, Sneha Jakhotia, S. Sreenivasa Reddy, G. Bhanuprakash Reddy
Summary: Aging is a major risk factor for diseases, including neurodegenerative disorders. This study found that the accumulation of AGEs in the brain increases with age, which may lead to neuronal damage by affecting ER homeostasis, UPS, autophagic flux, and neuronal growth factors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Letter
Nutrition & Dietetics
Harshpal S. Sachdev, G. Bhanuprakash Reddy, Raghu Pullakhandam, Santu Ghosh, Hemalatha Rajkumar, Anura V. Kurpad
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
M. Nagaraju, Krishna K. Kalahasti, K. Prathap Reddy, Utkarsh R. Addi, M. Satyavani, G. Bhanuprakash Reddy, S. Sreenivasa Reddy
Summary: The functional food mix comprising turmeric, amla, and black pepper (TAB) showed a prophylactic effect against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. TAB partially ameliorated the increase in inflammatory cytokines and prevented lung histopathological changes. Furthermore, TAB suppressed ER stress and apoptotic markers in the lung.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Biochemistry & Molecular Biology
V. Sudhakar Reddy, G. Bhanuprakash Reddy
Summary: The small heat shock protein (sHsp) family includes proteins that are induced in response to external stimuli and those that are constitutively expressed. These proteins function as molecular chaperones, protecting cells and maintaining their structure. Short sequences derived from sHsps, known as mini-peptides/mini-chaperones, have shown therapeutic potential in various diseases due to their small size and easy uptake into cells. However, their limited stability and enzymatic degradation in circulation have hindered their therapeutic efficacy. Carrier molecules such as nanoparticles and cell penetration peptides have been used to enhance the effectiveness of sHsp mini-chaperones. This review highlights recent advances in the therapeutic potential of sHsp-derived mini-chaperones and strategies for improving their efficacy.
Review
Biochemistry & Molecular Biology
Digambar Kavitake, Palanisamy Bruntha Devi, Cedric Delattre, G. Bhanuprakash Reddy, Prathapkumar Halady Shetty
Summary: Exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) have unique characteristics that make them of great interest. Enterococcus spp. and other LAB genera have been extensively studied for their EPS production. Enterococcus EPS have various functional and technological properties with potential commercial applications. The review focuses on the characterization, bioactive potentials, and potential applications of Enterococcus EPS from different sources.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Pandarinath Savitikadi, Ramesh Gogulothu, Ayesha Ismail, Geereddy Bhanuprakash Reddy, Vadde Sudhakar Reddy
Summary: This study investigated the effects of a maternal low-protein diet and postnatal rehabilitation on muscle protein degradation in adult offspring. The results showed that chronic protein restriction led to muscle atrophy and increased protein degradation, while postnatal rehabilitation had little effect on these processes.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Digambar Kavitake, Swati Tiwari, Irshad Ahmad Shah, Palanisamy Bruntha Devi, Cedric Delattre, G. Bhanuprakash Reddy, Prathapkumar Halady Shetty
Summary: In recent years, there has been increasing interest in exopolysaccharides (EPS) of microbial origin, particularly those produced by lactic acid bacteria (LAB). These EPS exhibit diverse structures and physico-chemical properties with many potential applications, including anti-microbial and immune-modulatory effects. This review focuses on the anti-bacterial, anti-fungal, anti-viral, and anti-biofilm properties of LAB EPS, discussing their modes of action against pathogens. Additionally, the potential roles of LAB EPS in food preservation, food safety, and human health are explored.
Article
Biochemistry & Molecular Biology
Prathap Reddy Kallamadi, Deepshika Esari, Utkarsh Reddy Addi, Rushendhiran Kesavan, Uday Kumar Putcha, Siddavaram Nagini, Geereddy Bhanuprakash Reddy
Summary: Patients with comorbidities of obesity and diabetes are at high risk of breast cancer development and worse outcomes. This study investigated the molecular mechanisms underlying the increased risks using a rat model. The results showed that obese rats had higher tumor incidence and shorter latency periods, as well as elevated levels of markers for cell proliferation and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Paromita Banerjee, G. Bhanuprakash Reddy, Hrusikesh Panda, Kiran Kumar Angadi, Thirupathi Reddy, SubbaRao M. Gavaravarapu
Summary: This study aimed to assess the metabolic and lifestyle risk factors among IT employees in India. The results indicate a high risk of developing non-communicable diseases among employees in the IT industry, highlighting the need for lifestyle and workplace interventions.
Article
Nutrition & Dietetics
Tattari Shalini, Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, Hemalatha Rajkumar, Harshpal S. Sachdev, Anura V. Kurpad, Geereddy Bhanuprakash Reddy
Summary: There is a high prevalence of vitamin B-12 and folate deficiency among Indian children and adolescents, especially in adolescents. Although there are regional variations, there are no rural-urban differences. These findings suggest the need for further investigation.
